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The map label for this gene is tolC [H]

Identifier: 148360649

GI number: 148360649

Start: 872632

End: 873999

Strand: Reverse

Name: tolC [H]

Synonym: LPC_2595

Alternate gene names: 148360649

Gene position: 873999-872632 (Counterclockwise)

Preceding gene: 148360648

Following gene: 148360650

Centisome position: 24.44

GC content: 41.52

Gene sequence:

>1368_bases
ATGAGAAAATCTCTGTTTTGTTGGATTTTAACTTTAGGTGTTTCAACCCATGCGTTTGCAACAGACCTAATGGATATCTA
TCAACAAGCTCTGGAGAACGATACCATTTTTAAAGAGGCATATGATACCTATATGTCCAGTACTGAAGCCATTCCTCAAG
CTCGAGCAGCACTTTACCCTCAAGTAGGCCTTGGTTCACAGGCTGGCCGCAATTATCAGGATGCTGTTGCTGGAGCGTTC
AGTGCGAATCAGTACTATGGAAGCTATTTGTGGCAAGTCAAGGCTTCTCAGGCACTCTTTAACTATCAGGCATGGGCTCA
GGTAGCCCAGGCTAAAGCGTCTGTTAAAGCAGCACAAGCCAGTTTCAATGATGCAGCTCAGAATTTAATTCTAAGAACAG
CCAAAGCCTATTTTGATGTCCTGTTTGCCAAAGACACCTTAGACTTTGCCGAAGCAAAAAAACGGGCGAACAAAAGACAA
TATGATCAAGCAACTCAACGTTTTCAAGTTGGTCTGGATGCCATTACTTCTGTATATGAAGCGAAGGCAGCGTATGATCA
ATCCATAGCGACAGTTATCGCCGCACGCAATAATCAGATTAACCAGAGTGAAAATTTACGAAAACTTACTAATCACGTAT
ACGAAACACTCGCGCCACTCAAAGACAGTAAAATTCCTCTTGTTAAACCAGAGCCGAATGACGTGAATCAATGGATAGAT
ACCGGGCTTAAGCAAAACTATAAATTATATGCTGCAAAGTATAATCTTGAGGTGGCAAAAGAGAATGTAAAAGCGATCTC
TGCCGGTAACTGGCCAGTATTTTCGCTACAGAGCAATGCCAGTCAGGTACATAATAACGCATCTGGCAATAATGTTTTTA
TTCCATCAAAGCAAACCCAGGCTAATATTGCAATCGCAATGAATTTTCCTGTTTTTCAAGGCGGCCTGGTCCAGGCTCAG
ACCCGACAAGCTCAATATAACTTTCAGTCTACGAGTGAAAAACTGGAACAAACGTATCGTGATGTCATTGTAAACAGTCG
GATTGCTTTCAATACCATCACTGATGGGATAAGTAAGGTAAAGGCAGACAGACAAACAGTCATCTCCGTGCAAAATTCTT
TGCAAAGTACTGAAGCTCAATTTGAAGTTGGTACTCGAACCATGGTAGATGTGGTCAATGCTCAACAAAGATTGTTTGAA
GCACAGGAACAATTAGCCCGGGATCAATACGATTTGATTAATTCCATCCTTACGCTGAAATACCTTGCAGGGACATTAAA
CGTTAATGATCTCGAACAGATTAACTCATGGTTAGCAACTACACGTGTCAATGGATTTTCACCCGTAGATAACAAAACCT
CCAAATAA

Upstream 100 bases:

>100_bases
ATAATGCAATCTGGACAGAATCCATGCTTTTTGAAACGGATATACCTCCTCTGGTAGATCAATTGAAACCGAAAGAATTT
GTTTTCTAGGGAAAGCTCGA

Downstream 100 bases:

>100_bases
CAAATTTAGGTTTTCTTATGTCTTCCAATCCTTCTTCAGTTGAAAAAAAATTACTCCATTATACAGGTAAAGCCATAGCT
GATTTTAATATGATCCGGCA

Product: outer membrane protein TolC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MRKSLFCWILTLGVSTHAFATDLMDIYQQALENDTIFKEAYDTYMSSTEAIPQARAALYPQVGLGSQAGRNYQDAVAGAF
SANQYYGSYLWQVKASQALFNYQAWAQVAQAKASVKAAQASFNDAAQNLILRTAKAYFDVLFAKDTLDFAEAKKRANKRQ
YDQATQRFQVGLDAITSVYEAKAAYDQSIATVIAARNNQINQSENLRKLTNHVYETLAPLKDSKIPLVKPEPNDVNQWID
TGLKQNYKLYAAKYNLEVAKENVKAISAGNWPVFSLQSNASQVHNNASGNNVFIPSKQTQANIAIAMNFPVFQGGLVQAQ
TRQAQYNFQSTSEKLEQTYRDVIVNSRIAFNTITDGISKVKADRQTVISVQNSLQSTEAQFEVGTRTMVDVVNAQQRLFE
AQEQLARDQYDLINSILTLKYLAGTLNVNDLEQINSWLATTRVNGFSPVDNKTSK

Sequences:

>Translated_455_residues
MRKSLFCWILTLGVSTHAFATDLMDIYQQALENDTIFKEAYDTYMSSTEAIPQARAALYPQVGLGSQAGRNYQDAVAGAF
SANQYYGSYLWQVKASQALFNYQAWAQVAQAKASVKAAQASFNDAAQNLILRTAKAYFDVLFAKDTLDFAEAKKRANKRQ
YDQATQRFQVGLDAITSVYEAKAAYDQSIATVIAARNNQINQSENLRKLTNHVYETLAPLKDSKIPLVKPEPNDVNQWID
TGLKQNYKLYAAKYNLEVAKENVKAISAGNWPVFSLQSNASQVHNNASGNNVFIPSKQTQANIAIAMNFPVFQGGLVQAQ
TRQAQYNFQSTSEKLEQTYRDVIVNSRIAFNTITDGISKVKADRQTVISVQNSLQSTEAQFEVGTRTMVDVVNAQQRLFE
AQEQLARDQYDLINSILTLKYLAGTLNVNDLEQINSWLATTRVNGFSPVDNKTSK
>Mature_455_residues
MRKSLFCWILTLGVSTHAFATDLMDIYQQALENDTIFKEAYDTYMSSTEAIPQARAALYPQVGLGSQAGRNYQDAVAGAF
SANQYYGSYLWQVKASQALFNYQAWAQVAQAKASVKAAQASFNDAAQNLILRTAKAYFDVLFAKDTLDFAEAKKRANKRQ
YDQATQRFQVGLDAITSVYEAKAAYDQSIATVIAARNNQINQSENLRKLTNHVYETLAPLKDSKIPLVKPEPNDVNQWID
TGLKQNYKLYAAKYNLEVAKENVKAISAGNWPVFSLQSNASQVHNNASGNNVFIPSKQTQANIAIAMNFPVFQGGLVQAQ
TRQAQYNFQSTSEKLEQTYRDVIVNSRIAFNTITDGISKVKADRQTVISVQNSLQSTEAQFEVGTRTMVDVVNAQQRLFE
AQEQLARDQYDLINSILTLKYLAGTLNVNDLEQINSWLATTRVNGFSPVDNKTSK

Specific function: Required for proper expression of outer membrane protein genes such as ompF, nmpC, protein 2, hemolysin, colicin V, or colicin E1. May be specialized for signal sequence independent, extracellular secretion in Gram-negative bacteria [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI87082199, Length=428, Percent_Identity=36.4485981308411, Blast_Score=239, Evalue=2e-64,

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010130 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 50748; Mature: 50748

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS00589 PTS_HPR_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure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HHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8801424 [H]