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The map label for this gene is pncB2

Identifier: 148660342

GI number: 148660342

Start: 667161

End: 668552

Strand: Reverse

Name: pncB2

Synonym: MRA_0580

Alternate gene names: 148660342

Gene position: 668552-667161 (Counterclockwise)

Preceding gene: 148660343

Following gene: 148660341

Centisome position: 15.13

GC content: 66.24

Gene sequence:

>1392_bases
ATGGCGATCCGCCAACACGTCGGCGCGCTGTTCACCGACCTGTACGAGGTGACGATGGCCCAGGCCTACTGGGCCGAAAG
AATGTCGGGCACAGCGGTTTTCGAGATATTCTTCCGCAAGCTTCCGCCTGGCAGGTCCTACATCATGGCCGCCGGGCTGG
CCGATGTGGTCGAGTTCCTCGAAGCGTTTCGATTCGACGAGCAGGATCTGCGTTACCTGCGTGGCCTGGGCCAGTTTTCC
GACGAGTTCCTGAGGTGGCTGGCCGGAGTGCGTTTCACCGGAGATGTCTGGGCCGCGCCGGAAGGAACCGTGATTTTTCC
GAACGAACCCGCGGTCCAGCTGATCGCGCCAATCATCGAGGCCCAGCTTGTCGAGACGTTTGTGCTGAACCAGATTCATC
TGCAAAGCGTGCTCGCGAGCAAGGCCGCGCGGGTGGTCGCCGCCGCGCGCGGACGACCGGTGGTGGATTTCGGCGCGCGG
CGCGCTCACGGCACCGACGCGGCCTGCAAGGTCGCGCGCACCAGTTATCTCGCGGGCGCTGCGGGCACGTCGAATCTGCT
CGCGGCCCGCCAATATGGGATCCCGACGTTCGGCACCATGGCGCACAGCTTTGTTCAAGCCTTCGACAGTGAGGTGGCCG
CGTTCGAGGCGTTCGCCCGGCTCTACCCAGCCACCATGCTGCTCGTGGACACCTACGACACGCTACGCGGCGTCGATCAC
GTCATCGAGTTGGCCAAGCGGCTGGGCAATCGCTTCGATGTGCGCGCGGTCCGGCTGGATTCCGGCGACCTCGATGAGCT
GTCCAAGGCGACCCGTGCACGGCTCGACACCGCCGGTCTCGAGCAGGTCGAGATCTTCGCGTCGTCGGGCCTCGACGAAA
ACCGCATCGCCGCGCTTTTGGCTGCCCGCTGTCCGATCGACGGCTTCGGCGTGGGCACCCAGCTCGTCGTGGCTCAAGAC
GCGCCCGCGCTGGACATGGCCTACAAGCTGGTGGCATACGACGGCAGCGGGCGCACCAAGTTCTCCAGCGGCAAGGTGAT
CTACCCGGGACGCAAGCAGGTGTTCCGTAAGCTCGAGCACGGAGTCTTTTGCGGCGACACGCTCGGCGAGCACGGTGAAA
ACCTTCCCGGGGACCCGTTGCTGGTGCCCATCATGACCAACGGCCGACGCATCCGGCAGCATGCACCCACATTGGACGGC
GCGCGGGACTGGGCCCGCCAGCAGATCGACGCGCTCCCGCCGGAGCTGCGCTCGCTCGAGGACACCGGCTACTCGTATCC
GGTGGCGGTCAGCGACAGGATCGTGGGCGAACTCGCCCGGCTGCGGCACGCCGACACGGCCGAAGCCCACCCCGGGTCCA
ACGTCGTCGGGGCGAAGGCCAAACGACCCTAG

Upstream 100 bases:

>100_bases
CATCAGCCGCCGGTTCGGGATTCGAGTCGTGACTCGACCCGACAACCTGCTGGAGGTCGTTCCCGCTGCCAACCTAACGA
GCAAGGAGTAACCGGCAACC

Downstream 100 bases:

>100_bases
AACAACAAGTTCGTCGTCTCTAGATTTCGGACTGCCGACGCATCGAAAGCTTGCCGTTACCCCGAGTTCCGGAGGGACAC
CATGAGCACCGCCAGCCGAG

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase pncB2

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MAIRQHVGALFTDLYEVTMAQAYWAERMSGTAVFEIFFRKLPPGRSYIMAAGLADVVEFLEAFRFDEQDLRYLRGLGQFS
DEFLRWLAGVRFTGDVWAAPEGTVIFPNEPAVQLIAPIIEAQLVETFVLNQIHLQSVLASKAARVVAAARGRPVVDFGAR
RAHGTDAACKVARTSYLAGAAGTSNLLAARQYGIPTFGTMAHSFVQAFDSEVAAFEAFARLYPATMLLVDTYDTLRGVDH
VIELAKRLGNRFDVRAVRLDSGDLDELSKATRARLDTAGLEQVEIFASSGLDENRIAALLAARCPIDGFGVGTQLVVAQD
APALDMAYKLVAYDGSGRTKFSSGKVIYPGRKQVFRKLEHGVFCGDTLGEHGENLPGDPLLVPIMTNGRRIRQHAPTLDG
ARDWARQQIDALPPELRSLEDTGYSYPVAVSDRIVGELARLRHADTAEAHPGSNVVGAKAKRP

Sequences:

>Translated_463_residues
MAIRQHVGALFTDLYEVTMAQAYWAERMSGTAVFEIFFRKLPPGRSYIMAAGLADVVEFLEAFRFDEQDLRYLRGLGQFS
DEFLRWLAGVRFTGDVWAAPEGTVIFPNEPAVQLIAPIIEAQLVETFVLNQIHLQSVLASKAARVVAAARGRPVVDFGAR
RAHGTDAACKVARTSYLAGAAGTSNLLAARQYGIPTFGTMAHSFVQAFDSEVAAFEAFARLYPATMLLVDTYDTLRGVDH
VIELAKRLGNRFDVRAVRLDSGDLDELSKATRARLDTAGLEQVEIFASSGLDENRIAALLAARCPIDGFGVGTQLVVAQD
APALDMAYKLVAYDGSGRTKFSSGKVIYPGRKQVFRKLEHGVFCGDTLGEHGENLPGDPLLVPIMTNGRRIRQHAPTLDG
ARDWARQQIDALPPELRSLEDTGYSYPVAVSDRIVGELARLRHADTAEAHPGSNVVGAKAKRP
>Mature_462_residues
AIRQHVGALFTDLYEVTMAQAYWAERMSGTAVFEIFFRKLPPGRSYIMAAGLADVVEFLEAFRFDEQDLRYLRGLGQFSD
EFLRWLAGVRFTGDVWAAPEGTVIFPNEPAVQLIAPIIEAQLVETFVLNQIHLQSVLASKAARVVAAARGRPVVDFGARR
AHGTDAACKVARTSYLAGAAGTSNLLAARQYGIPTFGTMAHSFVQAFDSEVAAFEAFARLYPATMLLVDTYDTLRGVDHV
IELAKRLGNRFDVRAVRLDSGDLDELSKATRARLDTAGLEQVEIFASSGLDENRIAALLAARCPIDGFGVGTQLVVAQDA
PALDMAYKLVAYDGSGRTKFSSGKVIYPGRKQVFRKLEHGVFCGDTLGEHGENLPGDPLLVPIMTNGRRIRQHAPTLDGA
RDWARQQIDALPPELRSLEDTGYSYPVAVSDRIVGELARLRHADTAEAHPGSNVVGAKAKRP

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN)

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family

Homologues:

Organism=Homo sapiens, GI194394158, Length=514, Percent_Identity=33.0739299610895, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71997947, Length=421, Percent_Identity=33.2541567695962, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI71997952, Length=421, Percent_Identity=33.2541567695962, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI71997955, Length=215, Percent_Identity=37.6744186046512, Blast_Score=141, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24581587, Length=517, Percent_Identity=30.9477756286267, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI161076680, Length=209, Percent_Identity=36.8421052631579, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24581595, Length=209, Percent_Identity=36.8421052631579, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI28574709, Length=209, Percent_Identity=36.8421052631579, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24581593, Length=209, Percent_Identity=36.8421052631579, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24581591, Length=209, Percent_Identity=36.8421052631579, Blast_Score=137, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PNCB2_MYCTU (O53770)

Other databases:

- EMBL:   AE000516
- EMBL:   BX842573
- PIR:   D70933
- RefSeq:   NP_215087.1
- RefSeq:   NP_335010.1
- ProteinModelPortal:   O53770
- SMR:   O53770
- EnsemblBacteria:   EBMYCT00000002716
- EnsemblBacteria:   EBMYCT00000069853
- GeneID:   887716
- GeneID:   924994
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT0601
- KEGG:   mtu:Rv0573c
- TIGR:   MT0601
- TubercuList:   Rv0573c
- GeneTree:   EBGT00050000017207
- HOGENOM:   HBG292386
- OMA:   VWAIPEG
- ProtClustDB:   PRK12484
- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638
- PANTHER:   PTHR11098:SF1
- PIRSF:   PIRSF000484
- TIGRFAMs:   TIGR01513

Pfam domain/function: PF04095 NAPRTase; SSF51690 Q_phspho_trans

EC number: =2.4.2.11

Molecular weight: Translated: 50509; Mature: 50378

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIRQHVGALFTDLYEVTMAQAYWAERMSGTAVFEIFFRKLPPGRSYIMAAGLADVVEFL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
EAFRFDEQDLRYLRGLGQFSDEFLRWLAGVRFTGDVWAAPEGTVIFPNEPAVQLIAPIIE
HHHCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEECCCCCEECCCCCHHHHHHHHHH
AQLVETFVLNQIHLQSVLASKAARVVAAARGRPVVDFGARRAHGTDAACKVARTSYLAGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
AGTSNLLAARQYGIPTFGTMAHSFVQAFDSEVAAFEAFARLYPATMLLVDTYDTLRGVDH
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHH
VIELAKRLGNRFDVRAVRLDSGDLDELSKATRARLDTAGLEQVEIFASSGLDENRIAALL
HHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHH
AARCPIDGFGVGTQLVVAQDAPALDMAYKLVAYDGSGRTKFSSGKVIYPGRKQVFRKLEH
HHHCCCCCCCCCCEEEEECCCCHHHHEEEEEEECCCCCCCCCCCCEECCCHHHHHHHHHC
GVFCGDTLGEHGENLPGDPLLVPIMTNGRRIRQHAPTLDGARDWARQQIDALPPELRSLE
CCEECCHHHHCCCCCCCCCEEEEEECCCHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHH
DTGYSYPVAVSDRIVGELARLRHADTAEAHPGSNVVGAKAKRP
HCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AIRQHVGALFTDLYEVTMAQAYWAERMSGTAVFEIFFRKLPPGRSYIMAAGLADVVEFL
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
EAFRFDEQDLRYLRGLGQFSDEFLRWLAGVRFTGDVWAAPEGTVIFPNEPAVQLIAPIIE
HHHCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEECCCCCEECCCCCHHHHHHHHHH
AQLVETFVLNQIHLQSVLASKAARVVAAARGRPVVDFGARRAHGTDAACKVARTSYLAGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
AGTSNLLAARQYGIPTFGTMAHSFVQAFDSEVAAFEAFARLYPATMLLVDTYDTLRGVDH
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHH
VIELAKRLGNRFDVRAVRLDSGDLDELSKATRARLDTAGLEQVEIFASSGLDENRIAALL
HHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHH
AARCPIDGFGVGTQLVVAQDAPALDMAYKLVAYDGSGRTKFSSGKVIYPGRKQVFRKLEH
HHHCCCCCCCCCCEEEEECCCCHHHHEEEEEEECCCCCCCCCCCCEECCCHHHHHHHHHC
GVFCGDTLGEHGENLPGDPLLVPIMTNGRRIRQHAPTLDGARDWARQQIDALPPELRSLE
CCEECCHHHHCCCCCCCCCEEEEEECCCHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHH
DTGYSYPVAVSDRIVGELARLRHADTAEAHPGSNVVGAKAKRP
HCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036