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The map label for this gene is yhdH [C]

Identifier: 148659913

GI number: 148659913

Start: 177059

End: 178027

Strand: Direct

Name: yhdH [C]

Synonym: MRA_0156

Alternate gene names: 148659913

Gene position: 177059-178027 (Clockwise)

Preceding gene: 148659912

Following gene: 148659919

Centisome position: 4.01

GC content: 64.29

Gene sequence:

>969_bases
ATGAAGGCTTGTGTCGTAAAAGAACTTTCCGGCCCGTCCGGCATGGTGTACACCGACATCGACGAGGTATCCGGTGACGG
CGGAAAGGTTGTTATCGACGTACGGGCCGCCGGCGTCTGCTTTCCGGACCTGCTGCTGACCAAGGGCGAGTATCAACTGA
AGCTAACGCCGCCGTTCGTGCCCGGCATGGAAACGGCGGGTGTGGTGCGTTCGGCGCCGTCGGATGCGGGTTTTCATGTG
GGCGAACGTGTTTCAGCATTCGGAGTGCTCGGCGGCTACGCCGAACAAATAGCCGTACCGGTGGCCAATGTGGTTCGCAG
CCCCGTCGAGCTCGATGACGCCGGGGCGGTGTCGCTGTTGGTGAACTACAACACCATGTACTTCGCCCTGGCTCGGCGTG
CCGCGCTGCGACCGGGAGACACCGTGCTGGTGCTCGGCGCCGCCGGCGGAGTGGGCACGGCCGCCGTCCAGATCGCGAAG
GCGATGCAGGCTGGCAAGGTGATAGCCATGGTGCACCGCGAAGGTGCGATCGACTATGTCGCTTCGCTCGGTGCCGACGT
GGTGCTTCCGCTGACCGAGGGCTGGGCTCAGCAGGTGCGTGACCACACCTACGGTCAGGGGGTGGACATCGTCGTCGATC
CCATCGGCGGACCGACATTCGACGACGCGCTCGGCGTGCTGGCGATCGACGGCAAGTTATTGTTGATCGGCTTTGCCGCG
GGTGCTGTACCGACCCTCAAGGTCAACCGGCTGCTGGTGCGCAATATCAGCGTGGTGGGCGTCGGGTGGGGCGAGTATCT
CAACGCGGTTCCCGGTTCGGCCGCCTTGTTCGCCTGGGGGCTAAACCAGCTGGTCTTTCTGGGGCTCAGACCGCCTCCGC
CGCAACGCTATCCGTTGTCGGAAGCACAGGCCGCGTTGCAGAGTCTGGACGACGGCGGTGTGCTCGGCAAGGTTGTGCTC
GAGCCCTAA

Upstream 100 bases:

>100_bases
CTTCGACAAACCGCCGTCGGTACAAGATGTTGCGGCGCGGTGGGCCGAGATCACCGATCTGTCCGGTGCGAAAATTGCTG
GATTCAAGTTGTAGAAGTAA

Downstream 100 bases:

>100_bases
GCGCATGCTCGCGATTCGGCGATACGGTGATGCTGTGACGGATCGGCGGGCCAACACGAGGAATTCGCACCCGCTGCCGG
CGTGACCAACGCCACGCTGG

Product: putative quinone oxidoreductase

Products: NA

Alternate protein names: Acryloyl-CoA reductase [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MKACVVKELSGPSGMVYTDIDEVSGDGGKVVIDVRAAGVCFPDLLLTKGEYQLKLTPPFVPGMETAGVVRSAPSDAGFHV
GERVSAFGVLGGYAEQIAVPVANVVRSPVELDDAGAVSLLVNYNTMYFALARRAALRPGDTVLVLGAAGGVGTAAVQIAK
AMQAGKVIAMVHREGAIDYVASLGADVVLPLTEGWAQQVRDHTYGQGVDIVVDPIGGPTFDDALGVLAIDGKLLLIGFAA
GAVPTLKVNRLLVRNISVVGVGWGEYLNAVPGSAALFAWGLNQLVFLGLRPPPPQRYPLSEAQAALQSLDDGGVLGKVVL
EP

Sequences:

>Translated_322_residues
MKACVVKELSGPSGMVYTDIDEVSGDGGKVVIDVRAAGVCFPDLLLTKGEYQLKLTPPFVPGMETAGVVRSAPSDAGFHV
GERVSAFGVLGGYAEQIAVPVANVVRSPVELDDAGAVSLLVNYNTMYFALARRAALRPGDTVLVLGAAGGVGTAAVQIAK
AMQAGKVIAMVHREGAIDYVASLGADVVLPLTEGWAQQVRDHTYGQGVDIVVDPIGGPTFDDALGVLAIDGKLLLIGFAA
GAVPTLKVNRLLVRNISVVGVGWGEYLNAVPGSAALFAWGLNQLVFLGLRPPPPQRYPLSEAQAALQSLDDGGVLGKVVL
EP
>Mature_322_residues
MKACVVKELSGPSGMVYTDIDEVSGDGGKVVIDVRAAGVCFPDLLLTKGEYQLKLTPPFVPGMETAGVVRSAPSDAGFHV
GERVSAFGVLGGYAEQIAVPVANVVRSPVELDDAGAVSLLVNYNTMYFALARRAALRPGDTVLVLGAAGGVGTAAVQIAK
AMQAGKVIAMVHREGAIDYVASLGADVVLPLTEGWAQQVRDHTYGQGVDIVVDPIGGPTFDDALGVLAIDGKLLLIGFAA
GAVPTLKVNRLLVRNISVVGVGWGEYLNAVPGSAALFAWGLNQLVFLGLRPPPPQRYPLSEAQAALQSLDDGGVLGKVVL
EP

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the acryloyl- CoA dependent NADPH oxidation and formation of propionyl-CoA [H]

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=328, Percent_Identity=28.0487804878049, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI13236495, Length=328, Percent_Identity=28.0487804878049, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI24308257, Length=318, Percent_Identity=28.6163522012579, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI28557745, Length=252, Percent_Identity=31.7460317460317, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI18379349, Length=325, Percent_Identity=27.6923076923077, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI194239676, Length=164, Percent_Identity=35.9756097560976, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI22538446, Length=323, Percent_Identity=23.8390092879257, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI22538444, Length=323, Percent_Identity=23.8390092879257, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1789651, Length=270, Percent_Identity=28.8888888888889, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790485, Length=308, Percent_Identity=26.9480519480519, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17507255, Length=333, Percent_Identity=29.7297297297297, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319520, Length=338, Percent_Identity=26.3313609467456, Blast_Score=80, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.3.1.84 [H]

Molecular weight: Translated: 33279; Mature: 33279

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKACVVKELSGPSGMVYTDIDEVSGDGGKVVIDVRAAGVCFPDLLLTKGEYQLKLTPPFV
CCCEEEEECCCCCCEEEEEHHHHCCCCCEEEEEEEECCCCCHHHHCCCCCEEEEECCCCC
PGMETAGVVRSAPSDAGFHVGERVSAFGVLGGYAEQIAVPVANVVRSPVELDDAGAVSLL
CCCCCCCHHHCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCEEEEE
VNYNTMYFALARRAALRPGDTVLVLGAAGGVGTAAVQIAKAMQAGKVIAMVHREGAIDYV
EECCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHH
ASLGADVVLPLTEGWAQQVRDHTYGQGVDIVVDPIGGPTFDDALGVLAIDGKLLLIGFAA
HHCCCCEEEECCHHHHHHHHHCCCCCCCEEEEECCCCCCHHHCCEEEEECCEEEEEEEEC
GAVPTLKVNRLLVRNISVVGVGWGEYLNAVPGSAALFAWGLNQLVFLGLRPPPPQRYPLS
CCCCEEECCEEEEECEEEEEECHHHHHHCCCCCHHHHHHCCCCEEEEECCCCCCCCCCHH
EAQAALQSLDDGGVLGKVVLEP
HHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MKACVVKELSGPSGMVYTDIDEVSGDGGKVVIDVRAAGVCFPDLLLTKGEYQLKLTPPFV
CCCEEEEECCCCCCEEEEEHHHHCCCCCEEEEEEEECCCCCHHHHCCCCCEEEEECCCCC
PGMETAGVVRSAPSDAGFHVGERVSAFGVLGGYAEQIAVPVANVVRSPVELDDAGAVSLL
CCCCCCCHHHCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCEEEEE
VNYNTMYFALARRAALRPGDTVLVLGAAGGVGTAAVQIAKAMQAGKVIAMVHREGAIDYV
EECCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHH
ASLGADVVLPLTEGWAQQVRDHTYGQGVDIVVDPIGGPTFDDALGVLAIDGKLLLIGFAA
HHCCCCEEEECCHHHHHHHHHCCCCCCCEEEEECCCCCCHHHCCEEEEECCEEEEEEEEC
GAVPTLKVNRLLVRNISVVGVGWGEYLNAVPGSAALFAWGLNQLVFLGLRPPPPQRYPLS
CCCCEEECCEEEEECEEEEEECHHHHHHCCCCCHHHHHHCCCCEEEEECCCCCCCCCCHH
EAQAALQSLDDGGVLGKVVLEP
HHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA