Click here to switch to the map view.

The map label for this gene is hemD [H]

Identifier: 152976880

GI number: 152976880

Start: 3230883

End: 3231641

Strand: Reverse

Name: hemD [H]

Synonym: Bcer98_3179

Alternate gene names: 152976880

Gene position: 3231641-3230883 (Counterclockwise)

Preceding gene: 152976881

Following gene: 152976879

Centisome position: 79.07

GC content: 37.29

Gene sequence:

>759_bases
ATGAATGCCCTTATTGGAAAAAAAGTACTCGTTACACGTGCCCGGCATCAAGCTGGGCAAATGAGCGCAGCAGTAAGAAA
AGAGAGCGGAATTCCAATGGAAATTCCGCTTTTGCGTATGGATGGGGTATCTCAAGAAAAGCTTCAAAGTGTAGCCAAAC
AGTTGCATGTATACGATTGGATAATTTTTACGAGCAAAAATGGGGTAAGGTTCTTTTTGGAGGCAATCCATCAGAAACTT
CCGCCTGCTGTAAAAATTGCTGCAGTCGGTATAAAAACAGCTCAAGAACTAGAAGCAAGAGGATATCAAGTTCATTTTGT
TCCAACAGCGTTTGTTGCTGAAACGTTTGCGATGGAATTTGTGCAAACATTAAATGGGACAGAGCGTATTTTATTTCCAA
AAGGGAATTTAGCAAGAGATGTAATTTCAGTGAAGCTTCGTGAAGCTCATATACTTGTAGAAGAGTTGGTTGTCTATGAG
ACGAAACTAAATGATGAGAAAAAAGAAGACCTAATCGCAGCTTTACAATCGAATCAAATTGATGTGATTACATTTACAAG
CCCTTCTACAGTTGACAGCTTTGTAAAGTTACTTGAGGGTACAAACTGGAGAGAATGGATAAAAAAATGTACAATTGCTT
GTATAGGACCAATAACAGAAAAAGAGGCAAGAAAGTATTTTAAAAATGTGCTTGTTCCTGAAGAATATACGATAGAATCA
TTGATACAATGCATTTCCAAATTTTATGTGAATGCATAA

Upstream 100 bases:

>100_bases
GTACAAATCCCGAGACAGTAGGGTTAGAGGCGGCAGAGCGCTTGATTCATCAAGGTGCAAAAGAGCTCATTTCAGCTGCA
AATAAGGAGCAACAATAACT

Downstream 100 bases:

>100_bases
TGAAAATAAAAGAATGGGGATAGAATTCTATGAACTCTTTACAATTTAATCGTCATCGTCGTTTAAGACAAAGTGGAAAT
ATGCGTGCACTTGTACGTGA

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MNALIGKKVLVTRARHQAGQMSAAVRKESGIPMEIPLLRMDGVSQEKLQSVAKQLHVYDWIIFTSKNGVRFFLEAIHQKL
PPAVKIAAVGIKTAQELEARGYQVHFVPTAFVAETFAMEFVQTLNGTERILFPKGNLARDVISVKLREAHILVEELVVYE
TKLNDEKKEDLIAALQSNQIDVITFTSPSTVDSFVKLLEGTNWREWIKKCTIACIGPITEKEARKYFKNVLVPEEYTIES
LIQCISKFYVNA

Sequences:

>Translated_252_residues
MNALIGKKVLVTRARHQAGQMSAAVRKESGIPMEIPLLRMDGVSQEKLQSVAKQLHVYDWIIFTSKNGVRFFLEAIHQKL
PPAVKIAAVGIKTAQELEARGYQVHFVPTAFVAETFAMEFVQTLNGTERILFPKGNLARDVISVKLREAHILVEELVVYE
TKLNDEKKEDLIAALQSNQIDVITFTSPSTVDSFVKLLEGTNWREWIKKCTIACIGPITEKEARKYFKNVLVPEEYTIES
LIQCISKFYVNA
>Mature_252_residues
MNALIGKKVLVTRARHQAGQMSAAVRKESGIPMEIPLLRMDGVSQEKLQSVAKQLHVYDWIIFTSKNGVRFFLEAIHQKL
PPAVKIAAVGIKTAQELEARGYQVHFVPTAFVAETFAMEFVQTLNGTERILFPKGNLARDVISVKLREAHILVEELVVYE
TKLNDEKKEDLIAALQSNQIDVITFTSPSTVDSFVKLLEGTNWREWIKKCTIACIGPITEKEARKYFKNVLVPEEYTIES
LIQCISKFYVNA

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 28466; Mature: 28466

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALIGKKVLVTRARHQAGQMSAAVRKESGIPMEIPLLRMDGVSQEKLQSVAKQLHVYDW
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHEE
IIFTSKNGVRFFLEAIHQKLPPAVKIAAVGIKTAQELEARGYQVHFVPTAFVAETFAMEF
EEEECCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHH
VQTLNGTERILFPKGNLARDVISVKLREAHILVEELVVYETKLNDEKKEDLIAALQSNQI
HHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCE
DVITFTSPSTVDSFVKLLEGTNWREWIKKCTIACIGPITEKEARKYFKNVLVPEEYTIES
EEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHH
LIQCISKFYVNA
HHHHHHHHHCCC
>Mature Secondary Structure
MNALIGKKVLVTRARHQAGQMSAAVRKESGIPMEIPLLRMDGVSQEKLQSVAKQLHVYDW
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHEE
IIFTSKNGVRFFLEAIHQKLPPAVKIAAVGIKTAQELEARGYQVHFVPTAFVAETFAMEF
EEEECCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHH
VQTLNGTERILFPKGNLARDVISVKLREAHILVEELVVYETKLNDEKKEDLIAALQSNQI
HHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCE
DVITFTSPSTVDSFVKLLEGTNWREWIKKCTIACIGPITEKEARKYFKNVLVPEEYTIES
EEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHH
LIQCISKFYVNA
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1672867; 9384377; 2110138 [H]