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The map label for this gene is ydgK [H]

Identifier: 152974030

GI number: 152974030

Start: 194807

End: 196003

Strand: Direct

Name: ydgK [H]

Synonym: Bcer98_0184

Alternate gene names: 152974030

Gene position: 194807-196003 (Clockwise)

Preceding gene: 152974029

Following gene: 152974031

Centisome position: 4.77

GC content: 40.77

Gene sequence:

>1197_bases
ATGATTATTGTTTTAGGGACACTCACAGCAATTGGCCCATTATCTATTGATATGTACTTGCCTTCATTGCCAAAATTAAT
GGGGGATTTGCAAACGAGTGCCTCCCTTGCTCAGCTTACACTAACAGCATGTTTACTCGGACTTTCAGTAGGACAATTAT
TTGTTGGTTCTATTAGTGATATTTATGGGCGGCGCAAACCTTTGATTATTGCCCTTATTATTTATGTAGCATCTTCTTTA
CTTTGTGCGGTTGCTCCATCTATTTGGATTCTAGTGCTATTACGGTTTCTGCAAGGAGCTTCAGGTTCAGCGGGTATTGT
CATATCCCGTGCGATGGTACGTGATATGTATACAGGCCCTGAGATGACAAAGTTCTTTTCGTTACTTATGTTAGTAAACG
GGGCAGCGCCTATTTTGGCGCCTATTATTGGTGGACAATTGTTGCAATTTACTTCATGGCACGGTGTATTTATTGTTCTT
GGCGTAATCAGTATTTGTATGTTAATATCAGTTATTTTTGTACTGCGTGAAACATTGCCATTAGAAGAAAGGATAACAGG
AGGCGTAGCAGGGACGCTGTCGGTCTATGGGAAGTTATTGAAAGACCGCTTATTTATGGGGTATGCCGTATCACAAGGGT
TCGTTTCAGCGGCGATGTTTGCTTATATTTCTGGATCGCCGTTTGTATTACAAAATATATATGGGGCATCGCCACAAGCA
TTTAGCTTATTTTTTGCGATTAACGGAATCGGTATTATTATTGCCAGTCAAATTACGGGCCGCTTGGCAGGAAAGGTAAG
TGAAAAAGCGTTGTTTGTAGTAGGTATTGGAATTGCGGCTGTTGGAGGTACTTCCTTACTACTTACGATTGTATTTGGAA
TTGGATTAATCGGTGTATTATGTTCTTTATTTCTTGTTGTATCGAGTGTTGGTGTTGTATCAACAACAGGTTTTTCACTT
GCGATGAGAAATCAAAAACAAGCGGCTGGAACGGCTGCTGCATTACTTGGTCTGCTACAATTTATCTCCGGGGCACTTGT
TGCACCTTTAGTAGGTATCGGGGGAAGTAATACAGCGCTTCCTATGGGTGTTGTTATTGCGTTATGTGAAGCAGGTGCCG
TTTTATATTATTTACTCATGGCAAGGCCTAGTGAAAGAAAACTTGTATTGCCGGAAAAACAAGATATAGACGCATAA

Upstream 100 bases:

>100_bases
TATCAATTTAACCTTATATTTATAGTAGAAAGGATGAATCTTACAAGTGAATGAAATGAATCACGGTGTATATAAGCCTG
TAAAAACAAACAGGTTTTGG

Downstream 100 bases:

>100_bases
AAAAGAGGTGGTTCAAACATAAATTGAATCACCTCTTTTCATATTATAACTATGGTGAGATTGGTTGCATAAAGTGACGA
TACTGTGACAAAAATGATGG

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MIIVLGTLTAIGPLSIDMYLPSLPKLMGDLQTSASLAQLTLTACLLGLSVGQLFVGSISDIYGRRKPLIIALIIYVASSL
LCAVAPSIWILVLLRFLQGASGSAGIVISRAMVRDMYTGPEMTKFFSLLMLVNGAAPILAPIIGGQLLQFTSWHGVFIVL
GVISICMLISVIFVLRETLPLEERITGGVAGTLSVYGKLLKDRLFMGYAVSQGFVSAAMFAYISGSPFVLQNIYGASPQA
FSLFFAINGIGIIIASQITGRLAGKVSEKALFVVGIGIAAVGGTSLLLTIVFGIGLIGVLCSLFLVVSSVGVVSTTGFSL
AMRNQKQAAGTAAALLGLLQFISGALVAPLVGIGGSNTALPMGVVIALCEAGAVLYYLLMARPSERKLVLPEKQDIDA

Sequences:

>Translated_398_residues
MIIVLGTLTAIGPLSIDMYLPSLPKLMGDLQTSASLAQLTLTACLLGLSVGQLFVGSISDIYGRRKPLIIALIIYVASSL
LCAVAPSIWILVLLRFLQGASGSAGIVISRAMVRDMYTGPEMTKFFSLLMLVNGAAPILAPIIGGQLLQFTSWHGVFIVL
GVISICMLISVIFVLRETLPLEERITGGVAGTLSVYGKLLKDRLFMGYAVSQGFVSAAMFAYISGSPFVLQNIYGASPQA
FSLFFAINGIGIIIASQITGRLAGKVSEKALFVVGIGIAAVGGTSLLLTIVFGIGLIGVLCSLFLVVSSVGVVSTTGFSL
AMRNQKQAAGTAAALLGLLQFISGALVAPLVGIGGSNTALPMGVVIALCEAGAVLYYLLMARPSERKLVLPEKQDIDA
>Mature_398_residues
MIIVLGTLTAIGPLSIDMYLPSLPKLMGDLQTSASLAQLTLTACLLGLSVGQLFVGSISDIYGRRKPLIIALIIYVASSL
LCAVAPSIWILVLLRFLQGASGSAGIVISRAMVRDMYTGPEMTKFFSLLMLVNGAAPILAPIIGGQLLQFTSWHGVFIVL
GVISICMLISVIFVLRETLPLEERITGGVAGTLSVYGKLLKDRLFMGYAVSQGFVSAAMFAYISGSPFVLQNIYGASPQA
FSLFFAINGIGIIIASQITGRLAGKVSEKALFVVGIGIAAVGGTSLLLTIVFGIGLIGVLCSLFLVVSSVGVVSTTGFSL
AMRNQKQAAGTAAALLGLLQFISGALVAPLVGIGGSNTALPMGVVIALCEAGAVLYYLLMARPSERKLVLPEKQDIDA

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=386, Percent_Identity=30.8290155440415, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI48994889, Length=360, Percent_Identity=30.2777777777778, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790146, Length=383, Percent_Identity=24.8041775456919, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082312, Length=342, Percent_Identity=26.3157894736842, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1787065, Length=367, Percent_Identity=24.7956403269755, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6321838, Length=264, Percent_Identity=25.3787878787879, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319517, Length=184, Percent_Identity=27.1739130434783, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319657, Length=169, Percent_Identity=30.1775147928994, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41453; Mature: 41453

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCC
>Mature Secondary Structure
MIIVLGTLTAIGPLSIDMYLPSLPKLMGDLQTSASLAQLTLTACLLGLSVGQLFVGSISD
CEEEEEEHHHCCCCEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYGRRKPLIIALIIYVASSLLCAVAPSIWILVLLRFLQGASGSAGIVISRAMVRDMYTGP
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
EMTKFFSLLMLVNGAAPILAPIIGGQLLQFTSWHGVFIVLGVISICMLISVIFVLRETLP
HHHHHHHHHHHHCCCHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
LEERITGGVAGTLSVYGKLLKDRLFMGYAVSQGFVSAAMFAYISGSPFVLQNIYGASPQA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHH
FSLFFAINGIGIIIASQITGRLAGKVSEKALFVVGIGIAAVGGTSLLLTIVFGIGLIGVL
EEEHEECCCCCEEEEHHHHHHHHHHHCCCEEEEEEEHHHHHCHHHHHHHHHHHHHHHHHH
CSLFLVVSSVGVVSTTGFSLAMRNQKQAAGTAAALLGLLQFISGALVAPLVGIGGSNTAL
HHHHHHHHCCCHHEECCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
PMGVVIALCEAGAVLYYLLMARPSERKLVLPEKQDIDA
HHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]