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The map label for this gene is murE [H]

Identifier: 148651952

GI number: 148651952

Start: 162117

End: 163826

Strand: Direct

Name: murE [H]

Synonym: PsycPRwf_0135

Alternate gene names: 148651952

Gene position: 162117-163826 (Clockwise)

Preceding gene: 148651951

Following gene: 148651953

Centisome position: 5.44

GC content: 50.35

Gene sequence:

>1710_bases
ATGACACATACCCAACCTGCTCCTCACTTACGCTCTATAGTTAACGCCGCCGTCAAGATATTACCGCAGCATCAGTCCAC
CTTGCAGCTACTTAGAGTACCGGCAGTGCTTGATGTGCCTTTCTCAAAGTTTGTGCTCGATAGCCGTCAGTTGGCAAAGC
GTGACGCGTCATCCGCGCCGGCAGCCTTTGTGTTATTAAAAAGTCAGACTCAGCCTTTGCAAAAAAGCCAGCAGTATGTC
CAAACCGCCTTACCGCAAGCGGCATTTATCATTAGTGAGATTGACCCACAGCAGTTAGGCTTAGAGGGATTAGATAAACC
AAGCGACTCAAGTCCAGACTGTCCTATTTTATTTGTGCCCGATATCCGTGATGTACTGGGTACTTTGATTCAGTTGAGTC
TTTTGTCTGATGATGCGCTCTCACAGATCGGTGATGCACAGTCTTTGGCACAAACACTGCCGCAAGTTATCGCTGTAACC
GGCACCAATGGCAAAACCACCATTAGTCAGTTAATGGCTCAGTTGTGTCAGTTTTCAGAGGTCGCTCAATTACAAAACAG
TGCAGTGATGGGTACCGCGGGTAACGGTCGTCTAGACAGTCTCGTACAGGCCAGCCATACCACAGGCGATGCGCTAGCGG
TACAAGGCTTCTTACGTAAGATGGGTGATGAAGGGGTGGATTTATTAGCCCTAGAGGCCAGCTCACATGGTCTCGATCAG
CAGCGCTTGCAAGGCGTACCAGTCACGGTGGCACTGTATACCAACTTAAGCCGTGACCATTTAGACTATCACCCAGATAT
GCAAGATTATGCCCAAGCCAAGGCACGCTTATTTGATAAAGCTTATTTTCCACAGTTAACACATGCTGTGATTAATGCAG
ATGATGAGTTTGCGCCGCTGATGATTGAGACAGCGCAAAACTCAGGGGTTAGTGTCTGGTTGTACAGCTTACAGGGCGAT
TTTATCGAAAAAAGCGATCTGCAACGTAATGCCTACTTTATCGCCAAAACCATTGAGCCAAGCTTAGATGGGGTGAAAAT
TGAGGCCGCAACCAGCTTTGGGCCATTGACGTTGCACAGCCCCTTATTAGGCCGCTTTAACGTGGCCAACCTATTGGCAG
CTGTCGCCGGAGCGATCGCGTTAGGTATCGAGCCTGAGAGCATCCCCGCCTTAGTCAAACAGCTGCATGGTGCCAGTGGC
CGTATGCAGCGTGTGAGCTTAGATGAGCAAGGCTCACAGCCTGAGCAAGGGGTGTTTATTGTCGATTATGCGCACACGCC
GGATGCGTTAACCCAAGTGCTGACCAGTTTAAAATCGCATTGCAGCGGTAACTTATGGGCCATCTTTGGCTGCGGCGGTG
ACCGTGATAAGGGTAAGCGCCCTCTCATGGCGCAGGCGGGCTTGGCCACTGCCGATAAAGTGGTATTAACCTCTGACAAT
CCGCGCAGTGAAGATCCGCAAATGATCTTGCAGGACATGCAGCAAGGGATGAGTGACGAGCAGCATGCCAAAACCACAGT
CATTGCCGATCGAAAACAGGCCATCGAGTATGCCGTAGAGCACGCTGCCGCAGATGATATCGTGGTCATTGCTGGTAAAG
GGCATGAGACTTATCAAGAAATCAAAGGCGTGCGTTATGACTTCGATGACCGCTTAGTGCTACAGCAGGCATTAATTGCG
GCGCACAGTTCAGAGGCCTCAAGCCGCTAA

Upstream 100 bases:

>100_bases
TTTTAGGTGGCCAACTGTGGTAGTTGGCCGCTTAACTGGTCAATAGGCTACCGTTAGCGCTTTGGTCAATAAACACAAGT
AAATTATAAGGCCCTCTAGG

Downstream 100 bases:

>100_bases
CCTTATCACCTTCATATTTTATATTTCATATCCTGACCCATTAAACCAACGAGACGCAATCATCATGAGCCAACGACACC
CCGAGAATGGACTATTTATT

Product: UDP-N-acetylmuramyl-tripeptide synthetase

Products: NA

Alternate protein names: Meso-A2pm-adding enzyme; Meso-diaminopimelate-adding enzyme; UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase; UDP-MurNAc-tripeptide synthetase; UDP-N-acetylmuramyl-tripeptide synthetase [H]

Number of amino acids: Translated: 569; Mature: 568

Protein sequence:

>569_residues
MTHTQPAPHLRSIVNAAVKILPQHQSTLQLLRVPAVLDVPFSKFVLDSRQLAKRDASSAPAAFVLLKSQTQPLQKSQQYV
QTALPQAAFIISEIDPQQLGLEGLDKPSDSSPDCPILFVPDIRDVLGTLIQLSLLSDDALSQIGDAQSLAQTLPQVIAVT
GTNGKTTISQLMAQLCQFSEVAQLQNSAVMGTAGNGRLDSLVQASHTTGDALAVQGFLRKMGDEGVDLLALEASSHGLDQ
QRLQGVPVTVALYTNLSRDHLDYHPDMQDYAQAKARLFDKAYFPQLTHAVINADDEFAPLMIETAQNSGVSVWLYSLQGD
FIEKSDLQRNAYFIAKTIEPSLDGVKIEAATSFGPLTLHSPLLGRFNVANLLAAVAGAIALGIEPESIPALVKQLHGASG
RMQRVSLDEQGSQPEQGVFIVDYAHTPDALTQVLTSLKSHCSGNLWAIFGCGGDRDKGKRPLMAQAGLATADKVVLTSDN
PRSEDPQMILQDMQQGMSDEQHAKTTVIADRKQAIEYAVEHAAADDIVVIAGKGHETYQEIKGVRYDFDDRLVLQQALIA
AHSSEASSR

Sequences:

>Translated_569_residues
MTHTQPAPHLRSIVNAAVKILPQHQSTLQLLRVPAVLDVPFSKFVLDSRQLAKRDASSAPAAFVLLKSQTQPLQKSQQYV
QTALPQAAFIISEIDPQQLGLEGLDKPSDSSPDCPILFVPDIRDVLGTLIQLSLLSDDALSQIGDAQSLAQTLPQVIAVT
GTNGKTTISQLMAQLCQFSEVAQLQNSAVMGTAGNGRLDSLVQASHTTGDALAVQGFLRKMGDEGVDLLALEASSHGLDQ
QRLQGVPVTVALYTNLSRDHLDYHPDMQDYAQAKARLFDKAYFPQLTHAVINADDEFAPLMIETAQNSGVSVWLYSLQGD
FIEKSDLQRNAYFIAKTIEPSLDGVKIEAATSFGPLTLHSPLLGRFNVANLLAAVAGAIALGIEPESIPALVKQLHGASG
RMQRVSLDEQGSQPEQGVFIVDYAHTPDALTQVLTSLKSHCSGNLWAIFGCGGDRDKGKRPLMAQAGLATADKVVLTSDN
PRSEDPQMILQDMQQGMSDEQHAKTTVIADRKQAIEYAVEHAAADDIVVIAGKGHETYQEIKGVRYDFDDRLVLQQALIA
AHSSEASSR
>Mature_568_residues
THTQPAPHLRSIVNAAVKILPQHQSTLQLLRVPAVLDVPFSKFVLDSRQLAKRDASSAPAAFVLLKSQTQPLQKSQQYVQ
TALPQAAFIISEIDPQQLGLEGLDKPSDSSPDCPILFVPDIRDVLGTLIQLSLLSDDALSQIGDAQSLAQTLPQVIAVTG
TNGKTTISQLMAQLCQFSEVAQLQNSAVMGTAGNGRLDSLVQASHTTGDALAVQGFLRKMGDEGVDLLALEASSHGLDQQ
RLQGVPVTVALYTNLSRDHLDYHPDMQDYAQAKARLFDKAYFPQLTHAVINADDEFAPLMIETAQNSGVSVWLYSLQGDF
IEKSDLQRNAYFIAKTIEPSLDGVKIEAATSFGPLTLHSPLLGRFNVANLLAAVAGAIALGIEPESIPALVKQLHGASGR
MQRVSLDEQGSQPEQGVFIVDYAHTPDALTQVLTSLKSHCSGNLWAIFGCGGDRDKGKRPLMAQAGLATADKVVLTSDNP
RSEDPQMILQDMQQGMSDEQHAKTTVIADRKQAIEYAVEHAAADDIVVIAGKGHETYQEIKGVRYDFDDRLVLQQALIAA
HSSEASSR

Specific function: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan [H]

COG id: COG0769

COG function: function code M; UDP-N-acetylmuramyl tripeptide synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family. MurE subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786273, Length=390, Percent_Identity=41.025641025641, Blast_Score=256, Evalue=3e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR005761 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.13 [H]

Molecular weight: Translated: 61375; Mature: 61244

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHTQPAPHLRSIVNAAVKILPQHQSTLQLLRVPAVLDVPFSKFVLDSRQLAKRDASSAP
CCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCHHCCCCHHHHHHCHHHHHHCCCCCCC
AAFVLLKSQTQPLQKSQQYVQTALPQAAFIISEIDPQQLGLEGLDKPSDSSPDCPILFVP
EEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCEEECC
DIRDVLGTLIQLSLLSDDALSQIGDAQSLAQTLPQVIAVTGTNGKTTISQLMAQLCQFSE
CHHHHHHHHHHHHHHCHHHHHHHCCHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHH
VAQLQNSAVMGTAGNGRLDSLVQASHTTGDALAVQGFLRKMGDEGVDLLALEASSHGLDQ
HHHHHCCEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCH
QRLQGVPVTVALYTNLSRDHLDYHPDMQDYAQAKARLFDKAYFPQLTHAVINADDEFAPL
HHHCCCCEEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
MIETAQNSGVSVWLYSLQGDFIEKSDLQRNAYFIAKTIEPSLDGVKIEAATSFGPLTLHS
EEEECCCCCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCEEECC
PLLGRFNVANLLAAVAGAIALGIEPESIPALVKQLHGASGRMQRVSLDEQGSQPEQGVFI
CCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEE
VDYAHTPDALTQVLTSLKSHCSGNLWAIFGCGGDRDKGKRPLMAQAGLATADKVVLTSDN
EEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHCCCCCCCEEEEECCC
PRSEDPQMILQDMQQGMSDEQHAKTTVIADRKQAIEYAVEHAAADDIVVIAGKGHETYQE
CCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHH
IKGVRYDFDDRLVLQQALIAAHSSEASSR
HCCCCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
THTQPAPHLRSIVNAAVKILPQHQSTLQLLRVPAVLDVPFSKFVLDSRQLAKRDASSAP
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCHHCCCCHHHHHHCHHHHHHCCCCCCC
AAFVLLKSQTQPLQKSQQYVQTALPQAAFIISEIDPQQLGLEGLDKPSDSSPDCPILFVP
EEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCEEECC
DIRDVLGTLIQLSLLSDDALSQIGDAQSLAQTLPQVIAVTGTNGKTTISQLMAQLCQFSE
CHHHHHHHHHHHHHHCHHHHHHHCCHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHH
VAQLQNSAVMGTAGNGRLDSLVQASHTTGDALAVQGFLRKMGDEGVDLLALEASSHGLDQ
HHHHHCCEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCH
QRLQGVPVTVALYTNLSRDHLDYHPDMQDYAQAKARLFDKAYFPQLTHAVINADDEFAPL
HHHCCCCEEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
MIETAQNSGVSVWLYSLQGDFIEKSDLQRNAYFIAKTIEPSLDGVKIEAATSFGPLTLHS
EEEECCCCCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCEEECC
PLLGRFNVANLLAAVAGAIALGIEPESIPALVKQLHGASGRMQRVSLDEQGSQPEQGVFI
CCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEE
VDYAHTPDALTQVLTSLKSHCSGNLWAIFGCGGDRDKGKRPLMAQAGLATADKVVLTSDN
EEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHCCCCCCCEEEEECCC
PRSEDPQMILQDMQQGMSDEQHAKTTVIADRKQAIEYAVEHAAADDIVVIAGKGHETYQE
CCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHH
IKGVRYDFDDRLVLQQALIAAHSSEASSR
HCCCCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]