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The map label for this gene is panE [C]

Identifier: 148379156

GI number: 148379156

Start: 1285341

End: 1286252

Strand: Direct

Name: panE [C]

Synonym: CBO1170

Alternate gene names: 148379156

Gene position: 1285341-1286252 (Clockwise)

Preceding gene: 148379155

Following gene: 148379157

Centisome position: 33.07

GC content: 26.75

Gene sequence:

>912_bases
ATGAAAATTGCTATAGTGGGTTCTGGAGCTATGGGATCCTTATATGGAGCTTATTTACATAAAAGTGGAGAGGAAGTTTA
TTTAATTAATAAATGGAAAGAACATATAAACACTATAAATGAAGTGGGATTAGTAATAGAAGAAGGAGATAAAAAATTAA
AATTTTATCCAAAGGCTGTTACAAATTCTAAGGATATAGGTATAGTAGATTTGGCAATAGTATTTGTAAAATCTACAAAA
ACAGAGGAAGCAATTTTAGAAAATAAAAATATAATAGGAGAAAATACCTATGTTTTAACTCTTCAAAATGGATATGGAAA
TGGAGAAAAAATAGAAAAATATATAAATAAGAATAGAATAATAGTAGGAACTACTGGTGAAGGATGTACTACCATAAAGG
CAGGATATATAAAACATGCAGGTTCAGGAGATACTTACATAGGTATGTTTTCTGGGAAAGAAGATAATATTTTAAAAAGG
TTAGAAAATATTTTAAATAATAGCGGTTTTAATGCACATATATGCAAAGATCCTAGAGAACTTATCTGGGATAAACTTAT
TATAAATATTGGAATTAATGCTATAACAGCTATTTTAGGTATAAAAAATGGTGAAATTTTAAAGGAAATGGTTACAAAAA
AAATTATGAAAGATGCGGTTATAGAGGCAGTAAAGGTAGCTAATGCTAAAGGTCTTAGTTTTAATGAGGAAGAAATGATA
AAAAAAGTAGAAAATGTAGCCTTAAAAACAGCAGAAAATAAATCCTCTATGTTGCAAGATGTTCTAAATAATAAAAAAAC
AGAAATAGAGAATATAAATGGAGCTATTGTAAAAGAAGGAAGTAAATTTAATATAAAGACATCTGTAAACGAAACTCTAA
CTAATTTAATAATTTCTCTAGAAAAGAAATAG

Upstream 100 bases:

>100_bases
CTAGCACAATTATTTTTATTCATTTGAGTATTATTAACCGGAGAATGGTATAAGAATATTAAAAATGGTATAAAAAATTA
ATAAATTTGGGGGAGAGAAT

Downstream 100 bases:

>100_bases
GCTTCTAACACTGCAAAGATAAAAAATATGCTCATAAATCAATTCATTTCTCTAATAAGTTTTAAATATGACTTCATTAA
AATTATATTAAAGTTAAATT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MKIAIVGSGAMGSLYGAYLHKSGEEVYLINKWKEHINTINEVGLVIEEGDKKLKFYPKAVTNSKDIGIVDLAIVFVKSTK
TEEAILENKNIIGENTYVLTLQNGYGNGEKIEKYINKNRIIVGTTGEGCTTIKAGYIKHAGSGDTYIGMFSGKEDNILKR
LENILNNSGFNAHICKDPRELIWDKLIINIGINAITAILGIKNGEILKEMVTKKIMKDAVIEAVKVANAKGLSFNEEEMI
KKVENVALKTAENKSSMLQDVLNNKKTEIENINGAIVKEGSKFNIKTSVNETLTNLIISLEKK

Sequences:

>Translated_303_residues
MKIAIVGSGAMGSLYGAYLHKSGEEVYLINKWKEHINTINEVGLVIEEGDKKLKFYPKAVTNSKDIGIVDLAIVFVKSTK
TEEAILENKNIIGENTYVLTLQNGYGNGEKIEKYINKNRIIVGTTGEGCTTIKAGYIKHAGSGDTYIGMFSGKEDNILKR
LENILNNSGFNAHICKDPRELIWDKLIINIGINAITAILGIKNGEILKEMVTKKIMKDAVIEAVKVANAKGLSFNEEEMI
KKVENVALKTAENKSSMLQDVLNNKKTEIENINGAIVKEGSKFNIKTSVNETLTNLIISLEKK
>Mature_303_residues
MKIAIVGSGAMGSLYGAYLHKSGEEVYLINKWKEHINTINEVGLVIEEGDKKLKFYPKAVTNSKDIGIVDLAIVFVKSTK
TEEAILENKNIIGENTYVLTLQNGYGNGEKIEKYINKNRIIVGTTGEGCTTIKAGYIKHAGSGDTYIGMFSGKEDNILKR
LENILNNSGFNAHICKDPRELIWDKLIINIGINAITAILGIKNGEILKEMVTKKIMKDAVIEAVKVANAKGLSFNEEEMI
KKVENVALKTAENKSSMLQDVLNNKKTEIENINGAIVKEGSKFNIKTSVNETLTNLIISLEKK

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=298, Percent_Identity=28.5234899328859, Blast_Score=97, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33408; Mature: 33408

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAIVGSGAMGSLYGAYLHKSGEEVYLINKWKEHINTINEVGLVIEEGDKKLKFYPKAV
CEEEEEECCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCEEEECCCCEEEEEEHHH
TNSKDIGIVDLAIVFVKSTKTEEAILENKNIIGENTYVLTLQNGYGNGEKIEKYINKNRI
CCCCCCCCEEEEEEEEECCCHHHHHHHCCCEECCCEEEEEEECCCCCHHHHHHHHCCCCE
IVGTTGEGCTTIKAGYIKHAGSGDTYIGMFSGKEDNILKRLENILNNSGFNAHICKDPRE
EEEECCCCCEEEEECCEEECCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCHHH
LIWDKLIINIGINAITAILGIKNGEILKEMVTKKIMKDAVIEAVKVANAKGLSFNEEEMI
HHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
KKVENVALKTAENKSSMLQDVLNNKKTEIENINGAIVKEGSKFNIKTSVNETLTNLIISL
HHHHHHHHHCCCCHHHHHHHHHCCCCCHHHCCCCEEEECCCEEEEEECHHHHHHHHHHEE
EKK
CCC
>Mature Secondary Structure
MKIAIVGSGAMGSLYGAYLHKSGEEVYLINKWKEHINTINEVGLVIEEGDKKLKFYPKAV
CEEEEEECCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCEEEECCCCEEEEEEHHH
TNSKDIGIVDLAIVFVKSTKTEEAILENKNIIGENTYVLTLQNGYGNGEKIEKYINKNRI
CCCCCCCCEEEEEEEEECCCHHHHHHHCCCEECCCEEEEEEECCCCCHHHHHHHHCCCCE
IVGTTGEGCTTIKAGYIKHAGSGDTYIGMFSGKEDNILKRLENILNNSGFNAHICKDPRE
EEEECCCCCEEEEECCEEECCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCHHH
LIWDKLIINIGINAITAILGIKNGEILKEMVTKKIMKDAVIEAVKVANAKGLSFNEEEMI
HHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
KKVENVALKTAENKSSMLQDVLNNKKTEIENINGAIVKEGSKFNIKTSVNETLTNLIISL
HHHHHHHHHCCCCHHHHHHHHHCCCCCHHHCCCCEEEECCCEEEEEECHHHHHHHHHHEE
EKK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11016950 [H]