Click here to switch to the map view.

The map label for this gene is add

Identifier: 148378981

GI number: 148378981

Start: 1086105

End: 1087112

Strand: Reverse

Name: add

Synonym: CBO0991

Alternate gene names: 148378981

Gene position: 1087112-1086105 (Counterclockwise)

Preceding gene: 148378984

Following gene: 148378968

Centisome position: 27.97

GC content: 28.77

Gene sequence:

>1008_bases
TTGAATTTTAAAAAACTTCCTAAAATAGAGTTACATTGCCATTTAGATGGTTCATTGAGAATAGACACAATATTAGATAT
AGCTAAAAAAGATAATATTCCTCTTCCTAGCTATAATAAAAAGGAGCTTATAAATTATGTTTCCATAATGGATGACTGTA
ATTCCCTAGATGAATACTTAAATAAGTTTTTTATACCTAACAAAGTTATGCAAACAAAGGAAAATTTAAAAAGAATAGCA
TTTGAATTATTAGAAGATGTTGCAGCAGATAATGTAAAATATATAGAAGTAAGATTTGCCCCTCTTTTACATGTTGAAAA
AGGATTAAATATTGAAGAAATTATAGAAAGTGTATTAGCAGGAATTAAAGAAGCCGAAAAGCTTTATGATATAAAAGGTA
ATTTAATATTAGGTTGTATGAGAAATATGGATATTCCTTCAGCCTTTGAAGTTGTAAAAAAAGGAGCCAAATTTATTGGA
AAAGGTGTTGTTGCTATAGACCTTTGTGCTGGTGAAGAACCCCATTTTCCAGGAAAATATATAGAAGTTTTAAAATTAGC
CAAAGAATGTGGTTATAGAATAACTATACATGCTGGAGAAGCTGGCGTAGGCGAAAATGTTTTAGAAGCTATAAATCTTT
TAAATGCTGAAAGAATAGGCCATGGAATATATATTAAAAATTGTGCCGAAGCTTATAAACTTGTAAAAGAAAAAAATATT
CCACTAGAGGTGTGTCCAACAAGTAATCTGCATACTAAAGCTTTCGAAAGCTATGAAACCCATCCTTTTATGGATTTTCT
AAAAGATGGTATTAAGGTTACTATTAATACTGATAATATGACAGTATCTAATACTACCATAACAAAAGAACTAGAAATGC
TTAATAAGTTTTGCGGTTTATCTATAGAAGATTATAAAATACTATATCTAAATGCAGTAGAGGCATCTTTTGCATCTCCT
GAAACAAAAGAAATACTTAAATCATATGCTAATGAAATTACGGCTTAA

Upstream 100 bases:

>100_bases
TCTTTACACAAATTAAATAATAAATTATAATTAAGTTTAACATTTTTAATAGATTTACTATAAGAATTACCTTAACCGGT
AATAGCAAGGAGTGACTAAT

Downstream 100 bases:

>100_bases
AAGGGAGTTATACCTACCTTGGTTAAAAAAAGGATATATGGTTAGAAAGGCAGCTCACTTCGATAAGAGCTTCTAATTTA
TTTTTTCTTAAAATATATGA

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MNFKKLPKIELHCHLDGSLRIDTILDIAKKDNIPLPSYNKKELINYVSIMDDCNSLDEYLNKFFIPNKVMQTKENLKRIA
FELLEDVAADNVKYIEVRFAPLLHVEKGLNIEEIIESVLAGIKEAEKLYDIKGNLILGCMRNMDIPSAFEVVKKGAKFIG
KGVVAIDLCAGEEPHFPGKYIEVLKLAKECGYRITIHAGEAGVGENVLEAINLLNAERIGHGIYIKNCAEAYKLVKEKNI
PLEVCPTSNLHTKAFESYETHPFMDFLKDGIKVTINTDNMTVSNTTITKELEMLNKFCGLSIEDYKILYLNAVEASFASP
ETKEILKSYANEITA

Sequences:

