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The map label for this gene is qor [C]

Identifier: 148651922

GI number: 148651922

Start: 125180

End: 126169

Strand: Direct

Name: qor [C]

Synonym: PsycPRwf_0105

Alternate gene names: 148651922

Gene position: 125180-126169 (Clockwise)

Preceding gene: 148651921

Following gene: 148651926

Centisome position: 4.2

GC content: 47.58

Gene sequence:

>990_bases
ATGTCTTCAACGTATCCACAGACACAATCGGCCATCATCATCACAGAATTTGGTGAGGCAGATGTTTTGCAATATCGCTC
AGATATGGTGGTGCCTACTCTTGATACAGGTATGGTCTTAGTCAAGATTGCATACGCCGGCATTAACCCAGTCGATTATA
AAACCCGTCAAGGTTTGGGCTGGGGCGCACAAAATATCAAAGACAATCAGTTTGCTGCCAATCAGCCTGCAATATTGGGC
TTTGATATGGCAGGCGAGGTGGTCGACAGTACCGTAGCGGACTTTAAGCCAGGAGATAAGGTGGCTGCCTTAAATTTCCA
AGGCGGCTGCTATGCTCAATATAATACTGTGGACGCTCAAGTGTTGACAAAAGTGCCTGAAGCAGTCGATCTAAAGACAG
CCGGTGCGCTGCCTTGCGTCGGTACCACTGCCAAGCAAATGATTGATTTTGCTGATATTAAACCAGGTGAGCATGTGGTT
ATGAGTGCACCTGCCGGCGGGGTGGGCCATCTCACCTTACAAATGCTGGTGAATGCCATCGAGGAAAAAGGCATTAAGAT
TACCCTTATTTGCTCGGCTGAGAAATATCAAAAAATCGGTAGTTTCATTGACCCAAGCAAACTTGAAGGCTGGATCGACT
ACACCAAACAAGAGGCTTTTCCAGAGCTTGAGGCCGATTTATTATTAGACTTGGTGGGCGGTGAAGCGGGTAAAAAAGCA
TTAGCCGTGGTCAAGACCGGTGGCCGTGTGGTGGTATTGCCTTCGATTTGGGCCGATGAGCTAAAAAAAGCGGGGGCGGA
TAAACAGCTACAAGTAGAAGGCTTTATTGCTAAGCCCAATGCTCAAGACTTGGCCGCAGTCTTAAATCAGATTGCCCAAG
GTAAGCTTGTGCTTCAGATCCAAGATACTTATCCATTGGCAAAAACTGCCGACGCACATCAGGCGCTAGAGACAGTGGAC
AGCTTTGGTAAGATTGTGCTGGAGATGTAG

Upstream 100 bases:

>100_bases
ATGGCATCGATATACAGAGTTAGGCTAGAGTTCTTAGCGTAACGGTATTATGCTGTAGGACTACCACTCACTAAAGCAAT
AACAATACAAGGAGTATGTC

Downstream 100 bases:

>100_bases
GGCTTTATTTAAGTGTGATGCAAGCCAATTGTCTAAGACACAGCAGATTACCGTATTAAGATTACAGCTCTAAGATTACC
GTATTAATGCATTAAGGATG

Product: alcohol dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: Oxidoreductase; Quinone Oxidoreductase; NADPHQuinone Reductase; Dehydrogenase; Alcohol Dehydrogenase GroES Domain Protein; Alcohol Dehydrogenase GroES Domain-Containing Protein; Zinc-Containing Alcohol Dehydrogenase Superfamily Protein; NAD(P)H Quinone Oxidoreductase PIG3 Family; Alcohol Dehydrogenase Zinc-Containing; Alcohol Dehydrogenase Zinc-Dependent; Zinc-Containing Alcohol Dehydrogenase; Quinone Reductase; Zn-Dependent Oxidoreductase NADphQuinone Reductase; NADPH-Quinone Reductase; NADPHQuinone Reductase Related Zn-Dependent Oxidoreductase; Alcohol Dehydrogenase GroES-Like Protein; Zn-Dependent Oxidoreductase NADPHQuinone Reductase; Alcohol Dehydrogenase GroES-Like Domain Family; Zn-Dependent Oxidoreductase; NADPHQuinone Oxidoreductase; NADPH-Quinone Oxidoreductase Zn Containing; Zinc-Dependent Oxidoreductase; PIG3 Family NAD(P)H Quinone Oxidoreductase; Quinone Oxidoreductase-Like Protein

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MSSTYPQTQSAIIITEFGEADVLQYRSDMVVPTLDTGMVLVKIAYAGINPVDYKTRQGLGWGAQNIKDNQFAANQPAILG
FDMAGEVVDSTVADFKPGDKVAALNFQGGCYAQYNTVDAQVLTKVPEAVDLKTAGALPCVGTTAKQMIDFADIKPGEHVV
MSAPAGGVGHLTLQMLVNAIEEKGIKITLICSAEKYQKIGSFIDPSKLEGWIDYTKQEAFPELEADLLLDLVGGEAGKKA
LAVVKTGGRVVVLPSIWADELKKAGADKQLQVEGFIAKPNAQDLAAVLNQIAQGKLVLQIQDTYPLAKTADAHQALETVD
SFGKIVLEM

Sequences:

>Translated_329_residues
MSSTYPQTQSAIIITEFGEADVLQYRSDMVVPTLDTGMVLVKIAYAGINPVDYKTRQGLGWGAQNIKDNQFAANQPAILG
FDMAGEVVDSTVADFKPGDKVAALNFQGGCYAQYNTVDAQVLTKVPEAVDLKTAGALPCVGTTAKQMIDFADIKPGEHVV
MSAPAGGVGHLTLQMLVNAIEEKGIKITLICSAEKYQKIGSFIDPSKLEGWIDYTKQEAFPELEADLLLDLVGGEAGKKA
LAVVKTGGRVVVLPSIWADELKKAGADKQLQVEGFIAKPNAQDLAAVLNQIAQGKLVLQIQDTYPLAKTADAHQALETVD
SFGKIVLEM
>Mature_328_residues
SSTYPQTQSAIIITEFGEADVLQYRSDMVVPTLDTGMVLVKIAYAGINPVDYKTRQGLGWGAQNIKDNQFAANQPAILGF
DMAGEVVDSTVADFKPGDKVAALNFQGGCYAQYNTVDAQVLTKVPEAVDLKTAGALPCVGTTAKQMIDFADIKPGEHVVM
SAPAGGVGHLTLQMLVNAIEEKGIKITLICSAEKYQKIGSFIDPSKLEGWIDYTKQEAFPELEADLLLDLVGGEAGKKAL
AVVKTGGRVVVLPSIWADELKKAGADKQLQVEGFIAKPNAQDLAAVLNQIAQGKLVLQIQDTYPLAKTADAHQALETVDS
FGKIVLEM

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI194239674, Length=332, Percent_Identity=28.9156626506024, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI13236495, Length=332, Percent_Identity=28.9156626506024, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI47519420, Length=377, Percent_Identity=25.7294429708223, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI194239676, Length=321, Percent_Identity=27.1028037383178, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI22538446, Length=347, Percent_Identity=26.2247838616715, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI22538444, Length=347, Percent_Identity=26.2247838616715, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6319520, Length=357, Percent_Identity=27.7310924369748, Blast_Score=90, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 35130; Mature: 34999

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTYPQTQSAIIITEFGEADVLQYRSDMVVPTLDTGMVLVKIAYAGINPVDYKTRQGLG
CCCCCCCCCCEEEEEECCCHHHHHHHCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCC
WGAQNIKDNQFAANQPAILGFDMAGEVVDSTVADFKPGDKVAALNFQGGCYAQYNTVDAQ
CCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCEEEEEECCCEEEEECCCHHH
VLTKVPEAVDLKTAGALPCVGTTAKQMIDFADIKPGEHVVMSAPAGGVGHLTLQMLVNAI
HHHHCCCHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHH
EEKGIKITLICSAEKYQKIGSFIDPSKLEGWIDYTKQEAFPELEADLLLDLVGGEAGKKA
HHCCCEEEEEECHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCE
LAVVKTGGRVVVLPSIWADELKKAGADKQLQVEGFIAKPNAQDLAAVLNQIAQGKLVLQI
EEEEECCCEEEEECCCCHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHHHHCCEEEEEE
QDTYPLAKTADAHQALETVDSFGKIVLEM
CCCCCCCCCCHHHHHHHHHHHHHHEEECC
>Mature Secondary Structure 
SSTYPQTQSAIIITEFGEADVLQYRSDMVVPTLDTGMVLVKIAYAGINPVDYKTRQGLG
CCCCCCCCCEEEEEECCCHHHHHHHCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCC
WGAQNIKDNQFAANQPAILGFDMAGEVVDSTVADFKPGDKVAALNFQGGCYAQYNTVDAQ
CCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCEEEEEECCCEEEEECCCHHH
VLTKVPEAVDLKTAGALPCVGTTAKQMIDFADIKPGEHVVMSAPAGGVGHLTLQMLVNAI
HHHHCCCHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHH
EEKGIKITLICSAEKYQKIGSFIDPSKLEGWIDYTKQEAFPELEADLLLDLVGGEAGKKA
HHCCCEEEEEECHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCE
LAVVKTGGRVVVLPSIWADELKKAGADKQLQVEGFIAKPNAQDLAAVLNQIAQGKLVLQI
EEEEECCCEEEEECCCCHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHHHHCCEEEEEE
QDTYPLAKTADAHQALETVDSFGKIVLEM
CCCCCCCCCCHHHHHHHHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA