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The map label for this gene is nrdR

Identifier: 150396041

GI number: 150396041

Start: 880871

End: 881344

Strand: Direct

Name: nrdR

Synonym: Smed_0817

Alternate gene names: 150396041

Gene position: 880871-881344 (Clockwise)

Preceding gene: 150396040

Following gene: 150396042

Centisome position: 23.29

GC content: 61.6

Gene sequence:

>474_bases
ATGCGCTGCCCCTATTGCGGTTCCGAAGACAGTCAGGTGAAGGATTCCCGTCCGGCGGAGGACGGGAACGCCATTCGCCG
CCGCCGCATCTGCCCGGATTGCGGCGGCCGCTTCACGACCTTCGAGCGGGTGCAACTGCGGGAGCTGATGATCATCAAGA
AAACCGGCCGGAAGGTTCCTTTCGACCGGGACAAACTGTTGCGCTCCTTTGAGATCGCGCTTCGAAAGCGCCCGGTCGAT
CGTGACCGGATCGAGCGGGCGGTCTCAGGCATCGTCCGCCGGCTGGAAAGCTCCGGCGAAACCGAAATTCCGTCGGAAGA
AATAGGCCTTCAGGTTCTCGAGGCGCTGAAGAGCCTCGACGACGTCGCCTTCGTACGCTACGCGTCGGTCTATCGCGATT
TCTCCCACGCGGAGGATTTCGAGAAGGTCATCGCGGAAATCAGCGCAAAGATCGCACGCGATCCTGGCGAGTAG

Upstream 100 bases:

>100_bases
CGATGAAGGCAATGCTGCCGTCGAGGCCGGCGTGCGCGAGAAGGTGATGAAGCTCACCGGCCGTTTCCCAATGTATGGCT
ATATGTGATCGGACGGCTGC

Downstream 100 bases:

>100_bases
GCCGGAGGCGAAAGGCATGGTTAAGCCGGCGCACGAAGACGAGCGGTTCATGGCGGCGGCGCTGCGCCTTTCGAGGCGCA
ATCTTGGTCGGACTGGCACC

Product: transcriptional regulator NrdR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MRCPYCGSEDSQVKDSRPAEDGNAIRRRRICPDCGGRFTTFERVQLRELMIIKKTGRKVPFDRDKLLRSFEIALRKRPVD
RDRIERAVSGIVRRLESSGETEIPSEEIGLQVLEALKSLDDVAFVRYASVYRDFSHAEDFEKVIAEISAKIARDPGE

Sequences:

>Translated_157_residues
MRCPYCGSEDSQVKDSRPAEDGNAIRRRRICPDCGGRFTTFERVQLRELMIIKKTGRKVPFDRDKLLRSFEIALRKRPVD
RDRIERAVSGIVRRLESSGETEIPSEEIGLQVLEALKSLDDVAFVRYASVYRDFSHAEDFEKVIAEISAKIARDPGE
>Mature_157_residues
MRCPYCGSEDSQVKDSRPAEDGNAIRRRRICPDCGGRFTTFERVQLRELMIIKKTGRKVPFDRDKLLRSFEIALRKRPVD
RDRIERAVSGIVRRLESSGETEIPSEEIGLQVLEALKSLDDVAFVRYASVYRDFSHAEDFEKVIAEISAKIARDPGE

Specific function: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes

COG id: COG1327

COG function: function code K; Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain

Homologues:

Organism=Escherichia coli, GI1786615, Length=147, Percent_Identity=43.5374149659864, Blast_Score=124, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NRDR_RHIME (P58259)

Other databases:

- EMBL:   AL591688
- RefSeq:   NP_385315.1
- GeneID:   1232853
- GenomeReviews:   AL591688_GR
- KEGG:   sme:SMc01771
- HOGENOM:   HBG351755
- OMA:   FASVYRD
- ProtClustDB:   PRK00464
- BioCyc:   SMEL266834:SMC01771-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00440
- InterPro:   IPR005144
- InterPro:   IPR003796
- TIGRFAMs:   TIGR00244

Pfam domain/function: PF03477 ATP-cone

EC number: NA

Molecular weight: Translated: 18005; Mature: 18005

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: PS51161 ATP_CONE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCPYCGSEDSQVKDSRPAEDGNAIRRRRICPDCGGRFTTFERVQLRELMIIKKTGRKVP
CCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
FDRDKLLRSFEIALRKRPVDRDRIERAVSGIVRRLESSGETEIPSEEIGLQVLEALKSLD
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
DVAFVRYASVYRDFSHAEDFEKVIAEISAKIARDPGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRCPYCGSEDSQVKDSRPAEDGNAIRRRRICPDCGGRFTTFERVQLRELMIIKKTGRKVP
CCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
FDRDKLLRSFEIALRKRPVDRDRIERAVSGIVRRLESSGETEIPSEEIGLQVLEALKSLD
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
DVAFVRYASVYRDFSHAEDFEKVIAEISAKIARDPGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430