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The map label for this gene is lon2 [H]

Identifier: 152976886

GI number: 152976886

Start: 3238373

End: 3240043

Strand: Reverse

Name: lon2 [H]

Synonym: Bcer98_3185

Alternate gene names: 152976886

Gene position: 3240043-3238373 (Counterclockwise)

Preceding gene: 152976887

Following gene: 152976885

Centisome position: 79.28

GC content: 40.57

Gene sequence:

>1671_bases
ATGAGCTGGACAAACATATTCTTACTCGTTCAACTTGTTTTTGGTGTTATTGTCGGTTTATATTTCTGGCATTTGCTCCG
AAATCAGCGAACGCAAAAAGTTTCCATTGATCGAGAATCGAAAAAAGAATTAGAGCAACTTCGTAACATGCGTGAGATTT
CTTTAACAGAACCACTTGCGGAAAAAGTACGTCCCACATCTTTTTCAGATATCGTTGGACAAGAAGATGGGATTCGATCA
TTAAAGGCGGCACTTTGTGGACCAAACCCGCAACATGTCATTATATATGGACCTCCTGGAGTAGGGAAAACAGCGGCGGC
GCGTCTTGTGTTAGAAGAAGCAAAGAAAAATCAAAAATCTCCATTTCGTAAGAGCGCAGCATTTATTGAACTGGATGCAA
CAACCGCACGTTTTGATGAGCGCGGCATTGCTGATCCTTTAATCGGTTCAGTACATGATCCGATTTACCAAGGGGCAGGA
GCGATGGGACAAGCAGGAATTCCGCAACCTAAAAAAGGGGCTGTCACAGATGCACATGGCGGTATTTTATTTATTGATGA
AATTGGAGAACTTCATCCTATTCAAATGAATAAAATGTTGAAGGTGTTAGAAGATCGAAAAGTATTTTTGGAAAGTGCAT
ATTACAGTGAAGAAAACACGCTGATTCCAACGTACATACATGATATTTTTCAAAAAGGTTTACCGGCTGATTTTCGTCTT
GTTGGAGCAACAACGCGCTCGCCAGAAGAACTTCCACCTGCGATTCGTTCTCGTTGTTTAGAGGTGTTCTTCCGTGAATT
GGATACGGAAGAAGTTCAAAAAGTGGCAAAGAATGCAGCGGAAAAAATAGAGATGGAAATTGACGAGCAAGGAATTGAAA
TGATAGGAATGTATGCAAGAAATGGCCGGGAAGCCATTAATCTTGTGCAAATTTCTGCTGGGATGGCAATTAATGAAGAG
CGTTCCTTTATTAAGAATGAGGATGTTGAATGGGTGATTCATGCTAGTCAACTTACTCCAACGTATGAACGGCGAATATA
CCCCATTCCACGAATTGGCTTAGTGAATGGTCTGGCTGTATATGGGCCTAATACAGGAGCATTATTAGAAGTTGAAGTTA
CAGCTATTCCTTCTCAGGGTAAGGGGACAGTAAATGTGACAGGTATTGTAGAGGAAGAGAGTATCGGGAGTCAAACGAAA
TCGATTCGTCGTAAAAGCATGGCGAAAGGATCGGTTGATAATGTATTAACTGTACTTCGTTCTTTAGAATTATTGCCAGA
AGGATATGATATACATATTAACTTTCCTGGAGGGATTCCAGTTGATGGTCCATCAGCTGGAATTGCAATGGCTACGGGAG
TGTATTCCGCTTTACATCGCGTATATATAAGTAACGAAATTGCGATGACAGGGGAGATTAGTATTCACGGAGAAGTGAAA
CCAGTGGGTGGTGTATATGCAAAAGTGAAAGCGGCAAAAAAGGCAGGGGCAAAAAAAGTGATTATTCCTGCTGAAAATAT
GCAGCCATTTTTGTATACGATAAAAGGAATTGAAATTATTCCTGTTCGCAAGCTAAAAGAAGTGTTTGAATTGGCATTCG
TACAGGAAAATTTACATCGTGAACTGGATATGCGTAACGATTTAGAAGAAGGCGATGTACAATCTATGTAA

Upstream 100 bases:

>100_bases
AAGAAACAGCAATTTTTGTAATTGCTGTTTCTTCTTATGTTTAGCGCGATTCCTCTCCGGAAATACTAAAGAGTAAAAAC
GTAGCGGGAGGAAATGAATC

Downstream 100 bases:

>100_bases
ATAGGGTGAAGCTTTCGGTAACGCGTTTCATTACATACGAATCAGAGCGTTGTTCGGTAGGGATTTTTGTAGAAATAAGA
AGCATATTGCGCACAATGGT

Product: sporulation protease LonB

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 556; Mature: 555

Protein sequence:

>556_residues
MSWTNIFLLVQLVFGVIVGLYFWHLLRNQRTQKVSIDRESKKELEQLRNMREISLTEPLAEKVRPTSFSDIVGQEDGIRS
LKAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKKNQKSPFRKSAAFIELDATTARFDERGIADPLIGSVHDPIYQGAG
AMGQAGIPQPKKGAVTDAHGGILFIDEIGELHPIQMNKMLKVLEDRKVFLESAYYSEENTLIPTYIHDIFQKGLPADFRL
VGATTRSPEELPPAIRSRCLEVFFRELDTEEVQKVAKNAAEKIEMEIDEQGIEMIGMYARNGREAINLVQISAGMAINEE
RSFIKNEDVEWVIHASQLTPTYERRIYPIPRIGLVNGLAVYGPNTGALLEVEVTAIPSQGKGTVNVTGIVEEESIGSQTK
SIRRKSMAKGSVDNVLTVLRSLELLPEGYDIHINFPGGIPVDGPSAGIAMATGVYSALHRVYISNEIAMTGEISIHGEVK
PVGGVYAKVKAAKKAGAKKVIIPAENMQPFLYTIKGIEIIPVRKLKEVFELAFVQENLHRELDMRNDLEEGDVQSM

Sequences:

>Translated_556_residues
MSWTNIFLLVQLVFGVIVGLYFWHLLRNQRTQKVSIDRESKKELEQLRNMREISLTEPLAEKVRPTSFSDIVGQEDGIRS
LKAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKKNQKSPFRKSAAFIELDATTARFDERGIADPLIGSVHDPIYQGAG
AMGQAGIPQPKKGAVTDAHGGILFIDEIGELHPIQMNKMLKVLEDRKVFLESAYYSEENTLIPTYIHDIFQKGLPADFRL
VGATTRSPEELPPAIRSRCLEVFFRELDTEEVQKVAKNAAEKIEMEIDEQGIEMIGMYARNGREAINLVQISAGMAINEE
RSFIKNEDVEWVIHASQLTPTYERRIYPIPRIGLVNGLAVYGPNTGALLEVEVTAIPSQGKGTVNVTGIVEEESIGSQTK
SIRRKSMAKGSVDNVLTVLRSLELLPEGYDIHINFPGGIPVDGPSAGIAMATGVYSALHRVYISNEIAMTGEISIHGEVK
PVGGVYAKVKAAKKAGAKKVIIPAENMQPFLYTIKGIEIIPVRKLKEVFELAFVQENLHRELDMRNDLEEGDVQSM
>Mature_555_residues
SWTNIFLLVQLVFGVIVGLYFWHLLRNQRTQKVSIDRESKKELEQLRNMREISLTEPLAEKVRPTSFSDIVGQEDGIRSL
KAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKKNQKSPFRKSAAFIELDATTARFDERGIADPLIGSVHDPIYQGAGA
MGQAGIPQPKKGAVTDAHGGILFIDEIGELHPIQMNKMLKVLEDRKVFLESAYYSEENTLIPTYIHDIFQKGLPADFRLV
GATTRSPEELPPAIRSRCLEVFFRELDTEEVQKVAKNAAEKIEMEIDEQGIEMIGMYARNGREAINLVQISAGMAINEER
SFIKNEDVEWVIHASQLTPTYERRIYPIPRIGLVNGLAVYGPNTGALLEVEVTAIPSQGKGTVNVTGIVEEESIGSQTKS
IRRKSMAKGSVDNVLTVLRSLELLPEGYDIHINFPGGIPVDGPSAGIAMATGVYSALHRVYISNEIAMTGEISIHGEVKP
VGGVYAKVKAAKKAGAKKVIIPAENMQPFLYTIKGIEIIPVRKLKEVFELAFVQENLHRELDMRNDLEEGDVQSM

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG1067

COG function: function code O; Predicted ATP-dependent protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S16 family [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=208, Percent_Identity=31.7307692307692, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI31377667, Length=170, Percent_Identity=36.4705882352941, Blast_Score=84, Evalue=5e-16,
Organism=Escherichia coli, GI1786643, Length=198, Percent_Identity=37.3737373737374, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17505831, Length=464, Percent_Identity=25.4310344827586, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17556486, Length=86, Percent_Identity=40.6976744186046, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319449, Length=85, Percent_Identity=42.3529411764706, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221513036, Length=541, Percent_Identity=24.2144177449168, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24666867, Length=541, Percent_Identity=24.2144177449168, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR020568
- InterPro:   IPR014251 [H]

Pfam domain/function: PF00004 AAA; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 61433; Mature: 61301

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4 ; PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWTNIFLLVQLVFGVIVGLYFWHLLRNQRTQKVSIDRESKKELEQLRNMREISLTEPLA
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
EKVRPTSFSDIVGQEDGIRSLKAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKKNQKS
HHCCCCCHHHHCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCC
PFRKSAAFIELDATTARFDERGIADPLIGSVHDPIYQGAGAMGQAGIPQPKKGAVTDAHG
CHHHCCEEEEECCHHHHHCCCCCCCHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCEECCC
GILFIDEIGELHPIQMNKMLKVLEDRKVFLESAYYSEENTLIPTYIHDIFQKGLPADFRL
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEE
VGATTRSPEELPPAIRSRCLEVFFRELDTEEVQKVAKNAAEKIEMEIDEQGIEMIGMYAR
EECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEHHCCCCCHHHHHHHHC
NGREAINLVQISAGMAINEERSFIKNEDVEWVIHASQLTPTYERRIYPIPRIGLVNGLAV
CCCHHEEEEEEECCCEECCHHHHHCCCCCEEEEEECCCCCHHHHEECCCCCCHHHCCEEE
YGPNTGALLEVEVTAIPSQGKGTVNVTGIVEEESIGSQTKSIRRKSMAKGSVDNVLTVLR
ECCCCCCEEEEEEEEECCCCCCEEEEEEEEECHHCCHHHHHHHHHHHHCCCHHHHHHHHH
SLELLPEGYDIHINFPGGIPVDGPSAGIAMATGVYSALHRVYISNEIAMTGEISIHGEVK
HHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCC
PVGGVYAKVKAAKKAGAKKVIIPAENMQPFLYTIKGIEIIPVRKLKEVFELAFVQENLHR
CCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCEEEEEHHHHHHHHHHHHHHHHHHH
ELDMRNDLEEGDVQSM
HHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SWTNIFLLVQLVFGVIVGLYFWHLLRNQRTQKVSIDRESKKELEQLRNMREISLTEPLA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
EKVRPTSFSDIVGQEDGIRSLKAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKKNQKS
HHCCCCCHHHHCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCC
PFRKSAAFIELDATTARFDERGIADPLIGSVHDPIYQGAGAMGQAGIPQPKKGAVTDAHG
CHHHCCEEEEECCHHHHHCCCCCCCHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCEECCC
GILFIDEIGELHPIQMNKMLKVLEDRKVFLESAYYSEENTLIPTYIHDIFQKGLPADFRL
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEE
VGATTRSPEELPPAIRSRCLEVFFRELDTEEVQKVAKNAAEKIEMEIDEQGIEMIGMYAR
EECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEHHCCCCCHHHHHHHHC
NGREAINLVQISAGMAINEERSFIKNEDVEWVIHASQLTPTYERRIYPIPRIGLVNGLAV
CCCHHEEEEEEECCCEECCHHHHHCCCCCEEEEEECCCCCHHHHEECCCCCCHHHCCEEE
YGPNTGALLEVEVTAIPSQGKGTVNVTGIVEEESIGSQTKSIRRKSMAKGSVDNVLTVLR
ECCCCCCEEEEEEEEECCCCCCEEEEEEEEECHHCCHHHHHHHHHHHHCCCHHHHHHHHH
SLELLPEGYDIHINFPGGIPVDGPSAGIAMATGVYSALHRVYISNEIAMTGEISIHGEVK
HHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCC
PVGGVYAKVKAAKKAGAKKVIIPAENMQPFLYTIKGIEIIPVRKLKEVFELAFVQENLHR
CCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCEEEEEHHHHHHHHHHHHHHHHHHH
ELDMRNDLEEGDVQSM
HHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 7961402; 11325926 [H]