Click here to switch to the map view.

The map label for this gene is glpQ [H]

Identifier: 148827862

GI number: 148827862

Start: 1229064

End: 1229858

Strand: Direct

Name: glpQ [H]

Synonym: CGSHiGG_06740

Alternate gene names: 148827862

Gene position: 1229064-1229858 (Clockwise)

Preceding gene: 148827861

Following gene: 148827863

Centisome position: 65.13

GC content: 43.9

Gene sequence:

>795_bases
ATGGATAAATCATTAAAAGCGAACTGTATTGGCGAGTTTTTAGGTACAGCCTTATTGATTTTCTTTGGTGTGGGCTGCGT
TGCAGCACTAAAAGTAGCAGGCGCTAGTTTTGGCTTGTGGGAAATCAGCATTATGTGGGGGATGGGCGTTGCACTTGCAG
TATATGCAACAGCGGGGTTATCTGGCGCACATTTAAACCCTGCAGTAACCATTGCCCTTTGGAAATTTGCTTGCTTTGAT
GGCAAAAAAGTAATTCCTTACATCATTTCACAAATGCTCGGCGCATTCTTTGCTGCCGCATTAGTTTATGCCTTATACCG
CAATGTTTTTATCGATTATGAAACAGCCCACAATATTGTTCGTGGTACACAAGAAAGTTTAAGCCTTGCGGGTACATTCT
CCACTTATCCTCATCCAAGTTTAAGCATTGGTGGCGCCTTTGCTGTGGAATTCGTGATTACTGCAATTCTTATGGCATTA
ATTATGGCATTAACTGACGATGGAAACGGAGTACCTCGTGGTCCACTTGCCCCATTATTAATCGGTATCTTGATAGCCGT
TATTGGTGGTGCTATGGGACCATTAACTGGTTTTGCCATGAATCCAGCACGTGACTTCGGACCAAAATTCTTTGCTTATC
TCGCTGGCTGGGGCGAACTCGCTTTAACTGGCGGACGCGAAGTCCCTTATTTTATCGTTCCAATGGTTGCACCTGTTTTA
GGCGCATTAGCTGGTGCATGGTTATACAAAAAAGCAATTGGCGGCAATTTACCTTGTAATTGCGGCTGCGAATAA

Upstream 100 bases:

>100_bases
GAGGCTATTTCAAAACACTCCGTATTCTTTTTTAATAAATTCTTCCCCTTTACTTAGGGAAAACACTCTTCATTTCAACC
GCACTTCTAAGGAGTGATCT

Downstream 100 bases:

>100_bases
TTATTTGAAGGAGTAATACTATGACAGACAAAAAATACATCATTGCATTAGACCAAGGCACAACAAGCTCTCGCGCAGTA
TTATTAGATCATAATGCGAA

Product: glycerophosphodiester phosphodiesterase

Products: glycerol [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MDKSLKANCIGEFLGTALLIFFGVGCVAALKVAGASFGLWEISIMWGMGVALAVYATAGLSGAHLNPAVTIALWKFACFD
GKKVIPYIISQMLGAFFAAALVYALYRNVFIDYETAHNIVRGTQESLSLAGTFSTYPHPSLSIGGAFAVEFVITAILMAL
IMALTDDGNGVPRGPLAPLLIGILIAVIGGAMGPLTGFAMNPARDFGPKFFAYLAGWGELALTGGREVPYFIVPMVAPVL
GALAGAWLYKKAIGGNLPCNCGCE

Sequences:

>Translated_264_residues
MDKSLKANCIGEFLGTALLIFFGVGCVAALKVAGASFGLWEISIMWGMGVALAVYATAGLSGAHLNPAVTIALWKFACFD
GKKVIPYIISQMLGAFFAAALVYALYRNVFIDYETAHNIVRGTQESLSLAGTFSTYPHPSLSIGGAFAVEFVITAILMAL
IMALTDDGNGVPRGPLAPLLIGILIAVIGGAMGPLTGFAMNPARDFGPKFFAYLAGWGELALTGGREVPYFIVPMVAPVL
GALAGAWLYKKAIGGNLPCNCGCE
>Mature_264_residues
MDKSLKANCIGEFLGTALLIFFGVGCVAALKVAGASFGLWEISIMWGMGVALAVYATAGLSGAHLNPAVTIALWKFACFD
GKKVIPYIISQMLGAFFAAALVYALYRNVFIDYETAHNIVRGTQESLSLAGTFSTYPHPSLSIGGAFAVEFVITAILMAL
IMALTDDGNGVPRGPLAPLLIGILIAVIGGAMGPLTGFAMNPARDFGPKFFAYLAGWGELALTGGREVPYFIVPMVAPVL
GALAGAWLYKKAIGGNLPCNCGCE

