Click here to switch to the map view.

The map label for this gene is lplA [H]

Identifier: 148651887

GI number: 148651887

Start: 86426

End: 87457

Strand: Direct

Name: lplA [H]

Synonym: PsycPRwf_0070

Alternate gene names: 148651887

Gene position: 86426-87457 (Clockwise)

Preceding gene: 148651886

Following gene: 148651888

Centisome position: 2.9

GC content: 47.29

Gene sequence:

>1032_bases
GTGACCTTGCCCATTAAACTTCGTATTTTAAAATCCTCTGTGACCAATCCGTGGTTTAACTTGGCCACCGAAGATTGGAT
ATTCCAAGAGCTAGATGCCCATTCACACACCCTATTTTTATGGCGCAATAGCGAAACTGTGGTTATCGGCCGCTCACAAA
ACCCTTGGGTGGAGTGCAAAACCGATAAAATGGCAGAAGATGGGGTGTATTTAGCGCGCCGTCAAAGCGGGGGCGGGGCT
GTCTTCCATGATTTGGGCAATACCAACTTCACTTTTTTATCACCCAAAGACGGCTATGATCAGCAGGCCAACTTTGACAT
CATAATCAATGCACTAAAAAAATTGGGTATTGAGGCCAGCTTATCGGGGCGCAATGATATGCAAGTGGGCGATCGTAAAA
TCTCAGGCAGTGCCTTTAAGCACGCCACTGACCGCAGCTTTCACCATGGCACACTACTGGTCAATGCCAATATGCAAAAG
CTTGGCGATTACCTTAATCCGCATCCGTTAAAGCTGCAAGCCAAAGGCATCAAGTCGGTCCGCTCTCGAGTGGCAAATCT
GGTAGAGTTTAATGACAGCATCACTCACGAGTCACTATCACAGGCGATCATTGAGGCGTTTTGTGATTACTATGGCAAAA
CCGTAGAGATTGAGGAATTAGATGAGGATTCCTTAAAGCAGGAGCCTCATCTTAATAGATACTATGAGCAGATGGCCGAC
TGGGACTGGCGCTTTGGCAAAACCCCACAATTTAATCACCATATCGAGACCCGCTTTGAGTGGGGCATTATTGATTTGCA
CTTAGAGGTGGCGCAGGCGATCATGACAGAGGTGGTGATTTTCTCAGATGCCCTCAATGTTGAGCTGATTGAGGCGCTAA
AGCAGGCACTGACAGGTGCAAAATACACTGTTGATGCCGTCACATCTAGATTGAATGACTTAAAACAGCAGCCAGCGGCA
GGCTCAGAGTCAAGCTGGATAACACAAATCACTGACTTTGAGCAGTGGTTGACGGGGCAAATGGTAACCTAG

Upstream 100 bases:

>100_bases
GGGGTTAACCCTTATGTCTTTATTACTGGGCTTGCTGAGCGTAATATGGCCTATATCCTTCAACAAGACTTCTCGTCGTC
GACCCCTTAAGGAGGGCATT

Downstream 100 bases:

>100_bases
GTACTGTTTAACTTGCCAATGTTAAACGTAGTTTTACACTTGATAACCTAAAACAAGCCACATCTTTTGTAAGATAGATT
AATAAAATGAATCTTATAAA

Product: lipoyltransferase and lipoate-protein ligase

Products: NA

Alternate protein names: Lipoate--protein ligase [H]

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MTLPIKLRILKSSVTNPWFNLATEDWIFQELDAHSHTLFLWRNSETVVIGRSQNPWVECKTDKMAEDGVYLARRQSGGGA
VFHDLGNTNFTFLSPKDGYDQQANFDIIINALKKLGIEASLSGRNDMQVGDRKISGSAFKHATDRSFHHGTLLVNANMQK
LGDYLNPHPLKLQAKGIKSVRSRVANLVEFNDSITHESLSQAIIEAFCDYYGKTVEIEELDEDSLKQEPHLNRYYEQMAD
WDWRFGKTPQFNHHIETRFEWGIIDLHLEVAQAIMTEVVIFSDALNVELIEALKQALTGAKYTVDAVTSRLNDLKQQPAA
GSESSWITQITDFEQWLTGQMVT

Sequences:

>Translated_343_residues
MTLPIKLRILKSSVTNPWFNLATEDWIFQELDAHSHTLFLWRNSETVVIGRSQNPWVECKTDKMAEDGVYLARRQSGGGA
VFHDLGNTNFTFLSPKDGYDQQANFDIIINALKKLGIEASLSGRNDMQVGDRKISGSAFKHATDRSFHHGTLLVNANMQK
LGDYLNPHPLKLQAKGIKSVRSRVANLVEFNDSITHESLSQAIIEAFCDYYGKTVEIEELDEDSLKQEPHLNRYYEQMAD
WDWRFGKTPQFNHHIETRFEWGIIDLHLEVAQAIMTEVVIFSDALNVELIEALKQALTGAKYTVDAVTSRLNDLKQQPAA
GSESSWITQITDFEQWLTGQMVT
>Mature_342_residues
TLPIKLRILKSSVTNPWFNLATEDWIFQELDAHSHTLFLWRNSETVVIGRSQNPWVECKTDKMAEDGVYLARRQSGGGAV
FHDLGNTNFTFLSPKDGYDQQANFDIIINALKKLGIEASLSGRNDMQVGDRKISGSAFKHATDRSFHHGTLLVNANMQKL
GDYLNPHPLKLQAKGIKSVRSRVANLVEFNDSITHESLSQAIIEAFCDYYGKTVEIEELDEDSLKQEPHLNRYYEQMADW
DWRFGKTPQFNHHIETRFEWGIIDLHLEVAQAIMTEVVIFSDALNVELIEALKQALTGAKYTVDAVTSRLNDLKQQPAAG
SESSWITQITDFEQWLTGQMVT

Specific function: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes [H]

COG id: COG0095

COG function: function code H; Lipoate-protein ligase A

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lplA family [H]

Homologues:

Organism=Homo sapiens, GI7706252, Length=318, Percent_Identity=33.0188679245283, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI21729884, Length=318, Percent_Identity=33.0188679245283, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI21729882, Length=318, Percent_Identity=33.0188679245283, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI21729880, Length=318, Percent_Identity=33.0188679245283, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI21729878, Length=318, Percent_Identity=33.0188679245283, Blast_Score=167, Evalue=1e-41,
Organism=Escherichia coli, GI1790846, Length=303, Percent_Identity=50.4950495049505, Blast_Score=324, Evalue=5e-90,
Organism=Caenorhabditis elegans, GI71981909, Length=261, Percent_Identity=32.183908045977, Blast_Score=140, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6322415, Length=189, Percent_Identity=32.8042328042328, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28573464, Length=293, Percent_Identity=35.8361774744027, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI221330307, Length=175, Percent_Identity=28, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004143
- InterPro:   IPR005107
- InterPro:   IPR019491
- InterPro:   IPR004562 [H]

Pfam domain/function: PF03099 BPL_LipA_LipB; PF10437 Lip_prot_lig_C [H]

EC number: =2.7.7.63 [H]

Molecular weight: Translated: 38978; Mature: 38847

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPIKLRILKSSVTNPWFNLATEDWIFQELDAHSHTLFLWRNSETVVIGRSQNPWVECK
CCCCEEEEEEHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCEEEEECCCCCCEEEC
TDKMAEDGVYLARRQSGGGAVFHDLGNTNFTFLSPKDGYDQQANFDIIINALKKLGIEAS
CCCCCCCCEEEEEECCCCCEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCEEE
LSGRNDMQVGDRKISGSAFKHATDRSFHHGTLLVNANMQKLGDYLNPHPLKLQAKGIKSV
CCCCCCCCCCCEECCCCHHHHCCCCCCCCCEEEEECCHHHHHHCCCCCCEEEEHHHHHHH
RSRVANLVEFNDSITHESLSQAIIEAFCDYYGKTVEIEELDEDSLKQEPHLNRYYEQMAD
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHCCHHHHHCCCCHHHHHHHHCC
WDWRFGKTPQFNHHIETRFEWGIIDLHLEVAQAIMTEVVIFSDALNVELIEALKQALTGA
CCCCCCCCCCCCCCCCCEEECCEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
KYTVDAVTSRLNDLKQQPAAGSESSWITQITDFEQWLTGQMVT
CEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TLPIKLRILKSSVTNPWFNLATEDWIFQELDAHSHTLFLWRNSETVVIGRSQNPWVECK
CCCEEEEEEHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCEEEEECCCCCCEEEC
TDKMAEDGVYLARRQSGGGAVFHDLGNTNFTFLSPKDGYDQQANFDIIINALKKLGIEAS
CCCCCCCCEEEEEECCCCCEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCEEE
LSGRNDMQVGDRKISGSAFKHATDRSFHHGTLLVNANMQKLGDYLNPHPLKLQAKGIKSV
CCCCCCCCCCCEECCCCHHHHCCCCCCCCCEEEEECCHHHHHHCCCCCCEEEEHHHHHHH
RSRVANLVEFNDSITHESLSQAIIEAFCDYYGKTVEIEELDEDSLKQEPHLNRYYEQMAD
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHCCHHHHHCCCCHHHHHHHHCC
WDWRFGKTPQFNHHIETRFEWGIIDLHLEVAQAIMTEVVIFSDALNVELIEALKQALTGA
CCCCCCCCCCCCCCCCCEEECCEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
KYTVDAVTSRLNDLKQQPAAGSESSWITQITDFEQWLTGQMVT
CEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA