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The map label for this gene is thrB [H]

Identifier: 150395752

GI number: 150395752

Start: 570058

End: 571038

Strand: Direct

Name: thrB [H]

Synonym: Smed_0528

Alternate gene names: 150395752

Gene position: 570058-571038 (Clockwise)

Preceding gene: 150395751

Following gene: 150395753

Centisome position: 15.07

GC content: 62.59

Gene sequence:

>981_bases
TTGGCAGTTTATACCGACATCACGGAAGACGAGTTGATCCGCTTCCTCGCCGCCTATGAGGTGGGATCGCTGACCTCCTA
CAAGGGCATCGCCGAAGGCGTGGAGAATTCCAACTTCCTTCTCCACACGACCAGGGGAGCGTATATTCTCACGCTCTACG
AGAAGCGGGTCAATGCCGACGACCTGCCGTTTTTCCTGGGCCTCATGCATCACCTCGCCCAGAGGGGTCTCTCCTGCCCG
CTGCCCCTTCCTCGCGCCGACGGCAAGCTGCTCGGCACACTCTCCGGAAGGCCGGCGGCGGTGATCTCCTTTCTGGAAGG
CATGTGGCTGAGGAAGCCGGAGGCGCAGCACTGCCGCGAAGTCGGCCGGGCTCTCGCACTCATGCACCAGGCGAGCGAGG
GCTTTCGCCTGAAGCGCCCCAACGCGCTCTCCGTCGAGGGCTGGCGACCCCTCTGGCGGAACTCCGAAGCGCGCGCCGAT
GAGGTGCAAGCCGGCCTAAAGGACGAGATCGCGACGGAGCTCGCCTTTCTCGAGGAACACTGGCCGAGAGCTCTGCCGGA
GGGCGTGATCCACGCGGATCTCTTCCCGGACAACGTCTTCTTCCTCGGCGATCGCCTCTCCGGCCTTATCGATTTCTACT
TTGCCTGCAACGATTTCCTCGCCTACGACATCGCCATCTGCCTGAATTCCTGGTGCTTCGAGAAGGATGGCTCCTACAAC
ATCACCAAAGGCATGGCGCTTCTTTCCGGCTACGAGAGCGTTCGGAATTTGACCGCGGAAGAGGTCGAGGCGCTGCCGCT
GCTCGCGCGCGGATCCGCGCTCCGCTTCTTCCTGACACGCCTCTATGACTGGCTGACCACGCCGCCGGGCGCGCTTGTGG
TCAAGAAGGATCCGCTCGAATATCTGACGAAGATCCGCTTCCATCGCGCCATCGTCTCCAGCGCCGAGTACGGCCTGCGA
CGCGAAGAGGCATCGGCATGA

Upstream 100 bases:

>100_bases
TGGGGTGAACAGAGCGGGGGTGAATAGAGCGAGCCGGCGTACTTCCCCTCGCACGCCGCTCCAAATTCCTCCAATTTGCA
TCTCTGGAAAGTAGCGCGCC

Downstream 100 bases:

>100_bases
AACACGTCGACATCTACACGGACGGTGCCTGCTCGGGAAATCCCGGGCCGGGCGGGTGGGGCGCGGTCCTGCGCTATGGC
GACGTGGAAAAGGAGATGTC

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MAVYTDITEDELIRFLAAYEVGSLTSYKGIAEGVENSNFLLHTTRGAYILTLYEKRVNADDLPFFLGLMHHLAQRGLSCP
LPLPRADGKLLGTLSGRPAAVISFLEGMWLRKPEAQHCREVGRALALMHQASEGFRLKRPNALSVEGWRPLWRNSEARAD
EVQAGLKDEIATELAFLEEHWPRALPEGVIHADLFPDNVFFLGDRLSGLIDFYFACNDFLAYDIAICLNSWCFEKDGSYN
ITKGMALLSGYESVRNLTAEEVEALPLLARGSALRFFLTRLYDWLTTPPGALVVKKDPLEYLTKIRFHRAIVSSAEYGLR
REEASA

Sequences:

>Translated_326_residues
MAVYTDITEDELIRFLAAYEVGSLTSYKGIAEGVENSNFLLHTTRGAYILTLYEKRVNADDLPFFLGLMHHLAQRGLSCP
LPLPRADGKLLGTLSGRPAAVISFLEGMWLRKPEAQHCREVGRALALMHQASEGFRLKRPNALSVEGWRPLWRNSEARAD
EVQAGLKDEIATELAFLEEHWPRALPEGVIHADLFPDNVFFLGDRLSGLIDFYFACNDFLAYDIAICLNSWCFEKDGSYN
ITKGMALLSGYESVRNLTAEEVEALPLLARGSALRFFLTRLYDWLTTPPGALVVKKDPLEYLTKIRFHRAIVSSAEYGLR
REEASA
>Mature_325_residues
AVYTDITEDELIRFLAAYEVGSLTSYKGIAEGVENSNFLLHTTRGAYILTLYEKRVNADDLPFFLGLMHHLAQRGLSCPL
PLPRADGKLLGTLSGRPAAVISFLEGMWLRKPEAQHCREVGRALALMHQASEGFRLKRPNALSVEGWRPLWRNSEARADE
VQAGLKDEIATELAFLEEHWPRALPEGVIHADLFPDNVFFLGDRLSGLIDFYFACNDFLAYDIAICLNSWCFEKDGSYNI
TKGMALLSGYESVRNLTAEEVEALPLLARGSALRFFLTRLYDWLTTPPGALVVKKDPLEYLTKIRFHRAIVSSAEYGLRR
EEASA

Specific function: Unknown

COG id: COG2334

COG function: function code R; Putative homoserine kinase type II (protein kinase fold)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pseudomonas-type thrB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002575
- InterPro:   IPR005280
- InterPro:   IPR011009 [H]

Pfam domain/function: PF01636 APH [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 36633; Mature: 36502

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVYTDITEDELIRFLAAYEVGSLTSYKGIAEGVENSNFLLHTTRGAYILTLYEKRVNAD
CCEECCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEECCCEEEEEEEEHHCCCC
DLPFFLGLMHHLAQRGLSCPLPLPRADGKLLGTLSGRPAAVISFLEGMWLRKPEAQHCRE
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCHHHHHH
VGRALALMHQASEGFRLKRPNALSVEGWRPLWRNSEARADEVQAGLKDEIATELAFLEEH
HHHHHHHHHHHCCCCEECCCCCCCCCCCCHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHH
WPRALPEGVIHADLFPDNVFFLGDRLSGLIDFYFACNDFLAYDIAICLNSWCFEKDGSYN
HHHHCCCCCEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ITKGMALLSGYESVRNLTAEEVEALPLLARGSALRFFLTRLYDWLTTPPGALVVKKDPLE
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCHHH
YLTKIRFHRAIVSSAEYGLRREEASA
HHHHHHHHHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure 
AVYTDITEDELIRFLAAYEVGSLTSYKGIAEGVENSNFLLHTTRGAYILTLYEKRVNAD
CEECCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEECCCEEEEEEEEHHCCCC
DLPFFLGLMHHLAQRGLSCPLPLPRADGKLLGTLSGRPAAVISFLEGMWLRKPEAQHCRE
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCHHHHHH
VGRALALMHQASEGFRLKRPNALSVEGWRPLWRNSEARADEVQAGLKDEIATELAFLEEH
HHHHHHHHHHHCCCCEECCCCCCCCCCCCHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHH
WPRALPEGVIHADLFPDNVFFLGDRLSGLIDFYFACNDFLAYDIAICLNSWCFEKDGSYN
HHHHCCCCCEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ITKGMALLSGYESVRNLTAEEVEALPLLARGSALRFFLTRLYDWLTTPPGALVVKKDPLE
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCHHH
YLTKIRFHRAIVSSAEYGLRREEASA
HHHHHHHHHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]