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The map label for this gene is cobM

Identifier: 148823286

GI number: 148823286

Start: 2342834

End: 2343589

Strand: Reverse

Name: cobM

Synonym: TBFG_12107

Alternate gene names: 148823286

Gene position: 2343589-2342834 (Counterclockwise)

Preceding gene: 148823287

Following gene: 148823285

Centisome position: 52.97

GC content: 67.33

Gene sequence:

>756_bases
ATGACGGTCTATTTCATCGGAGCGGGCCCCGGCGCCGCCGACCTAATCACCGTCCGCGGCCAACGGCTCCTGCAACGATG
CCCGGTGTGCCTGTATGCGGGTTCGATCATGCCCGACGACCTGTTGGCGCAGTGTCCGCCCGGCGCGACGATTGTCGACA
CCGGTCCGCTGACCCTCGAACAAATCGTGCGCAAACTTGCCGACGCCGACGCCGACGGCCGCGACGTTGCCCGGCTGCAT
TCCGGCGACCCGTCGCTGTACAGCGCGCTGGCCGAACAGTGCCGCGAACTCGACGCGCTGGGCATCGGCTACGAAATCGT
GCCGGGCGTACCGGCTTTTGCCGCAGCCGCGGCGGCGCTAAAGCGCGAACTCACCGTGCCGGGCGTGGCGCAGACGGTGA
CGCTCACCCGGGTGGCGACGCTGTCCACACCCATACCGCCCGGTGAGGACCTGGCCGCGCTCGCCCGATCCCGCGCCACT
CTGGTCTTGCACCTGGCCGCAGCCCAGATCGACGCCATCGTTCCGCGACTGCTAGACGGTGGTTACCGACCCGAAACGCC
GGTTGCGGTGGTGGCTTTCGCGAGTTGGCCGCAACAGCGGACGCTACGCGGCACGTTGGCCGATATCGCCGCGCGGATGC
ACGATGCCAAGATCACCAGGACCGCCGTGATCGTTGTTGGCGACGTGCTGACCGCTGAGGGCTTTACCGACAGCTACCTA
TATTCGGTGGCACGGCACGGTCGGTATGCACAGTGA

Upstream 100 bases:

>100_bases
GCGAGCTACGACGATTCCAGCACTATCTCGGCGAACCGCTGGGCGGCTTCACCGGTTGGCGCCCACAGCTGCCGGTCACC
CAGTGGTCGGTGACCAAGCG

Downstream 100 bases:

>100_bases
CCCGGGTGTTGTTGCTCGGCGGCACCGCCGAGGGCCGTGCGCTGGCGAAAGAGTTGCACCCACACGTTGAGATCGTCAGC
TCGCTGGCCGGCCGGGTACC

Product: precorrin-4 C11-methyltransferase cobM

Products: NA

Alternate protein names: Precorrin-3 methylase

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLEQIVRKLADADADGRDVARLH
SGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAALKRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRAT
LVLHLAAAQIDAIVPRLLDGGYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL
YSVARHGRYAQ

Sequences:

>Translated_251_residues
MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLEQIVRKLADADADGRDVARLH
SGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAALKRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRAT
LVLHLAAAQIDAIVPRLLDGGYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL
YSVARHGRYAQ
>Mature_250_residues
TVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLEQIVRKLADADADGRDVARLHS
GDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAALKRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATL
VLHLAAAQIDAIVPRLLDGGYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYLY
SVARHGRYAQ

Specific function: Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5

COG id: COG2875

COG function: function code H; Precorrin-4 methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family

Homologues:

Organism=Escherichia coli, GI1789768, Length=235, Percent_Identity=29.7872340425532, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBM_MYCTU (Q10672)

Other databases:

- EMBL:   BX842578
- EMBL:   AE000516
- PIR:   B70765
- RefSeq:   NP_216587.1
- RefSeq:   NP_336597.1
- ProteinModelPortal:   Q10672
- SMR:   Q10672
- EnsemblBacteria:   EBMYCT00000002923
- EnsemblBacteria:   EBMYCT00000069296
- GeneID:   888521
- GeneID:   924599
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2131
- KEGG:   mtu:Rv2071c
- TIGR:   MT2131
- TubercuList:   Rv2071c
- GeneTree:   EBGT00050000016432
- HOGENOM:   HBG730212
- OMA:   ERTAIIF
- ProtClustDB:   CLSK791604
- BRENDA:   2.1.1.133
- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006362
- InterPro:   IPR003043
- Gene3D:   G3DSA:3.40.1010.10
- Gene3D:   G3DSA:3.30.950.10
- TIGRFAMs:   TIGR01465

Pfam domain/function: PF00590 TP_methylase; SSF53790 Cor/por_Metransf

EC number: =2.1.1.133

Molecular weight: Translated: 26421; Mature: 26289

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00839 SUMT_1; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE
CEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHCCCCCEEEECCCCCHH
QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL
HHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHH
KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG
HHHCCCCCCHHHHHHHHHHECCCCCCCCHHHHHHHHCCHHEEEHHHHHHHHHHHHHHHCC
GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEECHHHCCCCHHHHH
YSVARHGRYAQ
HHHHHCCCCCC
>Mature Secondary Structure 
TVYFIGAGPGAADLITVRGQRLLQRCPVCLYAGSIMPDDLLAQCPPGATIVDTGPLTLE
EEEEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHCCCCCEEEECCCCCHH
QIVRKLADADADGRDVARLHSGDPSLYSALAEQCRELDALGIGYEIVPGVPAFAAAAAAL
HHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHH
KRELTVPGVAQTVTLTRVATLSTPIPPGEDLAALARSRATLVLHLAAAQIDAIVPRLLDG
HHHCCCCCCHHHHHHHHHHECCCCCCCCHHHHHHHHCCHHEEEHHHHHHHHHHHHHHHCC
GYRPETPVAVVAFASWPQQRTLRGTLADIAARMHDAKITRTAVIVVGDVLTAEGFTDSYL
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEECHHHCCCCHHHHH
YSVARHGRYAQ
HHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036