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The map label for this gene is glcR [H]

Identifier: 153935325

GI number: 153935325

Start: 1722620

End: 1723387

Strand: Reverse

Name: glcR [H]

Synonym: CLC_1644

Alternate gene names: 153935325

Gene position: 1723387-1722620 (Counterclockwise)

Preceding gene: 153936398

Following gene: 153935864

Centisome position: 45.83

GC content: 28.65

Gene sequence:

>768_bases
TTGTATCAGGAAGAAAGAATGAATAAAATATTAGAATATTTAAAAATAAATAAACGGATAAAAGTAGATGAAATATGTAA
AATGTGTAATGTATCCAGAGATACAGCAAGACGCGACCTTGTAAATCTTGAAAAAGAAGGAGCAATCCTTCGAACTCATG
GTGGTGCTATATTACCTAATACGAGAGGTAAAGTAAAAAACTATGAGGACCGACTTCTTACTTATCCAACTGAAAAAAAA
CTTATAGCAAAACTTGCAACATCTTTAATCAAAAATACAGATAAATTAATAATGGACTCCTCAACTACAGTACAAATTTT
TGCAGAAATGCTTGAAGTAGAAAATTTATCTGTTATAACCAATTCAATAAATTTAGCACATAGATTATCGAAAAAAGCTA
ATATAGACATTCATTTATTAGGAGGAATTTTAGATTGTGAATATAAATTTTTATATGGTCCTAGTACCATAGATATGCTT
TCCAATTATTTTGCTGATAAAGCATGTATAGGAGCCCTCGGAATATCAGAAAAAGGTATAACTGTGGCACATGCAGAAGA
TGCTTCTGTTATGAAAAAAATGATTGAACAATCTAATGAAACTATAGTTCTAGTAGACCACAGCAAATTTGGAAATAATG
GTTTTTTTAAAGTATGTGATTTATGTGATATTGATTTAATAGTTACAGATAAACTGCCAAATAAAGATTTGACTAAAATA
TTTGAAGAAAATAACATAGACATTATGGCTGTAAATGAGAAAGGTTAA

Upstream 100 bases:

>100_bases
AAAAATTATAAATACTTAAAAAAGCTTATAAGGACTTGAAAGTTTACTTAAAATAACTTATAATTAAATTATTAAGTTTC
TACTGTGGAGGTTTAAAATA

Downstream 100 bases:

>100_bases
GGTGGATAATGATGAAGTTAATAGCATTAGATTTAGATGGTACTCTATTAAATAATAAAAGTATAATAAGTAATGAAAAT
GCAGCTGCCATTAGATATGC

Product: DeoR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MYQEERMNKILEYLKINKRIKVDEICKMCNVSRDTARRDLVNLEKEGAILRTHGGAILPNTRGKVKNYEDRLLTYPTEKK
LIAKLATSLIKNTDKLIMDSSTTVQIFAEMLEVENLSVITNSINLAHRLSKKANIDIHLLGGILDCEYKFLYGPSTIDML
SNYFADKACIGALGISEKGITVAHAEDASVMKKMIEQSNETIVLVDHSKFGNNGFFKVCDLCDIDLIVTDKLPNKDLTKI
FEENNIDIMAVNEKG

Sequences:

>Translated_255_residues
MYQEERMNKILEYLKINKRIKVDEICKMCNVSRDTARRDLVNLEKEGAILRTHGGAILPNTRGKVKNYEDRLLTYPTEKK
LIAKLATSLIKNTDKLIMDSSTTVQIFAEMLEVENLSVITNSINLAHRLSKKANIDIHLLGGILDCEYKFLYGPSTIDML
SNYFADKACIGALGISEKGITVAHAEDASVMKKMIEQSNETIVLVDHSKFGNNGFFKVCDLCDIDLIVTDKLPNKDLTKI
FEENNIDIMAVNEKG
>Mature_255_residues
MYQEERMNKILEYLKINKRIKVDEICKMCNVSRDTARRDLVNLEKEGAILRTHGGAILPNTRGKVKNYEDRLLTYPTEKK
LIAKLATSLIKNTDKLIMDSSTTVQIFAEMLEVENLSVITNSINLAHRLSKKANIDIHLLGGILDCEYKFLYGPSTIDML
SNYFADKACIGALGISEKGITVAHAEDASVMKKMIEQSNETIVLVDHSKFGNNGFFKVCDLCDIDLIVTDKLPNKDLTKI
FEENNIDIMAVNEKG

Specific function: Plays a role in carbon catabolite repression (CCR). Specifically required for transcriptional repression of the levanase operon by glucose but not by other sugars [H]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789829, Length=250, Percent_Identity=31.2, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1788069, Length=253, Percent_Identity=31.6205533596838, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1789059, Length=255, Percent_Identity=29.8039215686275, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1789519, Length=253, Percent_Identity=28.0632411067194, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI87082344, Length=256, Percent_Identity=25.78125, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI226510968, Length=256, Percent_Identity=30.078125, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789170, Length=229, Percent_Identity=27.5109170305677, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787540, Length=251, Percent_Identity=28.2868525896414, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1787063, Length=253, Percent_Identity=26.8774703557312, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1790753, Length=236, Percent_Identity=27.1186440677966, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790635, Length=252, Percent_Identity=22.2222222222222, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28722; Mature: 28722

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQEERMNKILEYLKINKRIKVDEICKMCNVSRDTARRDLVNLEKEGAILRTHGGAILPN
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCEECCC
TRGKVKNYEDRLLTYPTEKKLIAKLATSLIKNTDKLIMDSSTTVQIFAEMLEVENLSVIT
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHCCHHEEH
NSINLAHRLSKKANIDIHLLGGILDCEYKFLYGPSTIDMLSNYFADKACIGALGISEKGI
HHHHHHHHHHHHCCCEEEEECCEEECCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCE
TVAHAEDASVMKKMIEQSNETIVLVDHSKFGNNGFFKVCDLCDIDLIVTDKLPNKDLTKI
EEEECCCHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCCCEEEEECCCCCHHHHHH
FEENNIDIMAVNEKG
HHCCCEEEEEECCCC
>Mature Secondary Structure
MYQEERMNKILEYLKINKRIKVDEICKMCNVSRDTARRDLVNLEKEGAILRTHGGAILPN
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCEECCC
TRGKVKNYEDRLLTYPTEKKLIAKLATSLIKNTDKLIMDSSTTVQIFAEMLEVENLSVIT
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHCCHHEEH
NSINLAHRLSKKANIDIHLLGGILDCEYKFLYGPSTIDMLSNYFADKACIGALGISEKGI
HHHHHHHHHHHHCCCEEEEECCEEECCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCE
TVAHAEDASVMKKMIEQSNETIVLVDHSKFGNNGFFKVCDLCDIDLIVTDKLPNKDLTKI
EEEECCCHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCCCEEEEECCCCCHHHHHH
FEENNIDIMAVNEKG
HHCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]