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The map label for this gene is lysA [H]

Identifier: 148827915

GI number: 148827915

Start: 1310157

End: 1311509

Strand: Reverse

Name: lysA [H]

Synonym: CGSHiGG_07090

Alternate gene names: 148827915

Gene position: 1311509-1310157 (Counterclockwise)

Preceding gene: 148827916

Following gene: 148827914

Centisome position: 69.5

GC content: 38.65

Gene sequence:

>1353_bases
ATGAATTTCTTCCAATATAAACATAACAAACTTTATGCCGAAGATATTCCGGTTCAACAACTTGCTGAACAATTCGGTAC
ACCTCTTTATGTATATTCTCGCGCGACACTTGAACGCCATTGGCATGCTTTTGACTCAGCTTTCGGTAAGCGTCCTCACT
TAATTTGTTTTGCCGTGAAATCTTGCTCAAATATTGGCGTGTTAAATATTATGGCAAAACTTGGTTCAGGTTTCGATATT
GTCTCGCAAGGCGAACTTGAGCGTGTACTGGCAGCAGGTGGCAATGCGTCAAAAGTGGTCTTTTCTGGCGTTGCGAAATC
TCGAGAAGAAATTATGCGCGCATTAGAAGTTGGAATCCGTTGCTTTAATGTGGAATCAGTTTCTGAACTCAAGCACATTA
ACCAAATCGCAGGAGAAATGGGTAAAATCGCACCTATTTCTTTACGTGTAAATCCAGATGTTGATGCACATACACACCCT
TATATTTCAACAGGATTAAAAGAAAATAAATTTGGTGTAAGCGTAAATGAAGCTCGAGAGGTATATAAATTAGCCTCAAC
GCTACCAAACATAAAAATAACAGGGATGGATTGCCACATAGGCTCACAGCTCACTGAATTACAACCATTCTTAGATGCAA
CAGATCGCTTAATTGTCCTAATGGAACAATTAAAAGAAGATGGAATTACATTAAAACATCTCGATCTGGGCGGTGGTTTA
GGCGTGACTTATACGGATGAAACGCCTCCGCATCCAAGCGATTACGCAAATGCGTTATTAGAAAAACTAAAAGATTATCC
TGAACTTGAAATTATTCTTGAACCTGGCAGAGCAATTTCTGCAAATGCAGGAATTCTAGTAGCAAAAGTACAATACTTAA
AAAGTAATGAAAGCCGTAATTTCGCCATTACCGATACAGGAATGAATGATATGATTCGCCCAGCATTGTATGAGGCTTAC
ATGAATATCGTCGAAATTGACCGCACTTTAGCAAGAGAAAAAGCCATTTATGATGTTGTGGGACCAGTTTGCGAAACGTC
TGATTTCTTAGGCAAACAACGGGAACTTTCAATTGCCGAAGGGGATTATATTGCTCAATGTTCTGCTGGTGCCTATGGAG
CAAGTATGTCATCAAACTATAACTCAAGAGCCCGCACTGCAGAAGTTTTTAGTAGATGGCGATCAATCCTATCTAATTCG
TCGTCGAGAAACCTTACAGGAACTTTGGGCATTAGAATCGACCATTTAATATTTCTTATCTTAAAAAAGAGCGGTAAAAA
ATTATCTATTTTTCTACCGCACTTTTTCTATTTTTATCCATCAATAAACCTACCTCAAATAGTAAGTTTGTGA

Upstream 100 bases:

>100_bases
TAAAAGGTTCTTTATATTTTCCTGAAAAAGATCAAGCTCAACAAACTCAATAATCTATTATCTAATATCATTCCCAAAAT
AACTAAAACAGGCACACAAC

Downstream 100 bases:

>100_bases
TATAAATCAAATTTTTTTCTATTCTAGATTGGCATAGAATTGAATTCTTTATAAAATGTCATGCTTTTTAAAGTGGACTT
CTAACCACTAAAGGAGAAAT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MNFFQYKHNKLYAEDIPVQQLAEQFGTPLYVYSRATLERHWHAFDSAFGKRPHLICFAVKSCSNIGVLNIMAKLGSGFDI
VSQGELERVLAAGGNASKVVFSGVAKSREEIMRALEVGIRCFNVESVSELKHINQIAGEMGKIAPISLRVNPDVDAHTHP
YISTGLKENKFGVSVNEAREVYKLASTLPNIKITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKEDGITLKHLDLGGGL
GVTYTDETPPHPSDYANALLEKLKDYPELEIILEPGRAISANAGILVAKVQYLKSNESRNFAITDTGMNDMIRPALYEAY
MNIVEIDRTLAREKAIYDVVGPVCETSDFLGKQRELSIAEGDYIAQCSAGAYGASMSSNYNSRARTAEVFSRWRSILSNS
SSRNLTGTLGIRIDHLIFLILKKSGKKLSIFLPHFFYFYPSINLPQIVSL

Sequences:

>Translated_450_residues
MNFFQYKHNKLYAEDIPVQQLAEQFGTPLYVYSRATLERHWHAFDSAFGKRPHLICFAVKSCSNIGVLNIMAKLGSGFDI
VSQGELERVLAAGGNASKVVFSGVAKSREEIMRALEVGIRCFNVESVSELKHINQIAGEMGKIAPISLRVNPDVDAHTHP
YISTGLKENKFGVSVNEAREVYKLASTLPNIKITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKEDGITLKHLDLGGGL
GVTYTDETPPHPSDYANALLEKLKDYPELEIILEPGRAISANAGILVAKVQYLKSNESRNFAITDTGMNDMIRPALYEAY
MNIVEIDRTLAREKAIYDVVGPVCETSDFLGKQRELSIAEGDYIAQCSAGAYGASMSSNYNSRARTAEVFSRWRSILSNS
SSRNLTGTLGIRIDHLIFLILKKSGKKLSIFLPHFFYFYPSINLPQIVSL
>Mature_450_residues
MNFFQYKHNKLYAEDIPVQQLAEQFGTPLYVYSRATLERHWHAFDSAFGKRPHLICFAVKSCSNIGVLNIMAKLGSGFDI
VSQGELERVLAAGGNASKVVFSGVAKSREEIMRALEVGIRCFNVESVSELKHINQIAGEMGKIAPISLRVNPDVDAHTHP
YISTGLKENKFGVSVNEAREVYKLASTLPNIKITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKEDGITLKHLDLGGGL
GVTYTDETPPHPSDYANALLEKLKDYPELEIILEPGRAISANAGILVAKVQYLKSNESRNFAITDTGMNDMIRPALYEAY
MNIVEIDRTLAREKAIYDVVGPVCETSDFLGKQRELSIAEGDYIAQCSAGAYGASMSSNYNSRARTAEVFSRWRSILSNS
SSRNLTGTLGIRIDHLIFLILKKSGKKLSIFLPHFFYFYPSINLPQIVSL

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=350, Percent_Identity=24.8571428571429, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI22538418, Length=386, Percent_Identity=25.3886010362694, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI21361583, Length=386, Percent_Identity=25.3886010362694, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI16506287, Length=345, Percent_Identity=24.9275362318841, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1789203, Length=398, Percent_Identity=31.4070351758794, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17562780, Length=364, Percent_Identity=23.6263736263736, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24586474, Length=399, Percent_Identity=24.5614035087719, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 49924; Mature: 49924

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFFQYKHNKLYAEDIPVQQLAEQFGTPLYVYSRATLERHWHAFDSAFGKRPHLICFAVK
CCCCCCCCCEEECCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEC
SCSNIGVLNIMAKLGSGFDIVSQGELERVLAAGGNASKVVFSGVAKSREEIMRALEVGIR
CCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCE
CFNVESVSELKHINQIAGEMGKIAPISLRVNPDVDAHTHPYISTGLKENKFGVSVNEARE
EECCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCCCCHHHHHH
VYKLASTLPNIKITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKEDGITLKHLDLGGGL
HHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
GVTYTDETPPHPSDYANALLEKLKDYPELEIILEPGRAISANAGILVAKVQYLKSNESRN
EEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCEEEEEEHHHHCCCCCC
FAITDTGMNDMIRPALYEAYMNIVEIDRTLAREKAIYDVVGPVCETSDFLGKQRELSIAE
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHCCCCCCEEECC
GDYIAQCSAGAYGASMSSNYNSRARTAEVFSRWRSILSNSSSRNLTGTLGIRIDHLIFLI
CCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHE
LKKSGKKLSIFLPHFFYFYPSINLPQIVSL
ECCCCCEEEEEECHHHHHCCCCCCCHHHCC
>Mature Secondary Structure
MNFFQYKHNKLYAEDIPVQQLAEQFGTPLYVYSRATLERHWHAFDSAFGKRPHLICFAVK
CCCCCCCCCEEECCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEC
SCSNIGVLNIMAKLGSGFDIVSQGELERVLAAGGNASKVVFSGVAKSREEIMRALEVGIR
CCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCE
CFNVESVSELKHINQIAGEMGKIAPISLRVNPDVDAHTHPYISTGLKENKFGVSVNEARE
EECCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCCCCHHHHHH
VYKLASTLPNIKITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKEDGITLKHLDLGGGL
HHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
GVTYTDETPPHPSDYANALLEKLKDYPELEIILEPGRAISANAGILVAKVQYLKSNESRN
EEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCEEEEEEHHHHCCCCCC
FAITDTGMNDMIRPALYEAYMNIVEIDRTLAREKAIYDVVGPVCETSDFLGKQRELSIAE
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHCCCCCCEEECC
GDYIAQCSAGAYGASMSSNYNSRARTAEVFSRWRSILSNSSSRNLTGTLGIRIDHLIFLI
CCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHE
LKKSGKKLSIFLPHFFYFYPSINLPQIVSL
ECCCCCEEEEEECHHHHHCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]