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The map label for this gene is ctrA [H]

Identifier: 148550755

GI number: 148550755

Start: 216199

End: 216900

Strand: Direct

Name: ctrA [H]

Synonym: Swit_5319

Alternate gene names: 148550755

Gene position: 216199-216900 (Clockwise)

Preceding gene: 148550751

Following gene: 148550759

Centisome position: 69.69

GC content: 57.69

Gene sequence:

>702_bases
ATGCGGGTTTTGTTGATCGAAGACGACAATACGGTCGCGAGTGCCCTCGAGCTGATGCTGAGTGCCGAGGGGTTCAATGT
CTATTCGACCGACTTGGGCGAGGAAGGCCTCGATCTCGGCAAATCCTATGATTACGATCTCATCTGTCTCGACCTCAACC
TGCCGGACATGCACGGTTTCGACGTCCTCAAGAAGCTGCGGATGGGCCGGGTCGAGACACCGGTGCTGATCCTCTCGGGG
ATTTCGGAACTGGATTCCAAGGTCCGTGCCTTCGCCATGGGCGCGGACGAGTATCTGACCAAACCCTTCCACAAGGTCGA
GCTGGTCGCACGGATCAACGCCGTCGTCCGCCGGTCGAAGGGTCATGCCGAGTCCGTCATACGTATCGGCAAGATTGCCG
TGAACCTCGATGGGAAGGTCGCCGAAGTCGACGGGGCCCGAATACATCTGACAGGCAAGGAATATGCGATGCTCGAGCTG
CTGGCCCTGCGCCAGGGCTCAACGCTCACCAAGGAAATGTTCCTGAACCATCTTTATGGCGGCATTGACGAACCGGAGCT
CAAGATCATCGATGTTTTCATCTGCAAGCTACGAAAGAAATTGACCCTCGCATGCGGCGGCGAAAACTATATCGAAACGG
TGTGGGGCCGCGGCTACATGCTCCGGGCGCCAGGCGAGGAGGCCTTTGAGCAAGCAGCCTAA

Upstream 100 bases:

>100_bases
TGATCGCCAGCATGCCCGCCTCAGAAGAGGGGCGGAGCGAAGCTTGTTAACCAAGCCATGTCATAGCGCTTTAACCAGGC
TATCAACGTAGGGACATTGC

Downstream 100 bases:

>100_bases
AGCTTTGGGTGTTCCACACGCCTCGTATCTTTCGGCAGGGTGGATGTGCTGATGCCGTCCCTTTGAGCGCGGCAGTCCGC
GCTTTCCCCTTGGGTGCACC

Product: cell cycle transcriptional regulator CtrA

Products: NA

Alternate protein names: Response regulator SokA [H]

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MRVLLIEDDNTVASALELMLSAEGFNVYSTDLGEEGLDLGKSYDYDLICLDLNLPDMHGFDVLKKLRMGRVETPVLILSG
ISELDSKVRAFAMGADEYLTKPFHKVELVARINAVVRRSKGHAESVIRIGKIAVNLDGKVAEVDGARIHLTGKEYAMLEL
LALRQGSTLTKEMFLNHLYGGIDEPELKIIDVFICKLRKKLTLACGGENYIETVWGRGYMLRAPGEEAFEQAA

Sequences:

>Translated_233_residues
MRVLLIEDDNTVASALELMLSAEGFNVYSTDLGEEGLDLGKSYDYDLICLDLNLPDMHGFDVLKKLRMGRVETPVLILSG
ISELDSKVRAFAMGADEYLTKPFHKVELVARINAVVRRSKGHAESVIRIGKIAVNLDGKVAEVDGARIHLTGKEYAMLEL
LALRQGSTLTKEMFLNHLYGGIDEPELKIIDVFICKLRKKLTLACGGENYIETVWGRGYMLRAPGEEAFEQAA
>Mature_233_residues
MRVLLIEDDNTVASALELMLSAEGFNVYSTDLGEEGLDLGKSYDYDLICLDLNLPDMHGFDVLKKLRMGRVETPVLILSG
ISELDSKVRAFAMGADEYLTKPFHKVELVARINAVVRRSKGHAESVIRIGKIAVNLDGKVAEVDGARIHLTGKEYAMLEL
LALRQGSTLTKEMFLNHLYGGIDEPELKIIDVFICKLRKKLTLACGGENYIETVWGRGYMLRAPGEEAFEQAA

Specific function: Forms part of a two-component regulatory system CtrA/CckA that controls multiple events in the cell cycle, including cell division, stalk synthesis and cell cycle-specific transcription. Binds to a group of cell cycle-regulated promoters critical for DNA

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=36.6515837104072, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1790552, Length=229, Percent_Identity=36.6812227074236, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=33.7777777777778, Blast_Score=130, Evalue=5e-32,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=32.1266968325792, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=35.3711790393013, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=33.9285714285714, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1789809, Length=234, Percent_Identity=30.3418803418803, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=30.5936073059361, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=30.6306306306306, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=30.1310043668122, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=30.6306306306306, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=29.4642857142857, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=25.1101321585903, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1788550, Length=118, Percent_Identity=29.6610169491525, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1790299, Length=143, Percent_Identity=30.0699300699301, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790437, Length=160, Percent_Identity=25.625, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI145693140, Length=239, Percent_Identity=25.9414225941423, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25849; Mature: 25849

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLLIEDDNTVASALELMLSAEGFNVYSTDLGEEGLDLGKSYDYDLICLDLNLPDMHGF
CEEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCCCHHCCCCCCCEEEEEECCCCCCCHH
DVLKKLRMGRVETPVLILSGISELDSKVRAFAMGADEYLTKPFHKVELVARINAVVRRSK
HHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHCC
GHAESVIRIGKIAVNLDGKVAEVDGARIHLTGKEYAMLELLALRQGSTLTKEMFLNHLYG
CCHHHHHEEEEEEEECCCEEEEECCCEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHC
GIDEPELKIIDVFICKLRKKLTLACGGENYIETVWGRGYMLRAPGEEAFEQAA
CCCCCCHHHHHHHHHHHHHHEEEEECCCHHHHHHCCCCEEEECCCHHHHHHCC
>Mature Secondary Structure
MRVLLIEDDNTVASALELMLSAEGFNVYSTDLGEEGLDLGKSYDYDLICLDLNLPDMHGF
CEEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCCCHHCCCCCCCEEEEEECCCCCCCHH
DVLKKLRMGRVETPVLILSGISELDSKVRAFAMGADEYLTKPFHKVELVARINAVVRRSK
HHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHCC
GHAESVIRIGKIAVNLDGKVAEVDGARIHLTGKEYAMLELLALRQGSTLTKEMFLNHLYG
CCHHHHHEEEEEEEECCCEEEEECCCEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHC
GIDEPELKIIDVFICKLRKKLTLACGGENYIETVWGRGYMLRAPGEEAFEQAA
CCCCCCHHHHHHHHHHHHHHEEEEECCCHHHHHHCCCCEEEECCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8548829 [H]