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The map label for this gene is fabD [H]

Identifier: 150395968

GI number: 150395968

Start: 797820

End: 798764

Strand: Direct

Name: fabD [H]

Synonym: Smed_0744

Alternate gene names: 150395968

Gene position: 797820-798764 (Clockwise)

Preceding gene: 150395966

Following gene: 150395969

Centisome position: 21.1

GC content: 64.02

Gene sequence:

>945_bases
ATGAGCATCGCATTCACGTTCCCCGGCCAGGGCAGCCAGGCAGTCGGCATGGGCAAGGATCTTGCTGAAGCCTTTCCGGA
GGCGGCTGCCGTCTTCGCCGAGGTCGACGAAGCGCTCGGCGAAAAGCTTTCGCACATTATGTGGGATGGACCGGAGGAGA
CGCTGACGCTGACGGCGAATGCACAGCCGGCGCTGATGGCGGTGTCGATGGCGGTGATCCGCGTGCTCGAGTCCAGAGGA
CTCGATATCGGCAGCAAGGTTTCTTTCGTCGCCGGCCATTCGCTCGGGGAGTATTCGGCTCTCTGTGCTGCCGGTACGTT
CTCGCTCGCCGACACGGCGCGCCTTCTGCGCATTCGCGGCAATGCGATGCAGGCGGCCGTACCTGTCGGCAAAGGCGCGA
TGGCTGCGATCATCGGTCTGGAGCATGCCGACGTCGAAGCGATTTGCCGCGAGTCGTCATCGCTCGGTTCGTGTCAGATC
GCCAATGACAACGGCGGCGGTCAATTGGTGATCTCGGGCGAGAAGCCGGCGGTCGAGAAGGCAGCAGCGCTTGCTACGGA
GAAGGGTGCCAAGCGTGCGCTTATGTTGCCCGTTTCCGCCCCCTTCCATTCGGCACTGATGACACCTGCGGCCGAAGCCA
TGCGCGAAGCGCTTGCGACGGTCGGGAAGCACGATCCCGTGGTGCCTGTCGTCGCGAACGTGCTTGCCGCCCCGGTCCGC
GATGCGGTCGAGATCGCGCGCCTGCTTGTAGAACAGGTCACCGGCCCGGTCCGCTGGCGCGAGACGGTCGAGTGGTTTGC
GGCAAACGACGTGACGACGCTTTACGAAATCGGCTCAGGCAAGGTCCTGACCGGTCTTGCCCGGCGGATCGACAAGTCCG
TCACCGGCATCGCCGTCAATTCGCCCGCCGATATCGACGCAGTCCTTGCCGTTCTCTTGGCCTGA

Upstream 100 bases:

>100_bases
AATGCCCCGGGCGGTTCATCTGTACGCGCACGCACGATAGAAATGATCGCGGCTACTGGGTTGCTCCGAACCAGCCGTGA
CCAAGGAAGGGGCACTCTTG

Downstream 100 bases:

>100_bases
GTACCCTATTATAAGGAGAAATCCATGTTCGATCTTTCAGGCCGCAAGGCTCTCGTAACCGGCGCTTCGGGTGGCATTGG
CGAAGAAATCGCCCGCCTGC

Product: malonyl CoA-acyl carrier protein transacylase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MSIAFTFPGQGSQAVGMGKDLAEAFPEAAAVFAEVDEALGEKLSHIMWDGPEETLTLTANAQPALMAVSMAVIRVLESRG
LDIGSKVSFVAGHSLGEYSALCAAGTFSLADTARLLRIRGNAMQAAVPVGKGAMAAIIGLEHADVEAICRESSSLGSCQI
ANDNGGGQLVISGEKPAVEKAAALATEKGAKRALMLPVSAPFHSALMTPAAEAMREALATVGKHDPVVPVVANVLAAPVR
DAVEIARLLVEQVTGPVRWRETVEWFAANDVTTLYEIGSGKVLTGLARRIDKSVTGIAVNSPADIDAVLAVLLA

Sequences:

>Translated_314_residues
MSIAFTFPGQGSQAVGMGKDLAEAFPEAAAVFAEVDEALGEKLSHIMWDGPEETLTLTANAQPALMAVSMAVIRVLESRG
LDIGSKVSFVAGHSLGEYSALCAAGTFSLADTARLLRIRGNAMQAAVPVGKGAMAAIIGLEHADVEAICRESSSLGSCQI
ANDNGGGQLVISGEKPAVEKAAALATEKGAKRALMLPVSAPFHSALMTPAAEAMREALATVGKHDPVVPVVANVLAAPVR
DAVEIARLLVEQVTGPVRWRETVEWFAANDVTTLYEIGSGKVLTGLARRIDKSVTGIAVNSPADIDAVLAVLLA
>Mature_313_residues
SIAFTFPGQGSQAVGMGKDLAEAFPEAAAVFAEVDEALGEKLSHIMWDGPEETLTLTANAQPALMAVSMAVIRVLESRGL
DIGSKVSFVAGHSLGEYSALCAAGTFSLADTARLLRIRGNAMQAAVPVGKGAMAAIIGLEHADVEAICRESSSLGSCQIA
NDNGGGQLVISGEKPAVEKAAALATEKGAKRALMLPVSAPFHSALMTPAAEAMREALATVGKHDPVVPVVANVLAAPVRD
AVEIARLLVEQVTGPVRWRETVEWFAANDVTTLYEIGSGKVLTGLARRIDKSVTGIAVNSPADIDAVLAVLLA

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=309, Percent_Identity=31.7152103559871, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI27477045, Length=105, Percent_Identity=37.1428571428571, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1787334, Length=308, Percent_Identity=47.0779220779221, Blast_Score=239, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI71984332, Length=299, Percent_Identity=29.7658862876254, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17550940, Length=292, Percent_Identity=27.0547945205479, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24665753, Length=307, Percent_Identity=33.8762214983713, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 32420; Mature: 32288

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIAFTFPGQGSQAVGMGKDLAEAFPEAAAVFAEVDEALGEKLSHIMWDGPEETLTLTAN
CEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
AQPALMAVSMAVIRVLESRGLDIGSKVSFVAGHSLGEYSALCAAGTFSLADTARLLRIRG
CCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHHCCHHHHHHHHHHHHCC
NAMQAAVPVGKGAMAAIIGLEHADVEAICRESSSLGSCQIANDNGGGQLVISGEKPAVEK
CCCEEECCCCCCHHHHHHCCCCCCHHHHHHCCCCCCCEEEECCCCCCEEEECCCCCHHHH
AAALATEKGAKRALMLPVSAPFHSALMTPAAEAMREALATVGKHDPVVPVVANVLAAPVR
HHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
DAVEIARLLVEQVTGPVRWRETVEWFAANDVTTLYEIGSGKVLTGLARRIDKSVTGIAVN
HHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCEEEEC
SPADIDAVLAVLLA
CCCCHHHHHHHHHC
>Mature Secondary Structure 
SIAFTFPGQGSQAVGMGKDLAEAFPEAAAVFAEVDEALGEKLSHIMWDGPEETLTLTAN
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
AQPALMAVSMAVIRVLESRGLDIGSKVSFVAGHSLGEYSALCAAGTFSLADTARLLRIRG
CCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHHCCHHHHHHHHHHHHCC
NAMQAAVPVGKGAMAAIIGLEHADVEAICRESSSLGSCQIANDNGGGQLVISGEKPAVEK
CCCEEECCCCCCHHHHHHCCCCCCHHHHHHCCCCCCCEEEECCCCCCEEEECCCCCHHHH
AAALATEKGAKRALMLPVSAPFHSALMTPAAEAMREALATVGKHDPVVPVVANVLAAPVR
HHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
DAVEIARLLVEQVTGPVRWRETVEWFAANDVTTLYEIGSGKVLTGLARRIDKSVTGIAVN
HHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCEEEEC
SPADIDAVLAVLLA
CCCCHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9534248; 9384377 [H]