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The map label for this gene is glpK [H]

Identifier: 148827863

GI number: 148827863

Start: 1229879

End: 1231390

Strand: Direct

Name: glpK [H]

Synonym: CGSHiGG_06745

Alternate gene names: 148827863

Gene position: 1229879-1231390 (Clockwise)

Preceding gene: 148827862

Following gene: 148827865

Centisome position: 65.17

GC content: 42.39

Gene sequence:

>1512_bases
ATGACAGACAAAAAATACATCATTGCATTAGACCAAGGCACAACAAGCTCTCGCGCAGTATTATTAGATCATAATGCGAA
TGTGGTTGAAATTGCACAACGTGAATTTACCCAAATCTACCCTCGAGCTGGTTGGGTAGAACATAACCCAATGGAAATTT
GGGCAACTCAAAGCTCAACCTTAAACGAAGTCGTTGCAAAATCGGGCATTACATCTGATGAAATCGCTGCTATCGGTATC
ACCAACCAACGTGAAACCACCATTGTATGGGAAAAATCAACGGGTACACCTGTTTACAACGCTATCGTTTGGCAATGCCG
CCGTACTGCAGACATTACCGATAAATTAAAAGCCGATGGCTATGAAGAATATATTCGTAATACCACAGGCTTAGTGGTTG
ACCCTTACTTCTCTGGTACAAAAGTAAAATGGATTTTGGATAACGTTGAAGGCGCACGAGAAAAAGCTGAACGAGGCGAA
TTATTATTTGGTACCGTTGATACTTGGCTTGTATGGAAATTGACTCAAGGCCGAGTGCACGTAACCGATTATACCAACGC
ATCTCGTACCATGTTATTTAACATCCATACTAAACAATGGGATGACAAGATGCTTGAAATCTTGAATATTCCTCGTTCAA
TATTACCTGAAGTACGTAATTCTTCTGAAATTTACGGCCAAACCAATATCGGTGGTAAAGGTGGTGTGCGTATTCCTGTT
GCAGGGATTGCTGGTGACCAACAAGCCGCTCTTTACGGACATCTTTGCGTACATGCAGGCCAAGCCAAAAACACTTACGG
CACAGGTTGCTTTATGTTACTCCACACGGGTAACAAAGCTATTACATCCAAAAATGGACTACTCACAACCATTGCTTGTA
ATGCAAAAGGCGAACCAGAATATGCCTTAGAAGGTTCAGTATTTATCGCGGGTGCATCAATCCAATGGCTCCGTGATGAA
CTCAAAATTGTTCACGATAGTTTTGACTCTGAATACTTTGCACAAAAAGTGACTGATAGTAATGGCGTATATGTTGTTCC
AGCTTTCACAGGCTTAGGTGCACCATATTGGGATCCATATGCGCGCGGTGCGATTTTTGGTCTTTCTCGCGGTGCAAACT
GTAATCATATTGTTCGAGCAACCTTACAATCTATTGCTTACCAAACCCGTGATGTCTTAGAGGCTATGCAATCAGATTCG
GGTGAACGATTACAATATCTCCGTGTAGATGGTGGTGCGACAAACAATAACTTCTTAATGCAATTCCAAGCTGACATTTT
AGATGTAAATGTAGAGCGCCCAGTTGTGAAAGAAGTGACCGCTCTAGGTGCAGCTTATCTTGCTGGTTTAGCAACAGGCT
TCTGGAAAGATTTAGACGAGCTTCGCGATAAAGCCCGTGTAGAACGCACTTTCAGCCCAGACAGCGACAATGAAAAACGT
GAACGTCGCTACAAAGGCTGGAAAAAAGCAGTTAAACGCTCATTAGAATGGGCAAAAGAAGATGAAGAATAA

Upstream 100 bases:

>100_bases
TTTTAGGCGCATTAGCTGGTGCATGGTTATACAAAAAAGCAATTGGCGGCAATTTACCTTGTAATTGCGGCTGCGAATAA
TTATTTGAAGGAGTAATACT

Downstream 100 bases:

>100_bases
TTTATAAATTAATTCTCATACAAAAAGAGCGGTCAAAACTTCTTTTATTTTGACCGCTCTTTTATTCTGTATCTGTATAA
AAATTATTTTCTAGAGAGAG

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MTDKKYIIALDQGTTSSRAVLLDHNANVVEIAQREFTQIYPRAGWVEHNPMEIWATQSSTLNEVVAKSGITSDEIAAIGI
TNQRETTIVWEKSTGTPVYNAIVWQCRRTADITDKLKADGYEEYIRNTTGLVVDPYFSGTKVKWILDNVEGAREKAERGE
LLFGTVDTWLVWKLTQGRVHVTDYTNASRTMLFNIHTKQWDDKMLEILNIPRSILPEVRNSSEIYGQTNIGGKGGVRIPV
AGIAGDQQAALYGHLCVHAGQAKNTYGTGCFMLLHTGNKAITSKNGLLTTIACNAKGEPEYALEGSVFIAGASIQWLRDE
LKIVHDSFDSEYFAQKVTDSNGVYVVPAFTGLGAPYWDPYARGAIFGLSRGANCNHIVRATLQSIAYQTRDVLEAMQSDS
GERLQYLRVDGGATNNNFLMQFQADILDVNVERPVVKEVTALGAAYLAGLATGFWKDLDELRDKARVERTFSPDSDNEKR
ERRYKGWKKAVKRSLEWAKEDEE

Sequences:

>Translated_503_residues
MTDKKYIIALDQGTTSSRAVLLDHNANVVEIAQREFTQIYPRAGWVEHNPMEIWATQSSTLNEVVAKSGITSDEIAAIGI
TNQRETTIVWEKSTGTPVYNAIVWQCRRTADITDKLKADGYEEYIRNTTGLVVDPYFSGTKVKWILDNVEGAREKAERGE
LLFGTVDTWLVWKLTQGRVHVTDYTNASRTMLFNIHTKQWDDKMLEILNIPRSILPEVRNSSEIYGQTNIGGKGGVRIPV
AGIAGDQQAALYGHLCVHAGQAKNTYGTGCFMLLHTGNKAITSKNGLLTTIACNAKGEPEYALEGSVFIAGASIQWLRDE
LKIVHDSFDSEYFAQKVTDSNGVYVVPAFTGLGAPYWDPYARGAIFGLSRGANCNHIVRATLQSIAYQTRDVLEAMQSDS
GERLQYLRVDGGATNNNFLMQFQADILDVNVERPVVKEVTALGAAYLAGLATGFWKDLDELRDKARVERTFSPDSDNEKR
ERRYKGWKKAVKRSLEWAKEDEE
>Mature_502_residues
TDKKYIIALDQGTTSSRAVLLDHNANVVEIAQREFTQIYPRAGWVEHNPMEIWATQSSTLNEVVAKSGITSDEIAAIGIT
NQRETTIVWEKSTGTPVYNAIVWQCRRTADITDKLKADGYEEYIRNTTGLVVDPYFSGTKVKWILDNVEGAREKAERGEL
LFGTVDTWLVWKLTQGRVHVTDYTNASRTMLFNIHTKQWDDKMLEILNIPRSILPEVRNSSEIYGQTNIGGKGGVRIPVA
GIAGDQQAALYGHLCVHAGQAKNTYGTGCFMLLHTGNKAITSKNGLLTTIACNAKGEPEYALEGSVFIAGASIQWLRDEL
KIVHDSFDSEYFAQKVTDSNGVYVVPAFTGLGAPYWDPYARGAIFGLSRGANCNHIVRATLQSIAYQTRDVLEAMQSDSG
ERLQYLRVDGGATNNNFLMQFQADILDVNVERPVVKEVTALGAAYLAGLATGFWKDLDELRDKARVERTFSPDSDNEKRE
RRYKGWKKAVKRSLEWAKEDEE

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=502, Percent_Identity=47.0119521912351, Blast_Score=439, Evalue=1e-123,
Organism=Homo sapiens, GI4504007, Length=502, Percent_Identity=47.0119521912351, Blast_Score=438, Evalue=1e-123,
Organism=Homo sapiens, GI42794763, Length=506, Percent_Identity=46.6403162055336, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI41393575, Length=506, Percent_Identity=45.8498023715415, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI88196792, Length=508, Percent_Identity=33.6614173228346, Blast_Score=317, Evalue=1e-86,
Organism=Escherichia coli, GI1790361, Length=502, Percent_Identity=76.2948207171315, Blast_Score=832, Evalue=0.0,
Organism=Escherichia coli, GI1789987, Length=495, Percent_Identity=24.040404040404, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1787789, Length=507, Percent_Identity=23.6686390532544, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1789138, Length=511, Percent_Identity=22.7005870841487, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1790005, Length=509, Percent_Identity=22.9862475442043, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1789168, Length=499, Percent_Identity=21.2424849699399, Blast_Score=79, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17535599, Length=504, Percent_Identity=42.0634920634921, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71986140, Length=527, Percent_Identity=24.8576850094877, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71986147, Length=301, Percent_Identity=30.8970099667774, Blast_Score=138, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6321755, Length=557, Percent_Identity=36.8043087971275, Blast_Score=324, Evalue=2e-89,
Organism=Drosophila melanogaster, GI17864214, Length=506, Percent_Identity=43.0830039525692, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24655555, Length=474, Percent_Identity=41.9831223628692, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24655560, Length=474, Percent_Identity=41.9831223628692, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24655570, Length=474, Percent_Identity=41.9831223628692, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24655574, Length=474, Percent_Identity=41.9831223628692, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24655565, Length=474, Percent_Identity=41.9831223628692, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24654573, Length=435, Percent_Identity=45.5172413793103, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI19922058, Length=516, Percent_Identity=34.4961240310078, Blast_Score=291, Evalue=6e-79,
Organism=Drosophila melanogaster, GI24652871, Length=495, Percent_Identity=34.3434343434343, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24656367, Length=514, Percent_Identity=28.4046692607004, Blast_Score=225, Evalue=4e-59,
Organism=Drosophila melanogaster, GI21357867, Length=530, Percent_Identity=27.9245283018868, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24656372, Length=365, Percent_Identity=30.1369863013699, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI45552909, Length=303, Percent_Identity=27.7227722772277, Blast_Score=123, Evalue=3e-28,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 56112; Mature: 55981

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKKYIIALDQGTTSSRAVLLDHNANVVEIAQREFTQIYPRAGWVEHNPMEIWATQSST
CCCCEEEEEEECCCCCCCEEEEECCCCEEHHHHHHHHHHCCCCCCCCCCCEEEEECCCHH
LNEVVAKSGITSDEIAAIGITNQRETTIVWEKSTGTPVYNAIVWQCRRTADITDKLKADG
HHHHHHHCCCCCCCEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHCCC
YEEYIRNTTGLVVDPYFSGTKVKWILDNVEGAREKAERGELLFGTVDTWLVWKLTQGRVH
HHHHHCCCCCEEEECCCCCCEEEEEEECCHHHHHHHHCCCEEEEECCEEEEEEEECCEEE
VTDYTNASRTMLFNIHTKQWDDKMLEILNIPRSILPEVRNSSEIYGQTNIGGKGGVRIPV
EEECCCCCEEEEEEEECCCHHHHHHHHHHCCHHHHHHHCCCCCEEEECCCCCCCCEEEEE
AGIAGDQQAALYGHLCVHAGQAKNTYGTGCFMLLHTGNKAITSKNGLLTTIACNAKGEPE
EECCCCCCHHHHEEHEEECCCCCCCCCCEEEEEEECCCEEEECCCCEEEEEEECCCCCCC
YALEGSVFIAGASIQWLRDELKIVHDSFDSEYFAQKVTDSNGVYVVPAFTGLGAPYWDPY
EEECCCEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCHH
ARGAIFGLSRGANCNHIVRATLQSIAYQTRDVLEAMQSDSGERLQYLRVDGGATNNNFLM
HCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEE
QFQADILDVNVERPVVKEVTALGAAYLAGLATGFWKDLDELRDKARVERTFSPDSDNEKR
EEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
ERRYKGWKKAVKRSLEWAKEDEE
HHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TDKKYIIALDQGTTSSRAVLLDHNANVVEIAQREFTQIYPRAGWVEHNPMEIWATQSST
CCCEEEEEEECCCCCCCEEEEECCCCEEHHHHHHHHHHCCCCCCCCCCCEEEEECCCHH
LNEVVAKSGITSDEIAAIGITNQRETTIVWEKSTGTPVYNAIVWQCRRTADITDKLKADG
HHHHHHHCCCCCCCEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHCCC
YEEYIRNTTGLVVDPYFSGTKVKWILDNVEGAREKAERGELLFGTVDTWLVWKLTQGRVH
HHHHHCCCCCEEEECCCCCCEEEEEEECCHHHHHHHHCCCEEEEECCEEEEEEEECCEEE
VTDYTNASRTMLFNIHTKQWDDKMLEILNIPRSILPEVRNSSEIYGQTNIGGKGGVRIPV
EEECCCCCEEEEEEEECCCHHHHHHHHHHCCHHHHHHHCCCCCEEEECCCCCCCCEEEEE
AGIAGDQQAALYGHLCVHAGQAKNTYGTGCFMLLHTGNKAITSKNGLLTTIACNAKGEPE
EECCCCCCHHHHEEHEEECCCCCCCCCCEEEEEEECCCEEEECCCCEEEEEEECCCCCCC
YALEGSVFIAGASIQWLRDELKIVHDSFDSEYFAQKVTDSNGVYVVPAFTGLGAPYWDPY
EEECCCEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCHH
ARGAIFGLSRGANCNHIVRATLQSIAYQTRDVLEAMQSDSGERLQYLRVDGGATNNNFLM
HCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEE
QFQADILDVNVERPVVKEVTALGAAYLAGLATGFWKDLDELRDKARVERTFSPDSDNEKR
EEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
ERRYKGWKKAVKRSLEWAKEDEE
HHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA