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The map label for this gene is mepA [H]

Identifier: 153932640

GI number: 153932640

Start: 2636793

End: 2638142

Strand: Reverse

Name: mepA [H]

Synonym: CLB_2522

Alternate gene names: 153932640

Gene position: 2638142-2636793 (Counterclockwise)

Preceding gene: 153930898

Following gene: 153933343

Centisome position: 68.28

GC content: 29.04

Gene sequence:

>1350_bases
ATGACAAAGAATATAGAAGACAAACAGGGAAAATTTGAAGAACTTACTAAGACGCCAATTTCCAAATTAATATTGAAAAT
GGCTATACCGTCTATAATGGCAATGTTAATAGGAATTGCATACAGTTTAGCAGATACTTATTTTATATCCAAGATTGATA
CAATATCTACAGCATCAGTAGGGTTGGCATTTTCATTTATGAGTGTTACCCAGGCCTTTGGACTTTTATATGGACATGGT
TCAGGAAATTATATGTCAAGAATGGAAAGTGAAAAAAATAGAACAGAGTCATCAAAAATGGCAATAGATGGTCTTGTTAT
ATCATTTCTTACAGGGATAATTATAATGATTTTTGGGGAACTATATTTAAATGAATTAGCACTTTTTTTAGGAGCTACTA
ATTCTCTTTTATCTTCAACGAAAGAATATCTCTTAATACTATTAATAGGCACCCCATTTATGATTTCAGCTTTGACGATG
AATAATCAATTTAGATTACAAGGGAATCCAAGTTTGGGAGCAGCCGCCATTACATCTGGAGCAGTAATTAACTGTATACT
TGATCCTATTTTTATTTTTTATTTTAATTTAGGAATTAAAGGAGCCGCATATGCCACGGTTATTGGAGAAATAATAAGCT
TTATCATTTTAATTGTAGTTAGTGGAATGAGAGAGAATATAAAGTTTAATCTAAAAAATTTTTCTATAAATAAAAAAATA
TTGTCTGAGCTTTATGGAGGAGGGATACCGAATTTTACAAGAGAAATTTTTATAGGAATATCTCTTATGCTTTTGAATAA
TGAATTAAAAATTTTTGGTGAAGAATATATAGCTTCCTTTACTATAGTTAATAGATTAGTGCTTGCAGGAACTTATCTTA
TGGTAGGGCTTGGACATGGATTTCAGCCTGTGTGTATATTTAATTATGGTGCTAAGTTATATGAACGAGTAGAGAAAGCT
TTAAAATTTACATTAAGATCAGCTATAATATTTATGGTTTTTATTTCTATAATATTTTTAATGTACAGCGAAAATATGGT
AATGTTGTTCAGAAATGATAATGAAATAATTAATATAGGTTCACAAGTTCTAAGTATACAATCAATCACTTTACCACTCA
TAGGATATATTACTATAACGGGTATGTTCTTACAAAGTACGCATAAATTTAAAGAAGCTACTTTAATTACTTCATCTAGG
CAGGGTTATATATATATACCTCTAATTTTAATAATGCCTAAGATGTTGGGGGTAAAGGGGATATTGTATGTTCAACCTTT
ATCAGATTTTATTACTTTTGTTATTTCAGTTGTTTTAGTAGCTAAGTATAAAAAAGAGTTAAAATGTTAG

Upstream 100 bases:

>100_bases
TATTGGGTGTTGGAAATGCCACAGTAAATTTATCGGATGGGGAATATATATTATTAGACGGAAATAATGGTATTGTAAAG
CGATTATCAGAGGAAATAAT

Downstream 100 bases:

>100_bases
AGTATACTTTAATATAAAATAATTATAAACTACTACCAAGAAAATATGAATGGGAGTAGTTTTTTTTATATATAGTTCAT
AAAATTATAGATTTTAAAGA

Product: MATE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MTKNIEDKQGKFEELTKTPISKLILKMAIPSIMAMLIGIAYSLADTYFISKIDTISTASVGLAFSFMSVTQAFGLLYGHG
SGNYMSRMESEKNRTESSKMAIDGLVISFLTGIIIMIFGELYLNELALFLGATNSLLSSTKEYLLILLIGTPFMISALTM
NNQFRLQGNPSLGAAAITSGAVINCILDPIFIFYFNLGIKGAAYATVIGEIISFIILIVVSGMRENIKFNLKNFSINKKI
LSELYGGGIPNFTREIFIGISLMLLNNELKIFGEEYIASFTIVNRLVLAGTYLMVGLGHGFQPVCIFNYGAKLYERVEKA
LKFTLRSAIIFMVFISIIFLMYSENMVMLFRNDNEIINIGSQVLSIQSITLPLIGYITITGMFLQSTHKFKEATLITSSR
QGYIYIPLILIMPKMLGVKGILYVQPLSDFITFVISVVLVAKYKKELKC

Sequences:

>Translated_449_residues
MTKNIEDKQGKFEELTKTPISKLILKMAIPSIMAMLIGIAYSLADTYFISKIDTISTASVGLAFSFMSVTQAFGLLYGHG
SGNYMSRMESEKNRTESSKMAIDGLVISFLTGIIIMIFGELYLNELALFLGATNSLLSSTKEYLLILLIGTPFMISALTM
NNQFRLQGNPSLGAAAITSGAVINCILDPIFIFYFNLGIKGAAYATVIGEIISFIILIVVSGMRENIKFNLKNFSINKKI
LSELYGGGIPNFTREIFIGISLMLLNNELKIFGEEYIASFTIVNRLVLAGTYLMVGLGHGFQPVCIFNYGAKLYERVEKA
LKFTLRSAIIFMVFISIIFLMYSENMVMLFRNDNEIINIGSQVLSIQSITLPLIGYITITGMFLQSTHKFKEATLITSSR
QGYIYIPLILIMPKMLGVKGILYVQPLSDFITFVISVVLVAKYKKELKC
>Mature_448_residues
TKNIEDKQGKFEELTKTPISKLILKMAIPSIMAMLIGIAYSLADTYFISKIDTISTASVGLAFSFMSVTQAFGLLYGHGS
GNYMSRMESEKNRTESSKMAIDGLVISFLTGIIIMIFGELYLNELALFLGATNSLLSSTKEYLLILLIGTPFMISALTMN
NQFRLQGNPSLGAAAITSGAVINCILDPIFIFYFNLGIKGAAYATVIGEIISFIILIVVSGMRENIKFNLKNFSINKKIL
SELYGGGIPNFTREIFIGISLMLLNNELKIFGEEYIASFTIVNRLVLAGTYLMVGLGHGFQPVCIFNYGAKLYERVEKAL
KFTLRSAIIFMVFISIIFLMYSENMVMLFRNDNEIINIGSQVLSIQSITLPLIGYITITGMFLQSTHKFKEATLITSSRQ
GYIYIPLILIMPKMLGVKGILYVQPLSDFITFVISVVLVAKYKKELKC

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49859; Mature: 49728

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKNIEDKQGKFEELTKTPISKLILKMAIPSIMAMLIGIAYSLADTYFISKIDTISTASV
CCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
GLAFSFMSVTQAFGLLYGHGSGNYMSRMESEKNRTESSKMAIDGLVISFLTGIIIMIFGE
HHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LYLNELALFLGATNSLLSSTKEYLLILLIGTPFMISALTMNNQFRLQGNPSLGAAAITSG
HHHHHHHHHHCCCHHHHHCHHHHEEEEEECCCHHHEEEEECCEEEEECCCCCCHHHHHCC
AVINCILDPIFIFYFNLGIKGAAYATVIGEIISFIILIVVSGMRENIKFNLKNFSINKKI
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHCCEEEEECCCCCHHH
LSELYGGGIPNFTREIFIGISLMLLNNELKIFGEEYIASFTIVNRLVLAGTYLMVGLGHG
HHHHHCCCCCHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FQPVCIFNYGAKLYERVEKALKFTLRSAIIFMVFISIIFLMYSENMVMLFRNDNEIINIG
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEECC
SQVLSIQSITLPLIGYITITGMFLQSTHKFKEATLITSSRQGYIYIPLILIMPKMLGVKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEHHHHHHHHHCCCC
ILYVQPLSDFITFVISVVLVAKYKKELKC
EEEECCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKNIEDKQGKFEELTKTPISKLILKMAIPSIMAMLIGIAYSLADTYFISKIDTISTASV
CCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
GLAFSFMSVTQAFGLLYGHGSGNYMSRMESEKNRTESSKMAIDGLVISFLTGIIIMIFGE
HHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LYLNELALFLGATNSLLSSTKEYLLILLIGTPFMISALTMNNQFRLQGNPSLGAAAITSG
HHHHHHHHHHCCCHHHHHCHHHHEEEEEECCCHHHEEEEECCEEEEECCCCCCHHHHHCC
AVINCILDPIFIFYFNLGIKGAAYATVIGEIISFIILIVVSGMRENIKFNLKNFSINKKI
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHCCEEEEECCCCCHHH
LSELYGGGIPNFTREIFIGISLMLLNNELKIFGEEYIASFTIVNRLVLAGTYLMVGLGHG
HHHHHCCCCCHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FQPVCIFNYGAKLYERVEKALKFTLRSAIIFMVFISIIFLMYSENMVMLFRNDNEIINIG
CCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEECC
SQVLSIQSITLPLIGYITITGMFLQSTHKFKEATLITSSRQGYIYIPLILIMPKMLGVKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEHHHHHHHHHCCCC
ILYVQPLSDFITFVISVVLVAKYKKELKC
EEEECCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA