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The map label for this gene is acoC [H]

Identifier: 153935441

GI number: 153935441

Start: 1742272

End: 1743582

Strand: Direct

Name: acoC [H]

Synonym: CLC_1659

Alternate gene names: 153935441

Gene position: 1742272-1743582 (Clockwise)

Preceding gene: 153934661

Following gene: 153937778

Centisome position: 46.33

GC content: 32.04

Gene sequence:

>1311_bases
ATGGGTAAGCTAGAGGTTATGCCAAAGCTGGGATTAACTATGACAGAGGGTGAACTAGTTAAATGGCATAAAAAAGAAGG
AGATACTATAAAGGTAGGAGAGACCTTATTTGATGTAACAACGGATAAATTGACTAATAATGTGGAAGCAAAGGCTGATG
GAATTGTAAGAAAGATTTTAGTAGATGAAGGTACAGTAGTTGAATGTTTGAAACCAGTAGCCATAATTGGAGATAAAGAT
GAGGATATATCAAATCTATTAAGGGAATCTTTGCAAGATAGTAAGGGAAATGAGGTAGAAAAAGAAGTTAAAGAATCTAA
GGAGGAGATAAAAGATAATAGGAAAATAAAAAAAGGAGAAAGAACAAAGATATCCCCAATAGCAAAAAGACTTGCAAAGG
AAAATGATGTGGATATTCAACTATTAGATGGAACAGGGCCTGAAGGAAGAATAGTTTTAAAAGATGTAGAATCATATATA
GAAAATAATAAGAATAATATTAAAACTTCTCCAGTAGCAGAGAAGATAGCTAAAGATTTAGGCGTTAATTTAGAAGGTAT
AAAGAAAGACGGAAGAATAATGAAAGATGATATATTAGAATTTATCCAAAAATCTATTCCTTCTGTAGGAGAAGATTTAA
TGGATAGAAGAGTAAAAATGAGCACTATGAGAAAAGTAATTGCCTCAAGAATGAGCGAAAGTTCAAAGATTTCTCCTACA
GTGACCTATGACATTGAAGTGGATATGACTAATTTAAAAAGGTTAAAGGAACAAATTAAAAATGAATGGAAAGTTACTTA
TACAGATTTATTAGTAAAAATAGTTTCTAAAGTACTCATTCAATATCCTTTAGTTAATTGCTCAATAGAAGGAGATGAAA
TGATTTTTAGAAATTATTCAAATATTGGAGTAGCAGTGGCTTTAGAGGAAGGCCTTGTGGTACCAGTGGTTAAATATGCA
AACCAAAAGGGACTAAAGGATATTTCTATAGAAGTGAAAGAATTAGCCCACAAAGCTAAAAATAATGGACTTACTGAAGA
AAATAGTACTGGAGGAACTTTTACTATAACTAATCTTGGTATGTTTGGTATAAAGTCTTTTTCTCCAATTATAAATCAGC
CTGAAGTAGCTATATTAGGTGTGAATATGATAACTAATACTCCAGTGGTAGAGAATGGAGAAATAGTGATAAAACCTCTT
ATGAGTTTATCTCTTACTGCAGACCATAGGGCGGTAGATGGTGCTGTAGCGGCTCAATTCTTAAAAGCAGTTAAAAAATA
TATGGAAAAGCCAGAGTTGCTTATATTGTAG

Upstream 100 bases:

>100_bases
CTATTAGGGTTAATATAAAATCCGCATTAGAATTAGCACAAGCTCAGGGATTTTTTAATATATAACAATATTATTTACAA
TAGTTAAAGGAGGATTGTTT

Downstream 100 bases:

>100_bases
GAGGGATAAAAAATGAAGCTAGTAGTTATTGGAGGAGGACCAGGAGGATATGTGGCAGCTATTCGTGGAGCGCAATTAGG
AGCAGAGGTTACTCTTATTG

Product: TPP-dependent acetoin dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase

Products: NA

Alternate protein names: Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2 [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MGKLEVMPKLGLTMTEGELVKWHKKEGDTIKVGETLFDVTTDKLTNNVEAKADGIVRKILVDEGTVVECLKPVAIIGDKD
EDISNLLRESLQDSKGNEVEKEVKESKEEIKDNRKIKKGERTKISPIAKRLAKENDVDIQLLDGTGPEGRIVLKDVESYI
ENNKNNIKTSPVAEKIAKDLGVNLEGIKKDGRIMKDDILEFIQKSIPSVGEDLMDRRVKMSTMRKVIASRMSESSKISPT
VTYDIEVDMTNLKRLKEQIKNEWKVTYTDLLVKIVSKVLIQYPLVNCSIEGDEMIFRNYSNIGVAVALEEGLVVPVVKYA
NQKGLKDISIEVKELAHKAKNNGLTEENSTGGTFTITNLGMFGIKSFSPIINQPEVAILGVNMITNTPVVENGEIVIKPL
MSLSLTADHRAVDGAVAAQFLKAVKKYMEKPELLIL

Sequences:

>Translated_436_residues
MGKLEVMPKLGLTMTEGELVKWHKKEGDTIKVGETLFDVTTDKLTNNVEAKADGIVRKILVDEGTVVECLKPVAIIGDKD
EDISNLLRESLQDSKGNEVEKEVKESKEEIKDNRKIKKGERTKISPIAKRLAKENDVDIQLLDGTGPEGRIVLKDVESYI
ENNKNNIKTSPVAEKIAKDLGVNLEGIKKDGRIMKDDILEFIQKSIPSVGEDLMDRRVKMSTMRKVIASRMSESSKISPT
VTYDIEVDMTNLKRLKEQIKNEWKVTYTDLLVKIVSKVLIQYPLVNCSIEGDEMIFRNYSNIGVAVALEEGLVVPVVKYA
NQKGLKDISIEVKELAHKAKNNGLTEENSTGGTFTITNLGMFGIKSFSPIINQPEVAILGVNMITNTPVVENGEIVIKPL
MSLSLTADHRAVDGAVAAQFLKAVKKYMEKPELLIL
>Mature_435_residues
GKLEVMPKLGLTMTEGELVKWHKKEGDTIKVGETLFDVTTDKLTNNVEAKADGIVRKILVDEGTVVECLKPVAIIGDKDE
DISNLLRESLQDSKGNEVEKEVKESKEEIKDNRKIKKGERTKISPIAKRLAKENDVDIQLLDGTGPEGRIVLKDVESYIE
NNKNNIKTSPVAEKIAKDLGVNLEGIKKDGRIMKDDILEFIQKSIPSVGEDLMDRRVKMSTMRKVIASRMSESSKISPTV
TYDIEVDMTNLKRLKEQIKNEWKVTYTDLLVKIVSKVLIQYPLVNCSIEGDEMIFRNYSNIGVAVALEEGLVVPVVKYAN
QKGLKDISIEVKELAHKAKNNGLTEENSTGGTFTITNLGMFGIKSFSPIINQPEVAILGVNMITNTPVVENGEIVIKPLM
SLSLTADHRAVDGAVAAQFLKAVKKYMEKPELLIL

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0508

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI31711992, Length=461, Percent_Identity=31.236442516269, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI203098816, Length=456, Percent_Identity=28.2894736842105, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI203098753, Length=456, Percent_Identity=28.2894736842105, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI110671329, Length=425, Percent_Identity=29.4117647058824, Blast_Score=171, Evalue=9e-43,
Organism=Homo sapiens, GI19923748, Length=239, Percent_Identity=37.2384937238494, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI260898739, Length=165, Percent_Identity=36.969696969697, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1786946, Length=437, Percent_Identity=31.1212814645309, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI1786305, Length=313, Percent_Identity=30.0319488817891, Blast_Score=149, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17560088, Length=455, Percent_Identity=29.2307692307692, Blast_Score=174, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI25146366, Length=226, Percent_Identity=34.5132743362832, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17537937, Length=450, Percent_Identity=26, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17538894, Length=315, Percent_Identity=30.4761904761905, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320352, Length=226, Percent_Identity=42.9203539823009, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6324258, Length=471, Percent_Identity=29.9363057324841, Blast_Score=179, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6321632, Length=205, Percent_Identity=29.7560975609756, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24645909, Length=227, Percent_Identity=37.0044052863436, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI18859875, Length=463, Percent_Identity=26.7818574514039, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24582497, Length=236, Percent_Identity=31.3559322033898, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI20129315, Length=236, Percent_Identity=31.3559322033898, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3096 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR001078
- InterPro:   IPR006257
- InterPro:   IPR000089
- InterPro:   IPR023213
- InterPro:   IPR004167
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00198 2-oxoacid_dh; PF00364 Biotin_lipoyl; PF02817 E3_binding [H]

