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The map label for this gene is mtbA [H]

Identifier: 148379466

GI number: 148379466

Start: 1626744

End: 1627766

Strand: Direct

Name: mtbA [H]

Synonym: CBO1495

Alternate gene names: 148379466

Gene position: 1626744-1627766 (Clockwise)

Preceding gene: 148379465

Following gene: 148379468

Centisome position: 41.85

GC content: 30.01

Gene sequence:

>1023_bases
ATGTTAACACCAAAAGAAAGATTAAATTTAGCATTAAAAAACAAAGAAGTAGATAGGCCTCCTTGCATATGTCCAGGTGG
AATGATGAATATGATAATAGAAGATTTAATGGATATAAGCGGATATAAATGGCCAGAAGCTCATACAGATGCTGAAATTA
TGGCTAACTTAGCTATATCAATGTATGAACAGGGAGGATTTGAAAATTTTGGAGTACCTTTTTGTATGACCATAGAAGCG
GAATCTATGGGAGCTACAGTGGATTTAGGAGATAAAACTACTGAACCTAGAGTTATAAAATATCCAATAAAATCAGTAGT
AGAGTGGAGACAATTAAAAAGAATAGATTTAAATGAAGGAAGAGAAAAAGTAGTTTTAGATGCTATAAAAATTATAAAAG
ATAGAAATTTACCAGTACCCATAATGGCAAATTTAACAGGACCTATAAGCGTAGCATCATCTTTAATGGAGCCTATGTAT
TTTTATAAAGAATTAGTTAGAAAAAAAGATGAAGCTCACGAATTTATAAATTTTGTAACAGAAAATTTAATAGAATTTGG
GAAAGCTCAACTTTTAGCTGGAGCTAATGTTATAACTATATCGGATCCAAGTGGTACAGGAGAAATACTAGGACCAAAAT
TGTTTAAAGAATTTGTTATACCTTATATAAACAGAATAATAGATGAACTTAAAGACTACACAGATGGAACAATAGTACAT
ATCTGTGGAAGATTAAAAAGTATATATAAAGAATTAAATGATCTTAATAGTGATGTAGTAAGTTTTGATTCTATAAGCAG
TGTAACTCAAGTTCTTAAGAATGTACAAAATAAAGCTGTAATGGGAAATGTAAGTACATTAACTATACAAAATAGTAGCG
AAGAAGATGTAGAAAAACTAGCTAATGCTTGCATGAATTTAGGAGTGAATATATTATCACCAGCCTGCGGTATAGGAACT
AAAAGTCCTATAGAAAATGTAAGATCAATGGTAAATGCAGCTAAAAAAAGAAACGCAAAATAA

Upstream 100 bases:

>100_bases
AAAAGTTAAATGTTAATAATCTTATATTTAAATGAATAAGTTTTTTGTATATTTCACAGTTAATATAAGTAAAAATTTTA
AAATATATGAGGTGCATTAA

Downstream 100 bases:

>100_bases
GGAAATTGTGATTTAAAGGTAGTTTACCTTTGGCCTACCAAAAAAGGATATGTGACGAGATCGGCAAATCAATTCGCTAA
GAGATTCTAATTTGTTTTTT

Product: methylcobalamin:coenzyme M methyltransferase

Products: NA

Alternate protein names: MT2-A; Methylcobamide:CoM methyltransferase II isozyme A [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MLTPKERLNLALKNKEVDRPPCICPGGMMNMIIEDLMDISGYKWPEAHTDAEIMANLAISMYEQGGFENFGVPFCMTIEA
ESMGATVDLGDKTTEPRVIKYPIKSVVEWRQLKRIDLNEGREKVVLDAIKIIKDRNLPVPIMANLTGPISVASSLMEPMY
FYKELVRKKDEAHEFINFVTENLIEFGKAQLLAGANVITISDPSGTGEILGPKLFKEFVIPYINRIIDELKDYTDGTIVH
ICGRLKSIYKELNDLNSDVVSFDSISSVTQVLKNVQNKAVMGNVSTLTIQNSSEEDVEKLANACMNLGVNILSPACGIGT
KSPIENVRSMVNAAKKRNAK

Sequences:

>Translated_340_residues
MLTPKERLNLALKNKEVDRPPCICPGGMMNMIIEDLMDISGYKWPEAHTDAEIMANLAISMYEQGGFENFGVPFCMTIEA
ESMGATVDLGDKTTEPRVIKYPIKSVVEWRQLKRIDLNEGREKVVLDAIKIIKDRNLPVPIMANLTGPISVASSLMEPMY
FYKELVRKKDEAHEFINFVTENLIEFGKAQLLAGANVITISDPSGTGEILGPKLFKEFVIPYINRIIDELKDYTDGTIVH
ICGRLKSIYKELNDLNSDVVSFDSISSVTQVLKNVQNKAVMGNVSTLTIQNSSEEDVEKLANACMNLGVNILSPACGIGT
KSPIENVRSMVNAAKKRNAK
>Mature_340_residues
MLTPKERLNLALKNKEVDRPPCICPGGMMNMIIEDLMDISGYKWPEAHTDAEIMANLAISMYEQGGFENFGVPFCMTIEA
ESMGATVDLGDKTTEPRVIKYPIKSVVEWRQLKRIDLNEGREKVVLDAIKIIKDRNLPVPIMANLTGPISVASSLMEPMY
FYKELVRKKDEAHEFINFVTENLIEFGKAQLLAGANVITISDPSGTGEILGPKLFKEFVIPYINRIIDELKDYTDGTIVH
ICGRLKSIYKELNDLNSDVVSFDSISSVTQVLKNVQNKAVMGNVSTLTIQNSSEEDVEKLANACMNLGVNILSPACGIGT
KSPIENVRSMVNAAKKRNAK

Specific function: Catalyzes the transfer of the methyl group from the methylated corrinoid cofactor of mtmC, mtbC and mttC to coenzyme M [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family. MtbA/mtaA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006360
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: NA

Molecular weight: Translated: 37721; Mature: 37721

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTPKERLNLALKNKEVDRPPCICPGGMMNMIIEDLMDISGYKWPEAHTDAEIMANLAIS
CCCCHHHHCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
MYEQGGFENFGVPFCMTIEAESMGATVDLGDKTTEPRVIKYPIKSVVEWRQLKRIDLNEG
HHHCCCCCCCCCCEEEEEECCCCCCEEECCCCCCCCCEEECCHHHHHHHHHHHHCCCCCC
REKVVLDAIKIIKDRNLPVPIMANLTGPISVASSLMEPMYFYKELVRKKDEAHEFINFVT
HHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENLIEFGKAQLLAGANVITISDPSGTGEILGPKLFKEFVIPYINRIIDELKDYTDGTIVH
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
ICGRLKSIYKELNDLNSDVVSFDSISSVTQVLKNVQNKAVMGNVSTLTIQNSSEEDVEKL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCCHHHHHHH
ANACMNLGVNILSPACGIGTKSPIENVRSMVNAAKKRNAK
HHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLTPKERLNLALKNKEVDRPPCICPGGMMNMIIEDLMDISGYKWPEAHTDAEIMANLAIS
CCCCHHHHCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
MYEQGGFENFGVPFCMTIEAESMGATVDLGDKTTEPRVIKYPIKSVVEWRQLKRIDLNEG
HHHCCCCCCCCCCEEEEEECCCCCCEEECCCCCCCCCEEECCHHHHHHHHHHHHCCCCCC
REKVVLDAIKIIKDRNLPVPIMANLTGPISVASSLMEPMYFYKELVRKKDEAHEFINFVT
HHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENLIEFGKAQLLAGANVITISDPSGTGEILGPKLFKEFVIPYINRIIDELKDYTDGTIVH
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
ICGRLKSIYKELNDLNSDVVSFDSISSVTQVLKNVQNKAVMGNVSTLTIQNSSEEDVEKL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCCHHHHHHH
ANACMNLGVNILSPACGIGTKSPIENVRSMVNAAKKRNAK
HHHHHHCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]