Specific function: Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane [H]

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI157266307, Length=251, Percent_Identity=39.0438247011952, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI4826645, Length=256, Percent_Identity=38.28125, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI22538420, Length=256, Percent_Identity=35.546875, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI4502187, Length=261, Percent_Identity=32.5670498084291, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI310133356, Length=207, Percent_Identity=29.951690821256, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI310114181, Length=207, Percent_Identity=29.951690821256, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI45446752, Length=205, Percent_Identity=30.7317073170732, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI86792455, Length=256, Percent_Identity=31.640625, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI4502179, Length=241, Percent_Identity=31.1203319502075, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI6912506, Length=198, Percent_Identity=30.8080808080808, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI4502183, Length=246, Percent_Identity=30.8943089430894, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1790362, Length=258, Percent_Identity=73.2558139534884, Blast_Score=393, Evalue=1e-111,
Organism=Escherichia coli, GI1787101, Length=213, Percent_Identity=31.924882629108, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71994009, Length=260, Percent_Identity=33.8461538461538, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71992966, Length=252, Percent_Identity=35.7142857142857, Blast_Score=138, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI32564052, Length=258, Percent_Identity=34.1085271317829, Blast_Score=137, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17533613, Length=258, Percent_Identity=34.1085271317829, Blast_Score=137, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17531431, Length=262, Percent_Identity=33.206106870229, Blast_Score=131, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17531429, Length=262, Percent_Identity=33.206106870229, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17544068, Length=251, Percent_Identity=35.0597609561753, Blast_Score=117, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71992961, Length=252, Percent_Identity=32.5396825396825, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17558372, Length=251, Percent_Identity=26.6932270916335, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321054, Length=212, Percent_Identity=39.622641509434, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6322985, Length=233, Percent_Identity=35.1931330472103, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24762344, Length=247, Percent_Identity=28.7449392712551, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24762346, Length=247, Percent_Identity=28.7449392712551, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24762348, Length=247, Percent_Identity=28.7449392712551, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI20130305, Length=247, Percent_Identity=28.7449392712551, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45550503, Length=248, Percent_Identity=26.2096774193548, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24652747, Length=207, Percent_Identity=32.8502415458937, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45551084, Length=207, Percent_Identity=32.8502415458937, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24762342, Length=259, Percent_Identity=25.8687258687259, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 27568; Mature: 27568

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKSLKANCIGEFLGTALLIFFGVGCVAALKVAGASFGLWEISIMWGMGVALAVYATAGL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
SGAHLNPAVTIALWKFACFDGKKVIPYIISQMLGAFFAAALVYALYRNVFIDYETAHNIV
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RGTQESLSLAGTFSTYPHPSLSIGGAFAVEFVITAILMALIMALTDDGNGVPRGPLAPLL
HCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
IGILIAVIGGAMGPLTGFAMNPARDFGPKFFAYLAGWGELALTGGREVPYFIVPMVAPVL
HHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHH
GALAGAWLYKKAIGGNLPCNCGCE
HHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MDKSLKANCIGEFLGTALLIFFGVGCVAALKVAGASFGLWEISIMWGMGVALAVYATAGL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
SGAHLNPAVTIALWKFACFDGKKVIPYIISQMLGAFFAAALVYALYRNVFIDYETAHNIV
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RGTQESLSLAGTFSTYPHPSLSIGGAFAVEFVITAILMALIMALTDDGNGVPRGPLAPLL
HCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
IGILIAVIGGAMGPLTGFAMNPARDFGPKFFAYLAGWGELALTGGREVPYFIVPMVAPVL
HHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHH
GALAGAWLYKKAIGGNLPCNCGCE
HHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycerol [Periplasm] [C]

Specific reaction: glycerol [Periplasm] = glycerol [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]