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The map label for this gene is folK [H]

Identifier: 152973922

GI number: 152973922

Start: 79016

End: 79531

Strand: Direct

Name: folK [H]

Synonym: Bcer98_0069

Alternate gene names: 152973922

Gene position: 79016-79531 (Clockwise)

Preceding gene: 152973921

Following gene: 152973923

Centisome position: 1.93

GC content: 35.27

Gene sequence:

>516_bases
ATGAAAAATACAGTTTATATTGCTTTAGGATCGAATATTGGTGATCGCTATACGTACTTAACGCAAGCGGTTGATTTATT
GGATAAGAATTCTAATGTTCAAGTGGAAGATGTTTCTTCAGTCTATGAAACAGACCCAGTGGGATATACAGATCAAAATC
GCTTTTTAAATATAGTCATAAAAATTTCTACCAATTTATTGCCGCAAGAACTATTAACAGTAACACAAAAGATTGAGAAT
GAATTAGGAAGAAAAAGGGAGATAAGATGGGGTCCAAGGACCATCGACCTTGACATTCTACTTTATAATCAAGACAATAT
TGAAACAGAGAATCTTATTGTTCCGCATCCGCGGATGTTTGAAAGAGCTTTTGTTATCGTTCCGTTGTTAGAAATTAATC
AAGATATAGAACAAAATATTTCACGTTCACAAGTAGAAGAAATGAAAAGGCGAGAGGGAGTAACGGTATGGAAGCAGAAA
AATGGGGAAGACGCATTCGTGCTTTTCGGAAGTTGA

Upstream 100 bases:

>100_bases
ATGGAAGTGTGATGCGTTGCACAGTAAAAGTTATCAAACCTGATCCTCCCATACCAGGACATTATCGTTCTGTAGCGGTA
GAAATAACGAGAGAACGAAC

Downstream 100 bases:

>100_bases
AAGGTTATACGCAAGAAAGCTTTGCGAAGGAATTAGGGGTATCTGTATCAGTTTTAGGAGAAGTTGAGAGAGGGAATAGA
TCACCTTCTCAAGATTTTGT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MKNTVYIALGSNIGDRYTYLTQAVDLLDKNSNVQVEDVSSVYETDPVGYTDQNRFLNIVIKISTNLLPQELLTVTQKIEN
ELGRKREIRWGPRTIDLDILLYNQDNIETENLIVPHPRMFERAFVIVPLLEINQDIEQNISRSQVEEMKRREGVTVWKQK
NGEDAFVLFGS

Sequences:

>Translated_171_residues
MKNTVYIALGSNIGDRYTYLTQAVDLLDKNSNVQVEDVSSVYETDPVGYTDQNRFLNIVIKISTNLLPQELLTVTQKIEN
ELGRKREIRWGPRTIDLDILLYNQDNIETENLIVPHPRMFERAFVIVPLLEINQDIEQNISRSQVEEMKRREGVTVWKQK
NGEDAFVLFGS
>Mature_171_residues
MKNTVYIALGSNIGDRYTYLTQAVDLLDKNSNVQVEDVSSVYETDPVGYTDQNRFLNIVIKISTNLLPQELLTVTQKIEN
ELGRKREIRWGPRTIDLDILLYNQDNIETENLIVPHPRMFERAFVIVPLLEINQDIEQNISRSQVEEMKRREGVTVWKQK
NGEDAFVLFGS

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=133, Percent_Identity=42.8571428571429, Blast_Score=109, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324073, Length=140, Percent_Identity=42.8571428571429, Blast_Score=115, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19801; Mature: 19801

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNTVYIALGSNIGDRYTYLTQAVDLLDKNSNVQVEDVSSVYETDPVGYTDQNRFLNIVI
CCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHCCCCCCCCCCCEEEEEE
KISTNLLPQELLTVTQKIENELGRKREIRWGPRTIDLDILLYNQDNIETENLIVPHPRMF
EEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCCCEECCCCHHH
ERAFVIVPLLEINQDIEQNISRSQVEEMKRREGVTVWKQKNGEDAFVLFGS
HCEEEEEEHHHCCCCHHHCCCHHHHHHHHHHCCCEEEECCCCCEEEEEECC
>Mature Secondary Structure
MKNTVYIALGSNIGDRYTYLTQAVDLLDKNSNVQVEDVSSVYETDPVGYTDQNRFLNIVI
CCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHCCCCCCCCCCCEEEEEE
KISTNLLPQELLTVTQKIENELGRKREIRWGPRTIDLDILLYNQDNIETENLIVPHPRMF
EEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCCCEECCCCHHH
ERAFVIVPLLEINQDIEQNISRSQVEEMKRREGVTVWKQKNGEDAFVLFGS
HCEEEEEEHHHCCCCHHHCCCHHHHHHHHHHCCCEEEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 2123867 [H]