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The map label for this gene is gpsA

Identifier: 148824172

GI number: 148824172

Start: 3349704

End: 3350708

Strand: Reverse

Name: gpsA

Synonym: TBFG_12997

Alternate gene names: 148824172

Gene position: 3350708-3349704 (Counterclockwise)

Preceding gene: 148824176

Following gene: 148824171

Centisome position: 75.73

GC content: 67.36

Gene sequence:

>1005_bases
ATGGCCGGAATAGCAAGCACCGTCGCGGTGATGGGCGCCGGTGCATGGGGCACGGCCCTGGCTAAGGTGCTGGCCGACGC
GGGCGGAGAGGTCACGCTGTGGGCGCGGCGAGCTGAGGTGGCCGATCAGATCAATACCACCCGATATAACCCCGACTATC
TGCCCGGTGCGCTGTTACCACCGAGCATTCATGCCACCGCAGATGCCGAGGAGGCACTTGGGGGCGCATCCACGGTGCTG
TTGGGAGTGCCCGCGCAGACCATGCGGGCCAATCTCGAGCGGTGGGCTCCCCTGTTGCCCGAGGGTGCGACCTTGGTCAG
TCTGGCCAAGGGCATCGAGTTGGGCACCCTGATGCGGATGAGCCAGGTCATCATCTCGGTGACCGGTGCCGAGCCGGCGC
AGGTCGCGGTGATCTCTGGACCCAACCTGGCCAGCGAGATCGCCGAATGCCAGCCCGCCGCTACCGTCGTCGCGTGCAGC
GACTCCGGCCGCGCGGTTGCCTTGCAGCGCGCGCTGAACAGCGGGTACTTCCGCCCCTACACCAACGCCGATGTCGTCGG
CACCGAGATCGGCGGGGCGTGCAAGAACATCATCGCGCTTGCGTGCGGAATGGCGGTGGGCATCGGGCTGGGCGAAAACA
CCGCGGCCGCGATCATCACCCGGGGCCTGGCGGAGATCATCCGGCTCGGGACGGCGCTCGGCGCCAACGGCGCGACGTTG
GCCGGTCTGGCAGGGGTCGGTGATCTGGTGGCCACCTGCACCTCACCGCGTTCGCGCAACCGATCGTTTGGCGAACGCCT
GGGCCGGGGCGAAACGTTGCAGTCGGCGGGCAAGGCTTGTCATGTCGTCGAAGGCGTGACGTCGTGCGAATCCGTGCTCG
CGCTGGCGTCCAGCTACGACGTCGAAATGCCACTCACCGACGCGGTGCATCGGGTCTGTCATAAAGGGCTGTCGGTGGAC
GAGGCGATAACGCTGCTGCTGGGTCGCCGCACCAAGCCCGAATGA

Upstream 100 bases:

>100_bases
TCGATCCACGCGGCACACTTCGACGGCATTGCCGCCACGGTCGTGGCCGGGGCCCAGGCACGGTCCCGACGGCAACCGCG
GCGCAGATTAGTGTGTGTGG

Downstream 100 bases:

>100_bases
GCCTCGCACGGGCCGGCACGACCGAAAACTGCAGCTCGTGGGAGCCCGTCTGCCTGACCCGGTAGCCTCTGCAGGTTGTG
AGTGCTAACGACCGGCGTGA

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MAGIASTVAVMGAGAWGTALAKVLADAGGEVTLWARRAEVADQINTTRYNPDYLPGALLPPSIHATADAEEALGGASTVL
LGVPAQTMRANLERWAPLLPEGATLVSLAKGIELGTLMRMSQVIISVTGAEPAQVAVISGPNLASEIAECQPAATVVACS
DSGRAVALQRALNSGYFRPYTNADVVGTEIGGACKNIIALACGMAVGIGLGENTAAAIITRGLAEIIRLGTALGANGATL
AGLAGVGDLVATCTSPRSRNRSFGERLGRGETLQSAGKACHVVEGVTSCESVLALASSYDVEMPLTDAVHRVCHKGLSVD
EAITLLLGRRTKPE

Sequences:

>Translated_334_residues
MAGIASTVAVMGAGAWGTALAKVLADAGGEVTLWARRAEVADQINTTRYNPDYLPGALLPPSIHATADAEEALGGASTVL
LGVPAQTMRANLERWAPLLPEGATLVSLAKGIELGTLMRMSQVIISVTGAEPAQVAVISGPNLASEIAECQPAATVVACS
DSGRAVALQRALNSGYFRPYTNADVVGTEIGGACKNIIALACGMAVGIGLGENTAAAIITRGLAEIIRLGTALGANGATL
AGLAGVGDLVATCTSPRSRNRSFGERLGRGETLQSAGKACHVVEGVTSCESVLALASSYDVEMPLTDAVHRVCHKGLSVD
EAITLLLGRRTKPE
>Mature_333_residues
AGIASTVAVMGAGAWGTALAKVLADAGGEVTLWARRAEVADQINTTRYNPDYLPGALLPPSIHATADAEEALGGASTVLL
GVPAQTMRANLERWAPLLPEGATLVSLAKGIELGTLMRMSQVIISVTGAEPAQVAVISGPNLASEIAECQPAATVVACSD
SGRAVALQRALNSGYFRPYTNADVVGTEIGGACKNIIALACGMAVGIGLGENTAAAIITRGLAEIIRLGTALGANGATLA
GLAGVGDLVATCTSPRSRNRSFGERLGRGETLQSAGKACHVVEGVTSCESVLALASSYDVEMPLTDAVHRVCHKGLSVDE
AITLLLGRRTKPE

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=354, Percent_Identity=31.3559322033898, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI24307999, Length=357, Percent_Identity=28.0112044817927, Blast_Score=121, Evalue=9e-28,
Organism=Escherichia coli, GI1790037, Length=331, Percent_Identity=42.5981873111783, Blast_Score=235, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI32564399, Length=352, Percent_Identity=27.5568181818182, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI193210136, Length=363, Percent_Identity=26.9972451790634, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI32564403, Length=361, Percent_Identity=27.1468144044321, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17507425, Length=341, Percent_Identity=28.7390029325513, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI193210134, Length=351, Percent_Identity=24.7863247863248, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324513, Length=347, Percent_Identity=29.6829971181556, Blast_Score=129, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6320181, Length=279, Percent_Identity=30.8243727598566, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI17136204, Length=351, Percent_Identity=29.9145299145299, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17136202, Length=351, Percent_Identity=29.9145299145299, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17136200, Length=351, Percent_Identity=29.9145299145299, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI22026922, Length=330, Percent_Identity=28.1818181818182, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI45551945, Length=335, Percent_Identity=27.1641791044776, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI281362270, Length=297, Percent_Identity=27.6094276094276, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24648969, Length=319, Percent_Identity=26.6457680250784, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_MYCBO (P59961)

Other databases:

- EMBL:   BX248344
- RefSeq:   NP_856651.1
- ProteinModelPortal:   P59961
- SMR:   P59961
- EnsemblBacteria:   EBMYCT00000017240
- GeneID:   1093135
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3006c
- GeneTree:   EBGT00050000016691
- HOGENOM:   HBG586392
- OMA:   SQTLRGN
- ProtClustDB:   PRK00094
- BioCyc:   MBOV233413:MB3006C-MONOMER
- BRENDA:   1.1.1.94
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 33966; Mature: 33835

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 195-195 BINDING 110-110 BINDING 110-110 BINDING 144-144 BINDING 259-259 BINDING 284-284

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGIASTVAVMGAGAWGTALAKVLADAGGEVTLWARRAEVADQINTTRYNPDYLPGALLP
CCCHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCCC
PSIHATADAEEALGGASTVLLGVPAQTMRANLERWAPLLPEGATLVSLAKGIELGTLMRM
CCCCCCCCHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHH
SQVIISVTGAEPAQVAVISGPNLASEIAECQPAATVVACSDSGRAVALQRALNSGYFRPY
HHHHHEECCCCCCEEEEEECCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHCCCCCCC
TNADVVGTEIGGACKNIIALACGMAVGIGLGENTAAAIITRGLAEIIRLGTALGANGATL
CCCCEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHH
AGLAGVGDLVATCTSPRSRNRSFGERLGRGETLQSAGKACHVVEGVTSCESVLALASSYD
HHHHHHHHHHHHCCCCCCCCHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
VEMPLTDAVHRVCHKGLSVDEAITLLLGRRTKPE
CCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AGIASTVAVMGAGAWGTALAKVLADAGGEVTLWARRAEVADQINTTRYNPDYLPGALLP
CCHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCCC
PSIHATADAEEALGGASTVLLGVPAQTMRANLERWAPLLPEGATLVSLAKGIELGTLMRM
CCCCCCCCHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHH
SQVIISVTGAEPAQVAVISGPNLASEIAECQPAATVVACSDSGRAVALQRALNSGYFRPY
HHHHHEECCCCCCEEEEEECCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHCCCCCCC
TNADVVGTEIGGACKNIIALACGMAVGIGLGENTAAAIITRGLAEIIRLGTALGANGATL
CCCCEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHH
AGLAGVGDLVATCTSPRSRNRSFGERLGRGETLQSAGKACHVVEGVTSCESVLALASSYD
HHHHHHHHHHHHCCCCCCCCHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
VEMPLTDAVHRVCHKGLSVDEAITLLLGRRTKPE
CCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972