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The map label for this gene is thrC [H]

Identifier: 153936037

GI number: 153936037

Start: 1749896

End: 1751377

Strand: Direct

Name: thrC [H]

Synonym: CLC_1664

Alternate gene names: 153936037

Gene position: 1749896-1751377 (Clockwise)

Preceding gene: 153935827

Following gene: 153936225

Centisome position: 46.53

GC content: 29.76

Gene sequence:

>1482_bases
TTGTTTTATAAAAGTACTAGGGGAGAAGGGAAAAATGTTAAAGCATCAGAGGCAATAATTAGAGGAATAGCTGAGGATGG
AGGATTATATGTACCAGAAGAGCTTCCTAAAATAGATAAGAGTTTTAAAGAATTAAAAAACATGAATTATAAGGAATTAG
CATTTTATATTATGAAAAAGTACTTTGATGATTTTAATGAAGAGGAACTTAAAGAATGTATAGATAAAGCCTATGACAGT
AAGTTTGAGAATCCTCTTATAGCACCATTAAATTATAAAGCTGGAGCATATTTTTTAGAACTTTATCATGGGAAAACATT
AGCCTTTAAAGATATGGCTTTAAGTATACTTCCGCACCTTTTAAAAACCTCAGCAAAAAAGATGAATATAACTAAAGACA
TAGTTATATTAACAGCTACTTCAGGAGATACTGGAAAAGCTGCTCTAGAAGGATTTGATAGTGTAGAGGGCACAAAGATA
GTGGTATTTTATCCTAAGGATGGGGTAAGTGAAATTCAAAAAAGACAGATGGTTACACAAGAGGGGAAGAATACTTTCGT
AGTAGGCATAGATGGGAATTTCGATGATGCTCAAAGTGGAGTTAAGGAAATATTTAATGATAGAGATTTTAATGGATTAT
TAGAGGAAAGGGGATACATGTTTTCCTCTGCTAATTCTATAAATATAGGAAGACTAGTACCGCAAATAGTATACTATGTT
TATTCTTATGTGAATCTACTTAAAGATAAAAAAGTAGGGGAAGGAGAAAATATAAACATAGTTGTTCCTACAGGAAATTT
TGGTAACATTTTAGCAGCCTTTTACGCTAAAAATATGGGAATACCAGTGGGAAGATTAATTTGTGCATCTAATGAGAATA
AGGTGCTAACAGATTTTATAAATACTGGAATATACGATAGGAGAAGAAAATTTTCTGTTACTAATTCTCCTTCTATGGAT
ATTTTAATATCTAGTAACTTGGAAAGATTTTTGTATGAAATAAGTGGAAAAGATTCACGCCTTATAAAAAATCTCATGAC
AGAACTTAAAGAAAAGGGTAAATATGAGATAACAGAGGAAATGAAGAAGAGATTAGATATATTATATGGAGATTTTTCGG
ATGAAGATGATACACTTAAAGCTATTGAAAAAGTCTATGAAAGTTCTGATTATCTTATAGATACTCATACTGCAGTAGCT
TATGATGTTTATGAAAAATATAAAAATAAAACAGGAGATAATAGTGCTACTATAATAGCATCTACCGCAAGTCCATTTAA
ATTTCCCAAAAGTATAAATGAAGTATTAGATATGGGACATGAAAATGCTTCAGATTTTGAATTAGTTAATTTATTTTCAG
ATAAATTAAATTTAAAGTTGCCTAAAGGATTAGAAGGACTAGAGGAAAAAGAAATTTGTCATAAGGTCACTTGTAAAAAG
GATGAAATGAAGAAAGTAATTAAAAATTTTTTAGGAATATAG

Upstream 100 bases:

>100_bases
GACAGAATAATATATATATTATAACTTTAACAGAAGAGGAAAAAATAGAAAATGTAATAAAACATATAAAAATATATTTC
GTTAAAAGGGGGCTAATAAG

Downstream 100 bases:

>100_bases
GTGATTAAAATGGTAGAAGTTAGAGTGCCTGCTACAAGTGCAAATATAGGACCAGGATTTGATTGCTTAGGTGTAGCAGT
AAATATGTATAATAAATTCT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MFYKSTRGEGKNVKASEAIIRGIAEDGGLYVPEELPKIDKSFKELKNMNYKELAFYIMKKYFDDFNEEELKECIDKAYDS
KFENPLIAPLNYKAGAYFLELYHGKTLAFKDMALSILPHLLKTSAKKMNITKDIVILTATSGDTGKAALEGFDSVEGTKI
VVFYPKDGVSEIQKRQMVTQEGKNTFVVGIDGNFDDAQSGVKEIFNDRDFNGLLEERGYMFSSANSINIGRLVPQIVYYV
YSYVNLLKDKKVGEGENINIVVPTGNFGNILAAFYAKNMGIPVGRLICASNENKVLTDFINTGIYDRRRKFSVTNSPSMD
ILISSNLERFLYEISGKDSRLIKNLMTELKEKGKYEITEEMKKRLDILYGDFSDEDDTLKAIEKVYESSDYLIDTHTAVA
YDVYEKYKNKTGDNSATIIASTASPFKFPKSINEVLDMGHENASDFELVNLFSDKLNLKLPKGLEGLEEKEICHKVTCKK
DEMKKVIKNFLGI

Sequences:

>Translated_493_residues
MFYKSTRGEGKNVKASEAIIRGIAEDGGLYVPEELPKIDKSFKELKNMNYKELAFYIMKKYFDDFNEEELKECIDKAYDS
KFENPLIAPLNYKAGAYFLELYHGKTLAFKDMALSILPHLLKTSAKKMNITKDIVILTATSGDTGKAALEGFDSVEGTKI
VVFYPKDGVSEIQKRQMVTQEGKNTFVVGIDGNFDDAQSGVKEIFNDRDFNGLLEERGYMFSSANSINIGRLVPQIVYYV
YSYVNLLKDKKVGEGENINIVVPTGNFGNILAAFYAKNMGIPVGRLICASNENKVLTDFINTGIYDRRRKFSVTNSPSMD
ILISSNLERFLYEISGKDSRLIKNLMTELKEKGKYEITEEMKKRLDILYGDFSDEDDTLKAIEKVYESSDYLIDTHTAVA
YDVYEKYKNKTGDNSATIIASTASPFKFPKSINEVLDMGHENASDFELVNLFSDKLNLKLPKGLEGLEEKEICHKVTCKK
DEMKKVIKNFLGI
>Mature_493_residues
MFYKSTRGEGKNVKASEAIIRGIAEDGGLYVPEELPKIDKSFKELKNMNYKELAFYIMKKYFDDFNEEELKECIDKAYDS
KFENPLIAPLNYKAGAYFLELYHGKTLAFKDMALSILPHLLKTSAKKMNITKDIVILTATSGDTGKAALEGFDSVEGTKI
VVFYPKDGVSEIQKRQMVTQEGKNTFVVGIDGNFDDAQSGVKEIFNDRDFNGLLEERGYMFSSANSINIGRLVPQIVYYV
YSYVNLLKDKKVGEGENINIVVPTGNFGNILAAFYAKNMGIPVGRLICASNENKVLTDFINTGIYDRRRKFSVTNSPSMD
ILISSNLERFLYEISGKDSRLIKNLMTELKEKGKYEITEEMKKRLDILYGDFSDEDDTLKAIEKVYESSDYLIDTHTAVA
YDVYEKYKNKTGDNSATIIASTASPFKFPKSINEVLDMGHENASDFELVNLFSDKLNLKLPKGLEGLEEKEICHKVTCKK
DEMKKVIKNFLGI

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=436, Percent_Identity=42.4311926605505, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI149193323, Length=459, Percent_Identity=29.8474945533769, Blast_Score=220, Evalue=3e-57,
Organism=Escherichia coli, GI1786185, Length=459, Percent_Identity=28.7581699346405, Blast_Score=170, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6319901, Length=468, Percent_Identity=35.6837606837607, Blast_Score=280, Evalue=3e-76,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 55765; Mature: 55765

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYKSTRGEGKNVKASEAIIRGIAEDGGLYVPEELPKIDKSFKELKNMNYKELAFYIMKK
CCCCCCCCCCCCCHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
YFDDFNEEELKECIDKAYDSKFENPLIAPLNYKAGAYFLELYHGKTLAFKDMALSILPHL
HHCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEEECCCEEHHHHHHHHHHHHH
LKTSAKKMNITKDIVILTATSGDTGKAALEGFDSVEGTKIVVFYPKDGVSEIQKRQMVTQ
HHCCHHHCCCCEEEEEEEECCCCCCHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
EGKNTFVVGIDGNFDDAQSGVKEIFNDRDFNGLLEERGYMFSSANSINIGRLVPQIVYYV
CCCCEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHCCCEEECCCCCCHHHHHHHHHHHH
YSYVNLLKDKKVGEGENINIVVPTGNFGNILAAFYAKNMGIPVGRLICASNENKVLTDFI
HHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCHHEEEEECCCCCCHHHHH
NTGIYDRRRKFSVTNSPSMDILISSNLERFLYEISGKDSRLIKNLMTELKEKGKYEITEE
HCCHHHHHHCEECCCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHH
MKKRLDILYGDFSDEDDTLKAIEKVYESSDYLIDTHTAVAYDVYEKYKNKTGDNSATIIA
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHCCCCCCCEEEEE
STASPFKFPKSINEVLDMGHENASDFELVNLFSDKLNLKLPKGLEGLEEKEICHKVTCKK
ECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCEECCCCCCCCHHHHHHHHHCCCH
DEMKKVIKNFLGI
HHHHHHHHHHHCC
>Mature Secondary Structure
MFYKSTRGEGKNVKASEAIIRGIAEDGGLYVPEELPKIDKSFKELKNMNYKELAFYIMKK
CCCCCCCCCCCCCHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
YFDDFNEEELKECIDKAYDSKFENPLIAPLNYKAGAYFLELYHGKTLAFKDMALSILPHL
HHCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEEECCCEEHHHHHHHHHHHHH
LKTSAKKMNITKDIVILTATSGDTGKAALEGFDSVEGTKIVVFYPKDGVSEIQKRQMVTQ
HHCCHHHCCCCEEEEEEEECCCCCCHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
EGKNTFVVGIDGNFDDAQSGVKEIFNDRDFNGLLEERGYMFSSANSINIGRLVPQIVYYV
CCCCEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHCCCEEECCCCCCHHHHHHHHHHHH
YSYVNLLKDKKVGEGENINIVVPTGNFGNILAAFYAKNMGIPVGRLICASNENKVLTDFI
HHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCHHEEEEECCCCCCHHHHH
NTGIYDRRRKFSVTNSPSMDILISSNLERFLYEISGKDSRLIKNLMTELKEKGKYEITEE
HCCHHHHHHCEECCCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHH
MKKRLDILYGDFSDEDDTLKAIEKVYESSDYLIDTHTAVAYDVYEKYKNKTGDNSATIIA
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHCCCCCCCEEEEE
STASPFKFPKSINEVLDMGHENASDFELVNLFSDKLNLKLPKGLEGLEEKEICHKVTCKK
ECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCEECCCCCCCCHHHHHHHHHCCCH
DEMKKVIKNFLGI
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]