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The map label for this gene is hup

Identifier: 148824176

GI number: 148824176

Start: 3354885

End: 3355529

Strand: Reverse

Name: hup

Synonym: TBFG_13001

Alternate gene names: 148824176

Gene position: 3355529-3354885 (Counterclockwise)

Preceding gene: 148824177

Following gene: 148824172

Centisome position: 75.84

GC content: 64.65

Gene sequence:

>645_bases
ATGAACAAAGCAGAGCTCATTGACGTGCTCACACAGAAATTGGGCTCGGACCGTCGGCAGGCGACCGCCGCCGTCGAGAA
TGTCGTTGACACGATTGTGCGTGCGGTACACAAAGGCGACAGCGTCACCATTACCGGGTTCGGTGTGTTCGAACAGCGTC
GCCGCGCGGCTCGAGTGGCCCGCAATCCGCGTACCGGCGAGACAGTAAAGGTGAAGCCGACGTCGGTGCCGGCGTTCCGC
CCGGGCGCGCAATTCAAAGCGGTTGTGTCTGGCGCGCAGCGTCTCCCGGCAGAAGGACCCGCTGTTAAGCGTGGTGTGGG
GGCCAGTGCAGCCAAGAAGGTAGCGAAGAAGGCACCTGCCAAGAAGGCGACAAAGGCCGCCAAGAAGGCGGCGACCAAGG
CGCCCGCCAGGAAGGCGGCGACCAAGGCGCCCGCCAAGAAAGCGGCGACCAAGGCGCCCGCCAAGAAAGCTGTCAAGGCC
ACGAAGTCACCCGCCAAGAAGGTGACCAAGGCGGTGAAGAAGACCGCGGTCAAGGCATCGGTGCGTAAGGCGGCGACCAA
GGCGCCGGCAAAGAAGGCAGCGGCCAAGCGGCCGGCTACCAAGGCTCCCGCCAAGAAGGCAACCGCTCGGCGGGGTCGCA
AATAG

Upstream 100 bases:

>100_bases
TCAGTGAAATTGCGCGTGGCTCTTGGAAATCAGCCGGGTAAGGGTTTACCGTGTCCACTAGTCGGTTCCAAACGAGGACC
ACTGGTTTCGGAGGGTTGGG

Downstream 100 bases:

>100_bases
GTCAAGACACACGGATACCCTTTGCACGGTGGCAATGTGACGAAGGGTATCCGTGTGTTAGGCCCGCACGTTGGCGGCCA
GCGCACCGCCGATGTGGTCG

Product: DNA-binding protein hupB (histone-like protein)

Products: NA

Alternate protein names: Histone-like protein; Hlp

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MNKAELIDVLTQKLGSDRRQATAAVENVVDTIVRAVHKGDSVTITGFGVFEQRRRAARVARNPRTGETVKVKPTSVPAFR
PGAQFKAVVSGAQRLPAEGPAVKRGVGASAAKKVAKKAPAKKATKAAKKAATKAPARKAATKAPAKKAATKAPAKKAVKA
TKSPAKKVTKAVKKTAVKASVRKAATKAPAKKAAAKRPATKAPAKKATARRGRK

Sequences:

>Translated_214_residues
MNKAELIDVLTQKLGSDRRQATAAVENVVDTIVRAVHKGDSVTITGFGVFEQRRRAARVARNPRTGETVKVKPTSVPAFR
PGAQFKAVVSGAQRLPAEGPAVKRGVGASAAKKVAKKAPAKKATKAAKKAATKAPARKAATKAPAKKAATKAPAKKAVKA
TKSPAKKVTKAVKKTAVKASVRKAATKAPAKKAAAKRPATKAPAKKATARRGRK
>Mature_214_residues
MNKAELIDVLTQKLGSDRRQATAAVENVVDTIVRAVHKGDSVTITGFGVFEQRRRAARVARNPRTGETVKVKPTSVPAFR
PGAQFKAVVSGAQRLPAEGPAVKRGVGASAAKKVAKKAPAKKATKAAKKAATKAPARKAATKAPAKKAATKAPAKKAVKA
TKSPAKKVTKAVKKTAVKASVRKAATKAPAKKAAAKRPATKAPAKKATARRGRK

Specific function: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions

COG id: COG0776

COG function: function code L; Bacterial nucleoid DNA-binding protein

Gene ontology:

Cell location: Secreted, cell wall

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial histone-like protein family

Homologues:

Organism=Escherichia coli, GI1790433, Length=82, Percent_Identity=42.6829268292683, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI1788005, Length=92, Percent_Identity=39.1304347826087, Blast_Score=71, Evalue=4e-14,
Organism=Escherichia coli, GI1786644, Length=92, Percent_Identity=36.9565217391304, Blast_Score=66, Evalue=1e-12,

Paralogues:

None

Copy number: 1380 Molecules/Cell In: Growth-Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): DBH_MYCBO (Q9XB18)

Other databases:

- EMBL:   Y18421
- EMBL:   AB013441
- EMBL:   BX248344
- RefSeq:   NP_856655.1
- ProteinModelPortal:   Q9XB18
- SMR:   Q9XB18
- EnsemblBacteria:   EBMYCT00000014228
- GeneID:   1092720
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3010c
- GeneTree:   EBGT00050000014972
- HOGENOM:   HBG705085
- OMA:   HKGESVT
- ProtClustDB:   CLSK872125
- BioCyc:   MBOV233413:MB3010C-MONOMER
- InterPro:   IPR000119
- InterPro:   IPR020816
- InterPro:   IPR010992
- Gene3D:   G3DSA:4.10.520.10
- PRINTS:   PR01727
- SMART:   SM00411

Pfam domain/function: PF00216 Bac_DNA_binding; SSF47729 IHF_like_DNA_bnd

EC number: NA

Molecular weight: Translated: 22187; Mature: 22187

Theoretical pI: Translated: 12.48; Mature: 12.48

Prosite motif: PS00045 HISTONE_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKAELIDVLTQKLGSDRRQATAAVENVVDTIVRAVHKGDSVTITGFGVFEQRRRAARVA
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHH
RNPRTGETVKVKPTSVPAFRPGAQFKAVVSGAQRLPAEGPAVKRGVGASAAKKVAKKAPA
CCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCH
KKATKAAKKAATKAPARKAATKAPAKKAATKAPAKKAVKATKSPAKKVTKAVKKTAVKAS
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VRKAATKAPAKKAAAKRPATKAPAKKATARRGRK
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MNKAELIDVLTQKLGSDRRQATAAVENVVDTIVRAVHKGDSVTITGFGVFEQRRRAARVA
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHH
RNPRTGETVKVKPTSVPAFRPGAQFKAVVSGAQRLPAEGPAVKRGVGASAAKKVAKKAPA
CCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCH
KKATKAAKKAATKAPARKAATKAPAKKAATKAPAKKAVKATKSPAKKVTKAVKKTAVKAS
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VRKAATKAPAKKAAAKRPATKAPAKKATARRGRK
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972