EC number: =2.3.1.12 [H]

Molecular weight: Translated: 48434; Mature: 48303

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKLEVMPKLGLTMTEGELVKWHKKEGDTIKVGETLFDVTTDKLTNNVEAKADGIVRKIL
CCCCCCCCCCCCEECCCHHHEEECCCCCEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHH
VDEGTVVECLKPVAIIGDKDEDISNLLRESLQDSKGNEVEKEVKESKEEIKDNRKIKKGE
HCCCCHHHHHCCCEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCC
RTKISPIAKRLAKENDVDIQLLDGTGPEGRIVLKDVESYIENNKNNIKTSPVAEKIAKDL
CCCHHHHHHHHCCCCCCEEEEECCCCCCCEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHH
GVNLEGIKKDGRIMKDDILEFIQKSIPSVGEDLMDRRVKMSTMRKVIASRMSESSKISPT
CCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
VTYDIEVDMTNLKRLKEQIKNEWKVTYTDLLVKIVSKVLIQYPLVNCSIEGDEMIFRNYS
EEEEEEECHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHCCC
NIGVAVALEEGLVVPVVKYANQKGLKDISIEVKELAHKAKNNGLTEENSTGGTFTITNLG
CCEEEEEECCCCEEHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCC
MFGIKSFSPIINQPEVAILGVNMITNTPVVENGEIVIKPLMSLSLTADHRAVDGAVAAQF
HHHHCCCCCCCCCCCEEEEEEEEECCCCEEECCCEEEEEHHHHEECCCHHHHHHHHHHHH
LKAVKKYMEKPELLIL
HHHHHHHHCCCCEEEC
>Mature Secondary Structure 
GKLEVMPKLGLTMTEGELVKWHKKEGDTIKVGETLFDVTTDKLTNNVEAKADGIVRKIL
CCCCCCCCCCCEECCCHHHEEECCCCCEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHH
VDEGTVVECLKPVAIIGDKDEDISNLLRESLQDSKGNEVEKEVKESKEEIKDNRKIKKGE
HCCCCHHHHHCCCEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCC
RTKISPIAKRLAKENDVDIQLLDGTGPEGRIVLKDVESYIENNKNNIKTSPVAEKIAKDL
CCCHHHHHHHHCCCCCCEEEEECCCCCCCEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHH
GVNLEGIKKDGRIMKDDILEFIQKSIPSVGEDLMDRRVKMSTMRKVIASRMSESSKISPT
CCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
VTYDIEVDMTNLKRLKEQIKNEWKVTYTDLLVKIVSKVLIQYPLVNCSIEGDEMIFRNYS
EEEEEEECHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHCCC
NIGVAVALEEGLVVPVVKYANQKGLKDISIEVKELAHKAKNNGLTEENSTGGTFTITNLG
CCEEEEEECCCCEEHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCC
MFGIKSFSPIINQPEVAILGVNMITNTPVVENGEIVIKPLMSLSLTADHRAVDGAVAAQF
HHHHCCCCCCCCCCCEEEEEEEEECCCCEEECCCEEEEEHHHHEECCCHHHHHHHHHHHH
LKAVKKYMEKPELLIL
HHHHHHHHCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA