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The map label for this gene is iclR [H]

Identifier: 148652108

GI number: 148652108

Start: 351076

End: 351834

Strand: Direct

Name: iclR [H]

Synonym: PsycPRwf_0296

Alternate gene names: 148652108

Gene position: 351076-351834 (Clockwise)

Preceding gene: 148652107

Following gene: 148652121

Centisome position: 11.79

GC content: 48.48

Gene sequence:

>759_bases
ATGCCCAAAGTCTCCTCTATTACTCGAGTGCTGCAAATCATTGAGGCGGTCTCTTATGCGGCAAAGCCCATCACACCTTT
AGAGTTATCACAAGAGCTCGATATCCCCAAACCCACCATCCATCGGCTGCTACAGCAGCTGGTAGATGAGGGGTTTGTCA
CCATAGACATTACCGGTGGCATTATTGCGGGACGCCGAGTGCGCAATTTAAGCGTTGAGCTGTGGCAACAGCGTCAGTTC
TATAGTGAGCGTCATGTCATCTTGCAGCGTTTGGTGCGTGATGTGAAAGAGACGTGCGGGATTAGTGTGCCGCACAATAT
GCATATGATTTATACCAACCGGGCGAAGACGGATTTGCCGCTACAAATCTACTTGCCTGTGGGCGCTAAGTCGCCGATGT
GGTGTACCGCAACCGGTAAGCTGTATCTGAGTCAACTATCGCCTGAGCGGCGCGATAAAATGCTACAAAACTTAAGCTTG
GATAAATTCACCAAAAACACCATCACCGATGTTGATAAGCTTAATATTGAACTTGATGCGATTGCCAAGACCGGTATCGG
TATCGACAATGAAGAGTTTATCTCAGAGATGGTCGCAGTCTCTGTGCCTATTTTGGATAAAAAAGATCGCTATTTGGCCT
CGTTATATATGCACGCACCGACCGTTCGGGTGTCACTTGAGGACATGATGCAGTCGGTGCCTCGCTTGCAGGAAGCGGCG
CTGGATATCCAAGCTTTGGTATATGAGCTACAAAGCTAA

Upstream 100 bases:

>100_bases
GCAGCGCCGCTGAGTCGTCTCTAAGCCAATGAGAGACACTAAGTAAGCCCGTTAGTTTTTATATTCAAAGGTATTTCTTA
CATTTAAAGGTATATGGATC

Downstream 100 bases:

>100_bases
CGCCGCCCTCACCACAAGTATCATACACATCAATAAGCCCAAGTCAGTGACTTGGGCTTATTGTTTTAGCAGAGGGACTG
TTAAATGTTAAAGTTAACGA

Product: transcriptional regulator IclR-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MPKVSSITRVLQIIEAVSYAAKPITPLELSQELDIPKPTIHRLLQQLVDEGFVTIDITGGIIAGRRVRNLSVELWQQRQF
YSERHVILQRLVRDVKETCGISVPHNMHMIYTNRAKTDLPLQIYLPVGAKSPMWCTATGKLYLSQLSPERRDKMLQNLSL
DKFTKNTITDVDKLNIELDAIAKTGIGIDNEEFISEMVAVSVPILDKKDRYLASLYMHAPTVRVSLEDMMQSVPRLQEAA
LDIQALVYELQS

Sequences:

>Translated_252_residues
MPKVSSITRVLQIIEAVSYAAKPITPLELSQELDIPKPTIHRLLQQLVDEGFVTIDITGGIIAGRRVRNLSVELWQQRQF
YSERHVILQRLVRDVKETCGISVPHNMHMIYTNRAKTDLPLQIYLPVGAKSPMWCTATGKLYLSQLSPERRDKMLQNLSL
DKFTKNTITDVDKLNIELDAIAKTGIGIDNEEFISEMVAVSVPILDKKDRYLASLYMHAPTVRVSLEDMMQSVPRLQEAA
LDIQALVYELQS
>Mature_251_residues
PKVSSITRVLQIIEAVSYAAKPITPLELSQELDIPKPTIHRLLQQLVDEGFVTIDITGGIIAGRRVRNLSVELWQQRQFY
SERHVILQRLVRDVKETCGISVPHNMHMIYTNRAKTDLPLQIYLPVGAKSPMWCTATGKLYLSQLSPERRDKMLQNLSLD
KFTKNTITDVDKLNIELDAIAKTGIGIDNEEFISEMVAVSVPILDKKDRYLASLYMHAPTVRVSLEDMMQSVPRLQEAAL
DIQALVYELQS

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=226, Percent_Identity=26.1061946902655, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788131, Length=243, Percent_Identity=26.7489711934156, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786468, Length=256, Percent_Identity=24.21875, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786715, Length=239, Percent_Identity=21.3389121338912, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1789999, Length=215, Percent_Identity=26.9767441860465, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 28585; Mature: 28454

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKVSSITRVLQIIEAVSYAAKPITPLELSQELDIPKPTIHRLLQQLVDEGFVTIDITGG
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEECCC
IIAGRRVRNLSVELWQQRQFYSERHVILQRLVRDVKETCGISVPHNMHMIYTNRAKTDLP
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCC
LQIYLPVGAKSPMWCTATGKLYLSQLSPERRDKMLQNLSLDKFTKNTITDVDKLNIELDA
EEEEEECCCCCCEEEEECCHHHHHHCCHHHHHHHHHHCCHHHHHHHHHCHHHHHCEEEEH
IAKTGIGIDNEEFISEMVAVSVPILDKKDRYLASLYMHAPTVRVSLEDMMQSVPRLQEAA
HHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHH
LDIQALVYELQS
HHHHHHHHHHCC
>Mature Secondary Structure 
PKVSSITRVLQIIEAVSYAAKPITPLELSQELDIPKPTIHRLLQQLVDEGFVTIDITGG
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEECCC
IIAGRRVRNLSVELWQQRQFYSERHVILQRLVRDVKETCGISVPHNMHMIYTNRAKTDLP
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCC
LQIYLPVGAKSPMWCTATGKLYLSQLSPERRDKMLQNLSLDKFTKNTITDVDKLNIELDA
EEEEEECCCCCCEEEEECCHHHHHHCCHHHHHHHHHHCCHHHHHHHHHCHHHHHCEEEEH
IAKTGIGIDNEEFISEMVAVSVPILDKKDRYLASLYMHAPTVRVSLEDMMQSVPRLQEAA
HHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHH
LDIQALVYELQS
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]