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The map label for this gene is mccB [H]

Identifier: 152976786

GI number: 152976786

Start: 3126762

End: 3127895

Strand: Reverse

Name: mccB [H]

Synonym: Bcer98_3084

Alternate gene names: 152976786

Gene position: 3127895-3126762 (Counterclockwise)

Preceding gene: 152976787

Following gene: 152976785

Centisome position: 76.53

GC content: 37.57

Gene sequence:

>1134_bases
ATGAGAGCAAAAACAAAATTAATTCATGGTATTCGCATAGGAGAACCTTCAACTGGATCTGTCAATGTGCCCATTTATCA
AACAAGTACGTACAGACAAGAAGCAGTTGGTAAGCATAAAGGTTATGAATATTCACGCACAGGAAACCCAACACGTGCAG
CTTTAGAAGAAATGATTGCAGTACTAGAAAACGGTCATGCGGGATTTGCATTTGGATCCGGAATGGCTGCAATTACAGCA
ACAATCATGTTATTCTCAAAAGGAGATCATATCATTTTAACGGATGATGTGTATGGTGGAACATATCGTGTTGTGACAAA
AGTATTGAACCGCTTTGGTGTTGAACATACATTTGTAGATACGACAAATTTGGATGAAGTAGCTACGGCAGTACGTCCAA
ATACAAAAGCGATTTATGTTGAAACACCAACAAACCCACTATTAAAGATTACAGATATCAAAGCAATTTCTACATTTGCC
AAAGAAAAGGGTTTGCTAACAATTATTGATAACACATTTATGACTCCTTATTGGCAGTCACCTATTTCTCTGGGAGCAGA
TATTGTCCTTCACAGTGCAACGAAATACTTAGGGGGACATAGTGATGTAGTTGCTGGTTTAGTTGTTGTAAATAGTCCGC
AATTAGCAGAAGATCTTCATTTTGTTCAAAATTCAACAGGTGGTGTTCTTGGACCACAAGATAGTTTCTTATTACTACGC
GGTTTAAAAACATTAGGTATTCGCATGGAAGAACATGAAGTAAACTCACGTGCAATTGCCGAGTTTTTAAATAACCATCC
AAAGGTTAATAAAGTATACTATCCAGGGCTTGAATCGCATCCGAATCATGCACTAGCAAAGGAACAGGCAAACGGATACG
GTGCTATTATTTCATTCGATGTAGATAGTGAAGAAACATTAAATAAGGTACTTGAGAAAGTACAATATTTCACACTTGCT
GAAAGTTTAGGGGCTGTTGAAAGCTTAATTTCAATCCCGGCACAAATGACACATGCTTCTATTCCAGCTGACCGCCGTAA
AGAACTAGGTATTACAGATACATTAATTCGTATTTCTGTCGGTATTGAAGATGGTCAAGATTTAATTGAAGATTTAGCGC
AAGCGTTGGCATAA

Upstream 100 bases:

>100_bases
AAGCTGAGAAAGCAAAACCAGGCACAAATATTGTAACGATCTTTCCAGATAGCAGTGAGCGTTACTTAAGTAAAGATATA
TACAAAGGATGGGAATAAAA

Downstream 100 bases:

>100_bases
TGAAAGAGCCGTGAATAACGGCTCTTTTTTTTGGCAAACTTCTCCCTCATTGACTGTATTTACTTGCTTCAAAAACTATT
AGAATATGATAAAGTGATAG

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: Gamma-cystathionase; Homocysteine gamma-lyase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MRAKTKLIHGIRIGEPSTGSVNVPIYQTSTYRQEAVGKHKGYEYSRTGNPTRAALEEMIAVLENGHAGFAFGSGMAAITA
TIMLFSKGDHIILTDDVYGGTYRVVTKVLNRFGVEHTFVDTTNLDEVATAVRPNTKAIYVETPTNPLLKITDIKAISTFA
KEKGLLTIIDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPQLAEDLHFVQNSTGGVLGPQDSFLLLR
GLKTLGIRMEEHEVNSRAIAEFLNNHPKVNKVYYPGLESHPNHALAKEQANGYGAIISFDVDSEETLNKVLEKVQYFTLA
ESLGAVESLISIPAQMTHASIPADRRKELGITDTLIRISVGIEDGQDLIEDLAQALA

Sequences:

>Translated_377_residues
MRAKTKLIHGIRIGEPSTGSVNVPIYQTSTYRQEAVGKHKGYEYSRTGNPTRAALEEMIAVLENGHAGFAFGSGMAAITA
TIMLFSKGDHIILTDDVYGGTYRVVTKVLNRFGVEHTFVDTTNLDEVATAVRPNTKAIYVETPTNPLLKITDIKAISTFA
KEKGLLTIIDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPQLAEDLHFVQNSTGGVLGPQDSFLLLR
GLKTLGIRMEEHEVNSRAIAEFLNNHPKVNKVYYPGLESHPNHALAKEQANGYGAIISFDVDSEETLNKVLEKVQYFTLA
ESLGAVESLISIPAQMTHASIPADRRKELGITDTLIRISVGIEDGQDLIEDLAQALA
>Mature_377_residues
MRAKTKLIHGIRIGEPSTGSVNVPIYQTSTYRQEAVGKHKGYEYSRTGNPTRAALEEMIAVLENGHAGFAFGSGMAAITA
TIMLFSKGDHIILTDDVYGGTYRVVTKVLNRFGVEHTFVDTTNLDEVATAVRPNTKAIYVETPTNPLLKITDIKAISTFA
KEKGLLTIIDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPQLAEDLHFVQNSTGGVLGPQDSFLLLR
GLKTLGIRMEEHEVNSRAIAEFLNNHPKVNKVYYPGLESHPNHALAKEQANGYGAIISFDVDSEETLNKVLEKVQYFTLA
ESLGAVESLISIPAQMTHASIPADRRKELGITDTLIRISVGIEDGQDLIEDLAQALA

Specific function: Catalyzes the conversion of cystathionine to cysteine, and homocysteine to sulfide [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=355, Percent_Identity=49.0140845070423, Blast_Score=335, Evalue=5e-92,
Organism=Homo sapiens, GI299473759, Length=355, Percent_Identity=44.5070422535211, Blast_Score=285, Evalue=4e-77,
Organism=Homo sapiens, GI25453487, Length=354, Percent_Identity=44.0677966101695, Blast_Score=272, Evalue=4e-73,
Organism=Escherichia coli, GI1790375, Length=356, Percent_Identity=44.3820224719101, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI1789383, Length=392, Percent_Identity=30.3571428571429, Blast_Score=176, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17560056, Length=369, Percent_Identity=47.9674796747967, Blast_Score=340, Evalue=8e-94,
Organism=Caenorhabditis elegans, GI17538055, Length=375, Percent_Identity=47.4666666666667, Blast_Score=330, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI71980708, Length=367, Percent_Identity=42.2343324250681, Blast_Score=275, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6319307, Length=367, Percent_Identity=44.141689373297, Blast_Score=306, Evalue=4e-84,
Organism=Saccharomyces cerevisiae, GI6321254, Length=379, Percent_Identity=35.8839050131926, Blast_Score=228, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6323333, Length=419, Percent_Identity=34.6062052505967, Blast_Score=179, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6321170, Length=318, Percent_Identity=32.3899371069182, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6321904, Length=343, Percent_Identity=32.9446064139942, Blast_Score=159, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6322970, Length=346, Percent_Identity=25.7225433526012, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323557, Length=337, Percent_Identity=24.3323442136499, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322590, Length=304, Percent_Identity=23.6842105263158, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19922554, Length=376, Percent_Identity=47.8723404255319, Blast_Score=371, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.1; =4.4.1.2 [H]

Molecular weight: Translated: 41002; Mature: 41002

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAKTKLIHGIRIGEPSTGSVNVPIYQTSTYRQEAVGKHKGYEYSRTGNPTRAALEEMIA
CCCCHHEEEEEECCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
VLENGHAGFAFGSGMAAITATIMLFSKGDHIILTDDVYGGTYRVVTKVLNRFGVEHTFVD
HHHCCCCCEEECCCHHHHHHEEHEEECCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEC
TTNLDEVATAVRPNTKAIYVETPTNPLLKITDIKAISTFAKEKGLLTIIDNTFMTPYWQS
CCCHHHHHHHHCCCCCEEEEECCCCCCEEEECHHHHHHHHHHCCCEEEECCCCCCCCCCC
PISLGADIVLHSATKYLGGHSDVVAGLVVVNSPQLAEDLHFVQNSTGGVLGPQDSFLLLR
HHHCCHHHHHHHHHHHHCCCHHHHEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCHHHHH
GLKTLGIRMEEHEVNSRAIAEFLNNHPKVNKVYYPGLESHPNHALAKEQANGYGAIISFD
HHHHHCCEEHHHHCCHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHCCCCCEEEEEEE
VDSEETLNKVLEKVQYFTLAESLGAVESLISIPAQMTHASIPADRRKELGITDTLIRISV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHCCCCEEEEEEEE
GIEDGQDLIEDLAQALA
CCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MRAKTKLIHGIRIGEPSTGSVNVPIYQTSTYRQEAVGKHKGYEYSRTGNPTRAALEEMIA
CCCCHHEEEEEECCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
VLENGHAGFAFGSGMAAITATIMLFSKGDHIILTDDVYGGTYRVVTKVLNRFGVEHTFVD
HHHCCCCCEEECCCHHHHHHEEHEEECCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEC
TTNLDEVATAVRPNTKAIYVETPTNPLLKITDIKAISTFAKEKGLLTIIDNTFMTPYWQS
CCCHHHHHHHHCCCCCEEEEECCCCCCEEEECHHHHHHHHHHCCCEEEECCCCCCCCCCC
PISLGADIVLHSATKYLGGHSDVVAGLVVVNSPQLAEDLHFVQNSTGGVLGPQDSFLLLR
HHHCCHHHHHHHHHHHHCCCHHHHEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCHHHHH
GLKTLGIRMEEHEVNSRAIAEFLNNHPKVNKVYYPGLESHPNHALAKEQANGYGAIISFD
HHHHHCCEEHHHHCCHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHCCCCCEEEEEEE
VDSEETLNKVLEKVQYFTLAESLGAVESLISIPAQMTHASIPADRRKELGITDTLIRISV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHCCCCEEEEEEEE
GIEDGQDLIEDLAQALA
CCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377 [H]