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The map label for this gene is sdhA [H]

Identifier: 152976915

GI number: 152976915

Start: 3282472

End: 3284265

Strand: Reverse

Name: sdhA [H]

Synonym: Bcer98_3216

Alternate gene names: 152976915

Gene position: 3284265-3282472 (Counterclockwise)

Preceding gene: 152976916

Following gene: 152976914

Centisome position: 80.36

GC content: 39.3

Gene sequence:

>1794_bases
ATGAAAGGGAAACTTATAGTAGTCGGCGGTGGCTTGGCTGGCTTAATGGCAACGATTAAAGCGGCAGAAGCAGGAGTAAA
CGTGGAATTGTTTTCTTTAGTACCAGTAAAACGTTCGCATTCTGTATGTGCCCAAGGTGGTATTAACGGTGCCGTAAATA
CGAAAGGTGAAGGGGATTCTCCATGGATCCACTTTGACGATACAATTTATGGTGGGGACTTTTTAGCGAATCAACCACCA
GTTAAAGCAATGTGTGAAGCAGCACCTGGTATTATTCATTTAATGGATCGCATGGGTGTTATGTTCAACCGTACAGAAGA
GGGACTTCTTGATTTCCGCCGTTTCGGTGGAACGCAACATCATCGTACAGCATTCGCTGGTGCAACGACTGGTCAACAGT
TATTGTACGCATTAGATGAACAAGTGCGTCGTCATGAAGTAGCAGGACTTGTAACGAAATATGAAGGTTGGGATTTCTTA
CGAGCTGTTATTGATGATGAAGGTGTATGCCGAGGAATCGTTGCACAAGATTTACAATCTATGGAGATTAAAAGTTTCCG
AGCTGATGCCGTGATTATGGCAACAGGGGGCCCTGGTATCATCTTCGGAAAATCTACAAACTCTATTATTAATACAGGTA
CAGCAGCATCAGTTATTTATCAACAAGGTGCATATTATGCAAATGGTGAGTTCATTCAAATTCATCCAACAGCAATTCCT
GGTGATGATAAATTACGCTTAATGAGTGAATCTGCACGTGGTGAAGGTGGCCGTGTTTGGACATATAAAGACGGTAAACC
GTGGTATTTCTTAGAAGAGAAATATCCTGCATATGGAAACCTTGTACCTCGTGATATCGCAACACGTGAAATCTTTGACG
TATGTGTGGAACAAAAACTAGGTATTAATGGTGAAAATATGGTATATCTAGATCTTTCTCATAAAGACCCGAAAGAACTA
GATATTAAACTTGGTGGAATTATTGAAATTTATGAGAAGTTTACAGGTGATGACCCTCGTAAACTACCGATGAAAATCTT
CCCAGCTGTTCATTACTCAATGGGTGGATTATGGGTAGATTATAAGCAAATGACCAATATTCCAGGTTTGTTTGCAGCAG
GTGAGTGTGATTATTCTATGCACGGAGCAAACCGACTTGGAGCAAACTCTTTACTATCTGCAATTTATGGTGGTATGGTA
GCCGGTCCAAGTGCAATTGAATATATAAAAGGTCTAACAAAAGCATCGGATACTGTTTCATCAGCTGTCTATGAACAAAA
TGAATTGATCGAAACAGAGAAATTTAACAATATTTTATCATTAGATGGTAATGAAAATGCTTACATTCTTCATAAAGAAC
TTGGAGAATGGATGACGGATAATGTAACGGTAGTTCGTGAAAATAAAAAACTACTAGAAACAGATGATAAAATTCAAGAG
TTAATGGAGCGTTATAAACGCATTAACATTAACGATACAGCAAAATGGAGTAACCAAGGTGCTTCATTTACACGTCAACT
TGCAAATATGCTTCAATTAGCACGTGTTATTACAATTGGGGCATATAACCGTAATGAAAGTCGGGGAGCACATTATAAAC
CAGAATTCCCAGAGCGTGATGACGTGAACTTCTTGAAAACAACAATGGCGAAATTTGATGGCGAAGGAAATGCACCAGCA
TTCCATTATGAAGATGTTGATATTTCATTAATCAAACCGCGTAAGCGTGATTACACTTCAAAACATGAAGTAGCTTCTAA
GGGTGAAGAGAAGGGGGATAAACAACATGCCTGA

Upstream 100 bases:

>100_bases
GTAACTTTAGCAATTTTCTTAGGTTTATCTTATGTAGGTGTGAGTGCATTATTAGCGTTTGTTGATCCGCAGCTAGCAAA
TCAGTAAGGAGTGGGAGATC

Downstream 100 bases:

>100_bases
GAAAACAATCCGCCTCATCATTACACGACAAGACGGACCGAATTCACAGCCATATGATCAAGAATTTGAAATTCCATATC
GTCCTAATATGAACATTATT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 597; Mature: 597

Protein sequence:

>597_residues
MKGKLIVVGGGLAGLMATIKAAEAGVNVELFSLVPVKRSHSVCAQGGINGAVNTKGEGDSPWIHFDDTIYGGDFLANQPP
VKAMCEAAPGIIHLMDRMGVMFNRTEEGLLDFRRFGGTQHHRTAFAGATTGQQLLYALDEQVRRHEVAGLVTKYEGWDFL
RAVIDDEGVCRGIVAQDLQSMEIKSFRADAVIMATGGPGIIFGKSTNSIINTGTAASVIYQQGAYYANGEFIQIHPTAIP
GDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVEQKLGINGENMVYLDLSHKDPKEL
DIKLGGIIEIYEKFTGDDPRKLPMKIFPAVHYSMGGLWVDYKQMTNIPGLFAAGECDYSMHGANRLGANSLLSAIYGGMV
AGPSAIEYIKGLTKASDTVSSAVYEQNELIETEKFNNILSLDGNENAYILHKELGEWMTDNVTVVRENKKLLETDDKIQE
LMERYKRININDTAKWSNQGASFTRQLANMLQLARVITIGAYNRNESRGAHYKPEFPERDDVNFLKTTMAKFDGEGNAPA
FHYEDVDISLIKPRKRDYTSKHEVASKGEEKGDKQHA

Sequences:

>Translated_597_residues
MKGKLIVVGGGLAGLMATIKAAEAGVNVELFSLVPVKRSHSVCAQGGINGAVNTKGEGDSPWIHFDDTIYGGDFLANQPP
VKAMCEAAPGIIHLMDRMGVMFNRTEEGLLDFRRFGGTQHHRTAFAGATTGQQLLYALDEQVRRHEVAGLVTKYEGWDFL
RAVIDDEGVCRGIVAQDLQSMEIKSFRADAVIMATGGPGIIFGKSTNSIINTGTAASVIYQQGAYYANGEFIQIHPTAIP
GDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVEQKLGINGENMVYLDLSHKDPKEL
DIKLGGIIEIYEKFTGDDPRKLPMKIFPAVHYSMGGLWVDYKQMTNIPGLFAAGECDYSMHGANRLGANSLLSAIYGGMV
AGPSAIEYIKGLTKASDTVSSAVYEQNELIETEKFNNILSLDGNENAYILHKELGEWMTDNVTVVRENKKLLETDDKIQE
LMERYKRININDTAKWSNQGASFTRQLANMLQLARVITIGAYNRNESRGAHYKPEFPERDDVNFLKTTMAKFDGEGNAPA
FHYEDVDISLIKPRKRDYTSKHEVASKGEEKGDKQHA
>Mature_597_residues
MKGKLIVVGGGLAGLMATIKAAEAGVNVELFSLVPVKRSHSVCAQGGINGAVNTKGEGDSPWIHFDDTIYGGDFLANQPP
VKAMCEAAPGIIHLMDRMGVMFNRTEEGLLDFRRFGGTQHHRTAFAGATTGQQLLYALDEQVRRHEVAGLVTKYEGWDFL
RAVIDDEGVCRGIVAQDLQSMEIKSFRADAVIMATGGPGIIFGKSTNSIINTGTAASVIYQQGAYYANGEFIQIHPTAIP
GDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVEQKLGINGENMVYLDLSHKDPKEL
DIKLGGIIEIYEKFTGDDPRKLPMKIFPAVHYSMGGLWVDYKQMTNIPGLFAAGECDYSMHGANRLGANSLLSAIYGGMV
AGPSAIEYIKGLTKASDTVSSAVYEQNELIETEKFNNILSLDGNENAYILHKELGEWMTDNVTVVRENKKLLETDDKIQE
LMERYKRININDTAKWSNQGASFTRQLANMLQLARVITIGAYNRNESRGAHYKPEFPERDDVNFLKTTMAKFDGEGNAPA
FHYEDVDISLIKPRKRDYTSKHEVASKGEEKGDKQHA

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=539, Percent_Identity=32.4675324675325, Blast_Score=233, Evalue=4e-61,
Organism=Escherichia coli, GI1790597, Length=570, Percent_Identity=34.2105263157895, Blast_Score=281, Evalue=1e-76,
Organism=Escherichia coli, GI1786942, Length=562, Percent_Identity=32.3843416370107, Blast_Score=235, Evalue=8e-63,
Organism=Escherichia coli, GI1788928, Length=554, Percent_Identity=28.8808664259928, Blast_Score=173, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17505833, Length=541, Percent_Identity=31.9778188539741, Blast_Score=234, Evalue=9e-62,
Organism=Caenorhabditis elegans, GI17550100, Length=551, Percent_Identity=31.7604355716878, Blast_Score=229, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6322701, Length=553, Percent_Identity=32.1880650994575, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6322416, Length=568, Percent_Identity=30.4577464788732, Blast_Score=221, Evalue=2e-58,
Organism=Drosophila melanogaster, GI17137288, Length=558, Percent_Identity=31.8996415770609, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24655642, Length=558, Percent_Identity=31.8996415770609, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24655647, Length=558, Percent_Identity=31.8996415770609, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24663005, Length=547, Percent_Identity=31.9926873857404, Blast_Score=219, Evalue=5e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66085; Mature: 66085

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGKLIVVGGGLAGLMATIKAAEAGVNVELFSLVPVKRSHSVCAQGGINGAVNTKGEGDS
CCCCEEEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCCC
PWIHFDDTIYGGDFLANQPPVKAMCEAAPGIIHLMDRMGVMFNRTEEGLLDFRRFGGTQH
CEEEECCEEECCCCCCCCCCHHHHHHHCCHHHHHHHHHCHHHCCCHHHHHHHHHCCCCCH
HRTAFAGATTGQQLLYALDEQVRRHEVAGLVTKYEGWDFLRAVIDDEGVCRGIVAQDLQS
HCEEECCCCCHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHCCCCHHHHHHHHHHHH
MEIKSFRADAVIMATGGPGIIFGKSTNSIINTGTAASVIYQQGAYYANGEFIQIHPTAIP
HHHHHCCCCEEEEEECCCEEEEECCCCCEEECCCHHHHHHHCCCEEECCCEEEEECCCCC
GDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVEQKL
CCCCEEEEECCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHC
GINGENMVYLDLSHKDPKELDIKLGGIIEIYEKFTGDDPRKLPMKIFPAVHYSMGGLWVD
CCCCCCEEEEEECCCCCCCEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEE
YKQMTNIPGLFAAGECDYSMHGANRLGANSLLSAIYGGMVAGPSAIEYIKGLTKASDTVS
HHHHCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
SAVYEQNELIETEKFNNILSLDGNENAYILHKELGEWMTDNVTVVRENKKLLETDDKIQE
HHHHHHHHHHHHHHCCCEEEECCCCCEEEEHHHHHHHHCCCEEEEECCCHHHCCCHHHHH
LMERYKRININDTAKWSNQGASFTRQLANMLQLARVITIGAYNRNESRGAHYKPEFPERD
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCC
DVNFLKTTMAKFDGEGNAPAFHYEDVDISLIKPRKRDYTSKHEVASKGEEKGDKQHA
CCHHHHHHHHHHCCCCCCCEEEECCCEEEEECCCCCCCCHHHHHHHCCHHCCCCCCC
>Mature Secondary Structure
MKGKLIVVGGGLAGLMATIKAAEAGVNVELFSLVPVKRSHSVCAQGGINGAVNTKGEGDS
CCCCEEEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCCC
PWIHFDDTIYGGDFLANQPPVKAMCEAAPGIIHLMDRMGVMFNRTEEGLLDFRRFGGTQH
CEEEECCEEECCCCCCCCCCHHHHHHHCCHHHHHHHHHCHHHCCCHHHHHHHHHCCCCCH
HRTAFAGATTGQQLLYALDEQVRRHEVAGLVTKYEGWDFLRAVIDDEGVCRGIVAQDLQS
HCEEECCCCCHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHCCCCHHHHHHHHHHHH
MEIKSFRADAVIMATGGPGIIFGKSTNSIINTGTAASVIYQQGAYYANGEFIQIHPTAIP
HHHHHCCCCEEEEEECCCEEEEECCCCCEEECCCHHHHHHHCCCEEECCCEEEEECCCCC
GDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVEQKL
CCCCEEEEECCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHC
GINGENMVYLDLSHKDPKELDIKLGGIIEIYEKFTGDDPRKLPMKIFPAVHYSMGGLWVD
CCCCCCEEEEEECCCCCCCEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEE
YKQMTNIPGLFAAGECDYSMHGANRLGANSLLSAIYGGMVAGPSAIEYIKGLTKASDTVS
HHHHCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
SAVYEQNELIETEKFNNILSLDGNENAYILHKELGEWMTDNVTVVRENKKLLETDDKIQE
HHHHHHHHHHHHHHCCCEEEECCCCCEEEEHHHHHHHHCCCEEEEECCCHHHCCCHHHHH
LMERYKRININDTAKWSNQGASFTRQLANMLQLARVITIGAYNRNESRGAHYKPEFPERD
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCC
DVNFLKTTMAKFDGEGNAPAFHYEDVDISLIKPRKRDYTSKHEVASKGEEKGDKQHA
CCHHHHHHHHHHCCCCCCCEEEECCCEEEEECCCCCCCCHHHHHHHCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]