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The map label for this gene is coaE [H]

Identifier: 150398404

GI number: 150398404

Start: 3387340

End: 3387924

Strand: Direct

Name: coaE [H]

Synonym: Smed_3212

Alternate gene names: 150398404

Gene position: 3387340-3387924 (Clockwise)

Preceding gene: 150398403

Following gene: 150398405

Centisome position: 89.57

GC content: 61.2

Gene sequence:

>585_bases
ATGATCATCGTCGGCCTTACCGGTTCCATCGGGATGGGGAAATCGACCGCAGCAGGGATGTTCCGGGAACTGGGCGTGCC
GGTCAACGATGCCGACGAAGTGGTGCACCAGCTATATCGCGGGGAAGCGGTGGAGCCGATCGAAGCCGCCTTTCCGGGCG
TCGCGAAGGACGGCACCATCGACCGGTCGGAGCTTTCGCAGCGGCTTGTCGCGGCTCCCGAGCGCCTTGCCGAATTGGAG
CAAATCGTCCATCCCTTGGTGCGTGCCAGAGAGCAGGAATTCCTCGCGCGTTGCAAGGCAGCCGGCTCTCCTTTCGTGGT
TCTCGACATTCCGCTGCTCTTCGAGACCAAGGCCGAGACACGCGTCGACCGCGTCATAGTCGTGACCTGCGATCCCGAGA
TGCAGAAAGAACGCGTCTTGAAACGCCCGGGAATGACGGCCGAAAAATTCGCGATGATTCTCAAGCGGCAGGTGCCGGAC
AGCGAGAAACGCAGCCGTGCGGACTATGTCGTCGATACCAGCGACAGCTTCGATGTCACACGGCAGCAGATCCGCGCGAT
CGTCGACGATTTGAGGGCGAATTAG

Upstream 100 bases:

>100_bases
TCCACCAGGCGGCGCCCGGATTCGAAAAATGGTTCGGCCTCAGGCCGGTCGTCGACGAAGCGCTCAGAGAGATCATCATC
AGCGATATGGACAAGCACGC

Downstream 100 bases:

>100_bases
CCGTTCGCCGCGGAAAGGTGCTCGTATCAACGGTGCAAAGCCTTCGCCGCAACTTCAATTGACGGTCGAATGACACTAAG
AATGGAAAACAGCTTCGGGT

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase [H]

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MIIVGLTGSIGMGKSTAAGMFRELGVPVNDADEVVHQLYRGEAVEPIEAAFPGVAKDGTIDRSELSQRLVAAPERLAELE
QIVHPLVRAREQEFLARCKAAGSPFVVLDIPLLFETKAETRVDRVIVVTCDPEMQKERVLKRPGMTAEKFAMILKRQVPD
SEKRSRADYVVDTSDSFDVTRQQIRAIVDDLRAN

Sequences:

>Translated_194_residues
MIIVGLTGSIGMGKSTAAGMFRELGVPVNDADEVVHQLYRGEAVEPIEAAFPGVAKDGTIDRSELSQRLVAAPERLAELE
QIVHPLVRAREQEFLARCKAAGSPFVVLDIPLLFETKAETRVDRVIVVTCDPEMQKERVLKRPGMTAEKFAMILKRQVPD
SEKRSRADYVVDTSDSFDVTRQQIRAIVDDLRAN
>Mature_194_residues
MIIVGLTGSIGMGKSTAAGMFRELGVPVNDADEVVHQLYRGEAVEPIEAAFPGVAKDGTIDRSELSQRLVAAPERLAELE
QIVHPLVRAREQEFLARCKAAGSPFVVLDIPLLFETKAETRVDRVIVVTCDPEMQKERVLKRPGMTAEKFAMILKRQVPD
SEKRSRADYVVDTSDSFDVTRQQIRAIVDDLRAN

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A [H]

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain [H]

Homologues:

Organism=Homo sapiens, GI191252797, Length=197, Percent_Identity=29.4416243654822, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI191252795, Length=197, Percent_Identity=29.4416243654822, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI110227607, Length=188, Percent_Identity=27.1276595744681, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI110227605, Length=188, Percent_Identity=27.1276595744681, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI110227603, Length=188, Percent_Identity=27.1276595744681, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI110227601, Length=188, Percent_Identity=27.1276595744681, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI205277394, Length=188, Percent_Identity=27.1276595744681, Blast_Score=67, Evalue=8e-12,
Organism=Escherichia coli, GI1786292, Length=180, Percent_Identity=36.1111111111111, Blast_Score=100, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17554944, Length=202, Percent_Identity=29.2079207920792, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320402, Length=206, Percent_Identity=28.6407766990291, Blast_Score=91, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24644728, Length=204, Percent_Identity=28.4313725490196, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24658602, Length=192, Percent_Identity=28.6458333333333, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001977 [H]

Pfam domain/function: PF01121 CoaE [H]

EC number: =2.7.1.24 [H]

Molecular weight: Translated: 21504; Mature: 21504

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIVGLTGSIGMGKSTAAGMFRELGVPVNDADEVVHQLYRGEAVEPIEAAFPGVAKDGTI
CEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHCCCCCCCCCC
DRSELSQRLVAAPERLAELEQIVHPLVRAREQEFLARCKAAGSPFVVLDIPLLFETKAET
CHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHCCCHHH
RVDRVIVVTCDPEMQKERVLKRPGMTAEKFAMILKRQVPDSEKRSRADYVVDTSDSFDVT
CCCEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHCCCCEEEECCCCHHHH
RQQIRAIVDDLRAN
HHHHHHHHHHHCCC
>Mature Secondary Structure
MIIVGLTGSIGMGKSTAAGMFRELGVPVNDADEVVHQLYRGEAVEPIEAAFPGVAKDGTI
CEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHCCCCCCCCCC
DRSELSQRLVAAPERLAELEQIVHPLVRAREQEFLARCKAAGSPFVVLDIPLLFETKAET
CHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHCCCHHH
RVDRVIVVTCDPEMQKERVLKRPGMTAEKFAMILKRQVPDSEKRSRADYVVDTSDSFDVT
CCCEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHCCCCEEEECCCCHHHH
RQQIRAIVDDLRAN
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]