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The map label for this gene is clpP [H]

Identifier: 148827882

GI number: 148827882

Start: 1260986

End: 1261567

Strand: Direct

Name: clpP [H]

Synonym: CGSHiGG_06885

Alternate gene names: 148827882

Gene position: 1260986-1261567 (Clockwise)

Preceding gene: 148827881

Following gene: 148827883

Centisome position: 66.82

GC content: 41.24

Gene sequence:

>582_bases
ATGAGCGTAATTCCTATGGTCGTTGAACAGACTTCGCGTGGCGAGCGTTCGTACGACATTTATTCCCGTTTATTAAAAGA
ACGTGTGATTTTCCTAAGTGGAGAAGTGGAAGATCGTATGGCAAATTTAATTGTGGCACAGCTTCTTTTTTTAGAATCGG
AAGATCCAACTAAAGACATCAATATTTATATCAACTCTCCAGGCGGTTCTGTGACTGCAGGTATGGCAATTTACGACACA
ATGCAATTTATTAAGCCAGATATTCGCACTCTTTGTATTGGTCAAGCCTGTTCAATGGGCGCATTCTTGCTTGCTGGCGG
AACTGCTGGCAAACGAGCTGCATTGCCTAATGCACGAGTGATGATTCATCAACCTTTGGGTGGTTTCCGTGGTCAAGCAT
CGGATATTCAAATTCACGCACAAGAAATTTTGAAAATTAAACACACCTTAAATGATCGTTTAGCATTCCATACTGGACAA
AGTATTGAGCGTATTGAGAAAGATACCGACCGCGATAATTTTATGTCAGCGGAAGAAGCACAAGCGTATGGTTTGGTGGA
TGAAGTCTTAGTTAAACGTTAA

Upstream 100 bases:

>100_bases
ATAAAAGTGCGGTCGCTCTTTCTAATAAAAGCGATCGCATTTTTATTTGTGGGTTATTTACGATAAAATAATTAGCAGTT
TTAATGAAAAAGGTAAGAAA

Downstream 100 bases:

>100_bases
GGGTATACAATGACAGACAAAGATAAAGATTTGCACTGCTCTTTTTGCGGAAAAGAAAAAGGCGAAGTAGATAAATTAAT
TGCTGGCACAGGCGGTTATA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MSVIPMVVEQTSRGERSYDIYSRLLKERVIFLSGEVEDRMANLIVAQLLFLESEDPTKDINIYINSPGGSVTAGMAIYDT
MQFIKPDIRTLCIGQACSMGAFLLAGGTAGKRAALPNARVMIHQPLGGFRGQASDIQIHAQEILKIKHTLNDRLAFHTGQ
SIERIEKDTDRDNFMSAEEAQAYGLVDEVLVKR

Sequences:

>Translated_193_residues
MSVIPMVVEQTSRGERSYDIYSRLLKERVIFLSGEVEDRMANLIVAQLLFLESEDPTKDINIYINSPGGSVTAGMAIYDT
MQFIKPDIRTLCIGQACSMGAFLLAGGTAGKRAALPNARVMIHQPLGGFRGQASDIQIHAQEILKIKHTLNDRLAFHTGQ
SIERIEKDTDRDNFMSAEEAQAYGLVDEVLVKR
>Mature_192_residues
SVIPMVVEQTSRGERSYDIYSRLLKERVIFLSGEVEDRMANLIVAQLLFLESEDPTKDINIYINSPGGSVTAGMAIYDTM
QFIKPDIRTLCIGQACSMGAFLLAGGTAGKRAALPNARVMIHQPLGGFRGQASDIQIHAQEILKIKHTLNDRLAFHTGQS
IERIEKDTDRDNFMSAEEAQAYGLVDEVLVKR

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=191, Percent_Identity=59.1623036649215, Blast_Score=241, Evalue=3e-64,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=71.5025906735751, Blast_Score=305, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=55.3763440860215, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=58.9473684210526, Blast_Score=244, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21403; Mature: 21272

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVIPMVVEQTSRGERSYDIYSRLLKERVIFLSGEVEDRMANLIVAQLLFLESEDPTKDI
CCCCHHHHHHCCCCCCCHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCCCCCCEE
NIYINSPGGSVTAGMAIYDTMQFIKPDIRTLCIGQACSMGAFLLAGGTAGKRAALPNARV
EEEEECCCCCEEHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEE
MIHQPLGGFRGQASDIQIHAQEILKIKHTLNDRLAFHTGQSIERIEKDTDRDNFMSAEEA
EEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHCCCHHHH
QAYGLVDEVLVKR
HHHHHHHHHHHCC
>Mature Secondary Structure 
SVIPMVVEQTSRGERSYDIYSRLLKERVIFLSGEVEDRMANLIVAQLLFLESEDPTKDI
CCCHHHHHHCCCCCCCHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCCCCCCEE
NIYINSPGGSVTAGMAIYDTMQFIKPDIRTLCIGQACSMGAFLLAGGTAGKRAALPNARV
EEEEECCCCCEEHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEE
MIHQPLGGFRGQASDIQIHAQEILKIKHTLNDRLAFHTGQSIERIEKDTDRDNFMSAEEA
EEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHCCCHHHH
QAYGLVDEVLVKR
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA