Click here to switch to the map view.

The map label for this gene is aroE [H]

Identifier: 150398403

GI number: 150398403

Start: 3386483

End: 3387343

Strand: Direct

Name: aroE [H]

Synonym: Smed_3211

Alternate gene names: 150398403

Gene position: 3386483-3387343 (Clockwise)

Preceding gene: 150398402

Following gene: 150398404

Centisome position: 89.54

GC content: 62.6

Gene sequence:

>861_bases
ATGCGTGATTCACGTGAAACATTTGTTAACCATGCCTTCGTCGCGGGCTATCCGGTGAAGCATTCGCGCTCGCCGCTCAT
TCATGGCTACTGGCTGAAGCGCTTCGGAATTCAGGGAAGCTACCGTGCCCACGAGGTCACGTCCGACGCCTTCCCGGATT
TCATGCGGCAGATCAAGGAGGGAACCGCGGGCTTCTGCGGCGGCAATGTCACGATTCCGCATAAAGAGGCCGCCTTTCGG
CTGTCCGACCGGCCGGACGAATTGAGCGCCGAACTGGGGGCCGCCAACACGCTCTGGCTCGAGAATGGGACCATCCGCGC
GACGAACACCGATGGTCGCGGTTTCGTTGCCAATCTCGATGAGCGCGCCAAAGGCTGGGACCGCATCTCGGCCGCGGTCA
TTCTCGGCGCCGGCGGTGCCAGCCGTGCGGTGATCCAGGCAATCCGCGACCGCGGGGTGAAGGCGATCCATGTGGTGAAC
CGCACGCCCGAGCGGGCGAGGGAACTCGCGGATCGCTTCGGTAGCGCGGTGCACGCGCATTCCATGGCCGCGCTTCCAGA
AGTTCTTTCCGGCGCCGGGCTTTTCGTGAACACGACGTCACTCGGAATGGATGGCGAGCCTGCGCCGGCGATCGACTTTT
CGAAGCTGGCGCGGGACGCCGTCGTGACTGATATCGTCTATGTGCCGTTGAAGACGCCGCTGCTTCGGCAGGCCGAAGAA
CAGGGCTTTCGCGTTGTCGATGGACTTGGCATGCTCCTCCACCAGGCGGCGCCCGGATTCGAAAAATGGTTCGGCCTCAG
GCCGGTCGTCGACGAAGCGCTCAGAGAGATCATCATCAGCGATATGGACAAGCACGCATGA

Upstream 100 bases:

>100_bases
GGCATCCAGCTGTTCGAGAGGATAGATGGCGATTACTTCACCATCCTCGGACTGCCGATGCTGCCGCTCCTGTCCAGACT
TCGCGAAATGGGTGCGATCG

Downstream 100 bases:

>100_bases
TCATCGTCGGCCTTACCGGTTCCATCGGGATGGGGAAATCGACCGCAGCAGGGATGTTCCGGGAACTGGGCGTGCCGGTC
AACGATGCCGACGAAGTGGT

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MRDSRETFVNHAFVAGYPVKHSRSPLIHGYWLKRFGIQGSYRAHEVTSDAFPDFMRQIKEGTAGFCGGNVTIPHKEAAFR
LSDRPDELSAELGAANTLWLENGTIRATNTDGRGFVANLDERAKGWDRISAAVILGAGGASRAVIQAIRDRGVKAIHVVN
RTPERARELADRFGSAVHAHSMAALPEVLSGAGLFVNTTSLGMDGEPAPAIDFSKLARDAVVTDIVYVPLKTPLLRQAEE
QGFRVVDGLGMLLHQAAPGFEKWFGLRPVVDEALREIIISDMDKHA

Sequences:

>Translated_286_residues
MRDSRETFVNHAFVAGYPVKHSRSPLIHGYWLKRFGIQGSYRAHEVTSDAFPDFMRQIKEGTAGFCGGNVTIPHKEAAFR
LSDRPDELSAELGAANTLWLENGTIRATNTDGRGFVANLDERAKGWDRISAAVILGAGGASRAVIQAIRDRGVKAIHVVN
RTPERARELADRFGSAVHAHSMAALPEVLSGAGLFVNTTSLGMDGEPAPAIDFSKLARDAVVTDIVYVPLKTPLLRQAEE
QGFRVVDGLGMLLHQAAPGFEKWFGLRPVVDEALREIIISDMDKHA
>Mature_286_residues
MRDSRETFVNHAFVAGYPVKHSRSPLIHGYWLKRFGIQGSYRAHEVTSDAFPDFMRQIKEGTAGFCGGNVTIPHKEAAFR
LSDRPDELSAELGAANTLWLENGTIRATNTDGRGFVANLDERAKGWDRISAAVILGAGGASRAVIQAIRDRGVKAIHVVN
RTPERARELADRFGSAVHAHSMAALPEVLSGAGLFVNTTSLGMDGEPAPAIDFSKLARDAVVTDIVYVPLKTPLLRQAEE
QGFRVVDGLGMLLHQAAPGFEKWFGLRPVVDEALREIIISDMDKHA

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789675, Length=269, Percent_Identity=36.8029739776952, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1787983, Length=262, Percent_Identity=33.206106870229, Blast_Score=124, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6320332, Length=268, Percent_Identity=28.3582089552239, Blast_Score=96, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 31180; Mature: 31180

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDSRETFVNHAFVAGYPVKHSRSPLIHGYWLKRFGIQGSYRAHEVTSDAFPDFMRQIKE
CCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHC
GTAGFCGGNVTIPHKEAAFRLSDRPDELSAELGAANTLWLENGTIRATNTDGRGFVANLD
CCCCCCCCCCCCCCHHHHEECCCCCHHHHHHHCCCEEEEEECCEEEEECCCCCCEEECCH
ERAKGWDRISAAVILGAGGASRAVIQAIRDRGVKAIHVVNRTPERARELADRFGSAVHAH
HHHCCHHHHEEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
SMAALPEVLSGAGLFVNTTSLGMDGEPAPAIDFSKLARDAVVTDIVYVPLKTPLLRQAEE
HHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHEEEECCCCHHHHHHHH
QGFRVVDGLGMLLHQAAPGFEKWFGLRPVVDEALREIIISDMDKHA
CCCCHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRDSRETFVNHAFVAGYPVKHSRSPLIHGYWLKRFGIQGSYRAHEVTSDAFPDFMRQIKE
CCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHC
GTAGFCGGNVTIPHKEAAFRLSDRPDELSAELGAANTLWLENGTIRATNTDGRGFVANLD
CCCCCCCCCCCCCCHHHHEECCCCCHHHHHHHCCCEEEEEECCEEEEECCCCCCEEECCH
ERAKGWDRISAAVILGAGGASRAVIQAIRDRGVKAIHVVNRTPERARELADRFGSAVHAH
HHHCCHHHHEEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
SMAALPEVLSGAGLFVNTTSLGMDGEPAPAIDFSKLARDAVVTDIVYVPLKTPLLRQAEE
HHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHEEEECCCCHHHHHHHH
QGFRVVDGLGMLLHQAAPGFEKWFGLRPVVDEALREIIISDMDKHA
CCCCHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]