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The map label for this gene is aroA [H]

Identifier: 150398642

GI number: 150398642

Start: 3663656

End: 3665026

Strand: Direct

Name: aroA [H]

Synonym: Smed_3456

Alternate gene names: 150398642

Gene position: 3663656-3665026 (Clockwise)

Preceding gene: 150398640

Following gene: 150398643

Centisome position: 96.87

GC content: 64.77

Gene sequence:

>1371_bases
ATGTCCCACGGCTCGAACCCGCGACCCGCCACCGCACGCAAGTCTTCCGACCTCAAGGGCACGGTGCGCATCCCGGGCGA
CAAGTCGATCTCGCACCGCTCCTTCATGTTCGGCGGCCTTGCTTCGGGTGAGACGCGCATCACCGGACTCCTCGAAGGCG
AAGACGTGATCAATACCGGCAGGGCCATGCAGGCGATGGGTGCCAAAATTCGCAAGGAGGGCGACACCTGGATCATCGAC
GGCGTCGGGAACGGTGCGCTGCTCGCGCCCGAGGCGCCGCTCGACTTCGGCAATGCGGGAACCGGCTGCCGTCTGACCAT
GGGCCTCGTCGGCGTCTATGATTTCGATTCCACCTTCATCGGCGACGCCTCGCTGACGAAGCGCCCGATGGGCCGCGTGC
TCGATCCGCTCCGCGAAATGGGTGTCCAGGTGAAGTCGGCCGAGGGCGACCGGTTGCCGGTGACGCTGCGCGGACCGAAG
ACGCCGAACCCGATCACCTATCGCGTGCCGATGGCTTCGGCCCAGGTGAAATCCGCCGTGCTGCTCGCCGGGCTGAACAC
GCCCGGCATCACCACCGTCGTCGAGCCGGTAATGACCCGCGACCATACGGAAAAGATGCTCCAGGGCTTCGGCGCGGACC
TTTCGGTCGAGACCGACAGAGACGGCGTGCGCACCATCCGGCTCGAAGGCCGAGGCAAGCTGAGGGGTCAGGTGATCGAC
GTGCCGGGCGATCCGTCTTCCACGGCCTTTCCGCTGGTGGCGGCGCTTCTTGTGCCGGGGTCCGACCTTAGCATTTTCAA
CGTGCTGATGAACCCGACCCGTACAGGGCTCATTCTAACGCTTCAGGAAATGGGTGCCAGGATCGAAGTGCTGAGCAGCC
GGCTTGCCGGTGGCGAGGATGTCGCCGATCTGCGCGTACGCTATTCGGAACTCAAGGGCGTGACGGTACCGGAAGAGCGC
GCACCCTCGATGATCGACGAATATCCCGTGCTTGCCGTCGCGGCCGCCTTCGCCGAAGGCGCAACGGTGATGAACGGGCT
GGAGGAACTGAGGGTCAAGGAATCCGATCGCCTGTCCGCCGTTGCCGAGGGACTGAAGCTCAACGGCGTCGATTGCGACG
AGGGCGAGGCCTCGCTCGTCGTACGCGGCCGGCCGGGCGGCAAGGGCCTGGGCAATGATTCGGGCGGCCAGGTCAAAACC
CATCTCGATCACCGCATCGCCATGAGCTTCCTTGTCATGGGGCTTGCCTCGGAGCGTCCGGTGACGGTCGACGATGCGAC
GATGATCGCGACGTCCTTCCCCGAGTTCATGGGACTGATGACAGGGTTGGGCGCGAAGATCGAAGAGACGGAAAACAAGG
CGGCCCTATGA

Upstream 100 bases:

>100_bases
TGTGTTAGGGAGCCGGCGAGACCGGCGGCCCACCACCAGCGCGCCGGAAAGCACCACCTTCCGCGCCCGCCGTCAGCCGG
ATTGTTAGAGGAAAACCACC

Downstream 100 bases:

>100_bases
GCTTCGTAGTCGCCATCGACGGACCCGCAGCCGCCGGCAAGGGAACGCTGTCGCGCCTGATCGCCAAGCGGTACGGCTTT
CACCATCTCGACACCGGACT

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MSHGSNPRPATARKSSDLKGTVRIPGDKSISHRSFMFGGLASGETRITGLLEGEDVINTGRAMQAMGAKIRKEGDTWIID
GVGNGALLAPEAPLDFGNAGTGCRLTMGLVGVYDFDSTFIGDASLTKRPMGRVLDPLREMGVQVKSAEGDRLPVTLRGPK
TPNPITYRVPMASAQVKSAVLLAGLNTPGITTVVEPVMTRDHTEKMLQGFGADLSVETDRDGVRTIRLEGRGKLRGQVID
VPGDPSSTAFPLVAALLVPGSDLSIFNVLMNPTRTGLILTLQEMGARIEVLSSRLAGGEDVADLRVRYSELKGVTVPEER
APSMIDEYPVLAVAAAFAEGATVMNGLEELRVKESDRLSAVAEGLKLNGVDCDEGEASLVVRGRPGGKGLGNDSGGQVKT
HLDHRIAMSFLVMGLASERPVTVDDATMIATSFPEFMGLMTGLGAKIEETENKAAL

Sequences:

>Translated_456_residues
MSHGSNPRPATARKSSDLKGTVRIPGDKSISHRSFMFGGLASGETRITGLLEGEDVINTGRAMQAMGAKIRKEGDTWIID
GVGNGALLAPEAPLDFGNAGTGCRLTMGLVGVYDFDSTFIGDASLTKRPMGRVLDPLREMGVQVKSAEGDRLPVTLRGPK
TPNPITYRVPMASAQVKSAVLLAGLNTPGITTVVEPVMTRDHTEKMLQGFGADLSVETDRDGVRTIRLEGRGKLRGQVID
VPGDPSSTAFPLVAALLVPGSDLSIFNVLMNPTRTGLILTLQEMGARIEVLSSRLAGGEDVADLRVRYSELKGVTVPEER
APSMIDEYPVLAVAAAFAEGATVMNGLEELRVKESDRLSAVAEGLKLNGVDCDEGEASLVVRGRPGGKGLGNDSGGQVKT
HLDHRIAMSFLVMGLASERPVTVDDATMIATSFPEFMGLMTGLGAKIEETENKAAL
>Mature_455_residues
SHGSNPRPATARKSSDLKGTVRIPGDKSISHRSFMFGGLASGETRITGLLEGEDVINTGRAMQAMGAKIRKEGDTWIIDG
VGNGALLAPEAPLDFGNAGTGCRLTMGLVGVYDFDSTFIGDASLTKRPMGRVLDPLREMGVQVKSAEGDRLPVTLRGPKT
PNPITYRVPMASAQVKSAVLLAGLNTPGITTVVEPVMTRDHTEKMLQGFGADLSVETDRDGVRTIRLEGRGKLRGQVIDV
PGDPSSTAFPLVAALLVPGSDLSIFNVLMNPTRTGLILTLQEMGARIEVLSSRLAGGEDVADLRVRYSELKGVTVPEERA
PSMIDEYPVLAVAAAFAEGATVMNGLEELRVKESDRLSAVAEGLKLNGVDCDEGEASLVVRGRPGGKGLGNDSGGQVKTH
LDHRIAMSFLVMGLASERPVTVDDATMIATSFPEFMGLMTGLGAKIEETENKAAL

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1787137, Length=438, Percent_Identity=28.310502283105, Blast_Score=122, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6320332, Length=478, Percent_Identity=26.9874476987448, Blast_Score=106, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792 [H]

Pfam domain/function: PF00275 EPSP_synthase [H]

EC number: =2.5.1.19 [H]

Molecular weight: Translated: 48180; Mature: 48049

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00104 EPSP_SYNTHASE_1 ; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHGSNPRPATARKSSDLKGTVRIPGDKSISHRSFMFGGLASGETRITGLLEGEDVINTG
CCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEECCCCCCCEEEEEEECCCHHHHCC
RAMQAMGAKIRKEGDTWIIDGVGNGALLAPEAPLDFGNAGTGCRLTMGLVGVYDFDSTFI
HHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCEEEEEEEEEEECCCCEE
GDASLTKRPMGRVLDPLREMGVQVKSAEGDRLPVTLRGPKTPNPITYRVPMASAQVKSAV
CCCHHHHCHHHHHHHHHHHHCCEEECCCCCEEEEEEECCCCCCCEEEEECCCHHHHCCEE
LLAGLNTPGITTVVEPVMTRDHTEKMLQGFGADLSVETDRDGVRTIRLEGRGKLRGQVID
EEEECCCCCHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCCEEEEE
VPGDPSSTAFPLVAALLVPGSDLSIFNVLMNPTRTGLILTLQEMGARIEVLSSRLAGGED
CCCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEHHHHCCHHHHHHHHCCCCCC
VADLRVRYSELKGVTVPEERAPSMIDEYPVLAVAAAFAEGATVMNGLEELRVKESDRLSA
HHHHHHHHHHHCCCCCCHHHCCCHHHHCHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHH
VAEGLKLNGVDCDEGEASLVVRGRPGGKGLGNDSGGQVKTHLDHRIAMSFLVMGLASERP
HHCCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCC
VTVDDATMIATSFPEFMGLMTGLGAKIEETENKAAL
EEECCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCC
>Mature Secondary Structure 
SHGSNPRPATARKSSDLKGTVRIPGDKSISHRSFMFGGLASGETRITGLLEGEDVINTG
CCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEECCCCCCCEEEEEEECCCHHHHCC
RAMQAMGAKIRKEGDTWIIDGVGNGALLAPEAPLDFGNAGTGCRLTMGLVGVYDFDSTFI
HHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCEEEEEEEEEEECCCCEE
GDASLTKRPMGRVLDPLREMGVQVKSAEGDRLPVTLRGPKTPNPITYRVPMASAQVKSAV
CCCHHHHCHHHHHHHHHHHHCCEEECCCCCEEEEEEECCCCCCCEEEEECCCHHHHCCEE
LLAGLNTPGITTVVEPVMTRDHTEKMLQGFGADLSVETDRDGVRTIRLEGRGKLRGQVID
EEEECCCCCHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCCEEEEE
VPGDPSSTAFPLVAALLVPGSDLSIFNVLMNPTRTGLILTLQEMGARIEVLSSRLAGGED
CCCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEHHHHCCHHHHHHHHCCCCCC
VADLRVRYSELKGVTVPEERAPSMIDEYPVLAVAAAFAEGATVMNGLEELRVKESDRLSA
HHHHHHHHHHHCCCCCCHHHCCCHHHHCHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHH
VAEGLKLNGVDCDEGEASLVVRGRPGGKGLGNDSGGQVKTHLDHRIAMSFLVMGLASERP
HHCCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCC
VTVDDATMIATSFPEFMGLMTGLGAKIEETENKAAL
EEECCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8598558 [H]