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The map label for this gene is iscS1 [H]

Identifier: 152976811

GI number: 152976811

Start: 3150435

End: 3151580

Strand: Reverse

Name: iscS1 [H]

Synonym: Bcer98_3109

Alternate gene names: 152976811

Gene position: 3151580-3150435 (Counterclockwise)

Preceding gene: 152976812

Following gene: 152976810

Centisome position: 77.11

GC content: 40.75

Gene sequence:

>1146_bases
ATGGAACGCATTTACTTAGATCATGCAGCAACATCTAAAGTTCATCCAGAAGTGGTCGAAAAGATGATTCCATATATGAC
GGAAATGTTTGGAAACCCCTCTAGTATTCATTTTTATGGACGACAAGCCCGCCATGCTGTAGATGAAGCAAGACGCACTT
GTGCGCGCAGCATTAATGCCAATCCAAATGAAATTATTTTTACAAGCGGCGGTACAGAGGCTGACAATTTAGCGCTTTTA
GGTGTAACGCGTGCAAATCGTCATAAAGGGAACCATATTATTACGACAAAGATTGAACATCACGCTATTTTGCATACATG
TGAGGTGCTAGAGCGCGAGGGATTTGAAGTGACATATTTGCCCGTTGATGAAACAGGGCGCGTGCAAATGGATGATGTGA
AGGCGGCGTTAACGGATCAAACGATTCTTGTATCTGTTATGTTTGGAAATAATGAAGTGGGAACCGTTCAACCAATTGCA
GAAATTGGAGAACTTTTAAAAGAACATCAAGCTTATTTCCATACAGATGCTGTACAAGCCTATGGTTTAATGAAGATTGA
CGTACAAGAACTGGGAATTGATTTATTATCCATTTCTGCTCATAAGATTAATGGTCCAAAAGGTGTCGGTTTTTTATATG
CGAACGCACAAGTGAAATTTGAACCTTTATTAACAGGTGGAGAACAAGAGCGAAAGCGCCGGGCTGGTACGGAAAATGTG
CCAAGTATTGTCGGGCTTGGGCATGCTATTTCACTTGCGGAGGAAACGCGTGAGCAAAAAAGTGCCCACTATGAAGAATT
TAAAGATATAATGATAGCTGTCTTTCAAAAAGAAGACATTACTTTTGAGGTAAACGGAAATGTAGAATATCGCTTGCCGC
ATGTGTTGAATGTAAGTTTCACAGGGATGAATATTGAACCGTTTCTTGTGAACTTAGATTTAGCTGGTATTGCAGTATCA
AGTGGTTCTGCTTGTACAGCTGGTTCGATTGATCCATCACACGTATTAGTGGCGATGTTTGGAAAAGATTCCGATAAAAT
ACGTTCATCCGTACGCTTTAGTTTTGGGCTTGGGAATACGAAAGAACAAGTAGAAAAAGCGGCGTACGAAACAGTGAAAA
TCGTGAAGCGATTCTCGCAAAACTAG

Upstream 100 bases:

>100_bases
CAACATTGGAAGATTTAGTACGCTATGAGGAAGAAAATAATGGGGGTTATATGTTTTACATTTAATTCCTTGTGAAACGA
TTTGGAAAGAAGGAGATTGA

Downstream 100 bases:

>100_bases
CATGGGAGGTGACATGATGAACAAACTACCTCACGAAACGCGCGTTGTCATCGGGATGTCTGGTGGCGTCGATTCATCTG
TAGCTGCGCTTTTACTAAAA

Product: aminotransferase class V

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MERIYLDHAATSKVHPEVVEKMIPYMTEMFGNPSSIHFYGRQARHAVDEARRTCARSINANPNEIIFTSGGTEADNLALL
GVTRANRHKGNHIITTKIEHHAILHTCEVLEREGFEVTYLPVDETGRVQMDDVKAALTDQTILVSVMFGNNEVGTVQPIA
EIGELLKEHQAYFHTDAVQAYGLMKIDVQELGIDLLSISAHKINGPKGVGFLYANAQVKFEPLLTGGEQERKRRAGTENV
PSIVGLGHAISLAEETREQKSAHYEEFKDIMIAVFQKEDITFEVNGNVEYRLPHVLNVSFTGMNIEPFLVNLDLAGIAVS
SGSACTAGSIDPSHVLVAMFGKDSDKIRSSVRFSFGLGNTKEQVEKAAYETVKIVKRFSQN

Sequences:

>Translated_381_residues
MERIYLDHAATSKVHPEVVEKMIPYMTEMFGNPSSIHFYGRQARHAVDEARRTCARSINANPNEIIFTSGGTEADNLALL
GVTRANRHKGNHIITTKIEHHAILHTCEVLEREGFEVTYLPVDETGRVQMDDVKAALTDQTILVSVMFGNNEVGTVQPIA
EIGELLKEHQAYFHTDAVQAYGLMKIDVQELGIDLLSISAHKINGPKGVGFLYANAQVKFEPLLTGGEQERKRRAGTENV
PSIVGLGHAISLAEETREQKSAHYEEFKDIMIAVFQKEDITFEVNGNVEYRLPHVLNVSFTGMNIEPFLVNLDLAGIAVS
SGSACTAGSIDPSHVLVAMFGKDSDKIRSSVRFSFGLGNTKEQVEKAAYETVKIVKRFSQN
>Mature_381_residues
MERIYLDHAATSKVHPEVVEKMIPYMTEMFGNPSSIHFYGRQARHAVDEARRTCARSINANPNEIIFTSGGTEADNLALL
GVTRANRHKGNHIITTKIEHHAILHTCEVLEREGFEVTYLPVDETGRVQMDDVKAALTDQTILVSVMFGNNEVGTVQPIA
EIGELLKEHQAYFHTDAVQAYGLMKIDVQELGIDLLSISAHKINGPKGVGFLYANAQVKFEPLLTGGEQERKRRAGTENV
PSIVGLGHAISLAEETREQKSAHYEEFKDIMIAVFQKEDITFEVNGNVEYRLPHVLNVSFTGMNIEPFLVNLDLAGIAVS
SGSACTAGSIDPSHVLVAMFGKDSDKIRSSVRFSFGLGNTKEQVEKAAYETVKIVKRFSQN

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=383, Percent_Identity=42.2976501305483, Blast_Score=309, Evalue=3e-84,
Organism=Homo sapiens, GI156713448, Length=400, Percent_Identity=35.75, Blast_Score=221, Evalue=8e-58,
Organism=Escherichia coli, GI48994898, Length=381, Percent_Identity=43.8320209973753, Blast_Score=297, Evalue=1e-81,
Organism=Escherichia coli, GI1787970, Length=385, Percent_Identity=27.012987012987, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789175, Length=386, Percent_Identity=25.9067357512953, Blast_Score=95, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI25143064, Length=366, Percent_Identity=46.1748633879781, Blast_Score=315, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI17533177, Length=326, Percent_Identity=30.6748466257669, Blast_Score=144, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6319831, Length=383, Percent_Identity=44.3864229765013, Blast_Score=313, Evalue=2e-86,
Organism=Drosophila melanogaster, GI20129463, Length=388, Percent_Identity=42.5257731958763, Blast_Score=294, Evalue=6e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42125; Mature: 42125

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERIYLDHAATSKVHPEVVEKMIPYMTEMFGNPSSIHFYGRQARHAVDEARRTCARSINA
CCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHCCC
NPNEIIFTSGGTEADNLALLGVTRANRHKGNHIITTKIEHHAILHTCEVLEREGFEVTYL
CCCEEEEECCCCCCCCEEEEEEEECCCCCCCEEEEEEEHHHHHHHHHHHHHCCCCEEEEE
PVDETGRVQMDDVKAALTDQTILVSVMFGNNEVGTVQPIAEIGELLKEHQAYFHTDAVQA
ECCCCCCEEHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
YGLMKIDVQELGIDLLSISAHKINGPKGVGFLYANAQVKFEPLLTGGEQERKRRAGTENV
CCEEEEEHHHHCEEEEEEEEEECCCCCCEEEEEECCEEEEEEEECCCHHHHHHHCCCCCC
PSIVGLGHAISLAEETREQKSAHYEEFKDIMIAVFQKEDITFEVNGNVEYRLPHVLNVSF
CHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEECCCEEEECCEEEEEEE
TGMNIEPFLVNLDLAGIAVSSGSACTAGSIDPSHVLVAMFGKDSDKIRSSVRFSFGLGNT
ECCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCEEEEEEECCCHHHHHHHEEEEECCCCC
KEQVEKAAYETVKIVKRFSQN
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MERIYLDHAATSKVHPEVVEKMIPYMTEMFGNPSSIHFYGRQARHAVDEARRTCARSINA
CCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHCCC
NPNEIIFTSGGTEADNLALLGVTRANRHKGNHIITTKIEHHAILHTCEVLEREGFEVTYL
CCCEEEEECCCCCCCCEEEEEEEECCCCCCCEEEEEEEHHHHHHHHHHHHHCCCCEEEEE
PVDETGRVQMDDVKAALTDQTILVSVMFGNNEVGTVQPIAEIGELLKEHQAYFHTDAVQA
ECCCCCCEEHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
YGLMKIDVQELGIDLLSISAHKINGPKGVGFLYANAQVKFEPLLTGGEQERKRRAGTENV
CCEEEEEHHHHCEEEEEEEEEECCCCCCEEEEEECCEEEEEEEECCCHHHHHHHCCCCCC
PSIVGLGHAISLAEETREQKSAHYEEFKDIMIAVFQKEDITFEVNGNVEYRLPHVLNVSF
CHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEECCCEEEECCEEEEEEE
TGMNIEPFLVNLDLAGIAVSSGSACTAGSIDPSHVLVAMFGKDSDKIRSSVRFSFGLGNT
ECCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCEEEEEEECCCHHHHHHHEEEEECCCCC
KEQVEKAAYETVKIVKRFSQN
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]