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The map label for this gene is lon [H]

Identifier: 152976885

GI number: 152976885

Start: 3235768

End: 3238089

Strand: Reverse

Name: lon [H]

Synonym: Bcer98_3184

Alternate gene names: 152976885

Gene position: 3238089-3235768 (Counterclockwise)

Preceding gene: 152976886

Following gene: 152976884

Centisome position: 79.23

GC content: 39.36

Gene sequence:

>2322_bases
ATGAATACGAACGAAAGAATCTTGCCCCTCCTACCATTAAGAGGCGTTCTCGTATATCCGACGATGGTTCTGCATCTTGA
TGTAGGACGTGATAAGTCGATACAAGCACTAGAGCAGGCAGCAGTGGATGAAAATATTATCTTTTTAGCAATGCAAAAAG
AAATGAATATTGATGATCCGAAAGAAGATGACATATATAGTGTAGGTACAGTGGCGAAGGTAAAGCAGATGTTAAAGCTG
CCAAACGGTACGCTTCGTGTCCTGGTAGAAGGTTTACATAGAGCAAAAGTAGTAGAATTTACAGAATTAGAAAACGTAAT
ACAAGTTTCTGTTCAAACGATAGTAGAAGAAGAGGAAGGCGACTTAGAAGAAAAAGCTCTTATGCGCACATTGCTAGAGC
ATTTCGAACAGTATATTAAAGTTTCCAAAAAGATATCAAATGAAACATTCGCAACGGTAGCCGATGTGGAAGAACCTGGA
CGATTAGCGGATTTAATCGCTTCTCATTTACCAATTAAAACGAAACAAAAGCAAGAAATTTTGGAAATCGTATCTGTTAA
CGAAAGATTACATACTTTAATCTCTATTATTCAAGATGAACAAGAGCTATTAAGTTTAGAAAAGAAAATCGGACAAAAAG
TAAAACGTTCGATGGAACGTACGCAAAAAGAATATTTTCTGCGGGAACAAATGAAGGCTATTCAAACAGAACTTGGTGAC
AAAGAAGGAAAAGGCGGGGAAGTTGAAGAACTTCGTAAAAAAATTGAAGAGGCAGGAATGCCAGGAGAGACAAAGGAAGC
TGTCTTAAAAGAATTAGACCGCTATGAAAAATTACCAGTAAGTTCTGCGGAAAGCGGTGTGATTCGCAATTATATTGACT
GGTTATTAGCGCTCCCATGGACAGATGCAACAGATGATAAGATTGATCTTGCTCATTCTGAAATGGTCTTAAATAAAGAC
CATTATGGGCTGGAGAAAGTGAAAGAACGTGTATTGGAATATTTAGCTGTTCAAAAATTAACAAATTCACTAAAAGGACC
AATCTTATGTCTAGTAGGGCCTCCTGGGGTCGGAAAAACATCATTAGCACGTTCGATTGCAAAATCGCTAAATCGTAATT
TTGTCCGTGTTTCCCTTGGCGGTGTTCGGGATGAATCTGAGATTAGAGGGCATCGTCGTACATATGTTGGTGCTATGCCA
GGGCGGATTATACAAGGCATGAAAAAAGCAAAGACAATCAATCCGGTCTTTTTATTAGATGAGATTGATAAAATGTCCAA
TGATTTCCGTGGAGATCCATCTGCGGCGTTACTTGAAGTGTTAGACCCAGAACAAAATCATAATTTTAGCGATCATTATA
TTGAAGAACCGTATGATTTATCAAAGGTTATGTTTGTGGCAACTGCGAATACGCTTGCTAGCATTCCTGGGCCGCTTCTT
GATCGGATGGAAATCATATCAATTGCTGGTTATACAGAAATTGAAAAAGTGCATATTGCACGTGAACATTTATTATCGAA
GCAATTAAAAGAGCATGGTTTACGAAAAGGAAATTTACAGGTGCGCGATGAGGCTCTTCTTGAAATTATTCGTTATTATA
CACGTGAAGCGGGTGTACGTACGTTGGAACGTCAAATTGCTAAGATTTGTCGTAAATCAGCGAAAATTATCGTTACAGGG
GAACGTAAGCGCGTTGTTGTTACAGAGAAGAACATTACGGACCTTTTAGGAAAGCGTATATTCCGATATGGTCAGGCTGA
AAAGATCGATCAAGTTGGTATGGCAACAGGATTAGCTTATACATCTGCTGGCGGCGATACCCTTGCAATTGAAGTGGCTG
TATCTCCTGGGAAAGGGAAATTAATTTTAACAGGGAAGCTTGGAGATGTGATGAAAGAATCTGCGCAAGCAGCTTTTAGT
TATATTCGTTCTCGCGCAGAGGAACTTCATATTGACCCGGATTTCCATGAAAAAAATGACATCCATATTCACGTTCCAGA
AGGGGCAGTTCCGAAAGATGGACCATCAGCAGGTATTACGATGGCAACAGCACTTATTTCTGCCCTAACAGGTATTCCTG
TAAGTAAAGAAGTAGGGATGACGGGTGAAATTACGCTTCGCGGCCGTGTATTACCAATCGGTGGCTTGAAAGAAAAAACA
TTAAGTGCTCACCGCGCAGGCTTAACAAAAATTATTTTGCCGGCAGAAAACGAAAAAGATTTAGATGATATTCCAGAAAG
CGTAAAGGAAAATCTTACGTTTGTGCTTGTATCTCATTTAGATGAAGTGTTAGAGCATGCCTTAGTAGGAGTGAAACAAT
GA

Upstream 100 bases:

>100_bases
AATTGCGATGATACAGAATCTCTGTAATTGCATCAGGGTGTATTGTAATATAAAATAGTTGAACAGGAGTTTAATTTATT
ATGGAGGTGCTATGTCTAGT

Downstream 100 bases:

>100_bases
AAGTAACAAAAGCAGAGATTGTTATTAGTGCTGTTAGACCAGACCAATATCCAGGAGGTGACTTGCCGGAAATTGCTTTA
GCAGGTCGTTCGAATGTTGG

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 773; Mature: 773

Protein sequence:

>773_residues
MNTNERILPLLPLRGVLVYPTMVLHLDVGRDKSIQALEQAAVDENIIFLAMQKEMNIDDPKEDDIYSVGTVAKVKQMLKL
PNGTLRVLVEGLHRAKVVEFTELENVIQVSVQTIVEEEEGDLEEKALMRTLLEHFEQYIKVSKKISNETFATVADVEEPG
RLADLIASHLPIKTKQKQEILEIVSVNERLHTLISIIQDEQELLSLEKKIGQKVKRSMERTQKEYFLREQMKAIQTELGD
KEGKGGEVEELRKKIEEAGMPGETKEAVLKELDRYEKLPVSSAESGVIRNYIDWLLALPWTDATDDKIDLAHSEMVLNKD
HYGLEKVKERVLEYLAVQKLTNSLKGPILCLVGPPGVGKTSLARSIAKSLNRNFVRVSLGGVRDESEIRGHRRTYVGAMP
GRIIQGMKKAKTINPVFLLDEIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYDLSKVMFVATANTLASIPGPLL
DRMEIISIAGYTEIEKVHIAREHLLSKQLKEHGLRKGNLQVRDEALLEIIRYYTREAGVRTLERQIAKICRKSAKIIVTG
ERKRVVVTEKNITDLLGKRIFRYGQAEKIDQVGMATGLAYTSAGGDTLAIEVAVSPGKGKLILTGKLGDVMKESAQAAFS
YIRSRAEELHIDPDFHEKNDIHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVGMTGEITLRGRVLPIGGLKEKT
LSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLVSHLDEVLEHALVGVKQ

Sequences:

>Translated_773_residues
MNTNERILPLLPLRGVLVYPTMVLHLDVGRDKSIQALEQAAVDENIIFLAMQKEMNIDDPKEDDIYSVGTVAKVKQMLKL
PNGTLRVLVEGLHRAKVVEFTELENVIQVSVQTIVEEEEGDLEEKALMRTLLEHFEQYIKVSKKISNETFATVADVEEPG
RLADLIASHLPIKTKQKQEILEIVSVNERLHTLISIIQDEQELLSLEKKIGQKVKRSMERTQKEYFLREQMKAIQTELGD
KEGKGGEVEELRKKIEEAGMPGETKEAVLKELDRYEKLPVSSAESGVIRNYIDWLLALPWTDATDDKIDLAHSEMVLNKD
HYGLEKVKERVLEYLAVQKLTNSLKGPILCLVGPPGVGKTSLARSIAKSLNRNFVRVSLGGVRDESEIRGHRRTYVGAMP
GRIIQGMKKAKTINPVFLLDEIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYDLSKVMFVATANTLASIPGPLL
DRMEIISIAGYTEIEKVHIAREHLLSKQLKEHGLRKGNLQVRDEALLEIIRYYTREAGVRTLERQIAKICRKSAKIIVTG
ERKRVVVTEKNITDLLGKRIFRYGQAEKIDQVGMATGLAYTSAGGDTLAIEVAVSPGKGKLILTGKLGDVMKESAQAAFS
YIRSRAEELHIDPDFHEKNDIHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVGMTGEITLRGRVLPIGGLKEKT
LSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLVSHLDEVLEHALVGVKQ
>Mature_773_residues
MNTNERILPLLPLRGVLVYPTMVLHLDVGRDKSIQALEQAAVDENIIFLAMQKEMNIDDPKEDDIYSVGTVAKVKQMLKL
PNGTLRVLVEGLHRAKVVEFTELENVIQVSVQTIVEEEEGDLEEKALMRTLLEHFEQYIKVSKKISNETFATVADVEEPG
RLADLIASHLPIKTKQKQEILEIVSVNERLHTLISIIQDEQELLSLEKKIGQKVKRSMERTQKEYFLREQMKAIQTELGD
KEGKGGEVEELRKKIEEAGMPGETKEAVLKELDRYEKLPVSSAESGVIRNYIDWLLALPWTDATDDKIDLAHSEMVLNKD
HYGLEKVKERVLEYLAVQKLTNSLKGPILCLVGPPGVGKTSLARSIAKSLNRNFVRVSLGGVRDESEIRGHRRTYVGAMP
GRIIQGMKKAKTINPVFLLDEIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYDLSKVMFVATANTLASIPGPLL
DRMEIISIAGYTEIEKVHIAREHLLSKQLKEHGLRKGNLQVRDEALLEIIRYYTREAGVRTLERQIAKICRKSAKIIVTG
ERKRVVVTEKNITDLLGKRIFRYGQAEKIDQVGMATGLAYTSAGGDTLAIEVAVSPGKGKLILTGKLGDVMKESAQAAFS
YIRSRAEELHIDPDFHEKNDIHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVGMTGEITLRGRVLPIGGLKEKT
LSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLVSHLDEVLEHALVGVKQ

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=786, Percent_Identity=42.1119592875318, Blast_Score=580, Evalue=1e-165,
Organism=Homo sapiens, GI21396489, Length=678, Percent_Identity=42.6253687315634, Blast_Score=560, Evalue=1e-159,
Organism=Escherichia coli, GI1786643, Length=767, Percent_Identity=54.6284224250326, Blast_Score=846, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=656, Percent_Identity=40.3963414634146, Blast_Score=503, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17556486, Length=787, Percent_Identity=36.2134688691233, Blast_Score=479, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6319449, Length=675, Percent_Identity=38.6666666666667, Blast_Score=501, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24666867, Length=630, Percent_Identity=44.2857142857143, Blast_Score=540, Evalue=1e-153,
Organism=Drosophila melanogaster, GI221513036, Length=630, Percent_Identity=44.2857142857143, Blast_Score=539, Evalue=1e-153,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 86176; Mature: 86176

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTNERILPLLPLRGVLVYPTMVLHLDVGRDKSIQALEQAAVDENIIFLAMQKEMNIDDP
CCCCCCEEEECCCCCHHHHCEEEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
KEDDIYSVGTVAKVKQMLKLPNGTLRVLVEGLHRAKVVEFTELENVIQVSVQTIVEEEEG
CCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DLEEKALMRTLLEHFEQYIKVSKKISNETFATVADVEEPGRLADLIASHLPIKTKQKQEI
CHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHH
LEIVSVNERLHTLISIIQDEQELLSLEKKIGQKVKRSMERTQKEYFLREQMKAIQTELGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KEGKGGEVEELRKKIEEAGMPGETKEAVLKELDRYEKLPVSSAESGVIRNYIDWLLALPW
CCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCC
TDATDDKIDLAHSEMVLNKDHYGLEKVKERVLEYLAVQKLTNSLKGPILCLVGPPGVGKT
CCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
SLARSIAKSLNRNFVRVSLGGVRDESEIRGHRRTYVGAMPGRIIQGMKKAKTINPVFLLD
HHHHHHHHHHCCCEEEEEECCCCCHHHHCCCHHHEECCCCHHHHHHHHHHCCCCCCHHHH
EIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYDLSKVMFVATANTLASIPGPLL
HHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHEEEHHHHHHCCCHHH
DRMEIISIAGYTEIEKVHIAREHLLSKQLKEHGLRKGNLQVRDEALLEIIRYYTREAGVR
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
TLERQIAKICRKSAKIIVTGERKRVVVTEKNITDLLGKRIFRYGQAEKIDQVGMATGLAY
HHHHHHHHHHHCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHCCEE
TSAGGDTLAIEVAVSPGKGKLILTGKLGDVMKESAQAAFSYIRSRAEELHIDPDFHEKND
ECCCCCEEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
IHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVGMTGEITLRGRVLPIGGLKEKT
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCCCHHHH
LSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLVSHLDEVLEHALVGVKQ
HHHHHCCCEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNTNERILPLLPLRGVLVYPTMVLHLDVGRDKSIQALEQAAVDENIIFLAMQKEMNIDDP
CCCCCCEEEECCCCCHHHHCEEEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
KEDDIYSVGTVAKVKQMLKLPNGTLRVLVEGLHRAKVVEFTELENVIQVSVQTIVEEEEG
CCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DLEEKALMRTLLEHFEQYIKVSKKISNETFATVADVEEPGRLADLIASHLPIKTKQKQEI
CHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHH
LEIVSVNERLHTLISIIQDEQELLSLEKKIGQKVKRSMERTQKEYFLREQMKAIQTELGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KEGKGGEVEELRKKIEEAGMPGETKEAVLKELDRYEKLPVSSAESGVIRNYIDWLLALPW
CCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCC
TDATDDKIDLAHSEMVLNKDHYGLEKVKERVLEYLAVQKLTNSLKGPILCLVGPPGVGKT
CCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
SLARSIAKSLNRNFVRVSLGGVRDESEIRGHRRTYVGAMPGRIIQGMKKAKTINPVFLLD
HHHHHHHHHHCCCEEEEEECCCCCHHHHCCCHHHEECCCCHHHHHHHHHHCCCCCCHHHH
EIDKMSNDFRGDPSAALLEVLDPEQNHNFSDHYIEEPYDLSKVMFVATANTLASIPGPLL
HHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHEEEHHHHHHCCCHHH
DRMEIISIAGYTEIEKVHIAREHLLSKQLKEHGLRKGNLQVRDEALLEIIRYYTREAGVR
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
TLERQIAKICRKSAKIIVTGERKRVVVTEKNITDLLGKRIFRYGQAEKIDQVGMATGLAY
HHHHHHHHHHHCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHCCEE
TSAGGDTLAIEVAVSPGKGKLILTGKLGDVMKESAQAAFSYIRSRAEELHIDPDFHEKND
ECCCCCEEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
IHIHVPEGAVPKDGPSAGITMATALISALTGIPVSKEVGMTGEITLRGRVLPIGGLKEKT
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCCCHHHH
LSAHRAGLTKIILPAENEKDLDDIPESVKENLTFVLVSHLDEVLEHALVGVKQ
HHHHHCCCEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA