Click here to switch to the map view.

The map label for this gene is gmk [H]

Identifier: 150395983

GI number: 150395983

Start: 815218

End: 815877

Strand: Direct

Name: gmk [H]

Synonym: Smed_0759

Alternate gene names: 150395983

Gene position: 815218-815877 (Clockwise)

Preceding gene: 150395982

Following gene: 150395990

Centisome position: 21.56

GC content: 61.21

Gene sequence:

>660_bases
ATGAAACCGGCGACCGTTTCGCCCACAAAGATCGCTCGCCGCGGGCTGATGCTCGTGATCTCATCGCCGTCAGGTGCGGG
GAAGTCGACGATCGCCCGTAACCTGCTCGAAGCCGATCCGGACCTTAGCATTTCGGTGAGCGTGACCACGCGTTCGCGGC
GCCCGAGCGAGATCGAGGGACGACATTATTTTTTCAAGACCATCCGTGAGTTCGAGGCGCTGAAAGCAACGGATTCGCTG
CTTGAATGGGCGGAAGTGCACGGGAACTTCTACGGCACGCCACGCGATGCAGTGGAAAAGGCGATGGGCGAAGGCCGTGA
CATGCTGTTCGACATCGACTGGCAGGGTGCGCAGCAGCTGCAGGAGAAGATGGCGGGCGACGTGGTATCGATCTTCATCC
TGCCGCCCTCGATGGCCGAATTGCAGTCGAGGCTCCACCGGCGCGCCGAGGACAGCGAAGAGGTCATCGCGACCCGGCTC
GCCAACTCCCGGGCCGAAATAGAGCACTGGCGTGAATATGATTACATCGTGGTCAACGACGATCTCGACCGGGCCTTCTC
CTCCGTCCGGGCAATAGTCGAAGCCGAGCGCCTTCGCCGCGACAGGCGACCTGGCCTCTTCGAATTCGTCAACGGGCTGC
TGACCGAAAATCCGCTTTGA

Upstream 100 bases:

>100_bases
CTGTTCGAAGTCGAATGCCGCCGCCGTCTCGGCCGCCGGTATCGAGTTGAAGGTCGTAATCGACCATTTCCGCGAACAGG
TTCAGAATCTGGAGTAGGAT

Downstream 100 bases:

>100_bases
GCGCGCCGCTTGTGCTTCTCTACAGGCAGTTGGCCAAACGGCAGAATTCTTCGACGGAGAGCGTTTCCGCGCGCCGCTTC
GGATCGATGCCCGCCTTTGC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MKPATVSPTKIARRGLMLVISSPSGAGKSTIARNLLEADPDLSISVSVTTRSRRPSEIEGRHYFFKTIREFEALKATDSL
LEWAEVHGNFYGTPRDAVEKAMGEGRDMLFDIDWQGAQQLQEKMAGDVVSIFILPPSMAELQSRLHRRAEDSEEVIATRL
ANSRAEIEHWREYDYIVVNDDLDRAFSSVRAIVEAERLRRDRRPGLFEFVNGLLTENPL

Sequences:

>Translated_219_residues
MKPATVSPTKIARRGLMLVISSPSGAGKSTIARNLLEADPDLSISVSVTTRSRRPSEIEGRHYFFKTIREFEALKATDSL
LEWAEVHGNFYGTPRDAVEKAMGEGRDMLFDIDWQGAQQLQEKMAGDVVSIFILPPSMAELQSRLHRRAEDSEEVIATRL
ANSRAEIEHWREYDYIVVNDDLDRAFSSVRAIVEAERLRRDRRPGLFEFVNGLLTENPL
>Mature_219_residues
MKPATVSPTKIARRGLMLVISSPSGAGKSTIARNLLEADPDLSISVSVTTRSRRPSEIEGRHYFFKTIREFEALKATDSL
LEWAEVHGNFYGTPRDAVEKAMGEGRDMLFDIDWQGAQQLQEKMAGDVVSIFILPPSMAELQSRLHRRAEDSEEVIATRL
ANSRAEIEHWREYDYIVVNDDLDRAFSSVRAIVEAERLRRDRRPGLFEFVNGLLTENPL

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=194, Percent_Identity=35.5670103092784, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI4504221, Length=194, Percent_Identity=35.5670103092784, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI226874831, Length=194, Percent_Identity=35.5670103092784, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI14780902, Length=192, Percent_Identity=29.6875, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI38570142, Length=185, Percent_Identity=28.1081081081081, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI21361598, Length=193, Percent_Identity=26.4248704663212, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI111154074, Length=180, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1790080, Length=192, Percent_Identity=51.0416666666667, Blast_Score=203, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI193203132, Length=174, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17508835, Length=174, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=36.0655737704918, Blast_Score=134, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21356141, Length=193, Percent_Identity=34.7150259067358, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI116007136, Length=180, Percent_Identity=25.5555555555556, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI85724806, Length=176, Percent_Identity=26.1363636363636, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45554481, Length=176, Percent_Identity=26.1363636363636, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24640542, Length=176, Percent_Identity=26.1363636363636, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45554489, Length=180, Percent_Identity=25.5555555555556, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161077626, Length=180, Percent_Identity=25.5555555555556, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 24805; Mature: 24805

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPATVSPTKIARRGLMLVISSPSGAGKSTIARNLLEADPDLSISVSVTTRSRRPSEIEG
CCCCCCCHHHHHHCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCC
RHYFFKTIREFEALKATDSLLEWAEVHGNFYGTPRDAVEKAMGEGRDMLFDIDWQGAQQL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEECCCCCHHHH
QEKMAGDVVSIFILPPSMAELQSRLHRRAEDSEEVIATRLANSRAEIEHWREYDYIVVND
HHHHCCCEEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHCCCEEEEEC
DLDRAFSSVRAIVEAERLRRDRRPGLFEFVNGLLTENPL
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MKPATVSPTKIARRGLMLVISSPSGAGKSTIARNLLEADPDLSISVSVTTRSRRPSEIEG
CCCCCCCHHHHHHCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCC
RHYFFKTIREFEALKATDSLLEWAEVHGNFYGTPRDAVEKAMGEGRDMLFDIDWQGAQQL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEECCCCCHHHH
QEKMAGDVVSIFILPPSMAELQSRLHRRAEDSEEVIATRLANSRAEIEHWREYDYIVVND
HHHHCCCEEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHCCCEEEEEC
DLDRAFSSVRAIVEAERLRRDRRPGLFEFVNGLLTENPL
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]