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The map label for this gene is pkn1 [H]

Identifier: 148663567

GI number: 148663567

Start: 4154060

End: 4155337

Strand: Reverse

Name: pkn1 [H]

Synonym: MRA_3739

Alternate gene names: 148663567

Gene position: 4155337-4154060 (Counterclockwise)

Preceding gene: 148663568

Following gene: 148663566

Centisome position: 94.01

GC content: 68.78

Gene sequence:

>1278_bases
GTGACTTCACCCGAGCAGCTGGCTTGTCATCTGGCGCGGGCGCGGGCGCGGACGTTGCGGCTGGTCGACTTCGACGATGC
CGAGCTTTGCTGCCAGTATGACCCGTTGATGAGCCCGCTGGTGTGGGACCTGGCACACATCGGTCAGCAGGAGGAGTTGT
GGCTGCTACGCGGCGGCGACCCAGGCCAGCCCGGGCTTTTGCCGCCGGCGGTCGAGGGTCTCTACGACGCCTTCGAGCAT
TCCCGCGCCAGTCGCGTGGAACTGCCGTTGCTGTCCCCGGCGCGGGCGCGGTCCTACTGCGCAACGGTGCGCTCCGCTGC
GCTGGATGCCCTTGCCGCTCTACCTGAAGACGGCGACAGCTTCGTGTTCGCGATGGTGATCAGCCACGAAAACCAGCACG
ACGAAACCATGCTGCAGGCCTTGAACCTACGGACCGGCTCGCCACTGTTGGCCGCGACTTCCGCCCTGCCCGCCGGACGG
CCGAGGATGGCCGGAACGTCGGTGCTGGTAGCCGGCGGCCCGTTCGTGCTGGGCGTGGACGCCGCGGACGAACCGTGCTC
ATTGGACAACGAACGTCCGGCTCACGTCGTCGACGTGCCCGCATTCCGGATCGGCCGGGTTCCGGTCACCAACGGTGAAT
GGCAAGACTTCATCGACGACGGCGGTTACACCCAGTCGCGGTGGTGGTCGGAACGTGGCTGGCAGCACCGCCAGCGCGCG
GGGCTGACCGCTCCGCAATTCTGGAGGTCGGGCGGGCGGACGCGGACCCGGTTCGGGCACGTCGAGGACATTCCCGCCGA
TGAGCCGGTGCAGCATGTCAGCTACTTTGAGGCCGAGGCGTACGCCGCCTGGGCAGGCGCGCGGTTGCCCACCGAGGTGG
AGTGGGAGAAGGCTTGCGCGTGGGATCCGGCGACTGGTTCCCGCCGCCGCTACCCGTGGGGAACCGAGGAGCCCACAGAC
ACCTATGCCAACCTGGGCGGTCAAACGCTGCGCCCCGCGCCGGTGGGTGCCTACCCGGCCGGGGCATCGGCGTGCGGGGC
CGAGCAGATGCTGGGCGATGTCTGGGAGTGGACCACCTCGCCGTTGCGGCCCTGGCCGGGGTTCGTCCCGATGGTCTATG
AGCGGTACTCACAGCCGTTCTTCGGCGGCGACTATCGCGTGCTACGCGGCGGCTCGTGGGCGGTGGAGCCGGCCATCCTG
CGGCCCAGCTTCCGCAACTGGGATCACCCGTATCGCCGCCAGATCTTTGCCGGTGTCCGGTTGGCGTGGGACATCTGA

Upstream 100 bases:

>100_bases
ACCACGTCGACAGGGGTGTTTGCCCGGCAGACGATTTCTCCGACCGGGTGATCGCGGGCGGCATCGCGTCAGCCGTCACC
GGGATGATGCACGGGGCGTC

Downstream 100 bases:

>100_bases
TGTGTCGTCACCTGGGGTGGCTCGGGGCACAGGTCGCGGTTTCTTCGTTGGTGCTGGACCCGCCGCAGGGTCTGCGGGTG
CAGTCATATGCGCCGCGTCG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MTSPEQLACHLARARARTLRLVDFDDAELCCQYDPLMSPLVWDLAHIGQQEELWLLRGGDPGQPGLLPPAVEGLYDAFEH
SRASRVELPLLSPARARSYCATVRSAALDALAALPEDGDSFVFAMVISHENQHDETMLQALNLRTGSPLLAATSALPAGR
PRMAGTSVLVAGGPFVLGVDAADEPCSLDNERPAHVVDVPAFRIGRVPVTNGEWQDFIDDGGYTQSRWWSERGWQHRQRA
GLTAPQFWRSGGRTRTRFGHVEDIPADEPVQHVSYFEAEAYAAWAGARLPTEVEWEKACAWDPATGSRRRYPWGTEEPTD
TYANLGGQTLRPAPVGAYPAGASACGAEQMLGDVWEWTTSPLRPWPGFVPMVYERYSQPFFGGDYRVLRGGSWAVEPAIL
RPSFRNWDHPYRRQIFAGVRLAWDI

Sequences:

>Translated_425_residues
MTSPEQLACHLARARARTLRLVDFDDAELCCQYDPLMSPLVWDLAHIGQQEELWLLRGGDPGQPGLLPPAVEGLYDAFEH
SRASRVELPLLSPARARSYCATVRSAALDALAALPEDGDSFVFAMVISHENQHDETMLQALNLRTGSPLLAATSALPAGR
PRMAGTSVLVAGGPFVLGVDAADEPCSLDNERPAHVVDVPAFRIGRVPVTNGEWQDFIDDGGYTQSRWWSERGWQHRQRA
GLTAPQFWRSGGRTRTRFGHVEDIPADEPVQHVSYFEAEAYAAWAGARLPTEVEWEKACAWDPATGSRRRYPWGTEEPTD
TYANLGGQTLRPAPVGAYPAGASACGAEQMLGDVWEWTTSPLRPWPGFVPMVYERYSQPFFGGDYRVLRGGSWAVEPAIL
RPSFRNWDHPYRRQIFAGVRLAWDI
>Mature_424_residues
TSPEQLACHLARARARTLRLVDFDDAELCCQYDPLMSPLVWDLAHIGQQEELWLLRGGDPGQPGLLPPAVEGLYDAFEHS
RASRVELPLLSPARARSYCATVRSAALDALAALPEDGDSFVFAMVISHENQHDETMLQALNLRTGSPLLAATSALPAGRP
RMAGTSVLVAGGPFVLGVDAADEPCSLDNERPAHVVDVPAFRIGRVPVTNGEWQDFIDDGGYTQSRWWSERGWQHRQRAG
LTAPQFWRSGGRTRTRFGHVEDIPADEPVQHVSYFEAEAYAAWAGARLPTEVEWEKACAWDPATGSRRRYPWGTEEPTDT
YANLGGQTLRPAPVGAYPAGASACGAEQMLGDVWEWTTSPLRPWPGFVPMVYERYSQPFFGGDYRVLRGGSWAVEPAILR
PSFRNWDHPYRRQIFAGVRLAWDI

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth [H]

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI194248088, Length=266, Percent_Identity=33.0827067669173, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI194248087, Length=251, Percent_Identity=33.8645418326693, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI257470975, Length=222, Percent_Identity=30.6306306306306, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI257470977, Length=232, Percent_Identity=31.8965517241379, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI38202250, Length=232, Percent_Identity=31.8965517241379, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 47139; Mature: 47008

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPEQLACHLARARARTLRLVDFDDAELCCQYDPLMSPLVWDLAHIGQQEELWLLRGGD
CCCHHHHHHHHHHHHHHEEEEEECCCHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECCC
PGQPGLLPPAVEGLYDAFEHSRASRVELPLLSPARARSYCATVRSAALDALAALPEDGDS
CCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
FVFAMVISHENQHDETMLQALNLRTGSPLLAATSALPAGRPRMAGTSVLVAGGPFVLGVD
EEEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCEEEEECCCEEEEEC
AADEPCSLDNERPAHVVDVPAFRIGRVPVTNGEWQDFIDDGGYTQSRWWSERGWQHRQRA
CCCCCCCCCCCCCCEEEECCCEEECCCCCCCCCHHHHHCCCCCCHHHHHHHHCHHHHHHC
GLTAPQFWRSGGRTRTRFGHVEDIPADEPVQHVSYFEAEAYAAWAGARLPTEVEWEKACA
CCCCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCC
WDPATGSRRRYPWGTEEPTDTYANLGGQTLRPAPVGAYPAGASACGAEQMLGDVWEWTTS
CCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
PLRPWPGFVPMVYERYSQPFFGGDYRVLRGGSWAVEPAILRPSFRNWDHPYRRQIFAGVR
CCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCEEECCHHCCCCCCCCCCHHHHHHHHCCE
LAWDI
EEECC
>Mature Secondary Structure 
TSPEQLACHLARARARTLRLVDFDDAELCCQYDPLMSPLVWDLAHIGQQEELWLLRGGD
CCHHHHHHHHHHHHHHEEEEEECCCHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECCC
PGQPGLLPPAVEGLYDAFEHSRASRVELPLLSPARARSYCATVRSAALDALAALPEDGDS
CCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
FVFAMVISHENQHDETMLQALNLRTGSPLLAATSALPAGRPRMAGTSVLVAGGPFVLGVD
EEEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCEEEEECCCEEEEEC
AADEPCSLDNERPAHVVDVPAFRIGRVPVTNGEWQDFIDDGGYTQSRWWSERGWQHRQRA
CCCCCCCCCCCCCCEEEECCCEEECCCCCCCCCHHHHHCCCCCCHHHHHHHHCHHHHHHC
GLTAPQFWRSGGRTRTRFGHVEDIPADEPVQHVSYFEAEAYAAWAGARLPTEVEWEKACA
CCCCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCC
WDPATGSRRRYPWGTEEPTDTYANLGGQTLRPAPVGAYPAGASACGAEQMLGDVWEWTTS
CCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
PLRPWPGFVPMVYERYSQPFFGGDYRVLRGGSWAVEPAILRPSFRNWDHPYRRQIFAGVR
CCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCEEECCHHCCCCCCCCCCHHHHHHHHCCE
LAWDI
EEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]