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The map label for this gene is 148360321

Identifier: 148360321

GI number: 148360321

Start: 1226075

End: 1227436

Strand: Direct

Name: 148360321

Synonym: LPC_2258

Alternate gene names: NA

Gene position: 1226075-1227436 (Clockwise)

Preceding gene: 148360322

Following gene: 148360320

Centisome position: 34.28

GC content: 44.05

Gene sequence:

>1362_bases
ATGAAATTAACTTTTTTAGGAGCTACTCAGACCGTCACCGGCTCAAAATATCTTTTGACCATTGGTTCTAAAAAAATTCT
GATTGATTGCGGTCTTTTTCAAGGCTACAAAGAATTACGATTACGCAACTGGGCTCCTTTACCTATTGACCCCCATGACA
TCGATGCGGTGATTATCACTCATGCCCATATTGACCACACGGGTTATTTGCCCTTATTAGTAAAAAACGGATTCCAAGGT
AAAATTTATGCAACACCGGGTACCAAAGCACTGTGTTCCATATTATTACCCGACAGTGGTTATCTGCAGGAAGAAGAAGC
CCGCTTGGCCAATAAGTATGGATTCTCCAAGCACCAACCTGCTCTTCCTCTTTATACTGAAAAAGAAGCCAGGGCTGCAT
TGCAGTATTTTGAAACCATTGATTTTGATACCCCGCATCAATTATTCCACGAGTTCAGTTTTGAGTATCATCGTGCAGGT
CACATCGTCGGTGCGGCCATGGTCAAAATAAAAACCAAAAAGGGTTCCATTGTATTTACTGGAGACATTGGCCGCCCTCA
TGATCCCGTCATGAAATCCCCGAGCGCTATTGAAGAAGCGGATTTCCTGGTGATGGAATCGACCTATGGCGACCGATTGC
ATGATGCCACAGATCCTTTGCCTCAAATGGCTCAGGTGATTAATCAAACCGTTAAACGAGGGGGCTCAGTTATTATTCCT
GCTTTTGCAGTAGGGCGAGCGCAAAGCCTTCTTTATTTTATTTACGAACTGAAACGACAGGGGAAAATTCCCAAAGACAT
TCCTGTCTTTTTAGATAGCCCCATGGCCATTGATGCCACTCATTTACTCTGCACTTATAAAGAAGACCATCATTTAACTG
CAGAGCAATGTCGAGGGTTATGCCATGTTGCCACCTATGTGAACACACCTGAGGAATCTAAGGAGATTGACAGGCATCAC
ATGCCGCAAATCATCATAGCCGCCAGTGGCATGGCGCAAGGAGGTCGTATTCTGCATCATTTGAAAGCCTTTGCACCTAA
TCCTAGAAACACTTTGTTATTTACTGGCTTTCAGGCGGGCGGGACTCGTGGTGCTCGAATTGTGAATGGGGAGAGACAAG
TCAAAATTCATGGAAGCCTTATTCCGATACAAGCCCAGGTCGTGGTTATGAGCAGTACGTCAGCTCATGCTGATTATTTG
GAATTGTTAGAATGGCTACAACATTTTGCTCGTCCACCCCAAAAAGTCTTTATCACCCATGGGGAGCCTCACAGTGCTCA
AACTCTAAAAGAGAGGATTGAAAAGCAATTAGGTTTTTCTTGCACCATTCCTTCTTATCTGCAAATGGAGGAGTTGTTAT
GA

Upstream 100 bases:

>100_bases
TTTCTGCACTTGTGCTGACCTTAATTGTGATTCCCGTGGTTTATGTGATGTGGCGGGGCCAAGTGGATTTGAAAAAAACA
GCAGGCTTAATGGAGGCAAG

Downstream 100 bases:

>100_bases
GTAAGAAAACCGCTCATGGGCTTCGTTTAAAGCATTTAGGGATTAAAACCTACCATGAGGCCATTATTTACATGCGCGAG
GATTGTCATGTTTGTCATTC

Product: metallo-beta lactamase family transporter protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MKLTFLGATQTVTGSKYLLTIGSKKILIDCGLFQGYKELRLRNWAPLPIDPHDIDAVIITHAHIDHTGYLPLLVKNGFQG
KIYATPGTKALCSILLPDSGYLQEEEARLANKYGFSKHQPALPLYTEKEARAALQYFETIDFDTPHQLFHEFSFEYHRAG
HIVGAAMVKIKTKKGSIVFTGDIGRPHDPVMKSPSAIEEADFLVMESTYGDRLHDATDPLPQMAQVINQTVKRGGSVIIP
AFAVGRAQSLLYFIYELKRQGKIPKDIPVFLDSPMAIDATHLLCTYKEDHHLTAEQCRGLCHVATYVNTPEESKEIDRHH
MPQIIIAASGMAQGGRILHHLKAFAPNPRNTLLFTGFQAGGTRGARIVNGERQVKIHGSLIPIQAQVVVMSSTSAHADYL
ELLEWLQHFARPPQKVFITHGEPHSAQTLKERIEKQLGFSCTIPSYLQMEELL

Sequences:

>Translated_453_residues
MKLTFLGATQTVTGSKYLLTIGSKKILIDCGLFQGYKELRLRNWAPLPIDPHDIDAVIITHAHIDHTGYLPLLVKNGFQG
KIYATPGTKALCSILLPDSGYLQEEEARLANKYGFSKHQPALPLYTEKEARAALQYFETIDFDTPHQLFHEFSFEYHRAG
HIVGAAMVKIKTKKGSIVFTGDIGRPHDPVMKSPSAIEEADFLVMESTYGDRLHDATDPLPQMAQVINQTVKRGGSVIIP
AFAVGRAQSLLYFIYELKRQGKIPKDIPVFLDSPMAIDATHLLCTYKEDHHLTAEQCRGLCHVATYVNTPEESKEIDRHH
MPQIIIAASGMAQGGRILHHLKAFAPNPRNTLLFTGFQAGGTRGARIVNGERQVKIHGSLIPIQAQVVVMSSTSAHADYL
ELLEWLQHFARPPQKVFITHGEPHSAQTLKERIEKQLGFSCTIPSYLQMEELL
>Mature_453_residues
MKLTFLGATQTVTGSKYLLTIGSKKILIDCGLFQGYKELRLRNWAPLPIDPHDIDAVIITHAHIDHTGYLPLLVKNGFQG
KIYATPGTKALCSILLPDSGYLQEEEARLANKYGFSKHQPALPLYTEKEARAALQYFETIDFDTPHQLFHEFSFEYHRAG
HIVGAAMVKIKTKKGSIVFTGDIGRPHDPVMKSPSAIEEADFLVMESTYGDRLHDATDPLPQMAQVINQTVKRGGSVIIP
AFAVGRAQSLLYFIYELKRQGKIPKDIPVFLDSPMAIDATHLLCTYKEDHHLTAEQCRGLCHVATYVNTPEESKEIDRHH
MPQIIIAASGMAQGGRILHHLKAFAPNPRNTLLFTGFQAGGTRGARIVNGERQVKIHGSLIPIQAQVVVMSSTSAHADYL
ELLEWLQHFARPPQKVFITHGEPHSAQTLKERIEKQLGFSCTIPSYLQMEELL

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI33300633, Length=458, Percent_Identity=28.1659388646288, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI7706427, Length=437, Percent_Identity=29.7482837528604, Blast_Score=165, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI32564696, Length=465, Percent_Identity=27.3118279569892, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI32566029, Length=448, Percent_Identity=29.9107142857143, Blast_Score=162, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6323307, Length=452, Percent_Identity=26.1061946902655, Blast_Score=137, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24648013, Length=443, Percent_Identity=30.0225733634311, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI21358523, Length=458, Percent_Identity=27.9475982532751, Blast_Score=161, Evalue=8e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 50544; Mature: 50544

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTFLGATQTVTGSKYLLTIGSKKILIDCGLFQGYKELRLRNWAPLPIDPHDIDAVIIT
CEEEEECCCEEECCCEEEEEECCCEEEEEECHHHCHHHHHHCCCCCCCCCCCCCCEEEEE
HAHIDHTGYLPLLVKNGFQGKIYATPGTKALCSILLPDSGYLQEEEARLANKYGFSKHQP
EEEECCCCCEEEEEECCCCCEEEECCCCHHHHEEECCCCCCCCHHHHHHHHHCCCCCCCC
ALPLYTEKEARAALQYFETIDFDTPHQLFHEFSFEYHRAGHIVGAAMVKIKTKKGSIVFT
CCCCEECHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHCCCEEEEEEEEEEECCCCEEEE
GDIGRPHDPVMKSPSAIEEADFLVMESTYGDRLHDATDPLPQMAQVINQTVKRGGSVIIP
ECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEE
AFAVGRAQSLLYFIYELKRQGKIPKDIPVFLDSPMAIDATHLLCTYKEDHHLTAEQCRGL
EHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEEECEEEEEEECCCCCCCHHHHCCE
CHVATYVNTPEESKEIDRHHMPQIIIAASGMAQGGRILHHLKAFAPNPRNTLLFTGFQAG
EEEEHHCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEEECCC
GTRGARIVNGERQVKIHGSLIPIQAQVVVMSSTSAHADYLELLEWLQHFARPPQKVFITH
CCCCCEEECCCEEEEEECCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEC
GEPHSAQTLKERIEKQLGFSCTIPSYLQMEELL
CCCCCHHHHHHHHHHHCCCEECCCHHHHHHHCC
>Mature Secondary Structure
MKLTFLGATQTVTGSKYLLTIGSKKILIDCGLFQGYKELRLRNWAPLPIDPHDIDAVIIT
CEEEEECCCEEECCCEEEEEECCCEEEEEECHHHCHHHHHHCCCCCCCCCCCCCCEEEEE
HAHIDHTGYLPLLVKNGFQGKIYATPGTKALCSILLPDSGYLQEEEARLANKYGFSKHQP
EEEECCCCCEEEEEECCCCCEEEECCCCHHHHEEECCCCCCCCHHHHHHHHHCCCCCCCC
ALPLYTEKEARAALQYFETIDFDTPHQLFHEFSFEYHRAGHIVGAAMVKIKTKKGSIVFT
CCCCEECHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHCCCEEEEEEEEEEECCCCEEEE
GDIGRPHDPVMKSPSAIEEADFLVMESTYGDRLHDATDPLPQMAQVINQTVKRGGSVIIP
ECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEE
AFAVGRAQSLLYFIYELKRQGKIPKDIPVFLDSPMAIDATHLLCTYKEDHHLTAEQCRGL
EHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEEECEEEEEEECCCCCCCHHHHCCE
CHVATYVNTPEESKEIDRHHMPQIIIAASGMAQGGRILHHLKAFAPNPRNTLLFTGFQAG
EEEEHHCCCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEEECCC
GTRGARIVNGERQVKIHGSLIPIQAQVVVMSSTSAHADYLELLEWLQHFARPPQKVFITH
CCCCCEEECCCEEEEEECCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEC
GEPHSAQTLKERIEKQLGFSCTIPSYLQMEELL
CCCCCHHHHHHHHHHHCCCEECCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA