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The map label for this gene is hemC [H]

Identifier: 152976881

GI number: 152976881

Start: 3231644

End: 3232573

Strand: Reverse

Name: hemC [H]

Synonym: Bcer98_3180

Alternate gene names: 152976881

Gene position: 3232573-3231644 (Counterclockwise)

Preceding gene: 152976882

Following gene: 152976880

Centisome position: 79.09

GC content: 39.46

Gene sequence:

>930_bases
ATGCGCAAAATTATTGTAGGTTCAAGAAAGAGTAAGCTGGCATTAACGCAAACGAATTGGTTTATTGATCAATTACAAGC
GCTTGGCTTACCGTATGAATTTGAAGTAAAGGAAATTGTTACAAAAGGGGATGTCATTTTAGACGTTACGCTTTCTAAAG
TAGGCGGTAAAGGGTTGTTTGTAAAAGAGATTGAGCATGCTCTTCTTACAAAAGAAATCGATATGGCTGTACACAGTATG
AAAGATATGCCTGCTGTGCTCCCAGCTGGTTTAACAATTGGGTGTATACCAAAGCGTGTGGATCCGCGTGATGCATTTAT
TTCAAAGAATGGGAAATCGTTTAAGGAGTTAGCAAAGGGTGCAACTCTTGGTACGAGCAGTTTAAGACGTAGCGCACAAT
TATTAGCTGCTAGACCTGACTTACAAGTGAAATGGATTCGTGGAAATATCGATACGAGATTACGTAAATTACAAGAAGAA
AACTATGATGCAATTATTTTAGCAACAGCTGGACTAAAGCGGATGGGTTGGGATAATGATGTAATTACAGAACATCTGGA
CGAATCTTTATGTGTACCAGCTGTAGGACAAGGTGCTTTAGCTATTGAATGTCGTGAAGATGATAAGGACTTATTACAGT
TATTAGCACATATGAACGATGCAGCAACAGAACGAACAGTAGCGGCAGAAAGAGTGTTTCTTCATAAGCTTGAAGGAGGA
TGTCAAGTACCTATTGCAGGATATGCAACCCTTCAAGAAAATGGAAAAATTAAATTACATGCACTTGTTGGATCAACGGA
TGGCTCTGTCTTATTAAAAGAAACAGTAGTAGGTACAAATCCCGAGACAGTAGGGTTAGAGGCGGCAGAGCGCTTGATTC
ATCAAGGTGCAAAAGAGCTCATTTCAGCTGCAAATAAGGAGCAACAATAA

Upstream 100 bases:

>100_bases
ATGGAATATTGGTGCATTTCTAGTTATGCTAGTTAATATTTTCCTATTGAGCAGTTTATCCAACTTCCATTTTTGGTATT
TATAATGAGGAGAGAAAGTT

Downstream 100 bases:

>100_bases
CTATGAATGCCCTTATTGGAAAAAAAGTACTCGTTACACGTGCCCGGCATCAAGCTGGGCAAATGAGCGCAGCAGTAAGA
AAAGAGAGCGGAATTCCAAT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MRKIIVGSRKSKLALTQTNWFIDQLQALGLPYEFEVKEIVTKGDVILDVTLSKVGGKGLFVKEIEHALLTKEIDMAVHSM
KDMPAVLPAGLTIGCIPKRVDPRDAFISKNGKSFKELAKGATLGTSSLRRSAQLLAARPDLQVKWIRGNIDTRLRKLQEE
NYDAIILATAGLKRMGWDNDVITEHLDESLCVPAVGQGALAIECREDDKDLLQLLAHMNDAATERTVAAERVFLHKLEGG
CQVPIAGYATLQENGKIKLHALVGSTDGSVLLKETVVGTNPETVGLEAAERLIHQGAKELISAANKEQQ

Sequences:

>Translated_309_residues
MRKIIVGSRKSKLALTQTNWFIDQLQALGLPYEFEVKEIVTKGDVILDVTLSKVGGKGLFVKEIEHALLTKEIDMAVHSM
KDMPAVLPAGLTIGCIPKRVDPRDAFISKNGKSFKELAKGATLGTSSLRRSAQLLAARPDLQVKWIRGNIDTRLRKLQEE
NYDAIILATAGLKRMGWDNDVITEHLDESLCVPAVGQGALAIECREDDKDLLQLLAHMNDAATERTVAAERVFLHKLEGG
CQVPIAGYATLQENGKIKLHALVGSTDGSVLLKETVVGTNPETVGLEAAERLIHQGAKELISAANKEQQ
>Mature_309_residues
MRKIIVGSRKSKLALTQTNWFIDQLQALGLPYEFEVKEIVTKGDVILDVTLSKVGGKGLFVKEIEHALLTKEIDMAVHSM
KDMPAVLPAGLTIGCIPKRVDPRDAFISKNGKSFKELAKGATLGTSSLRRSAQLLAARPDLQVKWIRGNIDTRLRKLQEE
NYDAIILATAGLKRMGWDNDVITEHLDESLCVPAVGQGALAIECREDDKDLLQLLAHMNDAATERTVAAERVFLHKLEGG
CQVPIAGYATLQENGKIKLHALVGSTDGSVLLKETVVGTNPETVGLEAAERLIHQGAKELISAANKEQQ

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=283, Percent_Identity=48.7632508833922, Blast_Score=243, Evalue=1e-64,
Organism=Homo sapiens, GI66933009, Length=305, Percent_Identity=46.5573770491803, Blast_Score=243, Evalue=2e-64,
Organism=Escherichia coli, GI48994974, Length=299, Percent_Identity=49.4983277591973, Blast_Score=263, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6319996, Length=316, Percent_Identity=38.6075949367089, Blast_Score=190, Evalue=2e-49,
Organism=Drosophila melanogaster, GI20130425, Length=284, Percent_Identity=42.6056338028169, Blast_Score=202, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33703; Mature: 33703

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKIIVGSRKSKLALTQTNWFIDQLQALGLPYEFEVKEIVTKGDVILDVTLSKVGGKGLF
CCCEEECCCCCEEEEEEHHHHHHHHHHHCCCCEEHHHHHHCCCCEEEEEEEHHCCCCCEE
VKEIEHALLTKEIDMAVHSMKDMPAVLPAGLTIGCIPKRVDPRDAFISKNGKSFKELAKG
HHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEECCCCCCCCHHHHHCCCCHHHHHHHCC
ATLGTSSLRRSAQLLAARPDLQVKWIRGNIDTRLRKLQEENYDAIILATAGLKRMGWDND
CCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCEEEEEECCHHHCCCCCH
VITEHLDESLCVPAVGQGALAIECREDDKDLLQLLAHMNDAATERTVAAERVFLHKLEGG
HHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
CQVPIAGYATLQENGKIKLHALVGSTDGSVLLKETVVGTNPETVGLEAAERLIHQGAKEL
CCCCCCCEEEEECCCCEEEEEEEECCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
ISAANKEQQ
HHHHCCCCC
>Mature Secondary Structure
MRKIIVGSRKSKLALTQTNWFIDQLQALGLPYEFEVKEIVTKGDVILDVTLSKVGGKGLF
CCCEEECCCCCEEEEEEHHHHHHHHHHHCCCCEEHHHHHHCCCCEEEEEEEHHCCCCCEE
VKEIEHALLTKEIDMAVHSMKDMPAVLPAGLTIGCIPKRVDPRDAFISKNGKSFKELAKG
HHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEECCCCCCCCHHHHHCCCCHHHHHHHCC
ATLGTSSLRRSAQLLAARPDLQVKWIRGNIDTRLRKLQEENYDAIILATAGLKRMGWDND
CCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCEEEEEECCHHHCCCCCH
VITEHLDESLCVPAVGQGALAIECREDDKDLLQLLAHMNDAATERTVAAERVFLHKLEGG
HHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
CQVPIAGYATLQENGKIKLHALVGSTDGSVLLKETVVGTNPETVGLEAAERLIHQGAKEL
CCCCCCCEEEEECCCCEEEEEEEECCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
ISAANKEQQ
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA