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The map label for this gene is phoP [H]

Identifier: 148660534

GI number: 148660534

Start: 852914

End: 853657

Strand: Direct

Name: phoP [H]

Synonym: MRA_0767

Alternate gene names: 148660534

Gene position: 852914-853657 (Clockwise)

Preceding gene: 148660530

Following gene: 148660535

Centisome position: 19.3

GC content: 62.5

Gene sequence:

>744_bases
ATGCGGAAAGGGGTTGATCTCGTGACGGCGGGAACCCCAGGCGAAAACACCACACCGGAGGCTCGTGTCCTCGTGGTCGA
TGATGAGGCCAACATCGTTGAACTGCTGTCGGTGAGCCTCAAGTTCCAGGGCTTTGAAGTCTACACCGCGACCAACGGGG
CACAGGCGCTGGATCGGGCCCGGGAAACCCGGCCGGACGCGGTGATCCTCGATGTGATGATGCCCGGGATGGACGGCTTT
GGGGTGCTGCGCCGGCTGCGCGCCGACGGCATCGATGCCCCGGCGTTGTTCCTGACGGCCCGTGACTCGCTACAGGACAA
GATCGCGGGTCTGACCCTGGGTGGTGACGACTATGTGACAAAGCCCTTCAGTTTGGAGGAGGTCGTGGCCAGGCTGCGGG
TCATCCTGCGACGCGCGGGCAAGGGCAACAAGGAACCACGTAATGTTCGACTGACGTTCGCCGATATCGAGCTCGACGAG
GAGACCCACGAAGTGTGGAAGGCGGGCCAACCGGTGTCGCTGTCGCCCACCGAATTCACCCTGCTGCGCTATTTCGTGAT
CAACGCGGGCACCGTGCTGAGCAAGCCTAAGATTCTCGACCACGTTTGGCGCTACGACTTCGGTGGTGATGTCAACGTCG
TCGAGTCCTACGTGTTGTATCTGCGCCGCAAGATCGACACTGGGGAGAAGCGGCTGCTGCACACGCTGCGCGGGGTGGGC
TACGTACTGCGGGAGCCTCGATGA

Upstream 100 bases:

>100_bases
CGGTCCAAGCTGATTTGGCGATTCCTGGCAGACTGTTAGCAGACTACTGGCAACGAGCTTTCAGGAATTACACAATGACT
GTGAAGGTAACGTTCAACCA

Downstream 100 bases:

>100_bases
GTCTTGGTAGTTAATCGGATCGGCAGCCCGAGGAGAACGCGGCAATGGCCAGACACCTTCGAGGAAGGCTGCCCCTACGG
GTACGCCTGGTCGCAGCCAC

Product: putative two component system response transcriptional positive regulator PhoP

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MRKGVDLVTAGTPGENTTPEARVLVVDDEANIVELLSVSLKFQGFEVYTATNGAQALDRARETRPDAVILDVMMPGMDGF
GVLRRLRADGIDAPALFLTARDSLQDKIAGLTLGGDDYVTKPFSLEEVVARLRVILRRAGKGNKEPRNVRLTFADIELDE
ETHEVWKAGQPVSLSPTEFTLLRYFVINAGTVLSKPKILDHVWRYDFGGDVNVVESYVLYLRRKIDTGEKRLLHTLRGVG
YVLREPR

Sequences:

>Translated_247_residues
MRKGVDLVTAGTPGENTTPEARVLVVDDEANIVELLSVSLKFQGFEVYTATNGAQALDRARETRPDAVILDVMMPGMDGF
GVLRRLRADGIDAPALFLTARDSLQDKIAGLTLGGDDYVTKPFSLEEVVARLRVILRRAGKGNKEPRNVRLTFADIELDE
ETHEVWKAGQPVSLSPTEFTLLRYFVINAGTVLSKPKILDHVWRYDFGGDVNVVESYVLYLRRKIDTGEKRLLHTLRGVG
YVLREPR
>Mature_247_residues
MRKGVDLVTAGTPGENTTPEARVLVVDDEANIVELLSVSLKFQGFEVYTATNGAQALDRARETRPDAVILDVMMPGMDGF
GVLRRLRADGIDAPALFLTARDSLQDKIAGLTLGGDDYVTKPFSLEEVVARLRVILRRAGKGNKEPRNVRLTFADIELDE
ETHEVWKAGQPVSLSPTEFTLLRYFVINAGTVLSKPKILDHVWRYDFGGDVNVVESYVLYLRRKIDTGEKRLLHTLRGVG
YVLREPR

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=37.1681415929204, Blast_Score=147, Evalue=7e-37,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=39.1111111111111, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=34.5291479820628, Blast_Score=144, Evalue=4e-36,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=37.0535714285714, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=33.1838565022422, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=32.1266968325792, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1788394, Length=234, Percent_Identity=34.1880341880342, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=32.3144104803493, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=35.2941176470588, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=32.4561403508772, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=35.0877192982456, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788550, Length=178, Percent_Identity=31.4606741573034, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=29.5154185022026, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=29.3333333333333, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1790299, Length=130, Percent_Identity=32.3076923076923, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790437, Length=110, Percent_Identity=35.4545454545455, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI145693157, Length=120, Percent_Identity=32.5, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788713, Length=111, Percent_Identity=36.036036036036, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI1788191, Length=124, Percent_Identity=34.6774193548387, Blast_Score=60, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27540; Mature: 27540

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKGVDLVTAGTPGENTTPEARVLVVDDEANIVELLSVSLKFQGFEVYTATNGAQALDRA
CCCCCEEEECCCCCCCCCCCEEEEEEECCCCHHHHHHHHEEECCEEEEEECCCHHHHHHH
RETRPDAVILDVMMPGMDGFGVLRRLRADGIDAPALFLTARDSLQDKIAGLTLGGDDYVT
HHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHEEEECCCCCCC
KPFSLEEVVARLRVILRRAGKGNKEPRNVRLTFADIELDEETHEVWKAGQPVSLSPTEFT
CCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEECHHHHHHHHCCCCCCCCCHHHH
LLRYFVINAGTVLSKPKILDHVWRYDFGGDVNVVESYVLYLRRKIDTGEKRLLHTLRGVG
HHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
YVLREPR
HHHCCCC
>Mature Secondary Structure
MRKGVDLVTAGTPGENTTPEARVLVVDDEANIVELLSVSLKFQGFEVYTATNGAQALDRA
CCCCCEEEECCCCCCCCCCCEEEEEEECCCCHHHHHHHHEEECCEEEEEECCCHHHHHHH
RETRPDAVILDVMMPGMDGFGVLRRLRADGIDAPALFLTARDSLQDKIAGLTLGGDDYVT
HHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHEEEECCCCCCC
KPFSLEEVVARLRVILRRAGKGNKEPRNVRLTFADIELDEETHEVWKAGQPVSLSPTEFT
CCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEECHHHHHHHHCCCCCCCCCHHHH
LLRYFVINAGTVLSKPKILDHVWRYDFGGDVNVVESYVLYLRRKIDTGEKRLLHTLRGVG
HHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
YVLREPR
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA