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The map label for this gene is sdhL [H]

Identifier: 148360558

GI number: 148360558

Start: 972995

End: 974371

Strand: Reverse

Name: sdhL [H]

Synonym: LPC_2502

Alternate gene names: 148360558

Gene position: 974371-972995 (Counterclockwise)

Preceding gene: 148360554

Following gene: 148360564

Centisome position: 27.24

GC content: 41.25

Gene sequence:

>1377_bases
ATGAACATTAGTGTTTTTGATTTATTTTCTATAGGAATTGGGCCATCAAGCTCACACACAGTAGGCCCTATGTTAGCTGC
CAATGCTTTTTTGCAATTACTGGAACAAAAAAATCTGTTTGATAAAACTCAGAGAGTCAAAGTAGAGCTTTATGGTTCGC
TGGCGCTTACTGGCAAGGGGCACGGTACTGATAAAGCGATTTTAAATGGTCTTGAAAACAAAGCGCCCGAGACAGTTGAT
CCTGCCTCCATGATCCCAAGAATGCATGAAATTCTTGATTCTAATCTACTCAATTTGGCCGGCAAGAAAGAAATTCCTTT
TCATGAAGCGACCGATTTTTTATTTTTACAAAAAGAATTATTACCCAAACACAGTAATGGAATGCGCTTTTCTGCTTTTG
ATGGAAACGCTAATCTACTGATTGAGCAAGTCTATTACTCTATTGGCGGTGGTTTTATTACAACTGAAGAAGACTTTGAT
AAATCAACAACCGATACCAATCCCCCCCCTTACCCCTTTGCAACAGCAACTGAGTTATTGAAATTATGCAAAAAACATCA
CTTGACCATCGCTGAATTGATGTTAGTCAATGAAAAAACATGGAGAAGTACAGCAGAAATTCATAAAGGAATTCTTGATA
TTGCCAAAGTAATGGATGACTGCATCAACAACGGTTGCAAACATGATGGAGTGCTCCCCGGTGGCCTTAATTTAAAGCGA
CGGGCACCTGACTTGTATAGAAAACTAATAGAACAAAAAGGGGTTAAAAGTGTTTTTGAACAGTCAGATATTATGAATCA
TTTGAACCTTTATGCTATGGCTGTCAATGAAGAAAACGCAGCGGGAGGACGAATTGTCACAGCCCCAACAAATGGAGCTG
CCGGAATTATTCCAGCTGTTCTTAAATATTGTCAGCAAGCTCATGACAGGATGAGTAATGAAGACATCTACACTTATTTT
CTGACTGCCGCAGCAATTGGAATCCTTTATAAAAAAGGCGCTTCAATTTCTGGCGCTGAAGTAGGATGCCAAGGTGAGGT
TGGTGTTGCCTCTTCTATGGCAGCTGCTGGTTTGACAGCGGTTCTTGGCGGAACCATCGAGCAGGTTGAAAATGCTGCAG
AAATTGCAATGGAACATCATCTGGGAATGACCTGTGATCCCGTTCTGGGCCTTGTGCAAATCCCATGCATCGAGAGAAAT
GCCATGGGGGCTGTGAAAGCAGTTAATGCAACCCGAATGGCACTCATAGGTGATGGTCAGCATCAAATCTCTTTAGATAA
AGTCATCAAAACAATGAAGCAAACCGGCATGGATATGCAAAGTATCTATAAGGAAACTTCCATGGGTGGATTGGCTGTTA
ACTTGCCTGAGTGTTAG

Upstream 100 bases:

>100_bases
TTGCCCTGCAGTCATAAGCTATCATTTAATTATATAATGGACAAAAAGGTAATATCCTTCTACACTTGCCCCTAATAATG
AACAAGAGATTTTAACGGCG

Downstream 100 bases:

>100_bases
TTATCACCGCTCCCTCACGGTCGCGGCTCGGATGATTAAATCAAATGATAATTAAACCTGAGCCGCGACCGTGAAGGAGC
GGATAACAAATTATCTAATT

Product: L-serine dehydratase

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MNISVFDLFSIGIGPSSSHTVGPMLAANAFLQLLEQKNLFDKTQRVKVELYGSLALTGKGHGTDKAILNGLENKAPETVD
PASMIPRMHEILDSNLLNLAGKKEIPFHEATDFLFLQKELLPKHSNGMRFSAFDGNANLLIEQVYYSIGGGFITTEEDFD
KSTTDTNPPPYPFATATELLKLCKKHHLTIAELMLVNEKTWRSTAEIHKGILDIAKVMDDCINNGCKHDGVLPGGLNLKR
RAPDLYRKLIEQKGVKSVFEQSDIMNHLNLYAMAVNEENAAGGRIVTAPTNGAAGIIPAVLKYCQQAHDRMSNEDIYTYF
LTAAAIGILYKKGASISGAEVGCQGEVGVASSMAAAGLTAVLGGTIEQVENAAEIAMEHHLGMTCDPVLGLVQIPCIERN
AMGAVKAVNATRMALIGDGQHQISLDKVIKTMKQTGMDMQSIYKETSMGGLAVNLPEC

Sequences:

>Translated_458_residues
MNISVFDLFSIGIGPSSSHTVGPMLAANAFLQLLEQKNLFDKTQRVKVELYGSLALTGKGHGTDKAILNGLENKAPETVD
PASMIPRMHEILDSNLLNLAGKKEIPFHEATDFLFLQKELLPKHSNGMRFSAFDGNANLLIEQVYYSIGGGFITTEEDFD
KSTTDTNPPPYPFATATELLKLCKKHHLTIAELMLVNEKTWRSTAEIHKGILDIAKVMDDCINNGCKHDGVLPGGLNLKR
RAPDLYRKLIEQKGVKSVFEQSDIMNHLNLYAMAVNEENAAGGRIVTAPTNGAAGIIPAVLKYCQQAHDRMSNEDIYTYF
LTAAAIGILYKKGASISGAEVGCQGEVGVASSMAAAGLTAVLGGTIEQVENAAEIAMEHHLGMTCDPVLGLVQIPCIERN
AMGAVKAVNATRMALIGDGQHQISLDKVIKTMKQTGMDMQSIYKETSMGGLAVNLPEC
>Mature_458_residues
MNISVFDLFSIGIGPSSSHTVGPMLAANAFLQLLEQKNLFDKTQRVKVELYGSLALTGKGHGTDKAILNGLENKAPETVD
PASMIPRMHEILDSNLLNLAGKKEIPFHEATDFLFLQKELLPKHSNGMRFSAFDGNANLLIEQVYYSIGGGFITTEEDFD
KSTTDTNPPPYPFATATELLKLCKKHHLTIAELMLVNEKTWRSTAEIHKGILDIAKVMDDCINNGCKHDGVLPGGLNLKR
RAPDLYRKLIEQKGVKSVFEQSDIMNHLNLYAMAVNEENAAGGRIVTAPTNGAAGIIPAVLKYCQQAHDRMSNEDIYTYF
LTAAAIGILYKKGASISGAEVGCQGEVGVASSMAAAGLTAVLGGTIEQVENAAEIAMEHHLGMTCDPVLGLVQIPCIERN
AMGAVKAVNATRMALIGDGQHQISLDKVIKTMKQTGMDMQSIYKETSMGGLAVNLPEC

Specific function: Anaerobic degradation of L-threonine to propionate. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI48994925, Length=454, Percent_Identity=53.3039647577093, Blast_Score=449, Evalue=1e-127,
Organism=Escherichia coli, GI1788116, Length=455, Percent_Identity=50.989010989011, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1789161, Length=459, Percent_Identity=50.1089324618736, Blast_Score=422, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 49477; Mature: 49477

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNISVFDLFSIGIGPSSSHTVGPMLAANAFLQLLEQKNLFDKTQRVKVELYGSLALTGKG
CCCEEEEHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEEECCC
HGTDKAILNGLENKAPETVDPASMIPRMHEILDSNLLNLAGKKEIPFHEATDFLFLQKEL
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LPKHSNGMRFSAFDGNANLLIEQVYYSIGGGFITTEEDFDKSTTDTNPPPYPFATATELL
CCCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHH
KLCKKHHLTIAELMLVNEKTWRSTAEIHKGILDIAKVMDDCINNGCKHDGVLPGGLNLKR
HHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
RAPDLYRKLIEQKGVKSVFEQSDIMNHLNLYAMAVNEENAAGGRIVTAPTNGAAGIIPAV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCEEEECCCCCCCHHHHHH
LKYCQQAHDRMSNEDIYTYFLTAAAIGILYKKGASISGAEVGCQGEVGVASSMAAAGLTA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
VLGGTIEQVENAAEIAMEHHLGMTCDPVLGLVQIPCIERNAMGAVKAVNATRMALIGDGQ
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHCCHHEEEEEECCC
HQISLDKVIKTMKQTGMDMQSIYKETSMGGLAVNLPEC
CCEEHHHHHHHHHHHCCCHHHHHHHHCCCCEEEECCCC
>Mature Secondary Structure
MNISVFDLFSIGIGPSSSHTVGPMLAANAFLQLLEQKNLFDKTQRVKVELYGSLALTGKG
CCCEEEEHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEEECCC
HGTDKAILNGLENKAPETVDPASMIPRMHEILDSNLLNLAGKKEIPFHEATDFLFLQKEL
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LPKHSNGMRFSAFDGNANLLIEQVYYSIGGGFITTEEDFDKSTTDTNPPPYPFATATELL
CCCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHH
KLCKKHHLTIAELMLVNEKTWRSTAEIHKGILDIAKVMDDCINNGCKHDGVLPGGLNLKR
HHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
RAPDLYRKLIEQKGVKSVFEQSDIMNHLNLYAMAVNEENAAGGRIVTAPTNGAAGIIPAV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCEEEECCCCCCCHHHHHH
LKYCQQAHDRMSNEDIYTYFLTAAAIGILYKKGASISGAEVGCQGEVGVASSMAAAGLTA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
VLGGTIEQVENAAEIAMEHHLGMTCDPVLGLVQIPCIERNAMGAVKAVNATRMALIGDGQ
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHCCHHEEEEEECCC
HQISLDKVIKTMKQTGMDMQSIYKETSMGGLAVNLPEC
CCEEHHHHHHHHHHHCCCHHHHHHHHCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]