Click here to switch to the map view.

The map label for this gene is phoR [H]

Identifier: 148660535

GI number: 148660535

Start: 853702

End: 855159

Strand: Direct

Name: phoR [H]

Synonym: MRA_0768

Alternate gene names: 148660535

Gene position: 853702-855159 (Clockwise)

Preceding gene: 148660534

Following gene: 148660545

Centisome position: 19.31

GC content: 67.22

Gene sequence:

>1458_bases
ATGGCCAGACACCTTCGAGGAAGGCTGCCCCTACGGGTACGCCTGGTCGCAGCCACGCTGATCCTGGTGGCCACTGGACT
TGTGGCCTCGGGGATCGCGGTCACCTCGATGTTGCAGCACCGGCTGACCAGCCGGATCGATCGGGTGTTGCTCGAGGAAG
CCCAAATCTGGGCGCAGATCACGCTGCCCTTGGCGCCGGACCCCTACCCTGGTCATAACCCCGATCGGCCGCCGTCGAGG
TTCTACGTTCGGGTGATCAGCCCCGACGGCCAGAGCTATACGGCACTCAACGACAACACTGCCATACCGGCGGTGCCCGC
CAACAATGATGTCGGCCGGCACCCGACGACGCTGCCATCGATCGGCGGATCCAAGACTTTATGGCGCGCGGTCTCGGTGC
GCGCGTCGGATGGCTACTTGACCACCGTCGCCATTGATCTGGCCGACGTCCGGAGCACCGTGCGGTCACTGGTGCTGTTG
CAGGTCGGCATAGGCAGTGCGGTGCTGGTTGTCCCCGGGGTGGCGGGCTACGCTGTGGTTCGCCGCAGCCTGCGGCCGCT
GGCAGAATTCGAGCAGACGGCCGCGGCGATCGGCGCGGGGCAGCTGGATCGCCGGGTCCCGCAGTGGCATCCGCGAACTG
AGGTCGGCCGGCTTTCGTTGGCGCTCAACGGAATGCTGGCACAAATTCAGCGGGCGGTGGCGTCCGCGGAATCTTCCGCC
GAAAAGGCCCGGGATTCAGAGGACCGGATGCGACAGTTCATCACCGACGCCAGCCATGAACTGCGTACCCCGTTGACCAC
TATCCGCGGCTTCGCGGAGCTGTACCGACAAGGAGCCGCCCGCGACGTGGGCATGCTGCTGTCGCGGATTGAGAGCGAAG
CGAGCCGGATGGGGCTGCTGGTGGACGATTTGCTGCTGCTTGCCCGGCTAGATGCGCACCGGCCGTTGGAACTGTGCCGG
GTGGACCTGCTGGCGCTGGCCAGTGATGCCGCGCACGACGCGCGGGCGATGGACCCCAAACGCAGGATCACCCTGGAGGT
CCTTGACGGCCCCGGCACCCCGGAGGTCCTCGGCGACGAATCGCGGCTTCGGCAGGTGCTGCGCAATCTCGTTGCAAATG
CCATACAGCACACCCCGGAAAGCGCCGACGTCACCGTGCGAGTCGGCACCGAGGGCGACGACGCCATCCTCGAGGTCGCC
GATGACGGTCCGGGCATGAGTCAGGAGGATGCGCTGCGGGTGTTCGAGCGGTTCTATCGCGCCGACTCGTCGCGGGCGCG
CGCCAGCGGCGGGACCGGACTGGGGTTGTCGATCGTCGACTCTTTGGTGGCGGCCCATGGCGGAGCGGTCACCGTGACGA
CCGCGCTCGGGGAGGGTTGCTGCTTTCGTGTCTCGCTGCCGCGCGTCAGTGACGTGGACCAGCTGAGCCTCACGCCAGTT
GTGCCAGGGCCGCCCTGA

Upstream 100 bases:

>100_bases
AGCGGCTGCTGCACACGCTGCGCGGGGTGGGCTACGTACTGCGGGAGCCTCGATGAGTCTTGGTAGTTAATCGGATCGGC
AGCCCGAGGAGAACGCGGCA

Downstream 100 bases:

>100_bases
TCTTGGCCTGCGCTTCGTCCAGCGATCCCGGTGAGGGGTTGCGGTCGACGTTGGCAAAGCCGAAATCACTGAGGCTGCGG
GTGGGAAACACGTGGATGTG

Product: putative two component system response sensor kinase membrane associated PhoR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MARHLRGRLPLRVRLVAATLILVATGLVASGIAVTSMLQHRLTSRIDRVLLEEAQIWAQITLPLAPDPYPGHNPDRPPSR
FYVRVISPDGQSYTALNDNTAIPAVPANNDVGRHPTTLPSIGGSKTLWRAVSVRASDGYLTTVAIDLADVRSTVRSLVLL
QVGIGSAVLVVPGVAGYAVVRRSLRPLAEFEQTAAAIGAGQLDRRVPQWHPRTEVGRLSLALNGMLAQIQRAVASAESSA
EKARDSEDRMRQFITDASHELRTPLTTIRGFAELYRQGAARDVGMLLSRIESEASRMGLLVDDLLLLARLDAHRPLELCR
VDLLALASDAAHDARAMDPKRRITLEVLDGPGTPEVLGDESRLRQVLRNLVANAIQHTPESADVTVRVGTEGDDAILEVA
DDGPGMSQEDALRVFERFYRADSSRARASGGTGLGLSIVDSLVAAHGGAVTVTTALGEGCCFRVSLPRVSDVDQLSLTPV
VPGPP

Sequences:

>Translated_485_residues
MARHLRGRLPLRVRLVAATLILVATGLVASGIAVTSMLQHRLTSRIDRVLLEEAQIWAQITLPLAPDPYPGHNPDRPPSR
FYVRVISPDGQSYTALNDNTAIPAVPANNDVGRHPTTLPSIGGSKTLWRAVSVRASDGYLTTVAIDLADVRSTVRSLVLL
QVGIGSAVLVVPGVAGYAVVRRSLRPLAEFEQTAAAIGAGQLDRRVPQWHPRTEVGRLSLALNGMLAQIQRAVASAESSA
EKARDSEDRMRQFITDASHELRTPLTTIRGFAELYRQGAARDVGMLLSRIESEASRMGLLVDDLLLLARLDAHRPLELCR
VDLLALASDAAHDARAMDPKRRITLEVLDGPGTPEVLGDESRLRQVLRNLVANAIQHTPESADVTVRVGTEGDDAILEVA
DDGPGMSQEDALRVFERFYRADSSRARASGGTGLGLSIVDSLVAAHGGAVTVTTALGEGCCFRVSLPRVSDVDQLSLTPV
VPGPP
>Mature_484_residues
ARHLRGRLPLRVRLVAATLILVATGLVASGIAVTSMLQHRLTSRIDRVLLEEAQIWAQITLPLAPDPYPGHNPDRPPSRF
YVRVISPDGQSYTALNDNTAIPAVPANNDVGRHPTTLPSIGGSKTLWRAVSVRASDGYLTTVAIDLADVRSTVRSLVLLQ
VGIGSAVLVVPGVAGYAVVRRSLRPLAEFEQTAAAIGAGQLDRRVPQWHPRTEVGRLSLALNGMLAQIQRAVASAESSAE
KARDSEDRMRQFITDASHELRTPLTTIRGFAELYRQGAARDVGMLLSRIESEASRMGLLVDDLLLLARLDAHRPLELCRV
DLLALASDAAHDARAMDPKRRITLEVLDGPGTPEVLGDESRLRQVLRNLVANAIQHTPESADVTVRVGTEGDDAILEVAD
DGPGMSQEDALRVFERFYRADSSRARASGGTGLGLSIVDSLVAAHGGAVTVTTALGEGCCFRVSLPRVSDVDQLSLTPVV
PGPP

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=36.1607142857143, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1788393, Length=250, Percent_Identity=33.2, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1790346, Length=294, Percent_Identity=30.952380952381, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1787894, Length=326, Percent_Identity=30.3680981595092, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1786783, Length=351, Percent_Identity=29.6296296296296, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1790861, Length=239, Percent_Identity=31.7991631799163, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1789149, Length=397, Percent_Identity=26.1964735516373, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790551, Length=294, Percent_Identity=30.6122448979592, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI48994928, Length=223, Percent_Identity=32.2869955156951, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1790436, Length=212, Percent_Identity=31.1320754716981, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788279, Length=331, Percent_Identity=26.2839879154079, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1789808, Length=301, Percent_Identity=27.2425249169435, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI145693157, Length=246, Percent_Identity=26.4227642276423, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=29.3859649122807, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1786912, Length=250, Percent_Identity=29.2, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788713, Length=251, Percent_Identity=28.2868525896414, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87081816, Length=367, Percent_Identity=28.0653950953678, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1788549, Length=243, Percent_Identity=25.9259259259259, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1789403, Length=226, Percent_Identity=34.9557522123894, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52017; Mature: 51886

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARHLRGRLPLRVRLVAATLILVATGLVASGIAVTSMLQHRLTSRIDRVLLEEAQIWAQI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
TLPLAPDPYPGHNPDRPPSRFYVRVISPDGQSYTALNDNTAIPAVPANNDVGRHPTTLPS
EECCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCC
IGGSKTLWRAVSVRASDGYLTTVAIDLADVRSTVRSLVLLQVGIGSAVLVVPGVAGYAVV
CCCCHHHHHHHEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHH
RRSLRPLAEFEQTAAAIGAGQLDRRVPQWHPRTEVGRLSLALNGMLAQIQRAVASAESSA
HHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKARDSEDRMRQFITDASHELRTPLTTIRGFAELYRQGAARDVGMLLSRIESEASRMGLL
HHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHH
VDDLLLLARLDAHRPLELCRVDLLALASDAAHDARAMDPKRRITLEVLDGPGTPEVLGDE
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCH
SRLRQVLRNLVANAIQHTPESADVTVRVGTEGDDAILEVADDGPGMSQEDALRVFERFYR
HHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
ADSSRARASGGTGLGLSIVDSLVAAHGGAVTVTTALGEGCCFRVSLPRVSDVDQLSLTPV
CCCCHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCCCCEECCC
VPGPP
CCCCC
>Mature Secondary Structure 
ARHLRGRLPLRVRLVAATLILVATGLVASGIAVTSMLQHRLTSRIDRVLLEEAQIWAQI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
TLPLAPDPYPGHNPDRPPSRFYVRVISPDGQSYTALNDNTAIPAVPANNDVGRHPTTLPS
EECCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCC
IGGSKTLWRAVSVRASDGYLTTVAIDLADVRSTVRSLVLLQVGIGSAVLVVPGVAGYAVV
CCCCHHHHHHHEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHH
RRSLRPLAEFEQTAAAIGAGQLDRRVPQWHPRTEVGRLSLALNGMLAQIQRAVASAESSA
HHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKARDSEDRMRQFITDASHELRTPLTTIRGFAELYRQGAARDVGMLLSRIESEASRMGLL
HHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHH
VDDLLLLARLDAHRPLELCRVDLLALASDAAHDARAMDPKRRITLEVLDGPGTPEVLGDE
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCH
SRLRQVLRNLVANAIQHTPESADVTVRVGTEGDDAILEVADDGPGMSQEDALRVFERFYR
HHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
ADSSRARASGGTGLGLSIVDSLVAAHGGAVTVTTALGEGCCFRVSLPRVSDVDQLSLTPV
CCCCHHHCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCCCCEECCC
VPGPP
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]