>Translated_335_residues
MNFKKLPKIELHCHLDGSLRIDTILDIAKKDNIPLPSYNKKELINYVSIMDDCNSLDEYLNKFFIPNKVMQTKENLKRIA
FELLEDVAADNVKYIEVRFAPLLHVEKGLNIEEIIESVLAGIKEAEKLYDIKGNLILGCMRNMDIPSAFEVVKKGAKFIG
KGVVAIDLCAGEEPHFPGKYIEVLKLAKECGYRITIHAGEAGVGENVLEAINLLNAERIGHGIYIKNCAEAYKLVKEKNI
PLEVCPTSNLHTKAFESYETHPFMDFLKDGIKVTINTDNMTVSNTTITKELEMLNKFCGLSIEDYKILYLNAVEASFASP
ETKEILKSYANEITA
>Mature_335_residues
MNFKKLPKIELHCHLDGSLRIDTILDIAKKDNIPLPSYNKKELINYVSIMDDCNSLDEYLNKFFIPNKVMQTKENLKRIA
FELLEDVAADNVKYIEVRFAPLLHVEKGLNIEEIIESVLAGIKEAEKLYDIKGNLILGCMRNMDIPSAFEVVKKGAKFIG
KGVVAIDLCAGEEPHFPGKYIEVLKLAKECGYRITIHAGEAGVGENVLEAINLLNAERIGHGIYIKNCAEAYKLVKEKNI
PLEVCPTSNLHTKAFESYETHPFMDFLKDGIKVTINTDNMTVSNTTITKELEMLNKFCGLSIEDYKILYLNAVEASFASP
ETKEILKSYANEITA

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family

Homologues:

Organism=Homo sapiens, GI47078295, Length=340, Percent_Identity=32.9411764705882, Blast_Score=174, Evalue=9e-44,
Organism=Homo sapiens, GI226693318, Length=343, Percent_Identity=25.0728862973761, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI61175224, Length=252, Percent_Identity=26.1904761904762, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1787910, Length=324, Percent_Identity=32.7160493827161, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17538512, Length=334, Percent_Identity=30.2395209580838, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI32565969, Length=334, Percent_Identity=30.2395209580838, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI115537133, Length=329, Percent_Identity=28.2674772036474, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324188, Length=336, Percent_Identity=24.4047619047619, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24645260, Length=338, Percent_Identity=29.585798816568, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADD_CLOB1 (A7FSN7)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001383364.1
- ProteinModelPortal:   A7FSN7
- SMR:   A7FSN7
- STRING:   A7FSN7
- GeneID:   5397081
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_1030
- eggNOG:   COG1816
- HOGENOM:   HBG630382
- OMA:   PYYMAMN
- ProtClustDB:   PRK09358
- BioCyc:   CBOT441770:CLB_1030-MONOMER
- HAMAP:   MF_00540
- InterPro:   IPR001365
- InterPro:   IPR006330
- PANTHER:   PTHR11409
- TIGRFAMs:   TIGR01430

Pfam domain/function: PF00962 A_deaminase

EC number: =3.5.4.4

Molecular weight: Translated: 37683; Mature: 37683

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00485 A_DEAMINASE

Important sites: ACT_SITE 200-200 BINDING 14-14 BINDING 16-16

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFKKLPKIELHCHLDGSLRIDTILDIAKKDNIPLPSYNKKELINYVSIMDDCNSLDEYL
CCCCCCCCEEEEEECCCCEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
NKFFIPNKVMQTKENLKRIAFELLEDVAADNVKYIEVRFAPLLHVEKGLNIEEIIESVLA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHCCCCHHHHHHHHHH
GIKEAEKLYDIKGNLILGCMRNMDIPSAFEVVKKGAKFIGKGVVAIDLCAGEEPHFPGKY
HHHHHHHHHHCCCCEEEEEHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHH
IEVLKLAKECGYRITIHAGEAGVGENVLEAINLLNAERIGHGIYIKNCAEAYKLVKEKNI
HHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHCCC
PLEVCPTSNLHTKAFESYETHPFMDFLKDGIKVTINTDNMTVSNTTITKELEMLNKFCGL
CEEECCCCCCCHHHHHCCCCCHHHHHHHCCEEEEEECCCEEECCCHHHHHHHHHHHHHCC
SIEDYKILYLNAVEASFASPETKEILKSYANEITA
CCCCEEEEEEEEHHHHCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNFKKLPKIELHCHLDGSLRIDTILDIAKKDNIPLPSYNKKELINYVSIMDDCNSLDEYL
CCCCCCCCEEEEEECCCCEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
NKFFIPNKVMQTKENLKRIAFELLEDVAADNVKYIEVRFAPLLHVEKGLNIEEIIESVLA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHCCCCHHHHHHHHHH
GIKEAEKLYDIKGNLILGCMRNMDIPSAFEVVKKGAKFIGKGVVAIDLCAGEEPHFPGKY
HHHHHHHHHHCCCCEEEEEHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHH
IEVLKLAKECGYRITIHAGEAGVGENVLEAINLLNAERIGHGIYIKNCAEAYKLVKEKNI
HHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHCCC
PLEVCPTSNLHTKAFESYETHPFMDFLKDGIKVTINTDNMTVSNTTITKELEMLNKFCGL
CEEECCCCCCCHHHHHCCCCCHHHHHHHCCEEEEEECCCEEECCCHHHHHHHHHHHHHCC
SIEDYKILYLNAVEASFASPETKEILKSYANEITA
CCCCEEEEEEEEHHHHCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA