Click here to switch to the map view.

The map label for this gene is pdxB [H]

Identifier: 148360434

GI number: 148360434

Start: 1098181

End: 1099233

Strand: Reverse

Name: pdxB [H]

Synonym: LPC_2373

Alternate gene names: 148360434

Gene position: 1099233-1098181 (Counterclockwise)

Preceding gene: 148360433

Following gene: 148360440

Centisome position: 30.74

GC content: 38.65

Gene sequence:

>1053_bases
ATGAATATTTTAGCAGATGCTTTATTGCCAGGATTGGATAGTGCTTTTCCACCACCATTTACCGTAACCTTGTATCATAA
GGCCGATGAAATTCCAGAATTGCTTCATCATAAGGACGTTCTTCTTTGTCGTTCAACTCTAAAAATCAATGGCGATTTAC
TAAAAAACCATCAAATAAAGGTTGTTGCTACAGCAACCAGTGGAACCGATCATATTGATTTTCCTTTTTTAGAATCACAA
AACATATCTATTATTGATGCCAAAGGATGCAATGCCATATCGGTTGCTGACTATGTTGTTGCTTGCCTTGCCTATTTAGA
TAAACAGCAACTTATTCAAGGTAAAACAGCAGGAATTATTGGTTTAGGGCAAGTAGGTACTAAAGTTTATGAACGACTAA
ATGCTGCCGAATTTCAGTTATGCCTTTATGACCCACCCAAAGCAACCAGAGATACTTCTTTTCAAAGCTGCTCTCTTGAA
GATCTTTTTGAATGTGACCTCTTATGTGTTCATGCTGAATTACATAGCGATGCGCCCTACCCAAGCCTTAACTTAATTAA
TCGGGATTTTCTCAAGGAATTAAAACCTGGCTGCATTATCATCAATGCTTCTCGAGGAGGTATCGTTAATGAAGAAGCCC
TTTTGCATCTTGGCTCTGCCATACTTTATTGCACCGACGTCTACAATAACGAACCTCATATAGATAGCCGGATTGCCTCC
AAGGCAACTCTTTGCACACCACATATTGCAGGACACAGCCTCGAAGCTAAATTTGCTGCAGTCGCAATCGTCAGTCGTAA
ATTACATCAAATGCTTGGTCTTCCATACCCACAATTTGCAACCCCTGAAAAACCTTATAGGTTAAATGAAAACAGCGACT
GGAGAGAGTTGGCTTTATCAATATATAACCCGATTCATGAAACACTAGAATTAAAACACGCTGGAAATCTATCCTCAGCA
TTCTTGACTCTTCGCAAGAATCATCATCACCGCCATGATTTCACAACTTATTTTGATTCTGACTCAATAAAAAAGTATCC
ATTATTAGGTTAA

Upstream 100 bases:

>100_bases
TTTTAATATTGATTGTATTAATTTTTACTAATGTATTGGGATATATTCTTACTCCCCTCATCTATGGTTCATTATATATT
TTAAGCGCGATTTTTAATTT

Downstream 100 bases:

>100_bases
AGTGTTGATGTCTGTTTCTAATAATTAACCCCTGTCCCGAAATTTTAATTATTCATCAAACGTCTTACAACTTCCTGATC
AGAAAAAACATGTTTTGTAT

Product: erythronate-4-phosphate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MNILADALLPGLDSAFPPPFTVTLYHKADEIPELLHHKDVLLCRSTLKINGDLLKNHQIKVVATATSGTDHIDFPFLESQ
NISIIDAKGCNAISVADYVVACLAYLDKQQLIQGKTAGIIGLGQVGTKVYERLNAAEFQLCLYDPPKATRDTSFQSCSLE
DLFECDLLCVHAELHSDAPYPSLNLINRDFLKELKPGCIIINASRGGIVNEEALLHLGSAILYCTDVYNNEPHIDSRIAS
KATLCTPHIAGHSLEAKFAAVAIVSRKLHQMLGLPYPQFATPEKPYRLNENSDWRELALSIYNPIHETLELKHAGNLSSA
FLTLRKNHHHRHDFTTYFDSDSIKKYPLLG

Sequences:

>Translated_350_residues
MNILADALLPGLDSAFPPPFTVTLYHKADEIPELLHHKDVLLCRSTLKINGDLLKNHQIKVVATATSGTDHIDFPFLESQ
NISIIDAKGCNAISVADYVVACLAYLDKQQLIQGKTAGIIGLGQVGTKVYERLNAAEFQLCLYDPPKATRDTSFQSCSLE
DLFECDLLCVHAELHSDAPYPSLNLINRDFLKELKPGCIIINASRGGIVNEEALLHLGSAILYCTDVYNNEPHIDSRIAS
KATLCTPHIAGHSLEAKFAAVAIVSRKLHQMLGLPYPQFATPEKPYRLNENSDWRELALSIYNPIHETLELKHAGNLSSA
FLTLRKNHHHRHDFTTYFDSDSIKKYPLLG
>Mature_350_residues
MNILADALLPGLDSAFPPPFTVTLYHKADEIPELLHHKDVLLCRSTLKINGDLLKNHQIKVVATATSGTDHIDFPFLESQ
NISIIDAKGCNAISVADYVVACLAYLDKQQLIQGKTAGIIGLGQVGTKVYERLNAAEFQLCLYDPPKATRDTSFQSCSLE
DLFECDLLCVHAELHSDAPYPSLNLINRDFLKELKPGCIIINASRGGIVNEEALLHLGSAILYCTDVYNNEPHIDSRIAS
KATLCTPHIAGHSLEAKFAAVAIVSRKLHQMLGLPYPQFATPEKPYRLNENSDWRELALSIYNPIHETLELKHAGNLSSA
FLTLRKNHHHRHDFTTYFDSDSIKKYPLLG

Specific function: Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=259, Percent_Identity=27.027027027027, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4557497, Length=172, Percent_Identity=33.1395348837209, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI61743967, Length=172, Percent_Identity=33.1395348837209, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI145580575, Length=172, Percent_Identity=31.9767441860465, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI145580578, Length=172, Percent_Identity=31.9767441860465, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4557499, Length=172, Percent_Identity=31.9767441860465, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1788660, Length=354, Percent_Identity=31.9209039548023, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1787645, Length=207, Percent_Identity=23.1884057971014, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=290, Percent_Identity=26.8965517241379, Blast_Score=95, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324964, Length=250, Percent_Identity=27.6, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324055, Length=153, Percent_Identity=29.4117647058824, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921140, Length=287, Percent_Identity=24.7386759581882, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24646446, Length=292, Percent_Identity=27.3972602739726, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24646448, Length=292, Percent_Identity=27.3972602739726, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24646452, Length=292, Percent_Identity=27.3972602739726, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24646450, Length=292, Percent_Identity=27.3972602739726, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI62472511, Length=249, Percent_Identity=27.3092369477912, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR020921
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.290 [H]

Molecular weight: Translated: 38850; Mature: 38850

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILADALLPGLDSAFPPPFTVTLYHKADEIPELLHHKDVLLCRSTLKINGDLLKNHQIK
CCCCHHHHHCCCCCCCCCCEEEEEEECHHHHHHHHHCCHHEEEHHHHEECCCEECCCEEE
VVATATSGTDHIDFPFLESQNISIIDAKGCNAISVADYVVACLAYLDKQQLIQGKTAGII
EEEEECCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHCHHHHHCCCCCCEE
GLGQVGTKVYERLNAAEFQLCLYDPPKATRDTSFQSCSLEDLFECDLLCVHAELHSDAPY
EEHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHCCCEEEEEEECCCCCCC
PSLNLINRDFLKELKPGCIIINASRGGIVNEEALLHLGSAILYCTDVYNNEPHIDSRIAS
CCHHHHCHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCEEEEEEECCCCCCCHHHHHHC
KATLCTPHIAGHSLEAKFAAVAIVSRKLHQMLGLPYPQFATPEKPYRLNENSDWRELALS
CHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCHHHHHHH
IYNPIHETLELKHAGNLSSAFLTLRKNHHHRHDFTTYFDSDSIKKYPLLG
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCC
>Mature Secondary Structure
MNILADALLPGLDSAFPPPFTVTLYHKADEIPELLHHKDVLLCRSTLKINGDLLKNHQIK
CCCCHHHHHCCCCCCCCCCEEEEEEECHHHHHHHHHCCHHEEEHHHHEECCCEECCCEEE
VVATATSGTDHIDFPFLESQNISIIDAKGCNAISVADYVVACLAYLDKQQLIQGKTAGII
EEEEECCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHCHHHHHCCCCCCEE
GLGQVGTKVYERLNAAEFQLCLYDPPKATRDTSFQSCSLEDLFECDLLCVHAELHSDAPY
EEHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHCCCEEEEEEECCCCCCC
PSLNLINRDFLKELKPGCIIINASRGGIVNEEALLHLGSAILYCTDVYNNEPHIDSRIAS
CCHHHHCHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCEEEEEEECCCCCCCHHHHHHC
KATLCTPHIAGHSLEAKFAAVAIVSRKLHQMLGLPYPQFATPEKPYRLNENSDWRELALS
CHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCHHHHHHH
IYNPIHETLELKHAGNLSSAFLTLRKNHHHRHDFTTYFDSDSIKKYPLLG
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA