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The map label for this gene is proC [H]

Identifier: 148652149

GI number: 148652149

Start: 407667

End: 408515

Strand: Direct

Name: proC [H]

Synonym: PsycPRwf_0337

Alternate gene names: 148652149

Gene position: 407667-408515 (Clockwise)

Preceding gene: 148652148

Following gene: 148652150

Centisome position: 13.68

GC content: 48.53

Gene sequence:

>849_bases
ATGTCAGAGCTTAAAGGTAAAAAAATCAGCTTCATCGGTGGCGGCAATATGGCCCAAGCCCTTATTAGTGGTTTATTAGC
AAGAGGCATTAAGCCAAACGATATTACCGTAGCCGACCCTTCACAAGATATTCGCGATGTCTTAAAAAGCCAAAAGATAA
ACACCGTAGATCCGACAGGCACAACCGATACCAACAATCCCCAAATTGCCGCAAAAACAGCGGATGTGATTGTGTTGGCA
GTTAAGCCTCAAGTTATGGATAAAGTGGTGGCTGATTTTGCTGACGTCTTGGACAGACAATTGGTTATTTCTGTGGCGGC
AGGTTTGTCTACCGACAGCTTAAGTAAAATGCTTAGCGGCTATCAGAACATTGTCCGCGCTATGCCCAATACCCCAGCTA
TGATTCAAAAAGGCGCAACCGGTCTTTATGCCAATGACAGCATTAGTGAGACCGACAAGCAGCTTGCTGCGACACTTATG
GCCGCTTCAGGCTTGGTCAGCTGGGTAGAACAAGAAGAGCAGCTGCATGCCGTAACGGCCGTATCTGGCTCAGCGCCGGC
TTATTTCTTTTATATGATTGAGTCGATGATTGAAGCAGGTGTGGAGCAGGGACTAGATAGAAAGCAGGCGGCTGCTTTGG
CGATGCAAACTGCTTTGGGTGCCGCTCAAATGGCCATCACCAGCGGCGAAGCACCCGCTGAACTGCGCCGTAAAGTGACC
TCTCCAAACGGCACTACGCAAGCGGCTATTGAGTCACTACAGCAAGATGATTTTGCCGGTATCATTAAAAAAGCGATGCA
GGCTTGTTACACGCGTAGTGAACAGATTAGCCAAGAGCTGGCCGACTAA

Upstream 100 bases:

>100_bases
TTGTGCGCCAAAATAAACACACAGATGTGACGTGTAGTGTTAGACCGGAAGTCTAATTTCGCCCAAAAAATTAGGGTGCG
TGAAACCAACAGGAGTAATC

Downstream 100 bases:

>100_bases
TGATGTAGCGCTAAATTTTTACCGCTTTGCTTTAAGCGCACAGTTATTGTTTAAGCAACTAAATAAACCTGGTCGTCGCC
CCTTTATATAACGAATGAGT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MSELKGKKISFIGGGNMAQALISGLLARGIKPNDITVADPSQDIRDVLKSQKINTVDPTGTTDTNNPQIAAKTADVIVLA
VKPQVMDKVVADFADVLDRQLVISVAAGLSTDSLSKMLSGYQNIVRAMPNTPAMIQKGATGLYANDSISETDKQLAATLM
AASGLVSWVEQEEQLHAVTAVSGSAPAYFFYMIESMIEAGVEQGLDRKQAAALAMQTALGAAQMAITSGEAPAELRRKVT
SPNGTTQAAIESLQQDDFAGIIKKAMQACYTRSEQISQELAD

Sequences:

>Translated_282_residues
MSELKGKKISFIGGGNMAQALISGLLARGIKPNDITVADPSQDIRDVLKSQKINTVDPTGTTDTNNPQIAAKTADVIVLA
VKPQVMDKVVADFADVLDRQLVISVAAGLSTDSLSKMLSGYQNIVRAMPNTPAMIQKGATGLYANDSISETDKQLAATLM
AASGLVSWVEQEEQLHAVTAVSGSAPAYFFYMIESMIEAGVEQGLDRKQAAALAMQTALGAAQMAITSGEAPAELRRKVT
SPNGTTQAAIESLQQDDFAGIIKKAMQACYTRSEQISQELAD
>Mature_281_residues
SELKGKKISFIGGGNMAQALISGLLARGIKPNDITVADPSQDIRDVLKSQKINTVDPTGTTDTNNPQIAAKTADVIVLAV
KPQVMDKVVADFADVLDRQLVISVAAGLSTDSLSKMLSGYQNIVRAMPNTPAMIQKGATGLYANDSISETDKQLAATLMA
ASGLVSWVEQEEQLHAVTAVSGSAPAYFFYMIESMIEAGVEQGLDRKQAAALAMQTALGAAQMAITSGEAPAELRRKVTS
PNGTTQAAIESLQQDDFAGIIKKAMQACYTRSEQISQELAD

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=280, Percent_Identity=35, Blast_Score=151, Evalue=5e-37,
Organism=Homo sapiens, GI24797097, Length=280, Percent_Identity=33.5714285714286, Blast_Score=151, Evalue=8e-37,
Organism=Homo sapiens, GI24797095, Length=280, Percent_Identity=33.5714285714286, Blast_Score=151, Evalue=8e-37,
Organism=Homo sapiens, GI198041662, Length=276, Percent_Identity=28.6231884057971, Blast_Score=128, Evalue=6e-30,
Organism=Escherichia coli, GI1786585, Length=274, Percent_Identity=37.956204379562, Blast_Score=177, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17569021, Length=271, Percent_Identity=34.3173431734317, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17540664, Length=287, Percent_Identity=31.7073170731707, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320861, Length=277, Percent_Identity=29.2418772563177, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21358587, Length=271, Percent_Identity=36.1623616236162, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24648116, Length=284, Percent_Identity=32.3943661971831, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24647700, Length=170, Percent_Identity=35.8823529411765, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29781; Mature: 29650

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELKGKKISFIGGGNMAQALISGLLARGIKPNDITVADPSQDIRDVLKSQKINTVDPTG
CCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHCCCCCCCCCC
TTDTNNPQIAAKTADVIVLAVKPQVMDKVVADFADVLDRQLVISVAAGLSTDSLSKMLSG
CCCCCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
YQNIVRAMPNTPAMIQKGATGLYANDSISETDKQLAATLMAASGLVSWVEQEEQLHAVTA
HHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSGSAPAYFFYMIESMIEAGVEQGLDRKQAAALAMQTALGAAQMAITSGEAPAELRRKVT
CCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
SPNGTTQAAIESLQQDDFAGIIKKAMQACYTRSEQISQELAD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SELKGKKISFIGGGNMAQALISGLLARGIKPNDITVADPSQDIRDVLKSQKINTVDPTG
CCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHCCCCCCCCCC
TTDTNNPQIAAKTADVIVLAVKPQVMDKVVADFADVLDRQLVISVAAGLSTDSLSKMLSG
CCCCCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
YQNIVRAMPNTPAMIQKGATGLYANDSISETDKQLAATLMAASGLVSWVEQEEQLHAVTA
HHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSGSAPAYFFYMIESMIEAGVEQGLDRKQAAALAMQTALGAAQMAITSGEAPAELRRKVT
CCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
SPNGTTQAAIESLQQDDFAGIIKKAMQACYTRSEQISQELAD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]