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The map label for this gene is hppA [H]

Identifier: 150396048

GI number: 150396048

Start: 886442

End: 888577

Strand: Direct

Name: hppA [H]

Synonym: Smed_0824

Alternate gene names: 150396048

Gene position: 886442-888577 (Clockwise)

Preceding gene: 150396047

Following gene: 150396050

Centisome position: 23.44

GC content: 62.36

Gene sequence:

>2136_bases
ATGACCATACTATTGGGCGTGATCGCATGCGGGTTGCTTTCGGTGGTCTATGCCATCTGGGCGACACGGTCGGTGCTTGC
CGCCGACCAGGGGAATGCCCGCATGCAGGAAATCGCAGGCTTTATCAGAGAGGGGGCGCAAGCCTACCTCGCGCGTCAGT
ACACAACCATCGCCTTCGTCGGTGTCGTCGTTTTCATAGCCGCATGGGTTCTGCTCTCGGGTGCGGCCGCCATCGGCTTC
CTGATCGGTGCGGTGCTCTCGGGTGCCGCGGGCTTCATCGGCATGCATGTTTCGGTCAGAGCCAACGTCCGCACGGCCCA
GGCCGCTTCGGTCAGTCTTGCCTCCGGTCTGGACATCGCTTTCAAATCCGGCGCCATCACCGGCATGCTGGTTGCGGGCC
TCGCTCTCCTGGGCGTCTCGGTCTATTACCTCATCCTCACGGCAGGGCTTGGGCATGAGCCGGCCTCGCGCGAAGTCATC
GATGCGCTTGTCGCGCTGGGTTTCGGGGCGTCGTTGATCTCGATCTTCGCCCGTCTGGGCGGCGGCATCTTCACGAAAGG
CGCCGATGTCGGCGGCGACCTCGTCGGCAAGGTCGAAGCAGGGATCCCCGAGGATGATCCGCGCAACCCGGCGACGATCG
CCGACAATGTCGGCGACAATGTCGGCGACTGCGCAGGCATGGCAGCGGACCTCTTCGAGACCTATGCGGTCTCTGTCGTG
GCGACCATGGTACTTGCGTCGATCTTCTTCGCAGGTGCCCCTGTGCTGGCAACCGTCATGACCTATCCGCTGGCGATTTG
CGCGGCCTGCATCATCACCTCGATCATCGGCACCTTCTTCGTCAAGCTCGGCACCAATGGTTCCATCATGGGGGCGCTCT
ATCGCGGGCTGATCGTGACGGGCGCGCTTTCGATCCTTGGTCTTGGCGCAGCGACGTCGCTGACGATCGGATGGGGCTCG
ATCGGAACGGTCGCGGGCATGGATATCACCGGCTGGAACCTGTTTCTCTGCGGTATCATCGGTCTGATCGTCACGGCACT
GATCGTCGTGATCACCGAATATTATACGGGAACGAACAAGCGACCGGTGAACTCGATCGCGCAAGCCTCGGTCACCGGCC
ACGGCACCAATGTGATCCAGGGTCTTGCCGTATCGCTCGAGTCGACCGCCTTGCCGGCCATCGTCATCGTGGCCGGCATC
ATCTCGACATACCAGTTTGCCGGCCTCTTCGGGACGGCCATCGCGGTGACCGCGATGCTCGGCCTTGCCGGCATGATCGT
AGCGCTCGACGCCTTCGGGCCCGTGACGGACAATGCCGGCGGTATCGCCGAGATGTCGCATCTGCCACCAGAGGTGCGCA
AGGCGACCGACGCATTGGACGCCGTCGGCAACACCACCAAGGCCGTGACGAAAGGTTATGCGATCGGCTCCGCGGGTCTC
GGCGCCCTGGTGCTCTTCGCCGCCTATTCCAACGATCTTGCCTATTTTGCCGCCAATGGTGACAAGCATCCCTATTTCGC
CGACGTCGGGACGATTTCCTTCGACCTGTCGAATCCTTACGTTGTCGCCGGGCTGATCTTCGGCGGCCTCATCCCCTATC
TGTTCGGCGGTATAGCCATGACCGCCGTCGGAAGGGCAGGGAGCGCCGTCGTCGAGGAGGTTCGTCGTCAGTTCAAGGAG
AAGCCGGGCATCATGGAAGGCAAGGACCGGCCGGATTATGGCCGCGCCGTCGACATGCTGACCAAGGCGGCGATCCGTGA
AATGATCATTCCGTCGCTGCTCCCGGTGCTTGCGCCTATCGTCGTTTACTTCGGCGTGCTGCTGATCTCCGGCTCGAAGG
CTTCTGCCTTCGCGGCGCTTGGTGCCTCGCTCCTCGGCGTTATCGTCAACGGCCTTTTCGTAGCCATATCGATGACATCG
GGTGGCGGTGCCTGGGACAATGCGAAGAAGAGCTTCGAGGATGGCTTTGTCGATCGCAACGGTACCCGCCACATGAAGGG
GTCTGACGCGCACATGGCCTCGGTGACGGGCGACACCGTTGGCGATCCCTACAAGGACACGGCCGGTCCAGCCGTCAATC
CCGCGATCAAGATCACCAACATTGTCGCGCTCCTGCTGCTCGCCGTGCTCGCTTGA

Upstream 100 bases:

>100_bases
CGCCGCGAAAATGCGCCGCTCGAGGAGGCGGCGCGTGATTCGTGGAGAGGGGCCGGCGGGAGGGAGTGAACCCGCGGGTT
GTAACGGAGGAAAGTGCGAA

Downstream 100 bases:

>100_bases
CGGAAGCTTCGGAGCGGGATGAGGAAACTGTGCCGGGTTTTCTGCCCTCATTCCAGCGCAAATAGAAGAAAGCCCGCGAG
ATCCGGTCTCGCGGGCTTTC

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase [H]

Number of amino acids: Translated: 711; Mature: 710

Protein sequence:

>711_residues
MTILLGVIACGLLSVVYAIWATRSVLAADQGNARMQEIAGFIREGAQAYLARQYTTIAFVGVVVFIAAWVLLSGAAAIGF
LIGAVLSGAAGFIGMHVSVRANVRTAQAASVSLASGLDIAFKSGAITGMLVAGLALLGVSVYYLILTAGLGHEPASREVI
DALVALGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVSVV
ATMVLASIFFAGAPVLATVMTYPLAICAACIITSIIGTFFVKLGTNGSIMGALYRGLIVTGALSILGLGAATSLTIGWGS
IGTVAGMDITGWNLFLCGIIGLIVTALIVVITEYYTGTNKRPVNSIAQASVTGHGTNVIQGLAVSLESTALPAIVIVAGI
ISTYQFAGLFGTAIAVTAMLGLAGMIVALDAFGPVTDNAGGIAEMSHLPPEVRKATDALDAVGNTTKAVTKGYAIGSAGL
GALVLFAAYSNDLAYFAANGDKHPYFADVGTISFDLSNPYVVAGLIFGGLIPYLFGGIAMTAVGRAGSAVVEEVRRQFKE
KPGIMEGKDRPDYGRAVDMLTKAAIREMIIPSLLPVLAPIVVYFGVLLISGSKASAFAALGASLLGVIVNGLFVAISMTS
GGGAWDNAKKSFEDGFVDRNGTRHMKGSDAHMASVTGDTVGDPYKDTAGPAVNPAIKITNIVALLLLAVLA

Sequences:

>Translated_711_residues
MTILLGVIACGLLSVVYAIWATRSVLAADQGNARMQEIAGFIREGAQAYLARQYTTIAFVGVVVFIAAWVLLSGAAAIGF
LIGAVLSGAAGFIGMHVSVRANVRTAQAASVSLASGLDIAFKSGAITGMLVAGLALLGVSVYYLILTAGLGHEPASREVI
DALVALGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVSVV
ATMVLASIFFAGAPVLATVMTYPLAICAACIITSIIGTFFVKLGTNGSIMGALYRGLIVTGALSILGLGAATSLTIGWGS
IGTVAGMDITGWNLFLCGIIGLIVTALIVVITEYYTGTNKRPVNSIAQASVTGHGTNVIQGLAVSLESTALPAIVIVAGI
ISTYQFAGLFGTAIAVTAMLGLAGMIVALDAFGPVTDNAGGIAEMSHLPPEVRKATDALDAVGNTTKAVTKGYAIGSAGL
GALVLFAAYSNDLAYFAANGDKHPYFADVGTISFDLSNPYVVAGLIFGGLIPYLFGGIAMTAVGRAGSAVVEEVRRQFKE
KPGIMEGKDRPDYGRAVDMLTKAAIREMIIPSLLPVLAPIVVYFGVLLISGSKASAFAALGASLLGVIVNGLFVAISMTS
GGGAWDNAKKSFEDGFVDRNGTRHMKGSDAHMASVTGDTVGDPYKDTAGPAVNPAIKITNIVALLLLAVLA
>Mature_710_residues
TILLGVIACGLLSVVYAIWATRSVLAADQGNARMQEIAGFIREGAQAYLARQYTTIAFVGVVVFIAAWVLLSGAAAIGFL
IGAVLSGAAGFIGMHVSVRANVRTAQAASVSLASGLDIAFKSGAITGMLVAGLALLGVSVYYLILTAGLGHEPASREVID
ALVALGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVSVVA
TMVLASIFFAGAPVLATVMTYPLAICAACIITSIIGTFFVKLGTNGSIMGALYRGLIVTGALSILGLGAATSLTIGWGSI
GTVAGMDITGWNLFLCGIIGLIVTALIVVITEYYTGTNKRPVNSIAQASVTGHGTNVIQGLAVSLESTALPAIVIVAGII
STYQFAGLFGTAIAVTAMLGLAGMIVALDAFGPVTDNAGGIAEMSHLPPEVRKATDALDAVGNTTKAVTKGYAIGSAGLG
ALVLFAAYSNDLAYFAANGDKHPYFADVGTISFDLSNPYVVAGLIFGGLIPYLFGGIAMTAVGRAGSAVVEEVRRQFKEK
PGIMEGKDRPDYGRAVDMLTKAAIREMIIPSLLPVLAPIVVYFGVLLISGSKASAFAALGASLLGVIVNGLFVAISMTSG
GGAWDNAKKSFEDGFVDRNGTRHMKGSDAHMASVTGDTVGDPYKDTAGPAVNPAIKITNIVALLLLAVLA

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force [H]

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004131 [H]

Pfam domain/function: PF03030 H_PPase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 72311; Mature: 72180

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILLGVIACGLLSVVYAIWATRSVLAADQGNARMQEIAGFIREGAQAYLARQYTTIAFV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVVVFIAAWVLLSGAAAIGFLIGAVLSGAAGFIGMHVSVRANVRTAQAASVSLASGLDIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEEECCCHHHHHHHHHHCCCCCE
FKSGAITGMLVAGLALLGVSVYYLILTAGLGHEPASREVIDALVALGFGASLISIFARLG
ECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHC
GGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVSVV
CCEEECCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ATMVLASIFFAGAPVLATVMTYPLAICAACIITSIIGTFFVKLGTNGSIMGALYRGLIVT
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
GALSILGLGAATSLTIGWGSIGTVAGMDITGWNLFLCGIIGLIVTALIVVITEYYTGTNK
HHHHHHHCCCHHEEEECCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RPVNSIAQASVTGHGTNVIQGLAVSLESTALPAIVIVAGIISTYQFAGLFGTAIAVTAML
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLAGMIVALDAFGPVTDNAGGIAEMSHLPPEVRKATDALDAVGNTTKAVTKGYAIGSAGL
HHHHHHHHHHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHH
GALVLFAAYSNDLAYFAANGDKHPYFADVGTISFDLSNPYVVAGLIFGGLIPYLFGGIAM
HHHHHHHHHCCCEEEEEECCCCCCEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
TAVGRAGSAVVEEVRRQFKEKPGIMEGKDRPDYGRAVDMLTKAAIREMIIPSLLPVLAPI
HHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVYFGVLLISGSKASAFAALGASLLGVIVNGLFVAISMTSGGGAWDNAKKSFEDGFVDRN
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHCCCCCCC
GTRHMKGSDAHMASVTGDTVGDPYKDTAGPAVNPAIKITNIVALLLLAVLA
CCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
TILLGVIACGLLSVVYAIWATRSVLAADQGNARMQEIAGFIREGAQAYLARQYTTIAFV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVVVFIAAWVLLSGAAAIGFLIGAVLSGAAGFIGMHVSVRANVRTAQAASVSLASGLDIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEEECCCHHHHHHHHHHCCCCCE
FKSGAITGMLVAGLALLGVSVYYLILTAGLGHEPASREVIDALVALGFGASLISIFARLG
ECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHC
GGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVSVV
CCEEECCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ATMVLASIFFAGAPVLATVMTYPLAICAACIITSIIGTFFVKLGTNGSIMGALYRGLIVT
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
GALSILGLGAATSLTIGWGSIGTVAGMDITGWNLFLCGIIGLIVTALIVVITEYYTGTNK
HHHHHHHCCCHHEEEECCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RPVNSIAQASVTGHGTNVIQGLAVSLESTALPAIVIVAGIISTYQFAGLFGTAIAVTAML
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLAGMIVALDAFGPVTDNAGGIAEMSHLPPEVRKATDALDAVGNTTKAVTKGYAIGSAGL
HHHHHHHHHHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHH
GALVLFAAYSNDLAYFAANGDKHPYFADVGTISFDLSNPYVVAGLIFGGLIPYLFGGIAM
HHHHHHHHHCCCEEEEEECCCCCCEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
TAVGRAGSAVVEEVRRQFKEKPGIMEGKDRPDYGRAVDMLTKAAIREMIIPSLLPVLAPI
HHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVYFGVLLISGSKASAFAALGASLLGVIVNGLFVAISMTSGGGAWDNAKKSFEDGFVDRN
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHCCCCCCC
GTRHMKGSDAHMASVTGDTVGDPYKDTAGPAVNPAIKITNIVALLLLAVLA
CCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]