Click here to switch to the map view.

The map label for this gene is xseA [H]

Identifier: 150398684

GI number: 150398684

Start: 3704633

End: 3706213

Strand: Direct

Name: xseA [H]

Synonym: Smed_3498

Alternate gene names: 150398684

Gene position: 3704633-3706213 (Clockwise)

Preceding gene: 150398683

Following gene: 150398685

Centisome position: 97.96

GC content: 67.24

Gene sequence:

>1581_bases
ATGACTTCGTTCTTTGATTCCGAATCTCCGTCCAACGTCGCCGAATATTCGGTGTCAGAGCTGTCCGGCTCGATCAAGCG
CACGATCGAGCAGACCTTCGAGCACGTCCGCGTGCGCGGCGAGATTTCCGGCTATCGCGGCCCCCATTCCTCGGGTCACG
CCTATTTCACCTTGAAGGACGATCGCGCCCGCATCGACGCGGTGGTCTGGAAGGGCACCTTCGCGCGGCTGAAGTTCAGG
CCGGAGGAGGGGATGGAGGTTATCGCTACCGGCAGAGTCACCACTTTTCCGGGGTCATCCAAGTATCAGGTCGTCATCGA
TGCGCTGGAGCCGGCCGGCGCCGGGGCGCTGATGGCGCTCATCGAGGAACGCAAGCGCAAGCTTGCGGCAGAGGGCCTTT
TCGATGCCGGCCGCAAGCGGCCTCTGCCCTTCATGCCCAAGGTCATCGGCGTCGTGACCTCGCCGACGGGTGCTGTGATC
CGCGACATTTTGCACCGGATCGCCGACCGGTTCCCGGTCCATGTTCTCGTCTGGCCGGTGCGCGTGCAAGGCGATGGCGC
CTGCGAGGAGATCGTGGCCGCGATCGAAGGTTTCAACGCGCTGCAGCCCGGCGGCCCGATCGCTCGACCGGACGTGCTGA
TCGTTGCGCGCGGCGGCGGCAGCCTCGAGGATCTCTGGTGTTTCAACGACGAGGCCATGGTGCGTGCAGCGGCCGGCTCC
GCCATCCCGCTGATTTCGGCCGTGGGCCACGAGACGGACTGGACGCTGATCGACCATGCGGCCGACCAACGGGCGCCCAC
GCCGACGGGTGCGGCCGAAATGGCGGTTCCCGTGAAGGCTGATCTCGAGGCCCAGCTTGCCAGTCTCTCCGCCCGGCTCA
AGGGCGCAGCAGTGCGGCAGATGGATAACCGCCGCCAGACGCTGCGTTCGCTGGCGCGGGCGCTACCCTCGCTCGATCAA
CTGCTCGCCTTGCCACGGCGGCGCTTCGACGAGGCGGCCGCCGGCCTCGGTCGTGGCCTGCAGATGAACACCGCCAACAA
ACGGCGGAGCTTCGAACGGAGCGCGGCCCATCTCCGGCCTGACCTTCTGACGGCGAGGATCGTCGATCGCCGCCAGCGCG
TCGTGGACGCCGTCAACCGGGCCGAACGCATCGTCGAGCGTCAGGTTCATCGTGGCGCCGCGCGCGTCGCGTCTGCCGAC
GCCTCGCTTCGCGCTCTGCCCTCACGACTGATCGGCCAGGTTCATCGCGCTTCGGACCGCGTCTCCGCCATGAGCCGGCG
TGCCGATGCGGCGATCGCCGCCGATTTGCGCAGGCTGAAAAGCGCGGTCGCGGCCCAGGATCGCGTGCTGCAGTCGCTCT
CCTATCGCAATGTCCTGCAACGCGGCTTCGCGCTGGTGCGCGATGCAGCAGGCGAGCCGGTGAAACAGGCGGCTGCCGTG
CATTCCGGAATGGCGCTGTCGGTAGAATTTGCCGACGGCCGCGTTGCCGCCGTAGCGGGCGAGGACGGTACTCCTTCCCA
GGCGCCGAAAAAACGACCGGCACGAGCGGGCGAGCCGACGAAGCAGGGCAGCCTCTTCTGA

Upstream 100 bases:

>100_bases
GAGCAGGGACTCGGTGATCCGCTGTGCTACGATGTAGAAAAACGCCGGATAGCAGCGCCTTGCTGCTGATCTTCTCCGCA
CTGTCGGCTACAAGTGACGC

Downstream 100 bases:

>100_bases
TGCGGATACTCCTGGTGCTTGCCCACCCGCTCGAGAATAGCTTTGCGGCAAGCGTCGCCAGAACAGCCAAGGAGAGCCTG
GAGGCGAAAGGCCACACGGT

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit [H]

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MTSFFDSESPSNVAEYSVSELSGSIKRTIEQTFEHVRVRGEISGYRGPHSSGHAYFTLKDDRARIDAVVWKGTFARLKFR
PEEGMEVIATGRVTTFPGSSKYQVVIDALEPAGAGALMALIEERKRKLAAEGLFDAGRKRPLPFMPKVIGVVTSPTGAVI
RDILHRIADRFPVHVLVWPVRVQGDGACEEIVAAIEGFNALQPGGPIARPDVLIVARGGGSLEDLWCFNDEAMVRAAAGS
AIPLISAVGHETDWTLIDHAADQRAPTPTGAAEMAVPVKADLEAQLASLSARLKGAAVRQMDNRRQTLRSLARALPSLDQ
LLALPRRRFDEAAAGLGRGLQMNTANKRRSFERSAAHLRPDLLTARIVDRRQRVVDAVNRAERIVERQVHRGAARVASAD
ASLRALPSRLIGQVHRASDRVSAMSRRADAAIAADLRRLKSAVAAQDRVLQSLSYRNVLQRGFALVRDAAGEPVKQAAAV
HSGMALSVEFADGRVAAVAGEDGTPSQAPKKRPARAGEPTKQGSLF

Sequences:

>Translated_526_residues
MTSFFDSESPSNVAEYSVSELSGSIKRTIEQTFEHVRVRGEISGYRGPHSSGHAYFTLKDDRARIDAVVWKGTFARLKFR
PEEGMEVIATGRVTTFPGSSKYQVVIDALEPAGAGALMALIEERKRKLAAEGLFDAGRKRPLPFMPKVIGVVTSPTGAVI
RDILHRIADRFPVHVLVWPVRVQGDGACEEIVAAIEGFNALQPGGPIARPDVLIVARGGGSLEDLWCFNDEAMVRAAAGS
AIPLISAVGHETDWTLIDHAADQRAPTPTGAAEMAVPVKADLEAQLASLSARLKGAAVRQMDNRRQTLRSLARALPSLDQ
LLALPRRRFDEAAAGLGRGLQMNTANKRRSFERSAAHLRPDLLTARIVDRRQRVVDAVNRAERIVERQVHRGAARVASAD
ASLRALPSRLIGQVHRASDRVSAMSRRADAAIAADLRRLKSAVAAQDRVLQSLSYRNVLQRGFALVRDAAGEPVKQAAAV
HSGMALSVEFADGRVAAVAGEDGTPSQAPKKRPARAGEPTKQGSLF
>Mature_525_residues
TSFFDSESPSNVAEYSVSELSGSIKRTIEQTFEHVRVRGEISGYRGPHSSGHAYFTLKDDRARIDAVVWKGTFARLKFRP
EEGMEVIATGRVTTFPGSSKYQVVIDALEPAGAGALMALIEERKRKLAAEGLFDAGRKRPLPFMPKVIGVVTSPTGAVIR
DILHRIADRFPVHVLVWPVRVQGDGACEEIVAAIEGFNALQPGGPIARPDVLIVARGGGSLEDLWCFNDEAMVRAAAGSA
IPLISAVGHETDWTLIDHAADQRAPTPTGAAEMAVPVKADLEAQLASLSARLKGAAVRQMDNRRQTLRSLARALPSLDQL
LALPRRRFDEAAAGLGRGLQMNTANKRRSFERSAAHLRPDLLTARIVDRRQRVVDAVNRAERIVERQVHRGAARVASADA
SLRALPSRLIGQVHRASDRVSAMSRRADAAIAADLRRLKSAVAAQDRVLQSLSYRNVLQRGFALVRDAAGEPVKQAAAVH
SGMALSVEFADGRVAAVAGEDGTPSQAPKKRPARAGEPTKQGSLF

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides [H]

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family [H]

Homologues:

Organism=Escherichia coli, GI1788856, Length=495, Percent_Identity=33.5353535353535, Blast_Score=243, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365 [H]

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti [H]

EC number: =3.1.11.6 [H]

Molecular weight: Translated: 56764; Mature: 56633

Theoretical pI: Translated: 10.81; Mature: 10.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSFFDSESPSNVAEYSVSELSGSIKRTIEQTFEHVRVRGEISGYRGPHSSGHAYFTLKD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
DRARIDAVVWKGTFARLKFRPEEGMEVIATGRVTTFPGSSKYQVVIDALEPAGAGALMAL
CCCCEEEEEECCEEEEEEECCCCCCEEEEECEEEECCCCCCEEEEEEECCCCCCHHHHHH
IEERKRKLAAEGLFDAGRKRPLPFMPKVIGVVTSPTGAVIRDILHRIADRFPVHVLVWPV
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEEEE
RVQGDGACEEIVAAIEGFNALQPGGPIARPDVLIVARGGGSLEDLWCFNDEAMVRAAAGS
EECCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCHHHHHHHCCC
AIPLISAVGHETDWTLIDHAADQRAPTPTGAAEMAVPVKADLEAQLASLSARLKGAAVRQ
CHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHH
MDNRRQTLRSLARALPSLDQLLALPRRRFDEAAAGLGRGLQMNTANKRRSFERSAAHLRP
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHCCH
DLLTARIVDRRQRVVDAVNRAERIVERQVHRGAARVASADASLRALPSRLIGQVHRASDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
VSAMSRRADAAIAADLRRLKSAVAAQDRVLQSLSYRNVLQRGFALVRDAAGEPVKQAAAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
HSGMALSVEFADGRVAAVAGEDGTPSQAPKKRPARAGEPTKQGSLF
HCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TSFFDSESPSNVAEYSVSELSGSIKRTIEQTFEHVRVRGEISGYRGPHSSGHAYFTLKD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
DRARIDAVVWKGTFARLKFRPEEGMEVIATGRVTTFPGSSKYQVVIDALEPAGAGALMAL
CCCCEEEEEECCEEEEEEECCCCCCEEEEECEEEECCCCCCEEEEEEECCCCCCHHHHHH
IEERKRKLAAEGLFDAGRKRPLPFMPKVIGVVTSPTGAVIRDILHRIADRFPVHVLVWPV
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEEEE
RVQGDGACEEIVAAIEGFNALQPGGPIARPDVLIVARGGGSLEDLWCFNDEAMVRAAAGS
EECCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCHHHHHHHCCC
AIPLISAVGHETDWTLIDHAADQRAPTPTGAAEMAVPVKADLEAQLASLSARLKGAAVRQ
CHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHH
MDNRRQTLRSLARALPSLDQLLALPRRRFDEAAAGLGRGLQMNTANKRRSFERSAAHLRP
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHCCH
DLLTARIVDRRQRVVDAVNRAERIVERQVHRGAARVASADASLRALPSRLIGQVHRASDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
VSAMSRRADAAIAADLRRLKSAVAAQDRVLQSLSYRNVLQRGFALVRDAAGEPVKQAAAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
HSGMALSVEFADGRVAAVAGEDGTPSQAPKKRPARAGEPTKQGSLF
HCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]