Click here to switch to the map view.

The map label for this gene is uvrC

Identifier: 148652021

GI number: 148652021

Start: 242157

End: 244001

Strand: Direct

Name: uvrC

Synonym: PsycPRwf_0205

Alternate gene names: 148652021

Gene position: 242157-244001 (Clockwise)

Preceding gene: 148652020

Following gene: 148652029

Centisome position: 8.13

GC content: 50.14

Gene sequence:

>1845_bases
ATGGTGACTCCGTCTTTAACGGCTCAAGCCGATGACAAGCAAGCCCGTCTAAAGCATCTGATAAAAAGACTGCCTAATTT
ACCAGGGGTGTATAAGATGCTGGGTAAAAACGGCGATATTTTGTATGTCGGTAAAGCCAAATCGCTTAAAAGCCGCGTCA
ATAGCTATTTTGCCAAAACCATTGACCACCCTAAGACCCGTGCGCTGGTGTCTCGTATTCATGACATCGAGACCATCATT
ACCCGCAGTGAGACTGAAGCGCTATTGCTTGAGCAAAACCTGATTAAAGAGCATCGTCCGCCTTATAACGTGCTGCTGCG
CGATGACAAATCCTATCTGTATGTGTTTATCTCCGCTGACCAGCCTTATCCGCGTCTGGCTTATGGCCGGGGTAAGGCCA
AGCATCAAAAGGGCAAGTTTTTTGGACCCTTCCCCTCAGCACACGCTGCCAAAGAAACCTTGGTGCTGATGCAAAAGATG
TTTCAGATGCGCCAATGTACCAATACCTTTTTTCGTCAGCGCAAACGCCCCTGCCTTGAGTATCAGATTAAGCGGTGCCG
CGCCCCATGCGTCGGCTTGGTGTCTGCTGAAGAGTACGCAGCCGATGTACAAAACACCATCCGCTTTTTAAAGGGGGACT
CAAGCGACATTCACACCACCTTGATTGAGAAGATGGAACACTCTGCTGAAGCGCTAGACTTCGAAAAAGCAGCCTTTTAT
CGTGATCAACTCTCCATGCTGCGTGAAGTACAATCACGCCAAGCGGTGTATACGGTGCAAGGGGAGGCCGATATTATCTC
CATTGCCAGTCAAGCAGGTATGACCTGCGTTAATGTGCTAACCGTGCGTGGCGGGCGGGTATTGGGCGGCAAAAACTACT
TCCCTGATGTCGATAGCAATGAGCCGATCAATGACAACTTATCCGCCTTTATCACCTCATTTTATTTTCAAGTTACCGAT
GATTTGCCAGCAGAGATTATCATTAGCCACGAGTTGCCGGATCAGATGGCACTGCAAGAGGCGCTAAGCACCTACTTTGA
GGCTAAGACGGTCATCAAAACCAATGTGCGCGAGCACCGTGCAGAGTGGCTGGATTTGGCCAAACTAAATGCGCACAATG
CGTTAAAGACCAAGCTTGGCGATTATCTGGAGCTGCATGCCAGATTTGCTGCGTTAAAAGAGGTGCTCGAGCCGGTCAGC
CAAAGCAGCATAGACACCATAGAGTGCTTTGATATCTCACATACCATGGGTGAGGCGACCATTGCCAGCTGTGTGGTGTT
CGATCAAGGCGGCGCCCGTAAACGTGATTATCGGCAATACGCCATTCATGGGGTGCAAGATGGCGATGACTATGCTGCTA
TGGCGCAGGCGATTACCCGTCGTTATAAGAAGCATCCTTTGCCAGATGTACTGCTCATCGATGGGGGTAAGGGTCAGCTG
TCTATGGCCAAAAATGTGCTTACTGAGCTTGGCCTTTTAAATGACACCTTGCTGATTGGGGTGGCCAAAGGCGAGGGACG
TAAAGCGGGTCTTGAGGTGCTGCACTTTATTGAGCATGAGCCGCTCGACTTACCGATGGACTCTAAGGCGCTGCATTTAA
TTATGAACATTCGTGATGAGGCGCACCGCTTTGCCATCACGGCGCATCGCAAAAAACGCGATAAACGCCGCTCCTCATCG
GTACTTGAAGCCATTCCAGGTCTGGGAGAGAAGCGCCGCCGTGATTTACTCAACCACTTTGGCGGGCTGCAACAGCTACT
GGGCGCATCGCAGCAAGAGCTTGAAGGGGTGAACGGTATTGGTAAAGTGATGGCCAACACCATTTATAAAGTATTGCATG
AGTAG

Upstream 100 bases:

>100_bases
TAAAAAGCTGGCGTTATGCCAGCTTTTTTTTGTGCTTGCAATAGTGCCCCAAAAGCCCCATAAATAAAGGTATCTTTAAT
AATTTTTGGTTTAATACGTT

Downstream 100 bases:

>100_bases
ACTGAGCAGCAAGAATTGACTTCCTCCCCTCGCTAAACCGAGGGGATTCCTACAGCTAGACGGTCAAGCCCGACCGCAAG
GATGTTCTTAGCAGCATTGA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MVTPSLTAQADDKQARLKHLIKRLPNLPGVYKMLGKNGDILYVGKAKSLKSRVNSYFAKTIDHPKTRALVSRIHDIETII
TRSETEALLLEQNLIKEHRPPYNVLLRDDKSYLYVFISADQPYPRLAYGRGKAKHQKGKFFGPFPSAHAAKETLVLMQKM
FQMRQCTNTFFRQRKRPCLEYQIKRCRAPCVGLVSAEEYAADVQNTIRFLKGDSSDIHTTLIEKMEHSAEALDFEKAAFY
RDQLSMLREVQSRQAVYTVQGEADIISIASQAGMTCVNVLTVRGGRVLGGKNYFPDVDSNEPINDNLSAFITSFYFQVTD
DLPAEIIISHELPDQMALQEALSTYFEAKTVIKTNVREHRAEWLDLAKLNAHNALKTKLGDYLELHARFAALKEVLEPVS
QSSIDTIECFDISHTMGEATIASCVVFDQGGARKRDYRQYAIHGVQDGDDYAAMAQAITRRYKKHPLPDVLLIDGGKGQL
SMAKNVLTELGLLNDTLLIGVAKGEGRKAGLEVLHFIEHEPLDLPMDSKALHLIMNIRDEAHRFAITAHRKKRDKRRSSS
VLEAIPGLGEKRRRDLLNHFGGLQQLLGASQQELEGVNGIGKVMANTIYKVLHE

Sequences:

>Translated_614_residues
MVTPSLTAQADDKQARLKHLIKRLPNLPGVYKMLGKNGDILYVGKAKSLKSRVNSYFAKTIDHPKTRALVSRIHDIETII
TRSETEALLLEQNLIKEHRPPYNVLLRDDKSYLYVFISADQPYPRLAYGRGKAKHQKGKFFGPFPSAHAAKETLVLMQKM
FQMRQCTNTFFRQRKRPCLEYQIKRCRAPCVGLVSAEEYAADVQNTIRFLKGDSSDIHTTLIEKMEHSAEALDFEKAAFY
RDQLSMLREVQSRQAVYTVQGEADIISIASQAGMTCVNVLTVRGGRVLGGKNYFPDVDSNEPINDNLSAFITSFYFQVTD
DLPAEIIISHELPDQMALQEALSTYFEAKTVIKTNVREHRAEWLDLAKLNAHNALKTKLGDYLELHARFAALKEVLEPVS
QSSIDTIECFDISHTMGEATIASCVVFDQGGARKRDYRQYAIHGVQDGDDYAAMAQAITRRYKKHPLPDVLLIDGGKGQL
SMAKNVLTELGLLNDTLLIGVAKGEGRKAGLEVLHFIEHEPLDLPMDSKALHLIMNIRDEAHRFAITAHRKKRDKRRSSS
VLEAIPGLGEKRRRDLLNHFGGLQQLLGASQQELEGVNGIGKVMANTIYKVLHE
>Mature_614_residues
MVTPSLTAQADDKQARLKHLIKRLPNLPGVYKMLGKNGDILYVGKAKSLKSRVNSYFAKTIDHPKTRALVSRIHDIETII
TRSETEALLLEQNLIKEHRPPYNVLLRDDKSYLYVFISADQPYPRLAYGRGKAKHQKGKFFGPFPSAHAAKETLVLMQKM
FQMRQCTNTFFRQRKRPCLEYQIKRCRAPCVGLVSAEEYAADVQNTIRFLKGDSSDIHTTLIEKMEHSAEALDFEKAAFY
RDQLSMLREVQSRQAVYTVQGEADIISIASQAGMTCVNVLTVRGGRVLGGKNYFPDVDSNEPINDNLSAFITSFYFQVTD
DLPAEIIISHELPDQMALQEALSTYFEAKTVIKTNVREHRAEWLDLAKLNAHNALKTKLGDYLELHARFAALKEVLEPVS
QSSIDTIECFDISHTMGEATIASCVVFDQGGARKRDYRQYAIHGVQDGDDYAAMAQAITRRYKKHPLPDVLLIDGGKGQL
SMAKNVLTELGLLNDTLLIGVAKGEGRKAGLEVLHFIEHEPLDLPMDSKALHLIMNIRDEAHRFAITAHRKKRDKRRSSS
VLEAIPGLGEKRRRDLLNHFGGLQQLLGASQQELEGVNGIGKVMANTIYKVLHE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=606, Percent_Identity=48.8448844884488, Blast_Score=554, Evalue=1e-159,
Organism=Escherichia coli, GI1788037, Length=199, Percent_Identity=28.1407035175879, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_PSYWF (A5WBX3)

Other databases:

- EMBL:   CP000713
- RefSeq:   YP_001279114.1
- ProteinModelPortal:   A5WBX3
- STRING:   A5WBX3
- GeneID:   5205527
- GenomeReviews:   CP000713_GR
- KEGG:   prw:PsycPRwf_0205
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   PSP56811:PSYCPRWF_0205-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 69099; Mature: 69099

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTPSLTAQADDKQARLKHLIKRLPNLPGVYKMLGKNGDILYVGKAKSLKSRVNSYFAKT
CCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHH
IDHPKTRALVSRIHDIETIITRSETEALLLEQNLIKEHRPPYNVLLRDDKSYLYVFISAD
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEECC
QPYPRLAYGRGKAKHQKGKFFGPFPSAHAAKETLVLMQKMFQMRQCTNTFFRQRKRPCLE
CCCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
YQIKRCRAPCVGLVSAEEYAADVQNTIRFLKGDSSDIHTTLIEKMEHSAEALDFEKAAFY
HHHHHHCCCCEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RDQLSMLREVQSRQAVYTVQGEADIISIASQAGMTCVNVLTVRGGRVLGGKNYFPDVDSN
HHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCEEHHEEECCCEEECCCCCCCCCCCC
EPINDNLSAFITSFYFQVTDDLPAEIIISHELPDQMALQEALSTYFEAKTVIKTNVREHR
CCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEWLDLAKLNAHNALKTKLGDYLELHARFAALKEVLEPVSQSSIDTIECFDISHTMGEAT
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHCHHH
IASCVVFDQGGARKRDYRQYAIHGVQDGDDYAAMAQAITRRYKKHPLPDVLLIDGGKGQL
HHHEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHH
SMAKNVLTELGLLNDTLLIGVAKGEGRKAGLEVLHFIEHEPLDLPMDSKALHLIMNIRDE
HHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
AHRFAITAHRKKRDKRRSSSVLEAIPGLGEKRRRDLLNHFGGLQQLLGASQQELEGVNGI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHH
GKVMANTIYKVLHE
HHHHHHHHHHHHCC
>Mature Secondary Structure
MVTPSLTAQADDKQARLKHLIKRLPNLPGVYKMLGKNGDILYVGKAKSLKSRVNSYFAKT
CCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHH
IDHPKTRALVSRIHDIETIITRSETEALLLEQNLIKEHRPPYNVLLRDDKSYLYVFISAD
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEECC
QPYPRLAYGRGKAKHQKGKFFGPFPSAHAAKETLVLMQKMFQMRQCTNTFFRQRKRPCLE
CCCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
YQIKRCRAPCVGLVSAEEYAADVQNTIRFLKGDSSDIHTTLIEKMEHSAEALDFEKAAFY
HHHHHHCCCCEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RDQLSMLREVQSRQAVYTVQGEADIISIASQAGMTCVNVLTVRGGRVLGGKNYFPDVDSN
HHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCEEHHEEECCCEEECCCCCCCCCCCC
EPINDNLSAFITSFYFQVTDDLPAEIIISHELPDQMALQEALSTYFEAKTVIKTNVREHR
CCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEWLDLAKLNAHNALKTKLGDYLELHARFAALKEVLEPVSQSSIDTIECFDISHTMGEAT
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHCHHH
IASCVVFDQGGARKRDYRQYAIHGVQDGDDYAAMAQAITRRYKKHPLPDVLLIDGGKGQL
HHHEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHH
SMAKNVLTELGLLNDTLLIGVAKGEGRKAGLEVLHFIEHEPLDLPMDSKALHLIMNIRDE
HHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
AHRFAITAHRKKRDKRRSSSVLEAIPGLGEKRRRDLLNHFGGLQQLLGASQQELEGVNGI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHH
GKVMANTIYKVLHE
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA