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The map label for this gene is mazG [H]

Identifier: 148652088

GI number: 148652088

Start: 329219

End: 330088

Strand: Direct

Name: mazG [H]

Synonym: PsycPRwf_0276

Alternate gene names: 148652088

Gene position: 329219-330088 (Clockwise)

Preceding gene: 148652085

Following gene: 148652089

Centisome position: 11.05

GC content: 49.08

Gene sequence:

>870_bases
ATGTTAAAGACACCTGATATGCACGATAAAAAAATGATAGCGCCAAAACCTGTGATGGGCGTGCCTGAGCCAACGGCCAA
TATACACGACTTGTTGGCTTTAATGGCCAGACTACGCGCTGATTGTCCCTGGGATATTAAGCAGACCAATCACAGCTTAA
TCCCTTATGCGATAGAGGAGGCGTACGAGCTGGCAGAGGCAATTCAAGAGGGCGATATTGAGGATATCAAAGGTGAGCTT
GGTGATGTGCTACTGCAGGTTGTTTTTCATTGCCAAATCTATGCCGAGCAGCAGCAATTCGACTTAGGAGATGTGATCTA
TACGCTACAAAGCAAACTGATTCGTCGCCATCCCCATGTGTTTGAGGCCGATCAACTGCCCGATGAGGCGGCAGTAAAAA
AACGCTGGGATGAGATTAAAGCCATCGAGAATGCAGAGCGTGAACGCCGTGGCAAACCCAAACGAAGCCTAGATGCAGTC
AAGGCGGGCAGTGCTTTAATGCAGGCGCAAAGCTTACAACAAGCGGCCAGCAAATTGGGCTTTGATTGGGAAGGGGTGGC
GGGCGCAGTAGAAAAGCTGGAAGAAGAGATTAGCGAGTTAAAGCAAATTCTGCCGCAAGCCGGTGAGAGTATGGATGCAG
CATATAAGCAAGCGCTTGAAAAAGAGCTTGGCGACTGTGTGTTTGGCTTAGTCAATGTGGCACGAAAGCTTAATTTAGAT
GCAGAAGCGGCCACTTTGACCTGCGTGCATAAGTTTCGCTCACGCTTTGGATTTATTGAAGCCCAGCTGGCCAAGCAAGG
TAAGACGGCACAAACCAGCAGTTTAGAGGAGATGGATGCGCTATGGGAGCTGGCCAAACAGCATGAATAG

Upstream 100 bases:

>100_bases
GATGGGGTCATAATTACAATTTCAAAATGATACACTGCTGATATGACAAATTAAAAACGCTGCCATAAGCAGATAATATG
AACAACGAGAGTCCACCCTT

Downstream 100 bases:

>100_bases
GCGTACTAGCGCTTTAATTTTGGGGATGCTGTGCATGATGCAGGCGGTGTTAATGCCCGGTGCTTGGGCGCAGCAATGCT
TTGCCGATGCCCATCAAGCC

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MLKTPDMHDKKMIAPKPVMGVPEPTANIHDLLALMARLRADCPWDIKQTNHSLIPYAIEEAYELAEAIQEGDIEDIKGEL
GDVLLQVVFHCQIYAEQQQFDLGDVIYTLQSKLIRRHPHVFEADQLPDEAAVKKRWDEIKAIENAERERRGKPKRSLDAV
KAGSALMQAQSLQQAASKLGFDWEGVAGAVEKLEEEISELKQILPQAGESMDAAYKQALEKELGDCVFGLVNVARKLNLD
AEAATLTCVHKFRSRFGFIEAQLAKQGKTAQTSSLEEMDALWELAKQHE

Sequences:

>Translated_289_residues
MLKTPDMHDKKMIAPKPVMGVPEPTANIHDLLALMARLRADCPWDIKQTNHSLIPYAIEEAYELAEAIQEGDIEDIKGEL
GDVLLQVVFHCQIYAEQQQFDLGDVIYTLQSKLIRRHPHVFEADQLPDEAAVKKRWDEIKAIENAERERRGKPKRSLDAV
KAGSALMQAQSLQQAASKLGFDWEGVAGAVEKLEEEISELKQILPQAGESMDAAYKQALEKELGDCVFGLVNVARKLNLD
AEAATLTCVHKFRSRFGFIEAQLAKQGKTAQTSSLEEMDALWELAKQHE
>Mature_289_residues
MLKTPDMHDKKMIAPKPVMGVPEPTANIHDLLALMARLRADCPWDIKQTNHSLIPYAIEEAYELAEAIQEGDIEDIKGEL
GDVLLQVVFHCQIYAEQQQFDLGDVIYTLQSKLIRRHPHVFEADQLPDEAAVKKRWDEIKAIENAERERRGKPKRSLDAV
KAGSALMQAQSLQQAASKLGFDWEGVAGAVEKLEEEISELKQILPQAGESMDAAYKQALEKELGDCVFGLVNVARKLNLD
AEAATLTCVHKFRSRFGFIEAQLAKQGKTAQTSSLEEMDALWELAKQHE

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=267, Percent_Identity=38.5767790262172, Blast_Score=177, Evalue=9e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 32386; Mature: 32386

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLKTPDMHDKKMIAPKPVMGVPEPTANIHDLLALMARLRADCPWDIKQTNHSLIPYAIEE
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHH
AYELAEAIQEGDIEDIKGELGDVLLQVVFHCQIYAEQQQFDLGDVIYTLQSKLIRRHPHV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
FEADQLPDEAAVKKRWDEIKAIENAERERRGKPKRSLDAVKAGSALMQAQSLQQAASKLG
CCHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
FDWEGVAGAVEKLEEEISELKQILPQAGESMDAAYKQALEKELGDCVFGLVNVARKLNLD
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AEAATLTCVHKFRSRFGFIEAQLAKQGKTAQTSSLEEMDALWELAKQHE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]