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The map label for this gene is cobS [H]

Identifier: 148652653

GI number: 148652653

Start: 999485

End: 1000279

Strand: Direct

Name: cobS [H]

Synonym: PsycPRwf_0844

Alternate gene names: 148652653

Gene position: 999485-1000279 (Clockwise)

Preceding gene: 148652652

Following gene: 148652654

Centisome position: 33.55

GC content: 50.57

Gene sequence:

>795_bases
ATGTCTGTTAAGCACGAGTGGCGCTTATTACAGGTTGCTACTCAGTTTTTGACCCGCATTCCTGTAAAAATGGATGATTA
TCAGGCTGACTGGTTACATCAAAGCAGCCGTCATTTTTCGGGTGTCGGGCTATTGGTGGGCATACTTTGCGCCGCTGTGT
TTTGGGCAGTGAGCTTGGGGTTTCCCCCTTTGGTAGCAGCCATCGCCAGTACCACCTTTGGCATTAAACTGACGGGCGCT
TTTCATGAAGATGGGCTGGCGGATACTTGTGATGGGCTTGGCGGCGGGCTTACTCGAGAACGCACCTTAACCATTATGAA
AGACTCTCGTCTTGGTACTTATGGCACCCTAGGCTTGGTGTGTGCTTTGTTATTAAAAGTGAGTCTGCTTGCGGCAATGC
CGATTATGACAGCCGTGGTGGCTTTGATTGTCGCCCACAGTGCCTCGCGCCTGTTGTGCACCTCGCTGATAGTACTGCTG
CCTTATGGCGGTGAAATAGAGCACGCCAAGGCCAAGCCCATGGCGCAGCAAATGACATTTAGGCAGTGGCTGGCAAGTGC
GCTGTGGCTGATACTTATTGGTCTGCTACTGCCTTTGTTGCTGCCACAAGCTATGCACAGTATCAGCTTAAAGCAATGGG
TGCTGGCATTCATATTTGCCCTACTTGGGGTGACCCATATGTACCGTTTGCTTAAAAGACGCTTGCAAGGCTATACCGGT
GATGGCTTAGGAGCCACTCAGCAAATCACTGAGATTGCTATTTATGCTGGTCTAGCGGCCAATTTTACCGGATAG

Upstream 100 bases:

>100_bases
TGGCAAGCTTTAGTGATGCGGGGATTAGCACGCAAAGTGAGCCAGGTTCACAAGCCAATATAGCCGCAGTTGTGGCCACT
AGTGATGGGCAATAACGCCA

Downstream 100 bases:

>100_bases
ATGTTTCTCTTATGCAATTATACGTCTGGCGCCATCCTAAACCAAAGCAGGTGCAAGGGCTGTGCTTCGGTCAACATGAG
GTTATGGTTGATAGGCGCAA

Product: cobalamin 5'-phosphate synthase

Products: GMP; adenosylcobalamin

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MSVKHEWRLLQVATQFLTRIPVKMDDYQADWLHQSSRHFSGVGLLVGILCAAVFWAVSLGFPPLVAAIASTTFGIKLTGA
FHEDGLADTCDGLGGGLTRERTLTIMKDSRLGTYGTLGLVCALLLKVSLLAAMPIMTAVVALIVAHSASRLLCTSLIVLL
PYGGEIEHAKAKPMAQQMTFRQWLASALWLILIGLLLPLLLPQAMHSISLKQWVLAFIFALLGVTHMYRLLKRRLQGYTG
DGLGATQQITEIAIYAGLAANFTG

Sequences:

>Translated_264_residues
MSVKHEWRLLQVATQFLTRIPVKMDDYQADWLHQSSRHFSGVGLLVGILCAAVFWAVSLGFPPLVAAIASTTFGIKLTGA
FHEDGLADTCDGLGGGLTRERTLTIMKDSRLGTYGTLGLVCALLLKVSLLAAMPIMTAVVALIVAHSASRLLCTSLIVLL
PYGGEIEHAKAKPMAQQMTFRQWLASALWLILIGLLLPLLLPQAMHSISLKQWVLAFIFALLGVTHMYRLLKRRLQGYTG
DGLGATQQITEIAIYAGLAANFTG
>Mature_263_residues
SVKHEWRLLQVATQFLTRIPVKMDDYQADWLHQSSRHFSGVGLLVGILCAAVFWAVSLGFPPLVAAIASTTFGIKLTGAF
HEDGLADTCDGLGGGLTRERTLTIMKDSRLGTYGTLGLVCALLLKVSLLAAMPIMTAVVALIVAHSASRLLCTSLIVLLP
YGGEIEHAKAKPMAQQMTFRQWLASALWLILIGLLLPLLLPQAMHSISLKQWVLAFIFALLGVTHMYRLLKRRLQGYTGD
GLGATQQITEIAIYAGLAANFTG

Specific function: Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) [H]

COG id: COG0368

COG function: function code H; Cobalamin-5-phosphate synthase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobS family [H]

Homologues:

Organism=Escherichia coli, GI1788301, Length=243, Percent_Identity=32.0987654320988, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003805 [H]

Pfam domain/function: PF02654 CobS [H]

EC number: 2.7.8.26

Molecular weight: Translated: 28629; Mature: 28498

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVKHEWRLLQVATQFLTRIPVKMDDYQADWLHQSSRHFSGVGLLVGILCAAVFWAVSLG
CCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
FPPLVAAIASTTFGIKLTGAFHEDGLADTCDGLGGGLTRERTLTIMKDSRLGTYGTLGLV
CHHHHHHHHHHHCCEEEEECCCCCCCHHHHHCCCCCCCHHHEEEEEECCCCCCHHHHHHH
CALLLKVSLLAAMPIMTAVVALIVAHSASRLLCTSLIVLLPYGGEIEHAKAKPMAQQMTF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHH
RQWLASALWLILIGLLLPLLLPQAMHSISLKQWVLAFIFALLGVTHMYRLLKRRLQGYTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DGLGATQQITEIAIYAGLAANFTG
CCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SVKHEWRLLQVATQFLTRIPVKMDDYQADWLHQSSRHFSGVGLLVGILCAAVFWAVSLG
CCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
FPPLVAAIASTTFGIKLTGAFHEDGLADTCDGLGGGLTRERTLTIMKDSRLGTYGTLGLV
CHHHHHHHHHHHCCEEEEECCCCCCCHHHHHCCCCCCCHHHEEEEEECCCCCCHHHHHHH
CALLLKVSLLAAMPIMTAVVALIVAHSASRLLCTSLIVLLPYGGEIEHAKAKPMAQQMTF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHH
RQWLASALWLILIGLLLPLLLPQAMHSISLKQWVLAFIFALLGVTHMYRLLKRRLQGYTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DGLGATQQITEIAIYAGLAANFTG
CCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: adenosylcobinamide-GDP; alpha-ribazole

Specific reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA